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Search Results for " tlr "

Targets

112

Compounds

10

Natural Products

25

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T13932 TLR1 Others , MyD88
TLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses.
T8503 TLR4-IN-C34 TLR
TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis
T13167 TLR7/8 agonist 3 TLR
TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.
T4258 TLR7 agonist 2 TLR7-agonist-1,TLR7-IN-1 TLR
TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
T22698 TLR3-IN-1 CU CPT 4a TLR
TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cell...
T39669 TLR7/8/9-IN-1 TLR7/8/9-IN-1 TLR
TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.
T7317 CU-CPT-9a TLR
CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-
T15020 CU-CPT22 TLR
CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM). It competes with the synthetic triacylated lipoprotein (Pam3CSK4) ...
T9570 Enpatoran TLR
Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo.
T11598 IAXO-102 TLR
IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdomin...
T5561 TLR7/8 agonist 1 dihydrochloride TLR7/8 agonist-5d TLR
TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities.
T10899 CU-CPT17e TLR
CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).
T15777 Loxoribine RWJ 21757,7-Allyl-8-oxoguanosine Influenza Virus , TLR
Loxoribine (RWJ 21757) is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant ...
T7672 MD2-TLR4-IN-1 TLR
MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.
T4231 MD2-IN-1 TLR
MD2-IN-1 is a Myeloid differentiation protein 2 (MD2) inhibitor with a KD of 189  μM for the recombinant human MD2 (rhMD2).
T38078 TLR7/8-IN-1 TLR7/8-IN-1 TLR
TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research[1].
T16506 PF-4878691 3M-852A TLR
PF-4878691 (3M-852A) is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.
T3502 C29 TLR
C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages.
T39654 Afimetoran BMS-986256 TLR
Afimetoran (BMS-986256) is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases.
T40423 L48H37
L48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interactio...
T7347 CU-CPT-8m TLR8-specific antagonist TLR
CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
T8727 TH1020 TLR , Antibacterial
TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.
T15371 Gardiquimod TLR , HIV Protease
Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells...
T9765 TJ-M2010-5 MyD88
TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain to interfere with its homodimerization and suppress MyD88 signaling. TJ-M2010-5 can be used in myocardial ischemia/reperfusion injury studies.
T17032 Telratolimod MEDI9197,3M-052 TLR
Telratolimod (MEDI9197) is a toll-like receptors 7/8 agonist. It has an antitumor activity.
T23171 Polyinosinic-polycytidylic acid Poly(I:C) TLR
Polyinosinic-polycytidylic acid (Poly(I:C)) is a double-stranded RNA (dsRNA) and a TLR3 agonist. Polyinosinic-polycytidylic acid induces natural immunity in mammals.
T38423 CL097 CL097 Reactive Oxygen Species , TLR
CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.
T7860 SM-324405 SM 324405 TLR
SM-324405 is an agonist of TLR7.
T15017 CU-T12-9 TLR
CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activat...
T5521 Bropirimine U-54461 TLR
Bropirimine (U-54461) (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.
T12933 SM-276001 TLR , COX
SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.
T6898 Motolimod VTX-378,VTX-2337 TLR
Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.
T7302 CU-CPT9b CU-CPT-9b,TLR8-specific antagonist 1 TLR
CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 valu...
T8316 1V209 TLR7 agonist T7 TLR
1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
T9287 Hydroxychloroquine 2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol SARS-CoV , TLR , Parasite , Autophagy
Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It i...
T6846 Vesatolimod GS-9620 Apoptosis , HCV Protease , HBV , TLR , HIV Protease
Vesatolimod (GS-9620) is an effective and specific orally active agonist of Toll-like receptor 7.
T0951 Hydroxychloroquine sulfate Acidum iopanoicum,HCQ sulfate DNA , SARS-CoV , TLR , Parasite , Autophagy
Hydroxychloroquine sulfate (Acidum iopanoicum) inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in ...
T6964 Resiquimod R848,S28463 HCV Protease , TLR
Resiquimod (R848) is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and acti...
T13168 TLR7 agonist 1 TLR
TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).
T38614 TLR7 agonist 3
TLR7 agonist 3 (Compound 2), a potent activator of toll-like receptor 7 (TLR7), plays a critical role in initiating immune responses, positioning it as a promising target for immunomodulator development.
T40039 TLR8 agonist 2 TLR8 agonist 2
TLR8 agonist 2 is a highly effective and specific compound that activates TLR8, possessing an EC 50 of 3 nM in human TLR8. Notably, TLR8 agonist 2 demonstrates lower activity towards human TLR7, with an EC 50 of 33.33 μM...
T19675 SM360320 CL-087,SM 360320,CL 087,1V136,SM-360320,CL087 TLR
SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for ...
T40040 TLR8 agonist 2 hydrochloride
TLR8 agonist 2 hydrochloride is a highly potent and selective agonist for human TLR8, exhibiting an EC50 of 3 nM. However, its activity towards human TLR7 is considerably weaker, with an EC50 of 33.33 μM.
TP1067 Pam3CSK4 TFA (112208-00-1 free base) Pam3CSK4 TFA,Pam3Cys-Ser-(Lys)4 TFA TLR
Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is an agonist of toll-like receptor 1/2 (TLR1/2) (EC50 of 0.47 ng/mL for human TLR1/2).
T39969 TLR7/8 agonist 4 TFA
TLR7/8 agonist 4 TFA (compound 41) is a highly potent TLR7/8 agonist that exhibits significant anti-cancer activity.
T12516 Polyinosinic-polycytidylic acid sodium Poly(I:C) sodium Apoptosis , Others , TLR
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MD...
T0134 Imiquimod R 837,S-26308 SARS-CoV , TLR , Autophagy , HSV
Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist.
TQ0181 Resatorvid CLI-095,TAK-242 TNF , TLR , Autophagy , Interleukin
Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid binds directly to Cys747 and prevents TLR4 from binding to TIRAP, thereby blocking downstream signaling. Resatorvid has antitumor a...
TP1938 RS 09 TLR
TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enhances X-15 specific antibody serum concentrations, when adm...
T38547 TLR4-IN-C34-C2-COOH TLR4-IN-C34-C2-COOH
TLR4-IN-C34-C2-COO is a linker compound that incorporates TLR4 inhibitor TLR4-IN-C34. It effectively inhibits TLR4 activity in enterocytes and macrophages. Moreover, it demonstrates a notable ability to mitigate systemic...

Compounds

TLR1
T13932
Synonym:
Target: Others, MyD88
TLR4-IN-C34
T8503
Synonym:
Target: TLR
TLR7/8 agonist 3
T13167
Synonym:
Target: TLR
TLR7 agonist 2
T4258
Synonym: TLR7-agonist-1,TLR7-IN-1
Target: TLR
TLR3-IN-1
T22698
Synonym: CU CPT 4a
Target: TLR
TLR7/8/9-IN-1
T39669
Synonym: TLR7/8/9-IN-1
Target: TLR
CU-CPT-9a
T7317
Synonym:
Target: TLR
CU-CPT22
T15020
Synonym:
Target: TLR
Enpatoran
T9570
Synonym:
Target: TLR
IAXO-102
T11598
Synonym:
Target: TLR
TLR7/8 agonist 1 dihydrochloride
T5561
Synonym: TLR7/8 agonist-5d
Target: TLR
CU-CPT17e
T10899
Synonym:
Target: TLR
Loxoribine
T15777
Synonym: RWJ 21757,7-Allyl-8-oxoguanosine
Target: Influenza Virus, TLR
MD2-TLR4-IN-1
T7672
Synonym:
Target: TLR
MD2-IN-1
T4231
Synonym:
Target: TLR
TLR7/8-IN-1
T38078
Synonym: TLR7/8-IN-1
Target: TLR
PF-4878691
T16506
Synonym: 3M-852A
Target: TLR
C29
T3502
Synonym:
Target: TLR
Afimetoran
T39654
Synonym: BMS-986256
Target: TLR
L48H37
T40423
Synonym:
Target:
CU-CPT-8m
T7347
Synonym: TLR8-specific antagonist
Target: TLR
TH1020
T8727
Synonym:
Target: TLR, Antibacterial
Gardiquimod
T15371
Synonym:
Target: TLR, HIV Protease
TJ-M2010-5
T9765
Synonym:
Target: MyD88
Telratolimod
T17032
Synonym: MEDI9197,3M-052
Target: TLR
Polyinosinic-polycytidylic acid
T23171
Synonym: Poly(I:C)
Target: TLR
CL097
T38423
Synonym: CL097
Target: Reactive Oxygen Species, TLR
SM-324405
T7860
Synonym: SM 324405
Target: TLR
CU-T12-9
T15017
Synonym:
Target: TLR
Bropirimine
T5521
Synonym: U-54461
Target: TLR
SM-276001
T12933
Synonym:
Target: TLR, COX
Motolimod
T6898
Synonym: VTX-378,VTX-2337
Target: TLR
CU-CPT9b
T7302
Synonym: CU-CPT-9b,TLR8-specific antagonist 1
Target: TLR
1V209
T8316
Synonym: TLR7 agonist T7
Target: TLR
Hydroxychloroquine
T9287
Synonym: 2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol
Target: SARS-CoV, TLR, Parasite, Autophagy
Vesatolimod
T6846
Synonym: GS-9620
Target: Apoptosis, HCV Protease, HBV, TLR, HIV Protease
Hydroxychloroquine sulfate
T0951
Synonym: Acidum iopanoicum,HCQ sulfate
Target: DNA, SARS-CoV, TLR, Parasite, Autophagy
Resiquimod
T6964
Synonym: R848,S28463
Target: HCV Protease, TLR
TLR7 agonist 1
T13168
Synonym:
Target: TLR
TLR7 agonist 3
T38614
Synonym:
Target:
TLR8 agonist 2
T40039
Synonym: TLR8 agonist 2
Target:
SM360320
T19675
Synonym: CL-087,SM 360320,CL 087,1V136,SM-360320,CL087
Target: TLR
TLR8 agonist 2 hydrochloride
T40040
Synonym:
Target:
Pam3CSK4 TFA (112208-00-1 free base)
TP1067
Synonym: Pam3CSK4 TFA,Pam3Cys-Ser-(Lys)4 TFA
Target: TLR
TLR7/8 agonist 4 TFA
T39969
Synonym:
Target:
Polyinosinic-polycytidylic acid sodium
T12516
Synonym: Poly(I:C) sodium
Target: Apoptosis, Others, TLR
Imiquimod
T0134
Synonym: R 837,S-26308
Target: SARS-CoV, TLR, Autophagy, HSV
Resatorvid
TQ0181
Synonym: CLI-095,TAK-242
Target: TNF, TLR, Autophagy, Interleukin
RS 09
TP1938
Synonym:
Target: TLR
TLR4-IN-C34-C2-COOH
T38547
Synonym: TLR4-IN-C34-C2-COOH
Target:
1 2 3
Cat No. Product Name Synonyms Targets
T2S0265 Robinin NSC 9222 TLR
Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LR...
TN2008 Okanin NF-κB , TLR
Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
TQ0205 Procyanidin B1 TLR
Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.
T5S0167 Atractylenolide I IL Receptor , TNF , TLR , JAK , STAT
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reduction of pro-inflammatory cytokines and LPS. 2. Atractylenolide...
T8689 Chloroquine CQ SARS-CoV , TLR , HIV Protease , Antibiotic , Parasite , Autophagy
Chloroquine is a Toll-like receptor inhibitor that inhibits autophagy. Chloroquine has anti-malarial and anti-inflammatory activity and is widely used in the treatment of malaria and rheumatoid arthritis. Chloroquine als...
T3898 Schaftoside APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside Dynamin , Antioxidant , TLR , MyD88 , Mitochondrial Metabolism , Autophagy
Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.
T3826 Polygalasaponin F NF-κB , TLR , Akt , PI3K
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po...
T5S0045 Isofraxidin 6,8-Dimethoxyumbelliferone,Phytodolor MMP , ERK , p38 MAPK , TLR , COX
1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote...
T0194 Chloroquine phosphate Chloroquine diphosphate,Aralen phosphate,Chingamin phosphate SARS-CoV , TLR , HIV Protease , Antibiotic , Parasite , Autophagy
Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
T6S1487 Ginsenoside Rg5 NF-κB , COX , IGF-1R
1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02904 TLR4 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans...
TMPK-00406 TLR3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated Human HEK293 Cells
TLR3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 78.7 kDa and the accession number is Q6PCD4.
TMPK-00544 TLR3 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
TLR3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 78.04 kDa and the accession number is A0A2K5WT39.
TMPY-02794 TLR2 Protein, Human, Recombinant (aa 1-587, His) Human Baculovirus Insect Cells
TLR2 Protein, Human, Recombinant (aa 1-587, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 65.5 kDa and the accession number is O60603-1.
TMPH-02211 TLR7 Protein, Human, Recombinant (His & Myc) Human E. coli
Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine...
TMPH-02938 TLR7 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
TLR7 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 43.8 kDa and the accession number is P58681.
TMPH-02212 TLR8 Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially proc...
TMPY-02930 TLR2 Protein, Mouse, Recombinant (His) Mouse Baculovirus Insect Cells
TLR2 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 64.8 kDa and the accession number is Q9QUN7.
TMPH-02937 TLR11 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. TLR11 Protein, Mouse, Recombinant (His & Myc) ...
TMPY-06410 TLR3 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
TLR3 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 79.38 kDa and the accession number is Q6PCD4.
TMPY-03042 TLR2 Protein, Rat, Recombinant (His) Rat Baculovirus Insect Cells
TLR2 Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 67.5 kDa and the accession number is Q6YGU2.
TMPY-01396 TLR3 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
TLR3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78.7 kDa and the accession number is Q99MB1.
TMPH-02271 BTK Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activatio...
TMPY-04483 IRAK4 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4...
TMPJ-00177 BAFF/TNFSF13B Protein, Human, Recombinant (Avi & hFc), Biotinylated Human HEK293 Cells
B-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a transmembrane glycoprotein in the TNF ligand superfamily. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), T...
TMPH-02803 NRROS Protein, Mouse, Recombinant (His) Mouse E. coli
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifi...
TMPH-01265 PELI3 Protein, Human, Recombinant (His) Human E. coli
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Me...
TMPH-01195 Human cytomegalovirus (HCMV) (strain Merlin) Viral interleukin-10 homolog HCMV E. coli
Functional viral IL-10 homolog. Can bind to the human IL-10 receptor and compete with human IL-10 for binding sites. Requires both subunits of the human IL-10 receptor complex to induce signal transduction events and bio...
TMPJ-01325 TOLLIP Protein, Human, Recombinant (His) Human E. coli
Toll-Interacting Protein (TOLLIP) is a member of the tollip family. TOLLIP localizes to the cytoplasm. It contains one C2 domain and one CUE domain. TOLLIP is an inhibitory adaptor protein for Toll-like receptors (TLR). ...
TMPH-01702 SMAD6 Protein, Human, Recombinant (E. coli, His & Myc) Human E. coli
Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I tra...
TMPH-01551 IFNLR1 Protein, Human, Recombinant (His & SUMO) Human E. coli
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the ...
TMPH-03267 CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO) Rat E. coli
Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which...
TMPJ-01187 Siglec-E Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
Siglecs are sialic acid specific I‑type lectins that are characterized by an extracellular domain (ECD) with an N‑terminal Ig‑like V‑set domain followed by varying numbers of Ig‑like C2‑set domains. Mouse Siglec‑E, also ...
TMPY-01816 Pentraxin 3 Protein, Human, Recombinant (His) Human HEK293 Cells
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin dom...
TMPY-04408 CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Calcium/calmodulin-dependent protein kinase II beta (CAMK2B) is a member of the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. CaMKII is an important player in pro...
TLR4 Protein, Human, Recombinant (His)
TMPY-02904
Species: Human
Expression System: Baculovirus Insect Cells
TLR3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
TMPK-00406
Species: Human
Expression System: HEK293 Cells
TLR3 Protein, Cynomolgus, Recombinant (His)
TMPK-00544
Species: Cynomolgus
Expression System: HEK293 Cells
TLR2 Protein, Human, Recombinant (aa 1-587, His)
TMPY-02794
Species: Human
Expression System: Baculovirus Insect Cells
TLR7 Protein, Human, Recombinant (His & Myc)
TMPH-02211
Species: Human
Expression System: E. coli
TLR7 Protein, Mouse, Recombinant (His & Myc)
TMPH-02938
Species: Mouse
Expression System: E. coli
TLR8 Protein, Human, Recombinant (His)
TMPH-02212
Species: Human
Expression System: P. pastoris (Yeast)
TLR2 Protein, Mouse, Recombinant (His)
TMPY-02930
Species: Mouse
Expression System: Baculovirus Insect Cells
TLR11 Protein, Mouse, Recombinant (His & Myc)
TMPH-02937
Species: Mouse
Expression System: E. coli
TLR3 Protein, Human, Recombinant (His)
TMPY-06410
Species: Human
Expression System: Baculovirus Insect Cells
TLR2 Protein, Rat, Recombinant (His)
TMPY-03042
Species: Rat
Expression System: Baculovirus Insect Cells
TLR3 Protein, Mouse, Recombinant (His)
TMPY-01396
Species: Mouse
Expression System: HEK293 Cells
BTK Protein, Human, Recombinant (His)
TMPH-02271
Species: Human
Expression System: Baculovirus Insect Cells
IRAK4 Protein, Human, Recombinant (His)
TMPY-04483
Species: Human
Expression System: Baculovirus Insect Cells
BAFF/TNFSF13B Protein, Human, Recombinant (Avi & hFc), Biotinylated
TMPJ-00177
Species: Human
Expression System: HEK293 Cells
NRROS Protein, Mouse, Recombinant (His)
TMPH-02803
Species: Mouse
Expression System: E. coli
PELI3 Protein, Human, Recombinant (His)
TMPH-01265
Species: Human
Expression System: E. coli
Human cytomegalovirus (HCMV) (strain Merlin) Viral interleukin-10 homolog
TMPH-01195
Species: HCMV
Expression System: E. coli
TOLLIP Protein, Human, Recombinant (His)
TMPJ-01325
Species: Human
Expression System: E. coli
SMAD6 Protein, Human, Recombinant (E. coli, His & Myc)
TMPH-01702
Species: Human
Expression System: E. coli
IFNLR1 Protein, Human, Recombinant (His & SUMO)
TMPH-01551
Species: Human
Expression System: E. coli
CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO)
TMPH-03267
Species: Rat
Expression System: E. coli
Siglec-E Protein, Mouse, Recombinant (hFc)
TMPJ-01187
Species: Mouse
Expression System: HEK293 Cells
Pentraxin 3 Protein, Human, Recombinant (His)
TMPY-01816
Species: Human
Expression System: HEK293 Cells
CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST)
TMPY-04408
Species: Human
Expression System: Baculovirus Insect Cells
TargetMol