d12

Banoxantrone-D12 is the deuterium-labeled form of Banoxantrone(T70860), a bioreductive agent that can be metabolically converted to AQ4, a stable compound with DNA affinity and topoisomerase II inhibition properties.

Topiramate-D12 is a deuterium labeled Topiramate. Topiramate (T0675) is an agent of broad-spectrum antiepileptic. Topiramate (T0675) is an antagonist of GluR5 receptor.

3-Keto Sphinganine (d12:0) is a short-chain analog of 3-keto sphinganine (d18:0), which typically possesses a C18 chain length. The latter is a lyso-sphingolipid synthesized through the condensation of L-serine and palmitoyl-CoA mediated by the enzyme serine palmitoyl transferase (SPT). A deficiency in Vitamin K deactivates SPT, leading to a reduced synthesis of 3-keto sphinganine among other sphingolipids. [Matreya, LLC. Catalog No. 1893]

Vancomycin-D12 trifluoroacetate is a deuterated compound of Vancomycin trifluoroacetate (TMSM-2378). Vancomycin trifluoroacetic acid has a CAS number of 1404-90-6. Vancomycin is an antibiotic used to treat serious bacterial infections by stopping the growth of bacteria.

Tetramethylpyrazine-D12 is a deuterated compound of Tetramethylpyrazine. Tetramethylpyrazine (T2722) has a CAS number of 1124-11-4. Tetramethylpyrazine (T2722) (ligustrazine, TMP), a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) shows anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.

Chrysene-D12 is a deuterated compound of Chrysene. Chrysene (T14961) has a CAS number of 218-01-9. Chrysene (T14961) is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH).

Perylene-D12 is a deuterated compound of Perylene. Perylene (TYD-00680) has a CAS number of 198-55-0.

Hexamidine-d12 is the deuterium-labeled version of Hexamidine. It exhibits amoebicidal activity and can be utilized in research related to Acanthamoeba keratitis (Acanthamoebakeratitis).

TBHQ-d12 (tert-Butylhydroquinone-d12) is a deuterium-labeled form of TBHQ. This compound, known as TBHQ (tert-Butylhydroquinone), is a widely used Nrf2 activator that protects against heart toxicity induced by Doxorubicin (DOX) through Nrf2 activation. Additionally, TBHQ acts as an ERK activator, counteracting the inhibitory effects of Dehydrocorydaline (DHC) on melanoma cell proliferation.

Triethylene glycol-d12 (PROTACLinker 25-d12) is the deuterium-labeled version of Triethylene glycol. Classified as a PROTAC linker within the PEG category, Triethylene glycol (PROTACLinker 25) is utilized in the synthesis of PROTAC molecules.

Chrysene-D12 (Standard) is the standard substance of Chrysene-D12, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Chrysene-D12 is a deuterated compound of Chrysene. Chrysene (T14961) has a CAS number of 218-01-9. Chrysene (T14961) is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH).

Perylene-D12 (Standard) is the standard substance of Perylene-D12, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Perylene-D12 is a deuterated compound of Perylene. Perylene (TYD-00680) has a CAS number of 198-55-0.

Cyclosporin A-[D12] (Standard) is a reference standard of Cyclosporin A-[D12] intended for quantitative analysis, quality control, and related biochemical research applications.

Topiramate D12 (Standard) is a reference standard of Topiramate D12 intended for quantitative analysis, quality control, and related biochemical research applications.

Vancomycin-[D12] Tfa Salt (Standard) is a reference standard of Vancomycin-[D12] Tfa Salt intended for quantitative analysis, quality control, and related biochemical research applications.

Tenofovir Disoproxil Fumarate-[D12] (Standard) is a reference standard of Tenofovir Disoproxil Fumarate-[D12] intended for quantitative analysis, quality control, and related biochemical research applications.

C12-Sphingosine (Sphingosine (d12:1)) is a sphingosine congener with 12 carbon atoms, inducing serine palmitoyltransferase activity in a time- and concentration-dependent manner.

Banoxantrone-D12 dihydrochloride is the deuterium-labeled Banoxantrone dihydrochloride (T10459). Banoxantrone is a bioreductive agent that can be reduced to a stable, DNA-affinity compound AQ4, which is a topoisomerase II inhibitor.

3-Hydroxyoctanoic Acid-D12 is the deuterated analog of 3-Hydroxyoctanoic Acid (T9719).

Anti-MERS-D12 mAb is a fully human monoclonal neutralizing antibody isolated from a recovered patient. It binds specifically to the receptor-binding domain (RBD) of the MERS-CoV spike glycoprotein with extremely high affinity, effectively blocking the interaction between the virus and the host receptor dipeptidyl peptidase 4 (DPP4). This action exerts potent neutralizing activity by preventing viral attachment and entry into host cells.

Adenosine monophosphate-D12 dilithium is a deuterium-labeled variant of adenosine monophosphate. This compound acts as an agonist of the adenosine A1 receptor and exhibits significant antiviral activity against HSV-1 and HSV-2. Additionally, adenosine monophosphate is a crucial cellular metabolite involved in energy homeostasis and signal transduction regulation.

Benzyl benzoate-D12 is the deuterated form of Benzyl benzoate. Benzyl benzoate (T0729) (Benzoic acid benzyl ester) is used as a fragrance component in cosmetics. It can also be utilized in research related to inflammatory skin diseases associated with scabies and Demodex mites.

1,4-Diazabicyclo[2.2.2]octane-D12 is the deuterated form of 1,4-Diazabicyclo[2.2.2]octane (TMSM-0044).

2'-Deoxyadenosine-5'-monophosphate-D12 dilithium is the deuterium-labeled version of 2'-Deoxyadenosine-5'-monophosphate. This compound, a derivative of nucleic acid AMP, is a deoxyribonucleotide found in DNA. It is utilized in the study of adenosine-based interactions during DNA synthesis and damage processes.