T11441 |
GNE-987
|
2417371-71-0
|
98%
|
|
GNE-987 is a highly active chimeric BET degrader. GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50: 4.7 and...
|
T11597L |
IACS-9571 Hydrochloride (1800477-30-8 free base)
|
T11597L
|
98%
|
|
IACS-9571 Hydrochloride is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).
|
T5439 |
BRD4 degrader AT1
|
2098836-45-2
|
98%
|
|
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
|
T15400 |
GNE-272
|
1936428-93-1
|
98%
|
|
GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.
|
T13366 |
YHO-13351
|
1346753-00-1
|
98%
|
|
YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific BCRP inhibitor.
|
T12346 |
CBP/p300-IN-5
|
1889284-33-6
|
98%
|
|
P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).
|
T10702 |
CBP/p300-IN-2
|
2158265-96-2
|
98%
|
|
CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc) extracted from patent WO2017205538A1 (example 25).
|
T13715 |
GSK9311 hydrochloride
|
2253733-09-2
|
98%
|
|
GSK9311 hydrochloride, a less active analog of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain (pIC50s: 6.0 and 4.3 f...
|
T16139 |
MRS2698
|
934014-05-8
|
98%
|
|
MRS2698 is an effective and highly selective agonist of the P2Y2 receptor (EC50: 8 nM). MRS2698 also is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 recepto...
|
T13833 |
PROTAC BRD4 Degrader-1
|
2133360-00-4
|
98%
|
|
PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
|
T13105 |
TD-428
|
T13105
|
98%
|
|
TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD...
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T10522 |
BET-IN-6
|
2570470-39-0
|
98%
|
|
BET-IN-6 is a potent and high affnity BRD2/BRD4 inhibitor. BET-IN-6 is the ligand for target protein BRD2/4 that is used for the systhesis of PROTAC BRD2/BRD4 de...
|
T9703 |
GSK778
|
2451862-42-1
|
98%
|
|
GSK778 is a potent and selective inhibitor of BD1 bromodomain such as BRD2 BD1 (IC50s = 75 nM), BRD3 BD1 (IC50s = 41 nM), BRD4 BD1 (IC50s = 41 nM), and BRDT BD1 ...
|
T12660 |
(Rac)-BAY1238097
|
1564268-19-4
|
98%
|
|
(Rac)-BAY1238097 is a inhibitor of BET(IC50 of 1.02 μM for BRD4),used in cancer research.
|
TP2149L |
NP213
|
942577-31-3
|
98%
|
|
NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal...
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T13915 |
PROTAC BRD9-binding moiety 1
|
2097512-23-5
|
98%
|
|
PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
|
T13786 |
MZP-55
|
2010159-48-3
|
98%
|
|
MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)
|
T13834 |
PROTAC BRD4 Degrader-2
|
2185795-53-1
|
98%
|
|
PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
|
T11887 |
LT052
|
2543545-44-2
|
98%
|
|
LT052 is a highly active and selective inhibitor of BET BD1 with an IC 50 of 87.7 nM. LT052 exhibits nanomolar BRD4 BD1 potency and 138-fold selectivity over BRD...
|
T12798 |
(S)-GNE-987
|
T12798
|
98%
|
|
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
|