T15443 |
GSK8814
|
1997369-78-4
|
98%
|
|
GSK8814 is a selective and ATAD2/2B bromodomain chemical probe and inhibitor (binding constant pKd=8.1 and a pKi=8.9 in BROMOscan). GSK8814 displays 500-fold sel...
|
T15014 |
CTPB
|
586976-24-1
|
98%
|
|
CTPB is a p300 histone acetyltransferase (HAT) enzyme activator.
|
T13850 |
PROTAC BET degrader-3
|
T13850
|
98%
|
|
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.
|
T13105 |
TD-428
|
T13105
|
98%
|
|
TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD...
|
T12798 |
(S)-GNE-987
|
T12798
|
98%
|
|
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
|
T17294 |
ZL0454
|
2229042-77-5
|
98%
|
|
ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).
|
T11597 |
IACS-9571
|
1800477-30-8
|
98%
|
|
IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).
|
T13849 |
PROTAC BET Degrader-1
|
2093386-22-0
|
98%
|
|
PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.
|
T12346 |
CBP/p300-IN-5
|
1889284-33-6
|
98%
|
|
P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).
|
T12660L |
BAY1238097
|
1564268-08-1
|
98%
|
|
BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different MM (multiple myeloma) and AML (...
|
TP2149L |
NP213
|
942577-31-3
|
98%
|
|
NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal...
|
T10520 |
BET-IN-2
|
2104688-91-5
|
98%
|
|
BET-IN-2 is a BET inhibitor (IC50: 52 nM for BRD4-BD1).
|
T10702 |
CBP/p300-IN-2
|
2158265-96-2
|
98%
|
|
CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc) extracted from patent WO2017205538A1 (example 25).
|
T13785 |
MZP-54
|
2010159-47-2
|
98%
|
|
MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)
|
T13190 |
TP-472
|
2079895-62-6
|
98%
|
|
TP-472 is a selective inhibitor of BRD9 (Kd: 33 nM).
|
T16139 |
MRS2698
|
934014-05-8
|
98%
|
|
MRS2698 is an effective and highly selective agonist of the P2Y2 receptor (EC50: 8 nM). MRS2698 also is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 recepto...
|
T10879 |
CPI-0610 carboxylic acid
|
1380089-81-5
|
98%
|
|
CPI-0610 carboxylic acid is a ligand for target protein for PROTAC. It is a potent bromodomain and extra-terminal (BET) protein inhibitor with the potential in t...
|
T13915 |
PROTAC BRD9-binding moiety 1
|
2097512-23-5
|
98%
|
|
PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
|
T15399 |
GNE-207
|
2158266-58-9
|
98%
|
|
GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-207...
|
T13890 |
SMARCA-BD ligand 1 for Protac dihydrochloride
|
2369053-68-7
|
98%
|
|
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
|