Search Result

Search Results for " anti-proliferative "

Targets

256

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T7057	Methylstat		Histone Demethylase , Others
	Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD...		Histone Demethylase , Others
T3105	PFK-158		Apoptosis , Glucokinase , Autophagy
	PFK-158 is an effective and specific inhibitor PFKFB3.		Apoptosis , Glucokinase , Autophagy
T8874	FB23		Others
	FB23 directly binds to FTO and selectively inhibits FTO's m6A demethylase activity. (FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis.)		Others
T17350	ACBI1		Apoptosis , Epigenetic Reader Domain , PROTACs
	ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in ...		Apoptosis , Epigenetic Reader Domain , PROTACs
T4325	COTI-2	COTI 2,COTI2	Apoptosis , p53
	COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity.		Apoptosis , p53
T8554	KCC-07		DNA Alkylator/Crosslinker
	KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenes...		DNA Alkylator/Crosslinker
T11793	KY-05009		Wnt/beta-catenin
	KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces TNIK protein expression and the transcriptional activity o...		Wnt/beta-catenin
T22089	HPI 1		Hedgehog/Smoothened
	HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced a...		Hedgehog/Smoothened
T41323	Dihomo-γ-Linolenic acid methyl ester		Others
	Dihomo-γ-Linolenic acid methyl ester is the methyl ester form of Dihomo-γ-Linolenic acid which has anti-inflammatory and anti-proliferative effects.		Others
T8492	BO-264		Apoptosis , FGFR
	BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).		Apoptosis , FGFR
T8740	COH-SR4	COH-SR4 (Mitochondria uncoupler SR4)	Others , AMPK
	COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation. COH-SR4 modulates amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inhibiting proli...		Others , AMPK
T3467	Miransertib	ARQ-092,AKT inhibitor 2	Akt , Parasite
	Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor.		Akt , Parasite
T0314	Hexylresorcinol	4-Hexylresorcinol	Apoptosis , Tyrosinase , Antibacterial , Parasite
	Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.		Apoptosis , Tyrosinase , Antibacterial , Parasite
T5413	ML216	CID-49852229	DNA/RNA Synthesis
	ML216 (CID-49852229) is a small molecule inhibitor of BLM helicase (IC50: 1.8 μM). It showed 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s > 50 μM).		DNA/RNA Synthesis
T12477	Uzansertib phosphate	INCB053914 phosphate	Pim
	Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase(PIM1, PIM2, PIM3 with IC50s of 0.24 nM, 30 nM, 0.12 nM , respectively).		Pim
TQ0138	K145 hydrochloride		Apoptosis , S1P Receptor
	K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.		Apoptosis , S1P Receptor
T1640	Ciprofloxacin	Ciproxan,Ciprobay,Bay o 9867,Bay-09867	Topoisomerase , Antibacterial , Antibiotic
	Ciprofloxacin (Bay-09867), a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram-positive bacteria.		Topoisomerase , Antibacterial , Antibiotic
T0250	Ciprofloxacin monohydrochloride	Bay-09867 (hydrochloride),Ciprofloxacin HCl,Ciprofloxacin hydrochloride	DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
	Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.		DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
T5135	Flupentixol dihydrochloride	Fupentixol Dihydrochloride,Flupenthixol dihydrochloride,(E/Z)-Flupentixol Dihydrochloride	Dopamine Receptor
	Flupentixol dihydrochloride is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.		Dopamine Receptor
T5858	Sertindole	Lu 23-174	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy
	Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)
T1140	Doxycycline hydrochloride	Doxylin,Vibramycin,Hyclate	MMP , Antibacterial , Antibiotic
	Doxycycline hydrochloride (Hyclate) is a synthetic tetracycline derivative with similar antimicrobial activity.		MMP , Antibacterial , Antibiotic
T67699L	ALK/ROS1 inhibitor 2e HCL	(R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide hydrochloride(2365497-12-5 Free base)	Apoptosis
	ALK/ROS1 inhibitor 2e HCL possesses anti-apoptotic, anti-proliferative and anti-tumour activities.		Apoptosis
T60225	Biguanidinium-porphyrin		Others
	Biguanidinium-porphyrin is a phototoxic agent with anti-proliferative activity.		Others
T9582	CLEFMA		NF-κB
	CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.		NF-κB
T10839	Clozic	Clobuzarit,ICI 55897	Others
	Clozic (ICI 55897) exhibits reversible anti-proliferative effects and can be used in studies about serving as a potential anti-arthritic agent.		Others
T16343	NRC-2694		EGFR
	NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.		EGFR
T10111	3-Deazaadenosine hydrochloride		Others , HIV Protease
	3-Deazaadenosine hydrochloride is an inhibitor of S-adenosylhomocysteine hydrolase (Ki: 3.9 µM). It has anti-inflammatory, anti-proliferative, and anti-HIV activity.		Others , HIV Protease
T12883	Fezagepras	PBI-4050,Setogepram	GPR
	Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-proliferative actions.		GPR
T17098	Tilfrinib		BTK
	Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) which displays anti-proliferative and anti-tumor activities.		BTK
T60852	Anticancer agent 46
	Anticancer agent 46 is a potent anti-cancer agent, showing anti-proliferative activity in cellular assays, with an IC50 of 0.986 μM against MGC803 cells.
T77728	Tubulin polymerization-IN-55		Microtubule Associated
	Tubulin polymerization-IN-55 is a potent Tubulin Polymerization inhibitor with potential anti-angiogenic and anti-tumour activity, showing anti-proliferative effects against A549, K562, HepG2, MDA-MB-231 and HFL-1.		Microtubule Associated
T12375	Fezagepras sodium	Setogepram sodium salt,PBI-4050 sodium salt	GPR
	Fezagepras sodium (Setogepram sodium salt) is an orally active GPR40 agonist and is an antagonist or inverse agonist for GPR84, with anti-fibrotic, anti-inflammatory and anti-proliferative actions.		GPR
T64365	SG-094		Others
	SG-094 is a specific TPC2 inhibitor that shows anti-proliferative effects on RIL175 cells with an IC50 of 3.7μM and can be used in tumor research.		Others
TQ0318	Filanesib	ARRY-520,ARRY 520	KSP
	Filanesib (ARRY 520) is a selective inhibitor of kinesin spindle protein (KSP, IC50 = 6 nM) with potent anti-proliferative activity.		KSP
T10882	CPUY074020		Histone Methyltransferase
	CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.		Histone Methyltransferase
T60753	L82		DNA
	L82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells.		DNA
TQ0318L	ARRY 520 hydrochloride		KSP
	ARRY 520 hydrochloride is a kinesin spindle protein (KSP) inhibitor.ARRY 520 hydrochloride induces cell death by apoptosis and has potent anti-proliferative activity.		KSP
T3485	Probimane	AT-2153,MM-159	Others
	Probimane (AT-2153) had Anti-proliferative effects, cell cycle G2/M phase arrest and blocking of chromosome segregation in human tumor cell lines with MST-16.		Others
T3097	Mycophenolic Acid Impurity	5,7-dihydroxy-4-methylphthalide	Others
	Mycophenolic Acid Impurity (5,7-dihydroxy-4-methylphthalide) is an an immunosuppresant drug and potent anti-proliferative, and can be used in place of the older anti-proliferative azathioprine. It is usually used as part...		Others
T60558	NSC 694623		Histone Acetyltransferase
	NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with IC50 of 15.9 μM against recombinant HAT p300/CBP associated factor (PCAF). NSC 694623 shows anti-proliferative activity against some cancer cells, whi...		Histone Acetyltransferase
T76749	Zilovertamab	Cirmtuzumab,UC-961	Others
	Zilovertamab (UC-961) is a humanized anti-ROR1 monoclonal antibody that cuts off the WNT5A-induced ROR1 signaling pathway and shows anti-proliferative activity in ovarian and endometrial cancer cells. It can be used to s...		Others
T63399L	MTOR/HDAC-IN-1 HCl	mTOR/HDAC-IN-1 HCl（2815286-02-1 Free base)	HDAC , mTOR
	mTOR/HDAC-IN-1 HCl is a potent dual inhibitor of mTOR and HDAC with potential anti-inflammatory, anti-proliferative, autophagy and apoptosis-inducing effects for cancer research.		HDAC , mTOR
T60218	YAP/TAZ inhibitor-2		YAP
	YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC 50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative and antitumor activity [1].		YAP
T77780	Zamaporvint	RXC004	Others
	Zamaporvint (RXC004) is a selective, orally active and potent inhibitor of the Wnt pathway that acts on the membrane-bound fatty acyltransferase porcupine to block Wnt ligand palmitoylation, secretion, and pathway activa...		Others
T31615	Elsibucol	AGI-1096,UNII-O7T92N1Y8T,AGI 1096	Antioxidant
	Elsibucol (AGI 1096) is a VCAM1 inhibitor for the study of organ transplant rejection.Elsibucol is a metabolically stable propanol derivative with antioxidant, anti-inflammatory and anti-proliferative properties. It lowe...		Antioxidant
T5379	(Rac)-Antineoplaston A10	Antineoplaston A10	Apoptosis , Ras
	(Rac)-Antineoplaston A10 (Antineoplaston A10) is a naturally occurring substance and the first antineoplaston in the human body to be chemically identified. It displayed anti-proliferative action inhibiting cell growth.		Apoptosis , Ras
T9320	YK-3-237	B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid	Sirtuin
	YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells ca...		Sirtuin
T72048	CDK8-IN-12		GSK-3 , CDK
	CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showe...		GSK-3 , CDK
T64338	AKI603	AKI 603,AKI-603	Aurora Kinase
	AKI603 is a novel small molecule inhibitor of Aurora kinase A (AurA)(IC50 = 12.3 nM). AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in l...		Aurora Kinase
T2129	Zaprinast		PDE
	Zaprinast is a cGMP-selective phosphodiesterase (PDE) inhibitor and a GPR35 agonist. It has a strong activating effect on rat GPR35 and a certain activating effect on human GPR35. It reduces vascular remodeling through a...		PDE

Compounds

Methylstat

T7057

Synonym:

Target: Histone Demethylase, Others

PFK-158

T3105

Synonym:

Target: Apoptosis, Glucokinase, Autophagy

Target: Apoptosis, Epigenetic Reader Domain, PROTACs

COTI-2

T4325

Synonym: COTI 2,COTI2

Target: Apoptosis, p53

KCC-07

T8554

Synonym:

Target: DNA Alkylator/Crosslinker

KY-05009

T11793

Synonym:

Target: Wnt/beta-catenin

HPI 1

T22089

Synonym:

Target: Hedgehog/Smoothened

Dihomo-γ-Linolenic acid methyl ester

Target: Apoptosis, FGFR

COH-SR4

T8740

Synonym: COH-SR4 (Mitochondria uncoupler SR4)

Target: Others, AMPK

Miransertib

T3467

Synonym: ARQ-092,AKT inhibitor 2

Target: Akt, Parasite

Hexylresorcinol

T0314

Synonym: 4-Hexylresorcinol

Target: Apoptosis, Tyrosinase, Antibacterial, Parasite

ML216

T5413

Synonym: CID-49852229

Target: DNA/RNA Synthesis

Uzansertib phosphate

T12477

Synonym: INCB053914 phosphate

Target: Apoptosis, S1P Receptor

Ciprofloxacin

T1640

Synonym: Ciproxan,Ciprobay,Bay o 9867,Bay-09867

Target: Topoisomerase, Antibacterial, Antibiotic

Ciprofloxacin monohydrochloride

T0250

Synonym: Bay-09867 (hydrochloride),Ciprofloxacin HCl,Ciprofloxacin hydrochloride

Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic

Flupentixol dihydrochloride

T5135

Synonym: Fupentixol Dihydrochloride,Flupenthixol dihydrochloride,(E/Z)-Flupentixol Dihydrochloride

Target: Dopamine Receptor

Sertindole

T5858

Synonym: Lu 23-174

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Autophagy

Doxycycline hydrochloride

T1140

Synonym: Doxylin,Vibramycin,Hyclate

Target: MMP, Antibacterial, Antibiotic

ALK/ROS1 inhibitor 2e HCL

T67699L

Synonym: (R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide hydrochloride(2365497-12-5 Free base)

Target: Apoptosis

Biguanidinium-porphyrin

Synonym: Clobuzarit,ICI 55897

3-Deazaadenosine hydrochloride

T10111

Synonym:

Target: Others, HIV Protease

Fezagepras

T12883

Synonym: PBI-4050,Setogepram

Anticancer agent 46

T60852

Synonym:

Target:

Tubulin polymerization-IN-55

T77728

Synonym:

Target: Microtubule Associated

Fezagepras sodium

T12375

Synonym: Setogepram sodium salt,PBI-4050 sodium salt

Synonym: ARRY-520,ARRY 520

Target: Histone Methyltransferase

ARRY 520 hydrochloride

Synonym: AT-2153,MM-159

Target: Others

Mycophenolic Acid Impurity

T3097

Synonym: 5,7-dihydroxy-4-methylphthalide

Target: Histone Acetyltransferase

Zilovertamab

T76749

Synonym: Cirmtuzumab,UC-961

Target: Others

mTOR/HDAC-IN-1 HCl

T63399L

Synonym: mTOR/HDAC-IN-1 HCl（2815286-02-1 Free base)

Synonym: AGI-1096,UNII-O7T92N1Y8T,AGI 1096

Target: Antioxidant

(Rac)-Antineoplaston A10

T5379

Synonym: Antineoplaston A10

Target: Apoptosis, Ras

YK-3-237

T9320

Synonym: B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid

Synonym: AKI 603,AKI-603

Target: Aurora Kinase

Cat No.	Product Name	Synonyms	Targets
T5712	Zerumbone		Antioxidant , HSV
	Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities, contributing to immunomodulatory a...		Antioxidant , HSV
T6520	Grape Seed Extract	Grape Seed P.E.	Apoptosis , Others
	Grape Seed Extract (Grape Seed P.E.) is exudate from seeds of the grape plant Vitis vinifera, composed of oils and secondary plant metabolites (BIOFLAVONOIDS and polyphenols) credited with important medicinal properties.		Apoptosis , Others
TN1736	Hibifolin		Adenosine deaminase
	Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity.		Adenosine deaminase
TN1525	Convallatoxin		NF-κB , P-gp , PPAR
	Convallatoxin is a natural product		NF-κB , P-gp , PPAR
T1687	Doxycycline	Vibramycin,Doxiciclina,Doxytetracycline,Doxycyclinum	MMP , ribosome , Antibacterial , Antibiotic , Parasite
	Doxycycline (Doxiciclina) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline has antibacterial activity and antitumor activity.		MMP , ribosome , Antibacterial , Antibiotic , Parasite
T1687L	Doxycycline (hyclate)	Doxycycline hydrochloride hemiethanolate hemihydrate,WC2031,Doxycycline hyclate	MMP , ribosome , Antibacterial , Antibiotic
	Doxycycline hyclate (WC2031) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline hyclate has antibacterial activity and antitumor act...		MMP , ribosome , Antibacterial , Antibiotic
T8130	Ciprofloxacin hydrochloride monohydrate	Oftacilox,Ciprofloxacin hydrochloride hydrate,Bay-09867 hydrochloride monohydrate,Ceprimax,Ciloxan	Antibacterial , Antibiotic
	Ciprofloxacin hydrochloride monohydrate (Bay-09867 hydrochloride monohydrate) is a fluoroquinolone antibiotic,is an antibiotic used to treat a number of bacterial infections		Antibacterial , Antibiotic
TQ0134	Podocarpusflavone A		Topoisomerase
	Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.		Topoisomerase
T5S0803	Columbamine	Columbamin,Dehydroisocorypalmine	Others
	Columbamine (Columbamin) shows strong activity with IC5 48.1 μM.Columbamine exerts anti-proliferative and anti-vasculogenic effects on metastatic human osteosarcoma U2OS cells with low toxicity.		Others
TN2290	Uvaol		Endogenous Metabolite , JNK , PPAR
	Uvaol is present in olives and virgin olive oil with anti-inflammatory, anti-proliferative, and vasorelaxant activities.		Endogenous Metabolite , JNK , PPAR
TMS0943	Platicodigenin	Platycodigenin	Others
	Platicodigenin (Platycodigenin) isolated from platycodon grandiflorum, has in vitro anti-proliferative activity against the HSC-T6 cell line.		Others
T7927	β-Ionone	β-lonone	Apoptosis , Others
	β-Ionone (β-lonone) is an end-ring analog of β-carotenoids which widely distributed in fruit and vegetables,with anti-proliferative, anti-metastatic		Apoptosis , Others
T2179	Triptolide	PG490,NSC 163062	Apoptosis , Mdm2 , HSP , NF-κB
	Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and ...		Apoptosis , Mdm2 , HSP , NF-κB
T5758	Sphondin		COX , Prostaglandin Receptor
	Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.		COX , Prostaglandin Receptor
T3796	Betulinaldehyde	Betulinic aldehyde,Betulinal,Betunal	Apoptosis , Antibacterial
	Betulinaldehyde (Betunal) has the inhibition of Saccharomyces sp and alpha-glucosidase. Betulinaldehyde induces apoptosis in mouse B16 2F2 cells. Betulinaldehyde has anti-proliferative activity against mouse +SA mammary ...		Apoptosis , Antibacterial
T1335	Mycophenolic acid	Mycophenolate,RS-61443	Apoptosis , Dehydrogenase , Endogenous Metabolite , Antibacterial , Antibiotic , UGT , Antifungal
	Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.
T6S1683	Demethoxycurcumin	Curcumin II,Desmethoxycurcumin,Monodemethoxycurcumin	Apoptosis , Antioxidant , Antibacterial , Autophagy
	1. Demethoxycurcumin (Desmethoxycurcumin) has antioxidant activity. 2. Demethoxycurcumin has anti-inflammatory activity. 3. Demethoxycurcumin has anti-proliferative activity. 4. Demethoxycurcumin has anti-acanthamoebic e...		Apoptosis , Antioxidant , Antibacterial , Autophagy
T3019	Physcion	Physcione,Parietin,Rheochrysidin	Dehydrogenase , Antibacterial
	Physcion (Physcione) (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM...		Dehydrogenase , Antibacterial
T5S1103	Isoliensinine	Isoliensinin	Apoptosis , Antioxidant
	1. Isoliensinine (Isoliensinin), a natural phenolic bisbenzyltetrahydroisoquinoline alkaloid, has received considerable attention for its potential biological effects such as antioxidant and anti-HIV activities. 2. Isoli...		Apoptosis , Antioxidant
TN6594	Bidenoside C		Others
	Bidenoside C is a flavonoid found in brazilian propolis, the first of its kind to be isolated from a herb of the genus Leech, and has anti-proliferative activity against cancer cells.		Others
T5S1467	Cucurbitacin E		CDK , Autophagy
	Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has pot...		CDK , Autophagy
T4869	D-Allose	β-D-Allopyranose,D-(+)-ALLOSE	Others , Endogenous Metabolite
	D-Allose (β-D-Allopyranose) is a rare naturally occurring monosaccharide known to exert anti-proliferative effects on cancer cells. The effects of D-Allose on the cellular membranes of hormone-refractory prostate cancer ...		Others , Endogenous Metabolite
T2996	Tetrandrine	NSC-77037,d-Tetrandrine,Hanfangchin A,Fanchinine,Sinomenine A	Potassium Channel , Calcium Channel
	Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the c...		Potassium Channel , Calcium Channel
TN6508	Trachelogenin	(-)-Trachelogenin	Virus Protease , c-Myc , HCV Protease , Wnt/beta-catenin
	Trachelogenin ((-)-Trachelogenin), isolated from Combretum fruticosum, is an HCV entry inhibitor with anti-proliferative effects. Its mechanism is related to affecting the phosphorylation of key proteins such as β-Cateni...		Virus Protease , c-Myc , HCV Protease , Wnt/beta-catenin
T5S0890	Oleandrin	Neriostene,Folinerin,Foliandrin	Apoptosis , ATPase , Potassium Channel , Sodium Channel
	1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, ...		Apoptosis , ATPase , Potassium Channel , Sodium Channel
TN5538	6-Methoxykaempferol		Others
	6-Methoxykaempferol is a flavonoid found in brazilian propolis. 6-Methoxykaempferol has anti-proliferative activity against cancer cells, neuroprotective effects on isolated rat brain synaptosomes and reduces glutathione...		Others
TCS2170	2,5-Dihydroxyacetophenone	Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP	ERK , NF-κB , Tyrosinase
	1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK...		ERK , NF-κB , Tyrosinase
T3794	Pentagalloylglucose	Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose	Influenza Virus
	1, 2, 3, 4, 6-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) and gallic acid from Pistacia lentiscus have antimutagenic and antioxidant activities. 2. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose (PGG) possesses poten...		Influenza Virus
TN2655	17alpha-Neriifolin		Others
	17alpha-Neriifolin and 17alpha-Deacetyltanghinin have little anti-proliferative activity, indicating that the 17beta configuration is critical for the anti-proliferative activity of these compounds.		Others
TN2972	3-O-(E)-p-Coumaroylbetulin		Others
	3-β-O-trans-p-coumaroylbetulinol has anti-angiogenic effect, it possesses significant anti-proliferative activity with 66.7% inhibition at 100uM.		Others
TN4101	Ganoderenic acid H		Others
	Ganoderenic acid H is one compound of triterpenoids isolated from Ganoderma lucidum, triterpenoids exhibit a broad spectrum of anti-cancer properties, including anti-proliferative, anti-metastatic and anti-angiogenic act...		Others
TN4093	Galeopsin		TNF
	Galeopsin shows potential anti-inflammatory activity by inhibiting proinflammatory cytokine TNF-α, it has anti-proliferative effect on several cancer cell lines.		TNF
T81873	Malonylginsenoside Rc
	Malonylginsenoside Rc, a naturally occurring active compound, exhibits anti-proliferative activity [1].
T81189	Schizolaenone C
	Schizolaenone C, a natural compound isolated from Schizolaena hystrix, demonstrates anti-proliferative and anti-oxidative properties [1] [2].
T38036	Lumisterol
	Lumisterol (9β,10α-Ergosterol), a steroid compound and the (9β,10α)-stereoisomer of Ergosterol, serves as a photoprotective agent shielding against UVB-induced DNA damage and exhibits anti-proliferative activities[1].
T11223	Eriosematin		Others
	Eriosematin has anti-proliferative and apoptosis-inducing properties and is a compound extracted from the root of Flemingia philippinensis in the Philippines.		Others
T2S2104	Sinigrin hydrate	Sinigrin monohydrate,Allylglucosinolate monohydrate	Antibacterial
	Sinigrin hydrate (Allylglucosinolate monohydrate) has antimicrobial activity. Sinigrin hydrate (Allylglucosinolate monohydrate) exerts important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in...		Antibacterial
TN4903	Regiolone		Caspase
	Regiolone demonstrates phytotoxicity. Regiolone also has anti-proliferative and apoptotic activities, it can induce apoptosis in MCF-7 cells through the caspase-3 independent pathway.		Caspase
T16035	Meleagrin		Others
	Meleagrin, a roquefortine C-derived alkaloid produced by Penicillium fungi, serves as both a class of FabI inhibitors and a lead c-Met inhibitory entity for controlling c-Met-dependent metastatic and invasive breast mali...		Others
TN3726	Cudraflavone B		IκB/IKK , MAO , ROS , Akt , COX , PI3K , Nrf2 , Autophagy
	Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mouse melanoma cells, and hepatoprotective activity. It may b...		IκB/IKK , MAO , ROS , Akt , COX , PI3K , Nrf2 , Autophagy
T19886	Cirsilineol	Fastigenin,SPM 927,Eupatrin	Apoptosis , COX , STAT
	Cirsilineol (Eupatrin) is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selectively induces apoptosis via the mitochondrial pathw...		Apoptosis , COX , STAT
TN3495	Benzyl ferulate		TNF , Antifection
	Benzyl ferulate has antimicrobial activity. It also shows good anti-proliferative against three gastro-intestinal cancer cell lines(HCT-116 colon carcinoma, KYSE-30 oesophageal squamous cancer, and NCI-N87 gastric carcin...		TNF , Antifection
T72795	(S)-Erypoegin K
	(S)-Erypoegin K is a potent anticancer agent that demonstrates strong anti-proliferative activity against HL-60 cells and induces apoptosis.
TN5138	Teuclatriol		TNF , NF-κB , TLR
	Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-ÎºB signaling at doses of 312µM and higher. It showed a significant anti-proliferative e...		TNF , NF-κB , TLR
T68802	Vibsanin A
	Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.
TN5901	Cudratricusxanthone A
	Cudratricusxanthone A has potent anti-proliferative, antioxidative, and monoamine oxidase inhibitory effects, it also possesses anti-cancer activities and provide a basis for developing effective therapeutic agents to in...
TN2945	3-Hydroxybakuchiol		ATPase , Caspase
	3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, th...		ATPase , Caspase
TN4178	Gyrophoric acid		cAMP
	Vulpinic and gyrophoric acids are known as ultraviolet filters for natural lichen populations, they can effectively prevent cytotoxic, apoptotic and cytoskeleton alterative activities of 2.5 J/cm(2) UVB in a dose-depende...		cAMP
T75629	Ganoderic acid Mk
	Ganoderic acid Mk (GA-Mk), a triterpenoid acid derived from Ganoderma lucidum mycelia, exhibits potent anti-proliferative properties and can induce apoptosis in HeLa cells through a mitochondria-mediated pathway, making ...
TN5250	Vomifoliol		VEGFR , NF-κB , HIF
	Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major metabolise, and a cell-free extract exhibits vomifoliol deh...		VEGFR , NF-κB , HIF
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Natural Products

zerumbone

T5712

Synonym:

Target: Antioxidant, HSV

Grape Seed Extract

T6520

Synonym: Grape Seed P.E.

Target: Apoptosis, Others

Hibifolin

TN1736

Synonym:

Target: Adenosine deaminase

Convallatoxin

TN1525

Synonym:

Target: NF-κB, P-gp, PPAR

Doxycycline

T1687

Synonym: Vibramycin,Doxiciclina,Doxytetracycline,Doxycyclinum

Target: MMP, ribosome, Antibacterial, Antibiotic, Parasite

Doxycycline (hyclate)

T1687L

Synonym: Doxycycline hydrochloride hemiethanolate hemihydrate,WC2031,Doxycycline hyclate

Target: MMP, ribosome, Antibacterial, Antibiotic

Ciprofloxacin hydrochloride monohydrate

T8130

Synonym: Oftacilox,Ciprofloxacin hydrochloride hydrate,Bay-09867 hydrochloride monohydrate,Ceprimax,Ciloxan

Target: Antibacterial, Antibiotic

Podocarpusflavone A

TQ0134

Synonym:

Target: Topoisomerase

Columbamine

T5S0803

Synonym: Columbamin,Dehydroisocorypalmine

Target: Endogenous Metabolite, JNK, PPAR

Platicodigenin

TMS0943

Synonym: Platycodigenin

Target: Apoptosis, Others

Triptolide

T2179

Synonym: PG490,NSC 163062

Target: Apoptosis, Mdm2, HSP, NF-κB

sphondin

T5758

Synonym:

Target: COX, Prostaglandin Receptor

Betulinaldehyde

T3796

Synonym: Betulinic aldehyde,Betulinal,Betunal

Target: Apoptosis, Antibacterial

Mycophenolic acid

T1335

Synonym: Mycophenolate,RS-61443

Target: Apoptosis, Dehydrogenase, Endogenous Metabolite, Antibacterial, Antibiotic, UGT, Antifungal

Demethoxycurcumin

T6S1683

Synonym: Curcumin II,Desmethoxycurcumin,Monodemethoxycurcumin

Target: Apoptosis, Antioxidant, Antibacterial, Autophagy

Physcion

T3019

Synonym: Physcione,Parietin,Rheochrysidin

Target: Dehydrogenase, Antibacterial

Isoliensinine

T5S1103

Synonym: Isoliensinin

Target: Apoptosis, Antioxidant

Target: CDK, Autophagy

D-Allose

T4869

Synonym: β-D-Allopyranose,D-(+)-ALLOSE

Target: Others, Endogenous Metabolite

Tetrandrine

T2996

Synonym: NSC-77037,d-Tetrandrine,Hanfangchin A,Fanchinine,Sinomenine A

Target: Potassium Channel, Calcium Channel

Trachelogenin

TN6508

Synonym: (-)-Trachelogenin

Target: Virus Protease, c-Myc, HCV Protease, Wnt/beta-catenin

Oleandrin

T5S0890

Synonym: Neriostene,Folinerin,Foliandrin

Target: Apoptosis, ATPase, Potassium Channel, Sodium Channel

2,5-Dihydroxyacetophenone

TCS2170

Synonym: Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP

Target: ERK, NF-κB, Tyrosinase

Pentagalloylglucose

T3794

Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose

Target: Influenza Virus

3-O-(E)-p-Coumaroylbetulin

Malonylginsenoside Rc

Synonym: Sinigrin monohydrate,Allylglucosinolate monohydrate

Target: Antibacterial

Target: IκB/IKK, MAO, ROS, Akt, COX, PI3K, Nrf2, Autophagy

Cirsilineol

T19886

Synonym: Fastigenin,SPM 927,Eupatrin

Target: Apoptosis, COX, STAT

Benzyl ferulate

TN3495

Synonym:

Target: TNF, Antifection

Target: TNF, NF-κB, TLR

Cudratricusxanthone A

Target: ATPase, Caspase

Target: VEGFR, NF-κB, HIF

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His)	Human	Baculovirus
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections,...
TMPH-03753	MYLK Protein, Human, Recombinant (His)	Human	E. coli
	Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phos...

IRF1 Protein, Human, Recombinant (GST & His)

TMPH-01552

Species: Human

Expression System: Baculovirus

MYLK Protein, Human, Recombinant (His)

TMPH-03753

Species: Human

Expression System: E. coli