nav — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5142	NAV-2729		Others , GTPase
	NAV-2729 inhibits six ArfGEFs (human ARNO, EFA6, BIG1, and BRAG2 and Legionella and Rickettsia RalF), the strongest effects being against BRAG2, Arf1 and Arf6.		Others , GTPase
T24520	NAV26	NAV-26,NAV 26
	NAV26 is a selective blocker of the Nav1.7 channel.
T31828	AZD4694	Flutafuranol,AZD 4694,NAV-4694,AZD-4694,NAV 4694,NAV4694
	Flutafuranol, also known as AZD 4694 and NAV4694, is a bio-active chemical. AZD4694 shows high affinity for beta-amyloid fibrils in vitro (K(d) = 2.3 +/- 0.3 nM). The fluorine-18 labeled AZD4694 may have potential for PE...
T12181	NaV1.7 inhibitor-1		Sodium Channel
	NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).		Sodium Channel
T19723	AMTB hydrochloride	AMTB	TRP/TRPV Channel
	AMTB hydrochloride (AMTB HCl) is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive refl...		TRP/TRPV Channel
T12184	Nav1.7 inhibitor		Others
	Nav1.7 inhibitor is a potent inhibitor of Nav1.7.		Others
T12180	Nav1.7-IN-6		Others
	Nav1.7-IN-6, a selective inhibitor of Nav1.7.		Others
T7336	ICA-121431	2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl	Sodium Channel
	ICA-121431 (2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels.		Sodium Channel
T12179	Nav1.1 activator 1		Others
	Nav1.1 activator 1 is a highly potent activator of Nav1.1 with BBB penetration.		Others
T12182	Nav1.7-IN-2		Others
	Nav1.7-IN-2 is avoltage-gated sodium channels (Nav) inhibitor in particular Nav 1.7(IC50 of 80 nM).		Others
T12183	Nav1.7-IN-3		Others
	Nav1.7-IN-3 is a selective and orally bioavailable inhibitor of voltage-gated sodium channel Nav1.7(IC50 of 8 nM).		Others
T28132	NaV1.7 Blocker-801
	NaV1.7 Blocker-801 is a potent NaV1.7 blocker.
T38911	Nav1.7-IN-8	Nav1.7-IN-8
	Nav1.7-IN-8 is a highly potent and selective inhibitor of NaV1.7, exhibiting greater selectivity for inhibiting NaV1.7 compared to the subtypes hNaV1.1 and hNaV1.5. Additionally, Nav1.7-IN-8 has inhibitory effects on CYP...
T12186	Navitoclax-piperazine	ABT-263-piperazine	BCL , Ligands for Target Protein for PROTAC
	Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL).		BCL , Ligands for Target Protein for PROTAC
T8579	Nav1.8-IN-1	5-(4-Chlorophenyl)-N-[[2-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]pyridine-3-carboxamide,CHEMBL1270208	Sodium Channel
	Nav1.8-IN-1 (CHEMBL1270208) is an inhibitor of human NaV1.8		Sodium Channel
T8238	Fosamprenavir Calcium Salt	Diallyl Trisulfide,GW433908G	HIV Protease
	Fosamprenavir Calcium Salt (GW433908G) (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility. Fosamprenavir Calcium Salt has Anti-HIV infection.		HIV Protease
T1623	Lopinavir	ABT-378	SARS-CoV , HIV Protease
	Lopinavir (ABT-378) is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding to serum proteins than the structurally-related dr...		SARS-CoV , HIV Protease
T7130	Navarixin	MK-7123,SCH 527123	CXCR
	Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be benef...		CXCR
T7903	Saquinavir	Ro 31-8959	SARS-CoV , HIV Protease
	Saquinavir (Ro 31-8959) is a potent HIV protease inhibitor, is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS.		SARS-CoV , HIV Protease
T0100	Atazanavir sulfate	BMS-232632,BMS-232632 sulfate	P450 , SARS-CoV , HIV Protease , P-gp
	Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS.		P450 , SARS-CoV , HIV Protease , P-gp