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GluR

Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells.Glutamate receptors are responsible for the glutamate-mediated postsynaptic excitation of neural cells, and are important for neural communication, memory formation, learning, and regulation.
Cat. No. Product name CAS No. Purity Chemical Structure
T23010 MNI 137 946619-21-2 98%
MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.
T15692 L-AP4 23052-81-5 98%
L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).
T15369 Gamma-DGG 6729-55-1 98%
gamma-DGG is a competitive blocker of AMPA receptor.
T15819 LY377604 204592-94-9 98%
LY377604 is a human β3-adrenergic receptor agonist (EC50: 2.4 nM). It also a β1- and β2-adrenergic receptor antagonist.
T10808 CHPG sodium salt 1303993-73-8 98%
CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways. CHPG sodium salt can be used in studies about traumatic brain...
T15618 JNJ-46281222 1254980-38-5 98%
JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a hi...
T6562 Latrepirdine dihydrochloride 97657-92-6 98%
Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
T11906 LY 541850 852679-76-6 98%
LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human io...
T11311L Foliglurax 1883329-51-8 98%
Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).
T11911 LY3020371 hydrochloride 1377615-44-5 98%
LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu...
T12520 Pomaglumetad methionil 956385-05-0 98%
Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.
T4009 NS 1209 205645-02-9 98%
NS1209 is a AMPA receptor antagonist.
T35028 Valiglurax 1976050-09-5 98%
Valiglurax, also known as VU0652957 and VU2957, is a potent, selective, CNS penetrant, and orally bioavailable mGlu4 PAM. VU2957 possessed attractive in vitro an...
T15619 JNJ-46778212 1363281-27-9 98%
JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260 nM).
T15823 LYPLAL1-IN-1 1966129-74-7 98%
LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.
T15944 M77976 394237-61-7 98%
M77976 is the potential for the research of obesity and diabetes. M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms ...
T12025 MFZ 10-7 hydrochloride 1779796-36-9 98%
MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAM
T21935 AMN082 97075-46-2 98%
AMN 082 dihydrochloride is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity.
T14389 AZD 9272 327056-26-8 98%
AZD 9272 is a antagonist of brain penetrant mGluR5.
T13319 VU0652835 1848252-81-2 98%
VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).
MNI 137
T23010
MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.
L-AP4
T15692
L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).
gamma-DGG
T15369
gamma-DGG is a competitive blocker of AMPA receptor.
LY377604
T15819
LY377604 is a human β3-adrenergic receptor agonist (EC50: 2.4 nM). It also a β1- and β2-adrenergic receptor antagonist.
CHPG sodium salt
T10808
CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways. CHPG sodium salt can be used in studies about traumatic brain...
JNJ-46281222
T15618
JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a hi...
Latrepirdine dihydrochloride
T6562
Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
LY 541850
T11906
LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human io...
Foliglurax
T11311L
Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).
LY3020371 hydrochloride
T11911
LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu...
Pomaglumetad methionil
T12520
Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.
NS 1209
T4009
NS1209 is a AMPA receptor antagonist.
Valiglurax
T35028
Valiglurax, also known as VU0652957 and VU2957, is a potent, selective, CNS penetrant, and orally bioavailable mGlu4 PAM. VU2957 possessed attractive in vitro an...
JNJ-46778212
T15619
JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260 nM).
LYPLAL1-IN-1
T15823
LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.
M77976
T15944
M77976 is the potential for the research of obesity and diabetes. M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms ...
MFZ 10-7 hydrochloride
T12025
MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAM
AMN082
T21935
AMN 082 dihydrochloride is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity.
AZD 9272
T14389
AZD 9272 is a antagonist of brain penetrant mGluR5.
VU0652835
T13319
VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).
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