b4

12-oxo Leukotriene B4 (12-Oxo-LTB4) is a potent pro-inflammatory lipid mediator classified as a dihydroxy fatty acid that is enzymatically derived from arachidonic acid metabolism via the 5-lipoxygenase (5-LO) pathway, and it promotes a diverse array of leukocyte functional responses including cellular aggregation, stimulation of transmembrane ion fluxes, enhancement of lysosomal enzyme release, superoxide anion generation, chemotaxis, and chemokinesis; 12-oxo Leukotriene B4 is an initial oxidative metabolite formed from Leukotriene B4 via the LTB4 12-hydroxydehydrogenase pathway, which undergoes rapid enzymatic conversion first to 10,11-dihydro-12-oxo-LTB4 followed by reduction of the 12-oxo group to yield 10,11-dihydro-LTB4, and this metabolite exhibits significantly reduced biological potency, being approximately 70-fold less potent than LTB4 in stimulating Ca2+ mobilization in human neutrophils (EC50 = 33 nM vs. 0.46 nM) and also markedly less effective at stimulating neutrophil migration (EC50 = 170 nM vs. 2.7 nM).

Lipoxin B4 is a metabolite of arachidonic acid that inhibits leukocyte infiltration and mucus secretion in the nasal mucosa of the upper respiratory tract, exhibiting mucosal protective effects. It is commonly used in studies of allergic inflammation in the upper and lower respiratory tracts.

Saikosaponin B4 is isolated from the MeOH extract of the roots of Bupleurum falcatum L.

Procyanidin B4 reveals significant antioxidant activity

Pulchinenoside C (Anemoside B4) is an abundant triterpenoid saponin isolated from P. chinensis, exhibiting significant anti-inflammatory and antioxidant properties.

Pulchinenoside C (Standard) is a reference standard for research and analysis in studies involving Pulchinenoside C. Pulchinenoside C (Anemoside B4) is an abundant triterpenoid saponin isolated from P. chinensis and exerts anti-inflammatory and antioxidant effects.

Griffonia Simplicifolia Lectin I Isolectin B4 is an agglutinin isolated from the seeds of Griffonia simplicifolia. This compound recognizes and binds to glycan structures containing the Galα1-4Gal sequence, and is utilized in biochemical and immunological research.

Adenine is a purine-derived nucleobase and one of the four bases of DNA. It is an important chemical component of both DNA and RNA, involved in cellular respiration, the formation of ATP and coenzymes NAD and FAD, as well as protein synthesis. Adenine is commonly used to induce chronic kidney injury models.

Adenine hemisulfate is a purine-based nucleobase and an essential chemical component of DNA and RNA. It plays a key role in cellular respiration, the formation of ATP and coenzymes such as NAD and FAD, as well as in protein synthesis. It is commonly used to induce animal models of chronic liver and kidney injury and hyperuricemia.

Lipopolysaccharides from Escherichia coli O111:B4 are key components of the outer membrane of Gram-negative bacteria. As a smooth-type LPS, they consist of lipid A, an R3-type core oligosaccharide, and an O-specific polysaccharide. These LPS molecules exhibit high immunogenicity, can trigger strong immune responses and gastric disorders by activating the TLR-4 receptor on immune cells, and help maintain the structural integrity of the bacterial outer membrane while protecting against bile salts and lipid-based antibiotics. They are widely used to establish inflammation-related disease models, such as chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ARDS).

(-)-Asarinin (Eleutheroside B4) shows antibacterial activity.

Thymosin β4 (Tβ4) is a thymic hormone with multiple and different intracellular and extracellular activities affecting wound healing, inflammation, fibrosis and tissue regeneration.

Leukotriene B4 (LTB4) is a compound derived from arachidonic acid via the 5-lipoxygenase pathway that mediates certain inflammatory and immune responses. Leukotriene B4 induces neutrophil extracellular traps that impede the clearance of Pneumocystis japonicus.

Fumonisin B4, a fumonisin derivative, exhibits low albumin binding capacity [1].

Valtrate Hydrine B4 is a natural product demonstrating anti-leishmaniasis activity.

Fluvirucin B4 is a novel antibiotic effective against the influenza A virus.

Napyradiomycin B4 is a derivative of Napyradiomycin that inhibits the RANKL-induced MEK-ERK signaling pathway. It reduces osteoclastogenesis and prevents alveolar bone destruction in experimental periodontitis.

Arylomycin B4 is a lipidic hexapeptide antibiotic (antibiotic) targeting Gram-positive bacteria.

Cerexin B4 exhibits activity against Gram-positive bacteria.

Calystegine B4 is a useful organic compound for research related to life sciences and the catalog number is T125519.

Antibiotic AGI-B4 is a useful organic compound for research related to life sciences. The catalog number is T124954 and the CAS number is 359828-18-5.

Malformin-B4 is a useful organic compound for research related to life sciences. The catalog number is T125793 and the CAS number is 149596-55-4.

Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.

2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity.