泛素化

Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.

Bleomycin sulfate is a glycopeptide antibiotic with antitumor activity. It is commonly used as a DNA-damaging agent and DNA synthesis inhibitor. It functions by inducing DNA strand breaks without affecting RNA strands. Bleomycin sulfate is widely used in cancer research and for establishing pulmonary fibrosis animal models.

Rutin hydrate (Sophorin), a kind of glycoside, widely exists in many plants including citrus fruit.

Retinyl palmitate (Vitamin A palmitate) is a naturally-occurring phenyl analogue of retinol, with potential antineoplastic and chemopreventive activities.

L-aspartic acid potasium salt(VX-548) is an amino acid widely found in plants and animals.L-aspartic acid potasium salt drives the production of nitrogen oxides, which promotes phagocytosis and contributes to fish survival.L-aspartic acid potasium salt may stimulate antibiotics. The stimulatory effect may be related to precursors involved in aspartic acid-4-semialdehyde biosynthesis.

Laccase (Denilite IIS) is a polycopper oxidase (MCOs) widely found in microorganisms, plants, and fungi with antimicrobial activity and cytotoxicity that can be used in the study of cancer.Laccase promotes oxidative coupling of mono-lignin in lignin formation.

2-Methoxy-4-ethylphenol inhibits Flavin-containing monooxygenase 5 (NADPH oxidase) in human neutrophils and is widely used in biochemical experiments and drug synthesis research.

Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.

1. Protosappanin B (Q-100961) significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. 2. Protosappanin B induces the degradation of p53 protein, via activation of a MDM2-dependent ubiquitination process.

Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.

1-Benzyl-I3C is an NEDD4-1 inhibitor.

PHYTOL (trans-Phytol) , a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.

Panduratin A is a natural chalcone derivative with inhibitory activity against MMP-9 in human oral epidermoid carcinoma KB cells; inhibitory activity against the NS3 protease of DENV-2 (Ki=25 μM); significant cytotoxicity against human androgen-independent prostate cancer cells PC-3 and DU-145; and also able to activate the LKB1-AMPK- PPARα /δ signaling pathway and enhance the oxidative capacity of myocyte mitochondria.

Bavachalcone, a major bioactive compound isolated from *Psoralea corylifolia* L., may serve as a therapeutic drug for bone resorption-associated diseases. It protects endothelial function by increasing AMPK activity and MnSOD expression while reducing mitochondrial oxidative stress.

Farnesene(mixture of α & β isomers) is a natural sesquiterpene, naturally produced by aphids as an alarm pheromone. It is widely used in essential oils due to its volatility. α-Farnesene is also used in industrial production, including the synthesis of biofuels, lubricants, and cosmetics, and has potential neuroprotective and dental protective effects.

BYAKANGELICIN,a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor,and is effective for the treatment of sugar cataracts and diabetic neuropathy and hence might be useful as a lead compound for the development of new type drugs for clinical use.

HA Peptide (TFA), a nine amino acid sequence derived from human influenza hemagglutinin (HA), is widely employed in cell biology and biochemistry for the isolation, purification, detection, and tracking of target proteins [1] [2] [3].

cis-Nerolidol, a sesquiterpene alcohol present in numerous plants, exhibits antioxidant and antibacterial properties. Additionally, it can potentiate the effects of antibiotics [1].

α-Lactose (hydrate) (α-D-Lactose (hydrate)), the primary carbohydrate in mammalian milk, consists of two sugar units: glucose and galactose, and exists as two anomers, α and β. It serves various roles in the food and pharmaceutical industries, including as a free-flowing or agglomerating agent, and a diluent for pigments, flavors, or enzymes [1] [2] [3].

Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.

Anticancer Agent 141 (Compound AE), an antimycin alkaloid, exhibits inhibitory potential against HPV-infected cervical cancer. It impedes HeLa cell proliferation by arresting the cell cycle at the S phase and induces caspase-dependent apoptosis through mitochondrial disruption. This disruption activates the ROS-mediated ubiquitin-dependent proteasome system, leading to the degradation of E6 E7 oncoproteins [1].

18-O-Demethylpederin, a pederin analogue, is a natural polyketide first isolated from Paederus. This compound is a non-protein insect toxin and exhibits a range of biological activities, such as antibacterial, antiviral, and antitumor properties [1].

Sumaresinolic Acid is a natural lignan found in a variety of plants such as flaxseed, sesame and wheat bran and is a secondary metabolite of plants. It has been widely studied for its potential health benefits, including its ability to reduce inflammation, improve lipid metabolism and provide antioxidant protection.

Retinyl palmitate (Standard) is the standard substance of Retinyl palmitate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Retinyl palmitate (Vitamin A palmitate) is a naturally-occurring phenyl analogue of retinol, with potential antineoplastic and chemopreventive activities.