n-type

N-type calcium channel blocker-1 is an orally active analgesic agent with a high affinity for functionally blocking N-type calcium channels.

Ziconotide Acetate (107452-89-1 free base) (Prialt) is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide Acetate (107452-89-1 free base) acts by binding to N-type calcium channels situated on the terminal part of primary afferent neurons of the nociceptive pathway therefore reducing synaptic transmission with potent antinociceptive effects.

JNJ-26489112 is a CNS-active agent and inhibitor of voltage-gated Na+ channels and N-type Ca2+ channels with broad-spectrum anticonvulsant activity in rodents and can be used to study neurological disorders.

Cilnidipine (FRC-8653)(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.

BAMB-4 (ITPKA-IN-C14) is a highly membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA), effectively suppressing the metastasis-promoting effect of ITPKA in lung tumor cells (with IC50 of 37 μM in ADP-Glo Assay).

Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction.

GV-58 is a selective N- and P/Q-type Ca2+ channels agonist (EC50: 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel). The inhibitory of GV-58 is 20-fold fewer for CDK kinases activity.

PD 173212 is a blocker that blocks N-type voltage sensitive calcium channel (Cav2.2). PD173212 (0.0017-1.7 μmol/kg, Intraperitoneal Injection.) dose-dependently reduced DNBS-induced visceral hypersensitivity in mice.

sFTX-3.3 is a calcium ion channel antagonist, exhibiting IC50 values of approximately 0.24 mM and 0.70 mM against P-type and N-type channels respectively.

Ginsenoside Rf (Panaxoside Rf) is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.

NP118809 (39-1B4) is a potent N-type calcium channel blocker(IC50 : 0.11 μM).

L162441 is an antagonist of Angiotensin type 1 receptor.

AT56, a specific inhibitor of prostaglandin D2 synthase enzymatic activity, blunted adipogenic aldosterone effects.

(+)-pinoresinol-β-D-glucoside; (+)-pinor is the major active furanoid lignan in Lianxian. It shows antioxidant, hypotensive and cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitory activities.

Botulinum toxin type B, an antigen-specific exotoxin produced by the anaerobic bacterium Clostridium botulinum, is utilized in the study of neck dystonia. It inhibits the release of Acetylcholine from the neuromuscular junction, causing relaxation paralysis or muscle weakening in the targeted muscle [1].

Collagen, Type II (derived from bovine snout cartilage), is a homotrimeric helical protein composed of three identical α1(II) chains and is a major component of animal cartilage. It possesses multiple biological activities, including maintaining cartilage tissue integrity, inducing immune tolerance, and promoting chondrocyte growth and redifferentiation. It is commonly used to induce collagen-induced arthritis (CIA) models and has demonstrated significant efficacy in alleviating pain and inflammation associated with collagen-induced arthritis in mice, making it widely applicable in osteoarthritis-related research.

Fibronectin Type III Connecting Segment Fragment 1-25 is a peptide involved in melanoma cell adhesion and essential for the development of the chicken peripheral nervous system [1] [2].

Collagen type IV alpha1 (531-543) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of type IV collagen and plays a role in angiogenesis.

Collagen Type II Fragment is a peptide with anti-inflammatory properties that effectively inhibits collagen-induced arthritis (CIA) in mice. It is useful for research focused on inflammation and immunity [1].

Type V collagen (from bovine amnion) is a highly purified form of collagen. It serves as an immunogen capable of inducing the production of specific antibodies in animals. Additionally, this collagen acts as a substrate for MMP hydrolysis.

Type II collagen (from human sternal cartilage) is a collagen protein used to stimulate the animal immune system to produce specific antibodies against it. This collagen also serves as a hydrolytic substrate for MMP (matrix metalloproteinases).

Type XI collagen, highly purified and derived from human sternal cartilage (Human Type XI collagen, immunization grade), serves as an immunization-grade protein capable of inducing specific antibody production against this collagen in animals. Additionally, collagen functions as a hydrolytic substrate for MMP.

Human Amnion Type V collagen (immunization grade) is a highly purified form of collagen derived from human amnion. It has the ability to stimulate the immune system of animals to produce antibodies specific to this collagen. Additionally, this collagen serves as a hydrolytic substrate for MMP (matrix metalloproteinases).

Human Type III collagen, derived from human placenta (immunization grade), is a highly purified compound capable of eliciting an immune response in animals to produce specific antibodies against this collagen protein. Additionally, this collagen serves as a substrate for the hydrolysis by matrix metalloproteinases (MMPs).