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Cat No. | Product Name | Synonyms | Targets |
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T38332 | Complement factor D-IN-2 | Complement System | |
Complement factor D-IN-2 is an inhibitor of Complement factor D and reduces the excessive activation of complement factor D. | |||
T10863 | Complement C5-IN-1 | Complement System | |
Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5). | |||
T7497L | C3a 70-77 2TFA(63555-63-5(free base)) | Complement 3a (70-77) | Complement System |
C3a 70-77 2TFA(63555-63-5(free base)) (Complement 3a (70-77)) is an octapeptide corresponding to the COOH terminus of C3a. | |||
T16898 | Complement factor D-IN-1 | Others | |
Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively). | |||
T38287 | C3a Receptor Agonist | C3a receptor agonist 1,Complement 3a Receptor Agonist | Complement System |
C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestin... | |||
T80059 | Complement factor I | Endogenous Metabolite | |
Complement factor I, a serine protease, attenuates complement activity both in the fluid phase and on cell surfaces, working alongside cofactors such as factor H (FH), complement receptor 1 (CR1/CD35), C4 binding protein... | |||
T74816 | Complement C1s-IN-1 | ||
Complement C1s-IN-1 is a potent and selective C1s inhibitor that is orally active and capable of crossing the blood-brain barrier, demonstrating an IC50 value of 36 nM [1]. | |||
T9915 | Eculizumab | Complement System | |
Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5 | |||
TP1304 | Compstatin | Complement System | |
Compstatin, a cyclic tridecapeptide, which was originally discovered from phage-display libraries, is a highly potent and selective C3 inhibitor. | |||
T7497 | C3a (70-77) | Complement 3a (70-77),C3a 70-77 | Complement System |
C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a. | |||
T9316 | JR14a | 5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride | Complement System |
JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor. | |||
T9189 | Iptacopan hydrochloride | Iptacopan HCl,LNP023 hydrochloride | Complement System |
Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan hydrochloride shows direct, reversible, and high-affinity b... | |||
TP1193 | C3a (70-77) TFA (63555-63-5 free base) | C3a (70-77) TFA,Complement 3a (70-77) (TFA) | |
C3a (70-77) TFA (Complement 3a (70-77) TFA) is a COOH-terminal fragment of the C3a anaphylatoxin peptide. | |||
T8509 | Danicopan | ACH-4471 | Complement System |
Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the ... | |||
T3638 | Leukadherin-1 | Integrin , Complement System | |
Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendothelial migration; reduces inflammation. | |||
T12851 | SB290157 trifluoroacetate | Complement System | |
SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM). | |||
T17250 | W-54011 | ROS , Complement System | |
W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and g... | |||
T7776 | ADH-503 | GB1275 | Complement System |
ADH-503 (GB1275) is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression. | |||
T1076 | Dexamethasone | MK 125,Prednisolone F,NSC 34521,Hexadecadrol | Glucocorticoid Receptor , Mitophagy , IL Receptor , SARS-CoV , Antibacterial , Antibiotic , Autophagy , Complement System |
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activity and induces autophagy. Dexamethasone inhibits LPS-induced... | |||
T13379 | (Z)-Leukadherin-1 | ADH-503 free base | Complement System |
(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b. | |||
TP2180L | Compstatin control peptide acetate | Complement System | |
Compstatin control peptide acetate is an inhibitor of complement protein C3 by binding and inhibiting the cleavage of complement C3. | |||
T76867 | Ravulizumab | ALXN1210 | Complement System |
Ravulizumab (ALXN1210) is a humanized monoclonal antibody targeting complement factor 5 that specifically binds to human complement protein C5 with high affinity to block complement activation. Ravulizumab can be used fo... | |||
T64388 | 3-Phenoxybenzaldehyde | Complement System | |
3-Phenoxybenzaldehyde is a complement (classical pathway) inhibitor with IC50 of 1388μM. | |||
T12506L1 | PMX 205 acetate(514814-49-4 free base) | Complement System | |
PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88). | |||
T76702 | Sutimlimab | Complement System | |
Sutimlimab is a novel monoclonal antibody targeting complement protein C1. Sutimlimab is commonly used as a C1 inhibitor to treat cold agglutina-associated hemolysis. | |||
TP2296L | TLQP 21 acetate | Complement System | |
TLQP 21 acetate is a potent agonist of G-protein-coupled receptor complement-3a receptor 1 (C3aR1). The EC50 values are 10.3 μM for mouse and 68.8 μM for human. TLQP 21 acetate is a VGF-derived peptide with endocrine a... | |||
T38951 | Isatuximab | SAR-650984,hu38SB19,Isatuximab-irfc | Apoptosis , CD38 |
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and extracellular enzyme CD38 in malignant cells of the hematological system and is a highly expressed protein in multiple myeloma. Isatuximab has ... | |||
T12506L | PMX 205 | Others | |
PMX 205 is an effective complement antagonist of the C5a receptor. | |||
T39493 | Vemircopan | ACH0145228,ACH-5228,ALXN2050 | |
Vemircopan is a complement factor D inhibitor. | |||
T32353 | K 76 Carboxylic acid | K76 Carboxylic acid,K-76 Carboxylic acid | |
K 76 Carboxylic acid effectively blocks human complement from forming tumor cell chemokines. | |||
T77107 | Olendalizumab | ||
Olendalizumab (ALXN1007), a humanized IgG2-G4-κ antibody derived from mice, specifically targets Complement protein C5a with a binding affinity (K i) of 60 pM. This compound is designed to inhibit the complement inflamma... | |||
T74431 | Cemdisiran | ||
Cemdisiran, a conjugated siRNA with N-acetylgalactosamine (GalNAc), targets the liver to inhibit the production of complement 5 (C5) protein, serving as a potential therapeutic agent for the study of complement-mediated ... | |||
T69393 | SID-7977382 | ||
SID-7977382 is a complement factor C1 inhibitor. | |||
T12506 | PMX 205 Trifluoroacetate (514814-49-4 free base) | PMX 205 Trifluoroacetate | Others |
PMX 205 Trifluoroacetate is a potent complement antagonist of C5a receptor. | |||
T75966 | C3a (70-77) (TFA) | ||
Complement 3a (70-77) TFA is an octapeptide that corresponds to the COOH terminus of C3a and exhibits the specificity and 1 to 2% biological activities of C3a [1] [2]. | |||
T62276 | Factor B-IN-3 | ||
Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases. | |||
T73710 | PMX 205 Trifluoroacetate | ||
PMX 205 Trifluoroacetate is a potent complement C5a receptor ( C5aR ; CD88 ) antagonist. | |||
T62689 | Factor B-IN-5 | ||
Factor B-IN-5 is a potent inhibitor (IC50: 1.2 μM) of complement factor B. Factor B-IN-4 can be used to study inflammatory and immune-related diseases. | |||
T76913 | Avdoralimab | ||
Avdoralimab (IPH 5401), a fully human IgGκ monoclonal antibody, specifically inhibits the complement C5a receptor 1 (C5aR1) by preventing its interaction with C5a. This compound is utilized in research concerning complem... | |||
T77121 | Pozelimab | ||
Pozelimab (REGN3918), a fully human IgG4 monoclonal antibody, is designed to target and bind with high affinity to both C5 and its variants, effectively inhibiting complement-mediated hemolysis. It holds potential for re... | |||
T75775 | Compstatin TFA | ||
Compstatin TFA, a potent inhibitor of the complement system C3 characterized by species specificity, is a 13-residue cyclic peptide. It selectively binds to baboon C3 and demonstrates resistance to proteolytic cleavage i... | |||
T11269 | FD-IN-1 | Others | |
FD-IN-1 is a factor D (FD) inhibitor with an IC50 of 12 nM.FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5μM, respectively. Complement FD, a highly specific S1 serine protease, plays a... | |||
TP2139 | AMY-101 | Cp40 | Others |
AMY-101 (Cp40) is a peptidic inhibitor of the central complement component C3 (KD: 0.5 nM). AMY-101 shows a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation. | |||
TP2139L | AMY-101 TFA | Cp40 TFA | Others |
AMY-101 TFA (Cp40 TFA) is a peptidic inhibitor of the central complement component C3 (KD: 0.5 nM). AMY-101 TFA shows a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper in... | |||
T9695L | POT-4 acetate | POT-4 acetate (934461-40-2 free base) | Complement System |
POT-4 acetate inhibits Complement C3 activation. POT-4 acetate can be used for studies about age-related macular degeneration. | |||
T75106 | ARC186 | ||
ARC186 is a highly potent aptamer that serves as a complement inhibitor by blocking the convertase-catalyzed activation of C5. | |||
T76276 | Zilucoplan | ||
Zilucoplan (RA101495), a 15-amino acid macrocyclic peptide and potent complement component 5 (C5) inhibitor, is utilized in the study of immune-mediated necrotising myopathy (IMNM) [1] [2]. | |||
T76814 | Lampalizumab | ||
Lampalizumab (RG 7417), a humanized monoclonal antibody, selectively inhibits complement Factor D in the alternative complement pathway by binding to an exosite and sterically hindering Factor B's access to the active si... | |||
T62688 | Factor B-IN-4 | ||
Factor B-IN-4 is a potent inhibitor (IC50: 1 μM) of complement factor B. Factor B-IN-4 can be used to study inflammatory and immune-related diseases. | |||
T62292 | Factor B-IN-2 | ||
Factor B-IN-2 is a potent inhibitor (IC50: 1.5 μM) of complement factor B. Factor B-IN-2 can be used to study inflammatory and immune-related diseases. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0945 | Cyclosporin A | Cyclosporine A,Ciclosporin,Cyclosporine | Phosphatase , Antibiotic , Complement System |
Cyclosporin A is a naturally occurring cyclic polypeptide that is the active metabolite of a fungus. Cyclosporin A is an immunosuppressant that binds to procyclins and inhibits calcineurin (IC50=7 nM). | |||
T40646 | Lipoteichoic acid | Complement System | |
Lipoteichoic acid, a polymer of Staphylococcus aureus cell wall, activates the complement system by inducing C3 and inhibiting CD55, and reduces fat deposition via the IGF-1 pathway. | |||
T80869 | Versicolactone B | ||
Versicolactone B, a sesquiterpene extracted from Viola yedoensis, exhibits anti-complement activity affecting both the classical and alternative pathways [1]. | |||
T83339 | 3β-(Acetyloxy)stigmast-5-en-7-one | ||
3β-(Acetyloxy)stigmast-5-en-7-one exhibits anti-complement activity [1]. | |||
TN3430 | Apigenin 4'-O-rhamnoside | Others | |
Apigenin-4'-O-rhamnosylglucoside can strongly inhibit the classical pathway of the complement system. | |||
T82786 | Campneoside II | ||
Campneoside II, a compound extracted from the wood of Paulownia tomentosa var. tomentosa, demonstrates remarkable anti-complement activity [1]. | |||
T3S0964 | Thermopsoside | Chrysoeriol-7-O-glucoside | Others |
Chrysoeriol-7-O-glucoside can strongly inhibit the classical pathway of the complement system.Chrysoeriol-7-O-d-glucoside and luteolin-7-O-d-glucoside can inhibit palmitic acid uptake into small intestinal brush border m... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00653 | Complement C5 Protein, Human, Recombinant (Complement C5a) | Human | E. coli |
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway... | |||
TMPY-05732 | Complement C3 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
TMPY-04902 | Complement C5a Protein, Mouse, Recombinant | Mouse | E. coli |
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway... | |||
TMPY-05057 | Complement C5 Protein, Human, Recombinant (His & FLAG) | Human | HEK293 |
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway... | |||
TMPY-00686 | Complement C2 Protein, Human, Recombinant (His) | Human | HEK293 |
Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in ext... | |||
TMPY-05731 | Complement C3 Protein, Human, Recombinant (His) | Human | HEK293 |
TMPY-04921 | Complement factor B/CFB Protein, Human, Recombinant (His) | Human | HEK293 |
TMPJ-00417 | Complement C3a Protein, Human, Recombinant | Human | E. coli |
Complement is defined as key part of innate immunity and as the first line of defense in the fight against invading pathogens. Complement 3 (C3) is the most abundant component of the complement cascade and the convergent... | |||
TMPJ-00416 | Complement C3a Protein, Mouse, Recombinant | Mouse | E. coli |
Complement is defined as key part of innate immunity and as the first line of defense in the fight against invading pathogens. Complement 3 (C3) is the most abundant component of the complement cascade and the convergent... | |||
TMPY-03012 | Complement C7 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Complement component 7 is a component of the complement system. It belongs to the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and... | |||
TMPY-02892 | Complement C7 Protein, Human, Recombinant (His) | Human | HEK293 |
Complement component 7 is a component of the complement system. It belongs to the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and... | |||
TMPY-06538 | Complement C5 Protein, Cynomolgus, Recombinant | Cynomolgus | HEK293 |
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway... | |||
TMPY-06137 | Complement C5 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway... | |||
TMPY-02641 | Complement C6 Protein, Human, Recombinant (His) | Human | HEK293 |
TMPY-03447 | Complement C2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in ext... | |||
TMPY-05459 | Complement C5a Protein, Mouse, Recombinant, Biotinylated | Mouse | E. coli |
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway... | |||
TMPY-06814 | Complement C5 Protein, Human, Recombinant (Flag) | Human | HEK293 |
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway... | |||
TMPH-01133 | Complement C8b Protein, Human, Recombinant (His) | Human | E. coli |
Complement C8b Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01132 | Complement C8a Protein, Human, Recombinant (His) | Human | E. coli |
Complement C8a Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-03107 | Complement C5a Protein, Pig, Recombinant (His) | Sus scrofa (Pig) | Yeast |
Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, ... | |||
TMPH-03270 | Complement C5 Protein, Rat, Recombinant (His & Myc) | Rat | E. coli |
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the founda... | |||
TMPY-00687 | Complement C2 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in ext... | |||
TMPH-00231 | Complement C3 Protein, Bovine, Recombinant (His & SUMO) | Bovine | E. coli |
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently,... | |||
TMPH-02604 | Complement C3 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently,... | |||
TMPJ-00585 | Complement C8 gamma Protein, Human, Recombinant (His) | Human | E. coli |
Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 ... | |||
TMPY-02167 | Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293) | Mouse | HEK293 |
Complement factor D, also known as Adipsin, C3 convertase activator, Properdin factor D and CFD is a secreted protein which belongs to thepeptidase S1 family. CFD / Adipsin contains onepeptidase S1 domain. Complement ... | |||
TMPH-01134 | Complement C8g Protein, Human, Recombinant (His) | Human | E. coli |
Complement C8g Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPY-06767 | Complement C3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
TMPH-03273 | Complement factor I Protein, Rat, Recombinant (His & Myc) | Rat | Baculovirus |
Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and tw... | |||
TMPH-02607 | Complement factor B Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convert... | |||
TMPK-01268 | Complement C2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC). Significantly lower C2 expression was found at HCC compared to health... | |||
TMPY-04129 | Complement factor H/CFH Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defens... | |||
TMPJ-00980 | Complement Factor MASP3 Protein, Human, Recombinant (His) | Human | Human Cells |
MASP3 is a member of the MASPs involved in mannan-binding lectin (MBL) complement pathway. The MBL pathway is initiated by the binding of MBL to specific carbohydrate structures found on the surface of a variety of micro... | |||
TMPH-02605 | Complement C4-B Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of imm... | |||
TMPY-02183 | Complement Factor D/CFD Protein, Human, Recombinant (His) | Human | HEK293 |
Complement factor D, also known as Adipsin, C3 convertase activator, Properdin factor D and CFD is a secreted protein which belongs to thepeptidase S1 family. CFD / Adipsin contains onepeptidase S1 domain. Complement ... | |||
TMPK-01023 | Complement factor I Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes. | |||
TMPY-04141 | Complement factor H/CFH Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defens... | |||
TMPH-01131 | Complement C4-B Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Complement C4-B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPJ-00149 | Complement Factor D/CFD Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement a... | |||
TMPK-00776 | Complement factor I Protein, Human, Recombinant (His) | Human | HEK293 |
Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes. | |||
TMPH-03272 | Complement factor D Protein, Rat, Recombinant (His) | Rat | Yeast |
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classi... | |||
TMPK-00790 | Complement factor H/CFH Protein, Human, Recombinant (His) | Human | HEK293 |
Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations... | |||
TMPH-03271 | Complement factor D Protein, Rat, Recombinant (His & Myc) | Rat | HEK293 |
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classi... | |||
TMPK-00755 | Complement Factor D/CFD Protein, Human, Recombinant (hFc) | Human | HEK293 |
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge... | |||
TMPK-00151 | Complement Factor D/CFD Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge... | |||
TMPK-00671 | Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His) | Rhesus macaque | HEK293 |
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge... | |||
TMPJ-00809 | CFH Protein, Human, Recombinant (His) | Human | Human Cells |
Complement Factor H (CFH) is a secreted protein which is a member of the regulators of complement activation family and is a complement control protein. It is expressed by the liver and secreted in plasma. Its principal ... | |||
TMPH-02603 | C1SB Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. | |||
TMPY-06585 | C1s Protein, Human, Recombinant (His) | Human | HEK293 |
Complement is an integral component of the adaptive and innate immune systems and represents one of the major effector systems for the immune responses. The classical complement pathway is triggered by C1, a complex comp... | |||
TMPH-02597 | C1QA Protein, Mouse, Recombinant (His) | Mouse | Yeast |
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and effi... | |||
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