rar — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T18635	PROTAC RAR Degrader-1		Others
	PROTAC RAR Degrader-1, an RAR degrader, consists of a cIAP1 ligand binding group, a linker, and an RAR ligand binding group. It achieves maximal RAR degradation at a concentration of 30 μM in HT1080 cells. Degradation in...		Others
T18650	Ch55-O-C3-NH2	RAR ligand 1	Others
	Ch55-O-C3-NH2, also known as RAR ligand 1, is a ligand derived from the Ch55 compound that specifically targets RAR. Through a linker, Ch55-O-C3-NH2 interacts with cIAP1 ligand Bestatin to form SNIPER[1].		Others
T39250	Bevurogant		ROR
	Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases.		ROR
T7586	Trifarotene	CD5789	Retinoid Receptor , Autophagy
	Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM).		Retinoid Receptor , Autophagy
T1093	Adapalene	CD271	Apoptosis , Retinoid Receptor , Autophagy
	Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.		Apoptosis , Retinoid Receptor , Autophagy
T3S1251	Neoruscogenin		ROR
	1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.		ROR
T5163	SR1001		ROR
	SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).		ROR
TN6735	Bigelovin		Apoptosis , Reactive Oxygen Species , Retinoid Receptor , Autophagy , RAR/RXR
	Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a pote...
T4670	SR0987		ROR
	SR0987 is a RORγt agonist,		ROR
TQ0007	Cintirorgon	LYC-55716	ROR
	Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.		ROR
T4594	SR1078	SR 1078	ROR
	SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.		ROR
T7388	GSK805		ROR
	GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA bindi...		ROR
T22843	HX 531		Retinoid Receptor
	RXR antagonist		Retinoid Receptor
TQ0097	AGN 193109		Retinoid Receptor , Autophagy
	AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).		Retinoid Receptor , Autophagy
T17209	UVI 3003		Retinoid Receptor , Autophagy
	UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respectively).		Retinoid Receptor , Autophagy
T2834	Nobiletin	Hexamethoxyflavone	Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy
	Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (in water) and an extremely weak acidic...		Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy
T1330	Acitretin	Ro 10-1670,Etretin	Apoptosis , Retinoid Receptor , Autophagy
	Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.		Apoptosis , Retinoid Receptor , Autophagy
T3955	AR7		Retinoid Receptor
	AR7 is a retinoic acid receptor α (RARα) antagonist.		Retinoid Receptor
T9635	Cedirogant	ABBV-157	ROR
	Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.		ROR
T5341	WYC-209	WYC209	Apoptosis , Retinoid Receptor , Autophagy
	WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).		Apoptosis , Retinoid Receptor , Autophagy