T23010 |
MNI 137
|
946619-21-2
|
98%
|
|
MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.
|
T15692 |
L-AP4
|
23052-81-5
|
98%
|
|
L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).
|
T15369 |
Gamma-DGG
|
6729-55-1
|
98%
|
|
gamma-DGG is a competitive blocker of AMPA receptor.
|
T15819 |
LY377604
|
204592-94-9
|
98%
|
|
LY377604 is a human β3-adrenergic receptor agonist (EC50: 2.4 nM). It also a β1- and β2-adrenergic receptor antagonist.
|
T10808 |
CHPG sodium salt
|
1303993-73-8
|
98%
|
|
CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways. CHPG sodium salt can be used in studies about traumatic brain...
|
T15618 |
JNJ-46281222
|
1254980-38-5
|
98%
|
|
JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a hi...
|
T6562 |
Latrepirdine dihydrochloride
|
97657-92-6
|
98%
|
|
Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
|
T11906 |
LY 541850
|
852679-76-6
|
98%
|
|
LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human io...
|
T11311L |
Foliglurax
|
1883329-51-8
|
98%
|
|
Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).
|
T11911 |
LY3020371 hydrochloride
|
1377615-44-5
|
98%
|
|
LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu...
|
T12520 |
Pomaglumetad methionil
|
956385-05-0
|
98%
|
|
Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.
|
T4009 |
NS 1209
|
205645-02-9
|
98%
|
|
NS1209 is a AMPA receptor antagonist.
|
T35028 |
Valiglurax
|
1976050-09-5
|
98%
|
|
Valiglurax, also known as VU0652957 and VU2957, is a potent, selective, CNS penetrant, and orally bioavailable mGlu4 PAM. VU2957 possessed attractive in vitro an...
|
T15619 |
JNJ-46778212
|
1363281-27-9
|
98%
|
|
JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260 nM).
|
T15823 |
LYPLAL1-IN-1
|
1966129-74-7
|
98%
|
|
LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.
|
T15944 |
M77976
|
394237-61-7
|
98%
|
|
M77976 is the potential for the research of obesity and diabetes. M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms ...
|
T12025 |
MFZ 10-7 hydrochloride
|
1779796-36-9
|
98%
|
|
MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAM
|
T21935 |
AMN082
|
97075-46-2
|
98%
|
|
AMN 082 dihydrochloride is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity.
|
T14389 |
AZD 9272
|
327056-26-8
|
98%
|
|
AZD 9272 is a antagonist of brain penetrant mGluR5.
|
T13319 |
VU0652835
|
1848252-81-2
|
98%
|
|
VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).
|