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Cat No. | Product Name | Synonyms | Targets |
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T9973 | FAK-IN-7 | FAK | |
FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor. | |||
T11929 | M2N12 | Phosphatase | |
M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of 0.53 μM and 1.39 μM. Anti-tumor activity. M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhi... | |||
T1933 | NVP 231 | Apoptosis , ERK | |
NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK. | |||
T41248 | Thiocolchicine | Microtubule Associated | |
Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 µM and a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology. | |||
T9119 | SU0268 | Others | |
SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection. | |||
T9541 | CTB | Cholera Toxin B subunit | Epigenetic Reader Domain |
CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells. | |||
T8973 | HS-1793 | Others | |
HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model | |||
T8954 | ML179 | ML-179 | Others |
ML179 is a potent and selective inverse agonist of liver receptor homolog-1 (LRH1, NR5A2) with IC50 of 320 nM. | |||
T0308 | Etidronic acid | HEDPA,Etidronate,HEDP | Apoptosis , Phosphatase , Others , HBV |
Etidronic acid (HEDP) is a diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover. | |||
T50005 | Sertaconazole | Antifungal | |
Sertaconazole is a broad-spectrum antifungal. | |||
T9244 | σ1 Receptor antagonist-1 | Sigma receptor | |
σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist. | |||
T9812 | Tubulin inhibitor 24 | Microtubule Associated | |
Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization. | |||
T21806 | HNHA | HDAC | |
HNHA is an inhibitor of HDAC. | |||
T9595 | LP-261 | Microtubule Associated | |
LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest. | |||
T1579 | Mestranol | Devocin,Norquen,Menophase | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Mestranol (Devocin), a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active. | |||
T15249 | Estrogen receptor modulator 1 | Estrogen Receptor/ERR | |
Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.4... | |||
T1210 | Sodium etidronate | Didronel | Phosphatase |
Sodium etidronate (Didronel) is a synthetic therapeutic diphosphonate analog of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, Sodium etidronate differs from endogenous pyrophospha... | |||
T2085 | PQ401 | IGF-1R Inhibitor II | Apoptosis , IGF-1R |
PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM). | |||
T7856 | Naphthol AS-E | nAS-E | Epigenetic Reader Domain , Histone Acetyltransferase |
Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor. | |||
T6588 | Mitoxantrone | mitozantrone | Topoisomerase , PKC |
Mitoxantrone (mitozantrone) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisome... | |||
T22288 | (1E)-CFI-400437 dihydrochloride | CFI-400437 dihydrochloride | PLK |
(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor. | |||
T16812 | RWJ-67657 | JNJ 3026582 | p38 MAPK |
RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor (IC50s: 1 and 11 μM, respectively). RWJ-67657 shows no activity at p38γ and p38δ and shows a cardioprotective effect. | |||
T7698 | BS194 | CDK | |
BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor. | |||
T5858 | Sertindole | Lu 23-174 | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy |
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively) | |||
T6426 | Buclizine dihydrochloride | Longifene,Buclina,Buclizine HCl,UCB-4445 | 5-HT Receptor , AChR , Histamine Receptor |
Buclizine dihydrochloride (Buclina) is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine dihydrochloride binds to and ... | |||
T11847L | Liarozole | R75251 dihydrochloride | P450 , Retinoid Receptor |
Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 1... | |||
T6928 | Pantoprazole | SKF96022,BY1023 | Apoptosis , Proton pump , Autophagy |
Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. | |||
T5882 | 3-Bromopyruvic acid | Hexokinase II Inhibitor II, 3-BP,Bromopyruvic acid | Apoptosis , Hexokinase , Autophagy |
3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinu... | |||
T6665 | Sertaconazole nitrate | FI-7045,Ginedermofix,FI7056,Ertaczo | Antibiotic , Antifungal |
Sertaconazole nitrate (FI-7045), a topical broad-spectrum antifungal, is developed to supply an additional agent for the treatment of superficial cutaneous and mucosal infections. | |||
T33519 | MTOB | α-keto-γ-Methylthiobutyric acid,KMBA,MTOB salt,4-methylthio 2-oxobutyric acid | Others |
MTOB (α-keto-γ-Methylthiobutyric acid) is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, lea... | |||
T0158 | Mitoxantrone dihydrochloride | Mitoxantrone 2HCl,Mitoxantrone hydrochloride,NSC-301739,mitozantrone dihydrochloride | Topoisomerase , PKC |
Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor. | |||
T6010 | Idarubicin hydrochloride | Idamycin,4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl,4-Demethoxydaunorubicin hydrochloride,Idarubicin HCl,Zavedos | Topoisomerase , Antibacterial , Autophagy , Antifungal |
Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL). | |||
T0161 | Pantoprazole Sodium Hydrate | SKF96022 sodium hydrate,BY1023 (sodium hydrate),SKF96022 (sodium hydrate) | Apoptosis , Potassium Channel , Proton pump , Autophagy |
Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. | |||
T2657 | Elacridar | GW0918,GW120918,GF120918,GG918 | BCRP , P-gp |
Elacridar (GG918) (GF120918) is an effective BCRP and P-gp (MDR-1) inhibitor. | |||
T6929 | Pantoprazole sodium | Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc | Apoptosis , Others , Proton pump , HIF , Autophagy |
Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters... | |||
T15578 | Indotecan | NSC-724998,LMP-400 | Topoisomerase |
Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively). | |||
T72470 | Estrone O-sulfamate | Estrone 3-O-sulfamate | Others |
Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent inhibitor of steroid sulfatase (STS). Estrone O-sulfamate is a placental microsomal inhibitor (P.M.) with IC50 values of 18 nM. Estrone O-sulfamate showed inhibitor... | |||
T5350 | JG-98 | JG98,JG 98 | Apoptosis , HSP |
JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM). | |||
T10325 | ANI-7 | Chk | |
ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells and potently and selectively inhibits the growth of MCF-7 breast cancer cells (GI50: 0.56 μM). | |||
T64348 | Antiproliferative agent-16 | Antiproliferative agent-16 | Others |
Antiproliferative agent-16 (Antiproliferative agent-16) is an indolyl hydrazide-hydrazone compound with anticancer activity. Antiproliferative agent-16 exhibits specificity toward breast cancer cells (IC50 of 6.94 μM for... | |||
T36970 | STD1T | DUB | |
STD1T is a selective and potent inhibitor of the deubiquitinase USP2a with potential anticancer activity that reduces cell cycle protein D1 protein levels in HCT116 colon and MCF-7 breast cancer cells. | |||
T77718 | FAK-IN-10 | FAK | |
FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively. | |||
T36488 | LYG-202 | LYG202,LYG 202 | Apoptosis , ROS |
LYG-202 is a novel flavonoid with piperazine substitution and antitumor effects in vivo and in vitro.LYG-202 induced apoptosis in MCF-7, MDA-MB-231, and MDA-MB-435 cells, and increased intracellular ROS production. | |||
T62515 | SIRT2-IN-9 | Sirtuin | |
SIRT2-IN-9 is a selective SRIT2 inhibitor with an IC50 value of 1.3 μM.SIRT2-IN-9 inhibits the proliferation of MCF-7 breast cancer cells.SIRT2-IN-9 can be used for cancer research. | |||
T11098 | Droloxifene | 3-Hydroxytamoxifen | Estrogen Receptor/ERR |
Droloxifene (3-Hydroxytamoxifen), a tamoxifen derivative, is an oral active and selective estrogen receptor modulator.Droloxifene induced p53 expression and apoptosis in McF-7 cells.Fluroxifene has anti-estrogen and anti... | |||
T40233 | (Iso)-MS4322 | (Iso)-YS43-22,MS4322 (isomer),YS43-22 (isomer) | Histone Methyltransferase |
(Iso)-MS4322 ((Iso)-YS43-22) is a selective and potent protein arginine methyltransferase 5 (PRMT5) degrader with potential anticancer activity that effectively reduces PRMT5 protein levels in MCF-7 cells and inhibits th... | |||
T83627 | Pim-1 kinase inhibitor 8 | Pim , PKC | |
Pim-1 kinase inhibitor 8 is a potent Pim-1 kinase inhibitor with anticancer activity and can effectively inhibit cell migration.Pim-1 kinase inhibitor 8 is cytotoxic to MCF-7 and HepG2 cells, and is a candidate compound ... | |||
T21804 | GW 610 | Others | |
GW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI50) < 0.... | |||
T77575 | P-gb-IN-1 | P-gp | |
P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow. P-gb-IN-1 has been shown to inhibit P-gp by hydrogen bonding with residues Asn 721 and Met 986. P-gb-IN-1 s... | |||
T7057 | Methylstat | Histone Demethylase , Others | |
Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1768 | Iriflophenone | Estrogen Receptor/ERR , Estrogen/progestogen Receptor | |
Iriflophenone stimulates cells proliferation in MCF-7 and T-47D human breast cancer. | |||
TN7060 | Methyl oleanonate | PPAR | |
3-Oxoolean-12-en-28-oic acid methyl ester is a triterpenoid PPARγ agonist isolated from Pistacia with anticancer properties. | |||
T2882 | Genistin | Genistoside,Genistein glucoside,Genistein 7-glucoside,Genistine,Genistein 7-O-β-D-glucopyranoside | Apoptosis , Estrogen Receptor/ERR , Others |
Genistin (Genistoside) is the major isoflavonoid of soybeans and soy products.It has been reported to possess various therapeutic effects, including anti-inflammatory and anticancer activities | |||
TN7059 | Deoxylimonin | NSC 314317,desoxylimonin | Others |
Deoxylimonin (NSC 314317) is a triterpenoid isolated from grapefruit seeds. | |||
T5724 | Neogambogic acid | neo-gambogic acid | Apoptosis , Others , Antibacterial |
Neogambogic acid, an active ingredient in garcinia, can inhibit the growth of some solid tumors and result in an anticancer effect, it may be responsible for the inhibition of proliferation of human breast cancer cell li... | |||
T3322 | Trans-Chalcone | Chalcone,Cinnamophenone,Chalkone | Apoptosis , Others , Antifungal , Fatty Acid Synthase |
trans-Chalcone (Chalkone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones. | |||
T7786 | Tryptanthrin | DNA gyrase | |
Tryptanthrin is a natural DNA gyrase inhibitor. | |||
TN2105 | Proscillaridin A | Topoisomerase | |
Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively. | |||
T3981 | Acacetin | 4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin | Apoptosis , IAP , COX , Autophagy |
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models. | |||
T4454 | Traumatic Acid | Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,Trans-2-Dodecenedioic Acid | Antioxidant |
Traumatic Acid (Dodec-2-Enedioic Acid) is a product of the hydroperoxide lyase pathway in plants. Potential as a wound healing agent that stimulates cell division near a wound site to form a protective callus. | |||
T12581 | Puerarin-4'-O-β-D-glucopyranoside | Puerarin4'-O-glucoside | Others |
Puerarin-4'-O-β-D-glucopyranoside (Puerarin4'-O-glucoside) is a natural product isolated from Pueraria lobata root having estrogenic activity and anti-proliferation in MCF-7 human breast carcinoma cells. | |||
T19768 | γ-Tocotrienol | gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol | Others |
γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E. Itl is also a radioprotector, antioxidant. It shows antitumor and antihypertensive effects in vivo. | |||
T8724 | 6-Methoxydihydrosanguinarine | Others | |
6-Methoxydihydrosanguinarine is a natural product. 6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.It has antibacterial act... | |||
T1166 | Ellipticine | NSC 71795,Elliptisine | Topoisomerase |
Ellipticine (Elliptisine) is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.49±0.04, 0.44±0.03, and 1.48±0.62 μM for Leukemia HL-6... | |||
TN3049 | 4-Methoxycinnamyl alcohol | Others | |
4-Methoxycinnamyl alcohol showed toxicity to MCF-7, HeLa and DU145 cancer cell lines with IC50 values of 14.24, 7.82 and 22.10 μg/mL, respectively. 4-Methoxycinnamyl alcohol was isolated from Foeniculum vulgare. 4-Methox... | |||
TMS0879 | Asiaticoside B | Others | |
Asiaticoside B is a triterpene glycoside isolated from Actaea asiatica. It has notable cytotoxicity against HepG2 and MCF-7 cancer cell lines. | |||
T83321 | 4-Demethyldeoxypodophyllotoxin | Chk | |
4-Demethyldeoxypodophyllotoxin, an aryl tetrahydronaphthalenyl lignan analog from the roots of Podophyllum peltatum, has anticancer activity and modulates the Chk-2 signaling pathway in MCF-7 breast cancer cells. | |||
TN7041 | (-)-Epipodophyllotoxin | Apoptosis | |
(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vit... | |||
TMA2270 | Alisol F 24-acetate | P-gp | |
Alisol F 24-acetate is a natural product isolated from Alisma plantago-aquatica Linn[1]. Alisol F 24 Acetate enhances chemosensitivity and apoptosis of MCF-7/DOX Cells by inhibiting P-Glycoprotein-Mediated drug efflux[2]... | |||
T4519 | Alisol A | Alisol-A | Autophagy |
Alisol A (Alisol-A) may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cells). | |||
T3411 | Curdione | (+)-Curdione | P450 |
Curdione ((+)-Curdione) inhibits CYP3A4 activity and the production of prostaglandin E2. Curdione inhibits proliferation of MCF-7 cells by inducing apoptosis. Curdione may be a candidate for anti-inflammatory and Y chemo... | |||
T4S0544 | Furanodienone | Apoptosis , HER | |
1. Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling. 2. Furanodienone inhibits EGFR/HER2 signaling pathway in BT474 and SKBR3 cells, the effect is specifically dependen... | |||
TN1727 | Helichrysetin | Apoptosis , HIV Protease | |
Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29. | |||
T8190 | 5-Hydroxyflavone | Others | |
5-Hydroxyflavone is a natural product | |||
T5S1607 | Morusin | Mulberrochromene | NF-κB , Antibacterial , STAT |
1. Morusin (Mulberrochromene) possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apoptosis induction. 2. Morusin possesses anti... | |||
T5S0506 | Rotundic acid | Rutundic acid | Apoptosis , Others , p38 MAPK , Akt , mTOR |
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) c... | |||
T2S0265 | Robinin | NSC 9222 | TLR |
Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LR... | |||
TN3972 | Epimedokoreanin B | Apoptosis , Others , Antibacterial | |
Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.Epimedokoreanin B also possesses anti-... | |||
TJS0387 | Desoxyrhaponticin | Deoxyrhapontin,Deoxyrhaponticin | Apoptosis , Fatty Acid Synthase |
1. Desoxyrhaponticin (Deoxyrhaponticin) is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes, the in vivo antidiabetic action of this compound can be explained, in part at least... | |||
TN2755 | 2-Desoxy-4-epi-pulchellin | Anti-infection | |
2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7uM, while it shows sig... | |||
TN1853 | Lariciresinol | VEGFR , Antifection | |
Lariciresinol is an enterolignan precursor, it possesses fungicidal activities by disrupting the fungal plasma membrane and therapeutic potential as a novel antifungal agent for the treatment of fungal infectious disease... | |||
T5S2358 | Dehydrocorydaline | Dehydrocorydalin,13-Methylpalmatine | BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy |
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz... | |||
T3S1416 | Decursin | Decursinol angelate,(+)-Decursin | Apoptosis , PKC |
1. Decursin (Decursinol angelate) is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , potentially by inhibiting the TGF-β1 ... | |||
T2S1865 | Octyl gallate | Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8 | Antioxidant , Influenza Virus , Reactive Oxygen Species , Antibacterial , Antifungal , HSV |
1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive. 2. Octyl Gallate has antimetastatic activity. 3. Octyl Gallate shows antimicrobial activity against H. pylori, ... | |||
T3S2344 | β,β-Dimethylacrylshikonin | Dimethylacrylshikonin,β, β-Dimethylacrylshikonin | ERK , HIF/HIF Prolyl-Hydroxylase |
1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significant... | |||
T6S1315 | Oroxylin A | 6-Methoxybaicalein,Baicalein 6-methyl ether | Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy |
1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v... | |||
T3729 | Ethyl gallate | Nipagallin A,Phyllemblin,gallic acid ethyl ester | MMP , NF-κB , Akt , Antibacterial |
Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependent manner. Ethyl gallate can inhib... | |||
T17155 | Trabectedin | Ecteinascidin 743,ET-743 | Apoptosis , Reactive Oxygen Species |
Trabectedin (Ecteinascidin 743) has potent antitumor activity and the potential for soft tissue sarcoma and ovarian cancer research. Trabectedin inhibits cell growth of MX-1, MCF7 and MCF7/DXR cells with IC50 values of 0... | |||
T13551 | Araliadiol | Others | |
Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cell growth (IC50: 6.41 µg/mL). | |||
TN2979 | 3-Oxotirucalla-7,24-dien-21-oic acid | Others | |
3-Oxotirucalla-7,24-dien-21-oic acid is the first known compound isolated from Polygonum spp. and can be obtained from the roots of Black Cohosh. 3-Oxotirucalla-7,24-dien-21-oic acid showed potent cytotoxicity against MC... | |||
TN5287 | 3β,5α-Dihydroxyergosta-7,22-dien-6-one | ||
3β,5α-Dihydroxy-(22E,24R)-ergosta-7,22-dien-6-one exhibits strong or moderate cytotoxic activities against MCF-7, A549, Hela and KB cell lines with IC50 values 4.98 (MCF-7), 1.95 (A549), 0.68(Hela), and 1.50 uM (KB), res... | |||
TQ0164 | Dodecanoic acid ingenol ester | 13-Oxyingenol dodecanoat | Others |
Dodecanoic acid ingenol ester, a natural compound, shows moderate cytotoxicity with IC50 values being 35.59 μM (Caco-2), 24.04 μM (MCF-7), and 22.24 μM (MCF-7/ADM). | |||
TQ0134 | Podocarpusflavone A | Topoisomerase | |
Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7. | |||
TN2249 | (+)-Syringaresinol | Sirtuin , Antifection | |
(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2. | |||
T83301 | 5,7-Dimethoxy-2,3-phenanthrenediol | ||
5,7-Dimethoxy-2,3-phenanthrenediol exhibits estrogenic activity by promoting the proliferation of MCF-7 cells and enhancing the expression of ERβ within this cell line [1]. | |||
TN5538 | 6-Methoxykaempferol | Others | |
6-Methoxykaempferol is a flavonoid found in brazilian propolis. 6-Methoxykaempferol has anti-proliferative activity against cancer cells, neuroprotective effects on isolated rat brain synaptosomes and reduces glutathione... | |||
TN4307 | Isolimonexic acid | BCL , Caspase , COX , p53 | |
Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth. | |||
T40940 | 7,3′,5′-Trihydroxyflavanone | ||
7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, promotes apoptotic cell death in MCF-7 cells by augmenting Bax expression. Additionally, this compound demonstrates antioxidant properties. | |||
TN3825 | Demethylmurrayanine | Others | |
O-Demethylmurrayanine and clausine D exhibit strong cytotoxicity against MCF-7 and SMMC-7721 with IC50 values in the range 2.63-7.59 ug/ml. | |||
TN4116 | Garjasmin | Others | |
Garjasmine exhibits weak cytotoxic activity against KB and MCF-7 cell lines. | |||
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Cat No. | Product Name | Species | Expression System |
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TMPY-06036 | FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) | Human | HEK293 |
FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another i... | |||
TMPJ-00655 | TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His) | Human | Human Cells |
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TN... | |||
TMPY-01383 | PRMT6 Protein, Human, Recombinant (His & Flag) | Human | HEK293 |
Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly ex... | |||
TMPY-02763 | DEP-1 Protein, Human, Recombinant (aa 997-1337, His) | Human | E. coli |
DEP1 / PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, includin... | |||
TMPK-01371 | IGFBP-7 Protein, Human, Recombinant (hFc) | Human | HEK293 |
IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 ... | |||
TMPK-00828 | Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc) | Human | HEK293 |
MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire... | |||
TMPK-00394 | FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in num... | |||
TMPK-00395 | FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differen... | |||
TMPY-06035 | FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) | Human | HEK293 |
FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another i... | |||
TMPK-00392 | FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in num... | |||
TMPK-00393 | FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differen... |