nucleotide

Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus (HBV), herpes virus, and human immunodeficiency virus (HIV).

Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.

Clodronate disodium tetrahydrate (Clastoban) inhibits bone resorption and soft tissue calcification.

dGTP (2'-Deoxyguanosine-5'-triphosphate) is a guanosine nucleotide highly susceptible to oxidative damage, resulting in 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

(S)-crizotinib (ent-crizotinib) （IC50 of 72 nM）, an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib.

Bemnifosbuvir hemisulfate (AT-527) is a potent inhibitor of HCV virus replication.

Bemnifosbuvir (AT-511), a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate, exhibits potent in vitro activity against HCV.

β-nicotinamide mononucleotide (NMN) is a natural nucleotide and a key intermediate in the synthesis of coenzyme I (NAD+). β-nicotinamide mononucleotide is involved in a number of biochemical reactions in the human body, which are related to immunity and metabolism.

Nicotinic acid mononucleotide is composed of nicotinic acid, ribose, and phosphate groups, serving as a key intermediate in the intracellular synthesis of NAD+ (Coenzyme 1), closely associated with cellular metabolism.

Nicotinic Acid Adenine Dinucleotide is a precursor of NAD (Nicotinamide adenine dinucleotide) and a substrate for glutamine-dependent NAD+ synthase, widely used in biochemical experiments and drug synthesis research.

Flavin adenine dinucleotide disodium salt (FAD sodium salt) is a flavin dinucleotide that is synthesized when the AMP moiety from ATP is transferred onto riboflavin 5'-monophosphate. FAD functions as a coenzyme that facilitates the transfer of electrons by flavoenzymes in oxidation-reduction reactions in cells.

Flavin Adenine Dinucleotide DiSodium Salt xhydrate is a useful organic compound for research related to life sciences and the catalog number is T64590.

Flavin adenine dinucleotide (FAD) is a REDOX cofactor and protein cogroup involved in various metabolic reactions.

β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active, reduced coenzyme that functions as a donor of ADP-ribose units in ADP-ribosylation reactions and as a precursor of cyclic ADP-ribose. It also serves as a regenerative electron donor in essential cellular energy metabolism processes, including glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle [1].

Polydeoxyribonucleotide can improve secretion of various growth factors, promote collagen synthesis, and restore tensile strength of the Achilles tendon in a rat model with Achilles tendon injury.

β-Benzamide adenine dinucleotide is a bioactive metabolite of benzamide ribonucleoside and functions as an effective inhibitor of inosine monophosphate dehydrogenase (IMPDH). It also acts as a potent, competitive inhibitor of human NAD kinase with a Ki value of 90 µM.

3-Acetylpyridine adenine dinucleotide (3-APAD) is an analog of nicotinamide adenine dinucleotide (NAD). In conjunction with sulfites, 3-APAD effectively inhibits lactate dehydrogenase (LDH).

5-Aminoimidazole ribonucleotide sodium (AIR) is an intermediate in purine biosynthesis. It undergoes further enzymatic modification to eventually form inosine monophosphate (IMP), which can then be converted into the purine bases adenine (A) and guanine (G). 5-Aminoimidazole ribonucleotide sodium is considered an endogenous metabolite (endogenous metabolite).

5-Aminoimidazole ribonucleotide (AIR) serves as an intermediate in purine biosynthesis, undergoing enzymatic modifications to form inosine monophosphate (IMP), which is subsequently converted into the purine bases adenine (A) and guanine (G) [1].

Polynucleotide Kinase is a DNA repair enzyme. It exhibits 5'-kinase activity by catalyzing the transfer of phosphate from ATP to the 5'-hydroxyl (OH) end, and also shows 3'-phosphatase activity by converting the 3'-phosphate end into a 3'-OH end.

Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) sodium is a fluorescent analog of NAD, serving as a substrate for bacterial toxins that catalyze the G-ADP ribosylation of signal-transduction G proteins. Additionally, Nicotinamide 1,N6-ethenoadenine dinucleotide sodium can be used as a fluorescent substrate in the study of ADP ribosylation reactions.

3-Acetylpyridine adenine dinucleotide disodium is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a) (IC50=5-20 nM). Etomoxir inhibits fatty acid oxidation by inhibiting CPT-1a, inhibits palmitate oxidation, has an inhibitory effect on adenine nucleotide translocase, and can inhibit macrophage polarization by disrupting CoA homeostasis.

MSA-2 is an orally available non-nucleotide STING agonist. The non-covalent dimer of MSA-2 binds to STING with nanomolar affinity. It shows anti-tumor activity in syngeneic mouse tumor models, synergizes with anti-PD-1, stimulates tumor secretion of interferon-β, induces tumor regression, and has long-lasting anti-tumor immunity. [3]