Influenza Virus

Influenza virus-IN-9 (12) is an inhibitor of influenza virus endonuclease, exhibiting an IC50 value of 0.03 μM.

Influenza virus-IN-1 (compound 14) is a potent inhibitor of influenza A virus, demonstrating anti-influenza A virus activities with a CC50 of >200 μM and an EC50 of 2.46 μM. It exhibits concentration-dependent inhibition activity for PAN endonuclease with an EC50 of 312.36 nM [1].

Influenza virus-IN-2 (compound 19) is a potent inhibitor of influenza A virus with anti-influenza activities, exhibiting a CC50 of 150.85 μM and an EC50 of 2.58 μM. Concentration-dependently, Influenza virus-IN-2 inhibits the PAN endonuclease with an EC50 of 489.39 nM [1].

Influenza virus-IN-4 (compound 11e) is a potent inhibitor of influenza virus neuraminidase, effective against H5N1 (IC50: 3.4 μM), H5N2 (IC50: 0.094 μM), H5N6 (IC50: 0.79 μM), and H5N8 (IC50: 0.077 μM). It inhibits NA (neuraminidase) and exhibits low cytotoxicity (CC50 > 200 μM), and is not significantly toxic to mice at 1500 mg/kg.

Influenza virus-IN-5 (Compound 5f) is an inhibitor of influenza virus hemagglutinin (HA) with an EC50 of 1 nM against the A/H3N2 virus.

Influenza virus-IN-3 (compound 9) is a potent inhibitor of selective influenza viruses, with IC50 values of 0.88 μM for H5N1, 0.10 μM for H5N2, 5.5 μM for H5N6, and 0.51 μM for H5N8. Influenza virus-IN-3 exhibits antiviral and NA (neuraminidase) inhibitory effects with low cytotoxicity (CC50 > 200 μM).

Influenza virus-IN-6 (Compound 35) is a potent inhibitor of the N-terminal domain of the polymerase acidic protein (PA N) endonuclease subunit of the influenza virus, with an inhibitory concentration 50 (IC 50) value of 0.20 μM [1].

Influenza virus-IN-7 (Example 16) is an orally active cap-dependent endonuclease inhibitor used in influenza viral infectious disease research [1].

CEF8, Influenza Virus NP (383-391), is an influenza A virus nucleoprotein containing residues 383 to 391, and it is the most important HLA-B*2705-restricted epitope in the nucleoprotein of influenza A viruses, associated with escape from cytotoxic T lymphocytes-mediated immunity. [HLA-B*3501 restricted influenza virus nucleoprotein epitope (383-391).]

HLA-B*08 restricted influenza virus nucleoprotein epitope.

Influenza A virus-IN-15 (Compound 9b), a quinoline derivative, is a broad-spectrum anti-influenza inhibitor with an IC50 range of 0.88-6.33 μM and demonstrates acceptable cytotoxicity. It inhibits the transcription and replication of viral RNA, making it suitable for research on Influenza A virus (IAV).

Influenza A virus-IN-16 (compound 10) is an effective antiviral agent. It inhibits H7N1 pseudovirus with an EC50 of 0.09 μM.

Influenza A virus-IN-1, a dihydropyrrolidones derivative, is a highly effective inhibitor of various subtypes of influenza A virus (IAV) with IC 50 values ranging from 3.11 μM to 7.13 μM. It effectively suppresses IAV replication and enhances the expression of key antiviral cytokines, such as IFN-β, and the antiviral protein MxA.

Influenza A virus-IN-4 (compound 23b), a derivative of Oseltamivir, is a highly effective neuraminidase inhibitor that exerts potent inhibitory effects on influenza viruses [1].

Influenza A virus-IN-8 (S5), a macrocyclic peptide, exhibits no cytotoxicity and acts as a potent inhibitor of Influenza A Virus (IAV), demonstrating significant protease stability, with IC50 values of 6.7 nM for H1 and 6.6 nM for H5 variants. It has a high affinity for H1 variants, binding to a conserved region in the HA stem with a dissociation constant (Kd) of 1.0 nM [1].

Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus thickness, and has anti-influenza viral activity.

Tunicamycin is a mixture of antibiotics that inhibit N-linked glycosylation by blocking GlcNAc phosphotransferase (GPT). Tunicamycin has antitumor activity, as well as anti-bacterial, anti-fungal, and anti-viral activity.

Aprotinin (Traskolan) is a broad-spectrum serine protease (BPTI) inhibitor that inhibits the activity of a number of different esterases and proteases. Aprotinin is an antifibrinolytic agent used to minimize hemorrhage during complex surgical procedures.

Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without affecting blood flow in normal tissues.

6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is a glutaminase antagonist (Ki: 6 μM) and an antineoplastic antibiotic produced by an unidentified Streptomyces species from Peruvian soil.

Cletoquine hydrochloride is a major active metabolite of Hydroxychloroquine. Cletoquine hydrochloride is a Chloroquine derivative and exhibits the ability to against the chikungunya virus (CHIKV). Cletoquine hydrochloride exhibits antimalarial effects.

IHVR-17028 is a potent broad-spectrum ERα-glucosidase I (α-glucosidase I) inhibitor with IC50 of 0.24 μM and antiviral activity. IHVR-17028 inhibited BVDV, TCRV and DENV, and EC50 values were 0.4 μM, 0.26 μM and 0.3 μM, respectively. IHVR-17028 can be used to study infectious diseases.

NS1-IN-1 is a potent NS1 inhibitor.NS1-IN-1 displays antiviral activity by inhibiting mTORC1 activity in a TSC1-TSC2-dependent manner.NS1-IN-1 reduces the level of viral proteins and contributes to the reduction of viral replication.

Trifluoromethyl-tubercidin (TFMT) inhibits host MTr1 and suppresses virus replication. TFMT inhibits MTr1 through interaction at its S-adenosyl-l-methionine binding pocket to restrict influenza virus replication. TFMT was effective in inhibiting viral replication in mice, displayed little toxicity.