intermediate

Dolutegravir intermediate-1 (1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid) is a new synthetic Dolutegravir intermediate. Dolutegravir is an integrase inhibitor developed for the treatment of human immunodeficiency virus (HIV)-1 infection.

Sitagliptin Intermediate 2 is a useful organic compound that has been used in life science related research.

CRAC intermediate 1 is a key intermediate used in the synthesis of the CRAC ion channel series of compounds, details from patent WO 2010122089.

L96 intermediate is a GalNAc (N-acetylgalactosamine) analogue. GalNAc is an important glycosyl structure, which mainly has the functions of "recognition and targeted delivery" in the body. It is often used in the construction of targeted delivery systems, and is particularly widely applied in the field of liver-targeted delivery.

Alisporivir intermediate-1 is a crucial intermediate compound utilized in the synthesis process of Alisporivir, a therapeutic agent employed for the treatment of inflammatory and viral ailments.

Nivocasan Intermediate is an intermediate of Nivocasan. Nivocasan (GS-9450) is a pan-caspase inhibitor used in the study of HCV infection and non-alcoholic steatohepatitis.

Intermediate of Pregabalin.

Taltobulin intermediate-4 is a defined synthetic intermediate used in the multistep preparation of Taltobulin, a highly potent tubulin inhibitor and cytotoxic payload widely employed in antibody–drug conjugate development, where Taltobulin disrupts microtubule polymerization, induces mitotic arrest, and triggers apoptosis in rapidly dividing tumor cells.

p-Toluic Acid (4-Methylbenzoic acid) belongs to the class of organic compounds known as benzoic acids. 4-Methylbenzoic acid has been primarily detected in saliva. Within the cell, 4-methylbenzoic acid is primarily located in the cytoplasm.

Octodrine (2-Amino-6-methylheptane) is primarily used as a pharmaceutical intermediate for Octamylamine; it also functions as a local anesthetic and vasoconstrictor.

2'-Deoxy-2'-fluorouridine serves as an intermediate in the synthesis of antiviral agents targeting influenza viruses[1].

β-nicotinamide mononucleotide (NMN) is a natural nucleotide and a key intermediate in the synthesis of coenzyme I (NAD+). β-nicotinamide mononucleotide is involved in a number of biochemical reactions in the human body, which are related to immunity and metabolism.

It is an isomer of cresotinic acid (2-hydroxy-3-methylbenzoic acid) and oxymethylbenzoic acid (2-methoxybenzoic acid). Derivatives of mandelic acid are formed as a result of metabolism of adrenaline and noradrenaline by monoamine oxidase and catechol-o-methyl transferase. It is also present in certain skin care products, is an intermediate molecule in the production of other biochemicals, may be used as an analytical reagent and is a precursor in the manufacture of dyes. Mandelic acid (acidomandelico) is found to be associated with phenylketonuria, which is an inborn error of metabolism.

2-Ketoglutaric acid Sodium (AKG) is a key molecule in the TCA cycle. It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination reactions (mediated by branched-chain amino acid transaminases) in which glutamate is a common amino donor.

TriacetonaMine (Vincubine) protects the activitis of superoxide dismutase(SOD) and creatine phos-phate kinase (CPK); it also inhibits CaCl2 induced agglomeration of thromocyte. Triacetonamine can improve the constructile function of heart mus-cles of acute anemia and decrease the content of malodialdehyde (MDA) in the heart muscles.

cis,cis-Muconic acid (cis,cis-2,4-Hexadienedioic acid) is a naturally-occurring organic acid. It is used in the manufacture of several widely-used consumer plastics. Its microbial production via extending the shikimate pathway has been reported.

2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) and exhibits antioxidant activity. As an intermediate in the Krebs cycle, 2-Ketoglutaric acid can generate ATP or GTP. 2-Ketoglutaric acid also serves as the primary carbon skeleton for nitrogen assimilation reactions.

Acetagastrodin (Acegastrodine) has an antispasmodic effect on vascular smooth muscle.

3,4,5-Trimethoxybenzaldehyde shows anti-Candida efficacy and inhibits adhesion and biofilms.

Hydroxypyruvic acid lithium hydrate is an intermediate in the metabolism of serine, glycine, and threonine. It is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase.

TP748 is a key intermediate for fully synthetic tetracyclines, and is an isoxazole.

Chlorotrianisene (tri-p-anisylchloroethylene) is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), with predominantly estrogenic but also antiestrogenic activities.

Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.

Astragenol is an intermediate for the synthesis of astragenel derivatives. Astragenol derivatives are promising anti-inflammatory drugs in prostate cancer research.