Cart
Neuroscience GluR

GluR

Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells.Glutamate receptors are responsible for the glutamate-mediated postsynaptic excitation of neural cells, and are important for neural communication, memory formation, learning, and regulation.
Cat No. product name
T21935 AMN 082 dihydrochloride AMN 082 dihydrochloride is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity.
T3483 FTIDC FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibiti...
T0256 Lithium citrate tribasic tetrahydrate Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and me...
T6727 VU 0364770 VU 0364770(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGlu subtypes.
T6022 LY404039 LY404039 is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).
T3484 (±)-trans-ACPD (±)-trans-ACPD is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD. (±)-trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor)...
T0333 Aniracetam Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
T0426 Piracetam Piracetam, a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.
T2053 ADX 47273 ADX-47273 is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).
T3482 CFMTI CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist (IC50: 2.6 nM). The selectivity of CFMTI to mGluR1 is higher 2000...
T6457 CTEP CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over othe...
T6598 MPEP MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.
T3010 Xanthurenic Acid Xanthurenic acid, a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGl...
T0675 Topiramate Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepat...
T6562 Latrepirdine Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
T4113 NBQX disodium salt Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.
T4500 ADX88178 ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.
T4573 Cyclothiazide Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its r...
T5083 L-Cysteic acid monohydrate L-Cysteic acid is an oxidation product of L-cysteine that may be used as a competitive inhibitor of the bacterial aspartate: alanine antiporter (AspT) exchange o...
T5884 Chelidamic acid Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
T7304 DNQX DNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)
T7292 FITM FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM).
T7178 CNQX CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)
T6468 D-glutamine D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.
T0326L L-Glutamine L-glutamine, a non-essential amino acid, is synthesized from glutamic acid and ammonia.
T7494 TCN 238 TCN 238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).
T3464 PHCCC PHCCC is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mGl...
T6726 VU 0361737 VU 0361737 is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 i...
T6160 VU 0364439 VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).
T0024 Primidone Primidone is an anticonvulsant of the pyrimidinedione class.
T3451 JNJ42153605 JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).
T6871 L-Glutamic acid monosodium salt L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor.
T3539 Lu AF21934 Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).
T3479 (RS)-MCPG (RS)-MCPG is a non-selective group I/II metabotropic glutamate receptor antagonist.
T1884 Ampalex Ampalex (Ampakine CX516; CX516; BDP 12), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, ...
T6134 IEM 1754 2HBr IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
T3477 E4CPG E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG.
T3957 Farampator Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.
T3486 3-MATIDA 3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGlu...
T2497 MPEP hydrochloride MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).
T3473 ATPO ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
T2194 Chicago Sky Blue 6B Chicago sky blue 6B, a vesicular glutamate transporters inhibitor, attenuates methamphetamine-induced hyperactivity and behavioral sensitization in mice.
T3478 Ro 67-7476 Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 ...
T0313 Evans blue Evans blue is an azo dye, inhibits L-glutamate uptake via the membrane-bound excitatory amino acid transporter (EAAT).
T3379 Decanoic Acid Decanoic Acid acts as a non-competitive AMPA receptor antagonist.
T2811 Harmine hydrochloride Harmine hydrochloride is extracted from Peganum Harmala Genus.
T1443 Memantine hydrochloride Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
T6725 VU 0357121 VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.
T0051 Urethane Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
T7515 MTEP hydrochloride MTEP hydrochloride is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)
T7579 1-BCP 1-BCP is a centrally active drug that modulates AMPA receptor gated currents.
T9133 Caroverine HCL Caroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that...
T11911 LY3020371 hydrochloride LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGl...
T15692 L-APB L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively)....
T15819 LY377604 LY377604 is a human β3-adrenergic receptor agonist (EC50: 2.4 nM). It also a β1- and β2-adrenergic receptor antagonist.
T15823 LYPLAL1-IN-1 LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.
T15830 M-110 M-110 inhibits PIM-1 and PIM-2 with similar (IC50s: 2.5 μM) and it also inhibits the proliferation of prostate cancer cell lines (IC50s: 0.6 to 0.9 μM). M-110 ...
T15944 M77976 M77976 is the potential for the research of obesity and diabetes. M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms ...
T5509 FPTQ FPTQ is an antagonist of mGluR1.
T16402 Org-26576 Org-26576 is a positive allosteric modulator of the AMPA receptor.
T16524 Philanthotoxin 74 dihydrochloride Philanthotoxin 74 dihydrochloride is an AMPAR antagonist. Philanthotoxin 74 dihydrochloride inhibits GluR3 and GluR1 (IC50s: 263 and 296 nM, respectively).
T11906 LY 541850 LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human ...
T11907 LY2140023 LY2140023 has the potential for schizophrenia.LY2140023 is an orally active prodrug of LY404039. LY404039 is a selective metabotropic glutamate 2/3 receptor agon...
T17248 VU6001376 VU6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (EC50: 50.1 nM).
T15618 JNJ-46281222 JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a hi...
T8626 4-oxo-1,4-dihydroquinoline-2-carboxylic acid 4-oxo-1,4-dihydroquinoline-2-carboxylic acid is a GluR and NMDA inhibitor.
T22641 CDPPB CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).
T22730 DL-AP3 DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.
T23515 VU 29 VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC...
T8779 HBT1 HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons....
T8862 ML 254 ML254 competitively interacts with the MPEP allosteric binding site. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricer...
TP2111L TAT-GluA2 3Y acetate(1404188-93-7 free base) TAT-GluA2 3Y acetate is an inhibitor of AMPA receptor endocytosis. Induces increased hind paw withdrawal latencies following thermal and mechanical stimuli in ra...
T9021 Ro0711401 Ro0711401 is an agonist of mGlu1 receptor.
T5512 JNJ16259685 JNJ16259685 is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19 nM.
T15369L Gamma-DGG acetate(6729-55-1 free base) gamma-DGG acetate is a competitive blocker of AMPA receptor.
T15619 JNJ-46778212 JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260 nM).
T15456 GYKI53655 hydrochloride GYKI53655 hydrochloride is an antagonist of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA).
TQ0094 JNJ-40411813 JNJ-40411813 (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).
T11032 DHPG DHPG ((RS)-3,5-DHPG) is an effective antagonist of mGluR linked to phospholipase D. It is an amino acid that can be used as a selective and potent agonist for Gr...
TQ0114 CMPDA CMPDA is a positive allosteric modulator of AMPA receptors (EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor).
TQ0289 LY450108 LY450108 is a potentiator of the AMPA receptor.
T7706 LY404187 LY404187 is a positive allosteric modulator of AMPA receptors
T7823 IDRA-21 IDRA-21 is a positive AMPA receptor modulator.
T8435 YM90K hydrochloride YM90K hydrochloride is an antagonist of AMPA receptor.
T8457 NPS2390 NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)
T8434 SIB-1757 SIB-1757 is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)
T12025 MFZ 10-7 hydrochloride MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAM
T12118 MSOP MSOP is a selective antagonist of group III metabotropic glutamate receptor (KD of 51 μM for the L-AP4-sensitive presynaptic mGluR).
T12520 Pomaglumetad methionil Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.
T14389 AZD 9272 AZD 9272 is a antagonist of brain penetrant mGluR5.
T13323 VU6012962 VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
T14615 Biphenylindanone A Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.
T12717 Basimglurant Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).
T15090 Decoglurant Decoglurant is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant.
T15275 Fenobam Fenobam is a non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kds: 54 and 31 nM for rat and human recombinant mGlu5 receptors). Fenobam...
T11311L Foliglurax Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).
T15369 Gamma-DGG gamma-DGG is a competitive blocker of AMPA receptor.
T10432L AZD-8529 mesylate AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulato...
T10573 BMT-145027 BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50: 47 nM).
T13318 VU0650786 VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM), with ant...
T13319 VU0652835 VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).
T3565 UV0155041 UV0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).
AMN 082 dihydrochloride
T21935CAS 97075-46-2
AMN 082 dihydrochloride is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity.
FTIDC
T3483CAS 873551-53-2
FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibiti...
Lithium citrate tribasic tetrahydrate
T0256CAS 6080-58-6
Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and me...
VU 0364770
T6727CAS 61350-00-3
VU 0364770(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGlu subtypes.
LY404039
T6022CAS 635318-11-5
LY404039 is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).
(±)-trans-ACPD
T3484CAS 67684-64-4
(±)-trans-ACPD is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD. (±)-trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor)...
Aniracetam
T0333CAS 72432-10-1
Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
Piracetam
T0426CAS 7491-74-9
Piracetam, a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.
ADX 47273
T2053CAS 851881-60-2
ADX-47273 is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).
CFMTI
T3482CAS 864864-17-5
CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist (IC50: 2.6 nM). The selectivity of CFMTI to mGluR1 is higher 2000...
CTEP
T6457CAS 871362-31-1
CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over othe...
MPEP
T6598CAS 96206-92-7
MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.
Xanthurenic Acid
T3010CAS 59-00-7
Xanthurenic acid, a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGl...
Topiramate
T0675CAS 97240-79-4
Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepat...
Latrepirdine
T6562CAS 97657-92-6
Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
NBQX disodium salt
T4113CAS 118876-58-7
Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.
ADX88178
T4500CAS 1235318-89-4
ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.
Cyclothiazide
T4573CAS 2259-96-3
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its r...
L-Cysteic acid monohydrate
T5083CAS 23537-25-9
L-Cysteic acid is an oxidation product of L-cysteine that may be used as a competitive inhibitor of the bacterial aspartate: alanine antiporter (AspT) exchange o...
Chelidamic acid
T5884CAS 138-60-3
Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
DNQX
T7304CAS 2379-57-9
DNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)
FITM
T7292CAS 932737-65-0
FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM).
CNQX
T7178CAS 115066-14-3
CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)
D-glutamine
T6468CAS 5959-95-5
D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.
L-Glutamine
T0326LCAS 56-85-9
L-glutamine, a non-essential amino acid, is synthesized from glutamic acid and ammonia.
TCN 238
T7494CAS 125404-04-8
TCN 238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).
PHCCC
T3464CAS 179068-02-1
PHCCC is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mGl...
VU 0361737
T6726CAS 1161205-04-4
VU 0361737 is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 i...
VU 0364439
T6160CAS 1246086-78-1
VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).
Primidone
T0024CAS 125-33-7
Primidone is an anticonvulsant of the pyrimidinedione class.
JNJ42153605
T3451CAS 1254977-87-1
JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).
L-Glutamic acid monosodium salt
T6871CAS 142-47-2
L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor.
Lu AF21934
T3539CAS 1445605-23-1
Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).
(RS)-MCPG
T3479CAS 146669-29-6
(RS)-MCPG is a non-selective group I/II metabotropic glutamate receptor antagonist.
Ampalex
T1884CAS 154235-83-3
Ampalex (Ampakine CX516; CX516; BDP 12), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, ...
IEM 1754 2HBr
T6134CAS 162831-31-4
IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
E4CPG
T3477CAS 170846-89-6
E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG.
Farampator
T3957CAS 211735-76-1
Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.
3-MATIDA
T3486CAS 518357-51-2
3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGlu...
MPEP hydrochloride
T2497CAS 219911-35-0
MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).
ATPO
T3473CAS 252930-37-3
ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
Chicago Sky Blue 6B
T2194CAS 2610-05-1
Chicago sky blue 6B, a vesicular glutamate transporters inhibitor, attenuates methamphetamine-induced hyperactivity and behavioral sensitization in mice.
Ro 67-7476
T3478CAS 298690-60-5
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 ...
Evans blue
T0313CAS 314-13-6
Evans blue is an azo dye, inhibits L-glutamate uptake via the membrane-bound excitatory amino acid transporter (EAAT).
Decanoic Acid
T3379CAS 334-48-5
Decanoic Acid acts as a non-competitive AMPA receptor antagonist.
Harmine hydrochloride
T2811CAS 343-27-1
Harmine hydrochloride is extracted from Peganum Harmala Genus.
Memantine hydrochloride
T1443CAS 41100-52-1
Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
VU 0357121
T6725CAS 433967-28-3
VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.
Urethane
T0051CAS 51-79-6
Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
MTEP hydrochloride
T7515CAS 1186195-60-7
MTEP hydrochloride is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)
1-BCP
T7579CAS 34023-62-6
1-BCP is a centrally active drug that modulates AMPA receptor gated currents.
Caroverine HCL
T9133CAS 55750-05-5
Caroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that...
LY3020371 hydrochloride
T11911CAS 1377615-44-5
LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGl...
L-APB
T15692CAS 23052-81-5
L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively)....
LY377604
T15819CAS 204592-94-9
LY377604 is a human β3-adrenergic receptor agonist (EC50: 2.4 nM). It also a β1- and β2-adrenergic receptor antagonist.
LYPLAL1-IN-1
T15823CAS 1966129-74-7
LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.
M-110
T15830CAS 1395048-49-3
M-110 inhibits PIM-1 and PIM-2 with similar (IC50s: 2.5 μM) and it also inhibits the proliferation of prostate cancer cell lines (IC50s: 0.6 to 0.9 μM). M-110 ...
M77976
T15944CAS 394237-61-7
M77976 is the potential for the research of obesity and diabetes. M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms ...
FPTQ
T5509CAS 1025802-62-3
FPTQ is an antagonist of mGluR1.
Org-26576
T16402CAS 1026791-61-6
Org-26576 is a positive allosteric modulator of the AMPA receptor.
Philanthotoxin 74 dihydrochloride
T16524CAS 1227301-51-0
Philanthotoxin 74 dihydrochloride is an AMPAR antagonist. Philanthotoxin 74 dihydrochloride inhibits GluR3 and GluR1 (IC50s: 263 and 296 nM, respectively).
LY 541850
T11906CAS 852679-76-6
LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human ...
LY2140023
T11907CAS 635318-55-7
LY2140023 has the potential for schizophrenia.LY2140023 is an orally active prodrug of LY404039. LY404039 is a selective metabotropic glutamate 2/3 receptor agon...
VU6001376
T17248CAS 1968546-34-0
VU6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (EC50: 50.1 nM).
JNJ-46281222
T15618CAS 1254980-38-5
JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a hi...
4-oxo-1,4-dihydroquinoline-2-carboxylic acid
T8626CAS 13593-94-7
4-oxo-1,4-dihydroquinoline-2-carboxylic acid is a GluR and NMDA inhibitor.
CDPPB
T22641CAS 781652-57-1
CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).
DL-AP3
T22730CAS 20263-06-3
DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.
VU 29
T23515CAS 890764-36-0
VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC...
HBT1
T8779CAS 489408-02-8
HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons....
ML 254
T8862CAS 1428630-86-7
ML254 competitively interacts with the MPEP allosteric binding site. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricer...
TAT-GluA2 3Y acetate(1404188-93-7 free base)
TP2111LCAS TP2111L
TAT-GluA2 3Y acetate is an inhibitor of AMPA receptor endocytosis. Induces increased hind paw withdrawal latencies following thermal and mechanical stimuli in ra...
Ro0711401
T9021CAS 714971-87-6
Ro0711401 is an agonist of mGlu1 receptor.
JNJ16259685
T5512CAS 409345-29-5
JNJ16259685 is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19 nM.
gamma-DGG acetate(6729-55-1 free base)
T15369LCAS T15369L
gamma-DGG acetate is a competitive blocker of AMPA receptor.
JNJ-46778212
T15619CAS 1363281-27-9
JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260 nM).
GYKI53655 hydrochloride
T15456CAS 143692-48-2
GYKI53655 hydrochloride is an antagonist of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA).
JNJ-40411813
TQ0094CAS 1127498-03-6
JNJ-40411813 (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).
DHPG
T11032CAS 146255-66-5
DHPG ((RS)-3,5-DHPG) is an effective antagonist of mGluR linked to phospholipase D. It is an amino acid that can be used as a selective and potent agonist for Gr...
CMPDA
TQ0114CAS 380607-77-2
CMPDA is a positive allosteric modulator of AMPA receptors (EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor).
LY450108
TQ0289CAS 376594-67-1
LY450108 is a potentiator of the AMPA receptor.
LY404187
T7706CAS 211311-95-4
LY404187 is a positive allosteric modulator of AMPA receptors
IDRA-21
T7823CAS 22503-72-6
IDRA-21 is a positive AMPA receptor modulator.
YM90K hydrochloride
T8435CAS 154164-30-4
YM90K hydrochloride is an antagonist of AMPA receptor.
NPS2390
T8457CAS 226878-01-9
NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)
SIB-1757
T8434CAS 31993-01-8
SIB-1757 is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)
MFZ 10-7 hydrochloride
T12025CAS 1779796-36-9
MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAM
MSOP
T12118CAS 66515-29-5
MSOP is a selective antagonist of group III metabotropic glutamate receptor (KD of 51 μM for the L-AP4-sensitive presynaptic mGluR).
Pomaglumetad methionil
T12520CAS 956385-05-0
Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.
AZD 9272
T14389CAS 327056-26-8
AZD 9272 is a antagonist of brain penetrant mGluR5.
VU6012962
T13323CAS 2313526-86-0
VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
Biphenylindanone A
T14615CAS 866823-73-6
Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.
Basimglurant
T12717CAS 802906-73-6
Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).
Decoglurant
T15090CAS 911115-16-7
Decoglurant is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant.
Fenobam
T15275CAS 57653-26-6
Fenobam is a non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kds: 54 and 31 nM for rat and human recombinant mGlu5 receptors). Fenobam...
Foliglurax
T11311LCAS 1883329-51-8
Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).
gamma-DGG
T15369CAS 6729-55-1
gamma-DGG is a competitive blocker of AMPA receptor.
AZD-8529 mesylate
T10432LCAS 1314217-69-0
AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulato...
BMT-145027
T10573CAS 2018282-44-3
BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50: 47 nM).
VU0650786
T13318CAS 1809085-30-0
VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM), with ant...
VU0652835
T13319CAS 1848252-81-2
VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).
UV0155041
T3565CAS 1093757-42-6
UV0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).