Asp

ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experimental autoimmune encephalomyelitis in mice.

Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) is a broad range caspase inhibitor. Boc-Asp(OME)-Fluoromethyl Ketone inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.

Z-Asp(OBzl)-OH (N-Cbz-L-Aspartic acid 4-benzyl ester) is an aspartic acid derivative.

pro-asp TFA(85227-98-1 free base) (TLβ4) down-regulate skin inflammation in mouse skin.

Arg-Gly-Asp-Ser (RGDS peptide) is a conserved tetrapeptide sequence found on fibronectin, fibrinogen α, and von Willebrand factor. It binds to integrins on the cell surface, inhibiting thrombin-induced platelet-fibrinogen interaction.

Arg-Gly-Asp-Ser acetate is an integrin binding sequence that directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1. Arg-Gly-Asp-Ser acetate inhibits integrin receptor function.

Asp-AMS is a strong competitive inhibitor of the mitochondrial enzyme and also an aspartyl-tRNA synthetase inhibitor.

ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist with EC50 values of 7.12 nM and 517 nM for hS1P1 and hS1P3, respectively.

Arg-Gly-Asp-D-Phe-Val (TFA) has anti-tumor activity and is an inhibitor of integrin αvβ3.

Lith-O-Asp is a competitive, selective sialyltransferase inhibitor (ST3Gal Ki = 1.3 μM). It inhibits cancer cell adhesion and invasion by reducing surface sialylation in metastasis research.

Z-Asp-CH2-DCB is an irreversible inhibitor of broad-spectrum caspases.

ASP2535 is a potent, selective, orally bioavailable, brain-permeable, and centrally-active glycine transporter-1 (GlyT1) inhibitor that can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease[1].

ASP6432 is an antagonist of type 1 lysophosphatidic acid receptor (LPA1). For human LPA1 and rat LPA1, the IC50s are 11 nM and 30 nM , respectively.

ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS.

ASP8477 is a potent and selective FAAH inhibitor. It increases anandamide levels in the brain when administered orally. In rat models of neuropathic and osteoarthritic pain, ASP8477 demonstrates significant efficacy without causing motor coordination issues. A single oral dose of ASP8477 improves thermal hyperalgesia and cold allodynia in rats with chronic constriction nerve injury. Moreover, ASP8477 restores the decreased muscle pressure threshold in a myalgia model induced by reserpine. Research indicates that ASP8477 possesses analgesic effects effective for alleviating neuropathic and functional pain, making its pharmacological properties suitable for chronic pain treatment.

ASP-6537 is a selective and reversible inhibitor of cyclooxygenase-1.

ASP-1645 is a bio-active chemical.

ASP5878 is an oral bioavailable fibroblast growth factor receptor (FGFR) inhibitor with potential anti-tumor activity.

Z-VDVA-(DL-Asp)-FMK, a derivative of Z-VDVAD-FMK, is specifically designed as a caspase-2 inhibitor.

Arg-Gly-Asp-Cys TFA serves as the binding motif through which fibronectin interacts with cell adhesion molecules. This compound has the ability to hinder platelet aggregation and fibrinogen binding.

ASP2453 is a potent, selective, and covalent inhibitor of KRAS G12C that inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.

[Asp5]-Oxytocin is the first 5-position neurohypophyseal hormone analogue with significant biological activity.

ASP-9521 is a selective, potent and orally active indole-based AKR1C3 inhibitor with an IC50 of 11 nM for human AKR1C3.

Arg-Gly-Asp TFA (99896-85-2(free base)) (RGD Trifluoroacetate) is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.