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Serotonin Receptor

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    383
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bimu 8
T21946134296-40-5In house
BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4.
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Paliperidone
9-hydroxyrisperidone
T0076144598-75-4
Paliperidone (9-hydroxyrisperidone)(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older atypical antipsychotic risperidone.
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Urapidil hydrochloride
Urapidil HCl
T008864887-14-5
Urapidil hydrochloride (Urapidil HCl) is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist.
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TargetMol | Inhibitor Sale
Mirtazapine
Org3770, 6-Azamianserin
T013785650-52-8
Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
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Sumatriptan succinate
GR 43175
T0203103628-48-4
Sumatriptan succinate (GR 43175), a serotonin1 (5-HT1) receptor agonist, is used in the acute treatment of a migraine headache.
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Risperidone
Risperidal, R 64 766
T0351106266-06-2
Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
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Flopropione
Phloropropiophenone
T05252295-58-1
Flopropione (Phloropropiophenone), a spasmolytic or antispasmodic agent, is used as a 5-HT1A receptor antagonist.
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Amitriptyline hydrochloride
Tryptizol, Domical, Annoyltin, Amitriptyline HCl
T0678549-18-8
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
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Trimipramine maleate
Surmontil maleate
T1045521-78-8
Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Maleate is the maleate salt form of trimipramine, a tricyclic secondary amine of the dibenzazepine class, with an antidepressant property.
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Zolmitriptan
BW-311C90, 311C90
T1092139264-17-8
Zolmitriptan (311C90) selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brainstem sensory nuclei. Zolmitriptan is a member of the triptan class of agents with anti-migraine properties. Receptor binding results in constriction of cranial vessels, reduction of vessel pulsation and inhibition of nociceptive transmission, thereby providing relief of migraine headaches. Zolmitriptan may also relieve migraine headaches by inhibition of pro-inflammatory neuropeptide release.
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Agomelatine
Valdoxan, Thymanax, S-20098
T1445138112-76-2
Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.
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Iloperidone
HP 873
T1539133454-47-4
Iloperidone (HP 873) is an atypical antipsychotic agent that is used for treatment of schizophrenia.
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Olanzapine
LY170053
T1567132539-06-1
Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
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Harmine
Telepathine
T1711442-51-3
Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.
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Asenapine Maleate
Org 5222 maleate, Org 5222
T195185650-56-2
Asenapine Maleate (Org 5222 maleate) is a second generation (atypical) antipsychotic agent that is taken sublingually and used in the treatment of schizophrenia and manic or mixed episodes associated with bipolar 1 disorder. Asenapine is associated with a low rate of transient and mild serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury.
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Serotonin hydrochloride
Serotonin HCl, 5-Hydroxytryptamine hydrochloride, 5-HT hydrochloride, 5-HT HCl
T2209153-98-0
Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM).
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pCPA methyl ester hydrochloride
4-Chloro-DL-phenylalanine methyl ester hydrochloride
T4114314173-40-1
pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pCPA methyl ester hydrochloride is permeable across the blood-brain barrier and reduces 5-HT central availability.
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Sarpogrelate hydrochloride
MCI-9042
T4978135159-51-2
Sarpogrelate hydrochloride (MCI-9042) , a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD. Target: 5-HT2 Recepter Sarpogrelate is a drug which acts as an antagonist at the 5HT2A and 5-HT2B receptors. Sarpogrelate hydrochloride was shown to have the same affinity as ritanserin for 5-HT2A receptors, with a Ki value of 8.39 nM. Sarpogrelate hydrochloride lacked prominent 5-HT1-like, 5-HT3, beta, H1, H2 and M3 antagonist activity and weakly blocked alpha 1-adrenoceptors (pKB = 6.30). (S)-M-1 showed weak affinity for 5-HT1-like receptors (pKB = 6.30), alpha 1- (pKB = 6.80) and beta- (pKB = 6.54) adrenoceptors, while (R)-M-1 was a weak antagonist at histamine H1 receptors (pKB = 6.49). After 12 weeks of sarpogrelate administration, FBF and LBF responses during RH showed significant increases from 13.2 + - 1.7 to 18.1 + - 2.2 mL min per 100 mL tissue (P < 0.01) and from 8.2 + - 0.9 to 14.2 + - 2.1 mL min per 100 mL tissue (P < 0.05), respectively. Sarpogrelate hydrochloride -induced augmentation of FBF and LBF responses to RH was maintained at 24 weeks. Long-term oral administration of sarpogrelate improves vascular function in patients with PAD.
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Quetiapine hemifumarate
Quetiapine Fumarate, ICI-204636
T6241111974-72-2
Quetiapine hemifumarate (ICI-204636), an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression.
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Rotundine
L-Tetrahydropalmatine, Gindarine, Caseanine, (-)-Tetrahydropalmatine
T6648483-14-7
Rotundine (Gindarine) (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.
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Cyproheptadine hydrochloride
Periactin hydrochloride, Nuran, Cyproheptadine HCl, Anarexol
T6814969-33-5
Cyproheptadine hydrochloride (Periactin hydrochloride) is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist.
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Brexpiprazole HCl
OPC 34712 dihydrochloride
T8690913612-38-1
Brexpiprazole HCl (OPC 34712 dihydrochloride) is a new antipsychotic drug.
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(E)-3,4,5-Trimethoxycinnamic acid
O-Methylsinapic acid, 3,4,5-Trimethoxy-trans-cinnamic acid, 3,4,5-Trimethoxyphenylacrylic acid
TN286520329-98-0
(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) is a natural compound derived from the roots and rhizomes of Notopterygium incisum.
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Clozapine
LX 100-129, HF 1854
T04555786-21-0
Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A 2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity.
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