beta-catenin

Beta-Catenin Protein, Human, Recombinant (His) is expressed in E. coli. The accession number is P35222-1.

Beta-Catenin Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 113 kDa and the accession number is Q02248.

Expression system: Baculovirus Insect Cells
Length: 1-781, Full Length
Activity: Not Tested

CTNNB1 Protein, Human, Recombinant (GST) is expressed in E. coli. The accession number is P35222.

CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1 CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent studies suggest that complex mechanisms underlie CD82 loss of function, including altered transcriptional regulation, splice variant production and post-translational protein modifications, and indicate a central role for CD82 in controlling metastasis as a 'molecular facilitator'. The loss of KAI1 CD82 expression in invasive and metastatic cancers is due to a complex, epigenetic mechanism that probably involves transcription factors such as NFkappaB, p53, and beta-catenin. A loss of KAI1 expression is also associated with the advanced stages of many human malignancies and results in the acquisition of invasive and metastatic capabilities by tumour cells. Thus, KAI1 CD82 is regarded as a wide-spectrum tumor metastasis suppressor.

Expression system: HEK293 Cells
Length: 1-197, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 22-201, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 24-197, Extracellular Domain
Activity: ELISA

Expression system: E. coli
Length: 35-355, Partial
Activity: Not Tested

Expression system: E. coli
Length: 36-417, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 28-370, Full Length of Mature Protein
Activity: Not Tested

CCN4 Wnt-induced secreted protein 1 (WISP1) is a secreted, cysteine-rich, heparin-binding glycoprotein, belonging to the CCN (CTGF CYR61 NOV) family of growth factors, and is involved in diverse biological functions such as cell growth, adhesion, migration, angiogenesis, tissue repair, and regulation of extracellular matrix. Members of the CCN family demonstrate high structural homology sharing four conserved cysteine-rich modular domains: an IGFBP (insulin-like growth factor-binding) domain, a von Willebrand type C domain, a thrombospondin domain and a C-terminal cysteine -knot domain. WISP1 is a putative downstream effector of the Wnt Frizzled pathway that mediates diverse developmental processes, was identified as an oncogene regulated by the Wnt-1-beta-catenin pathway. Thus WISP1 may contribute to Wnt-1-mediated tumorigenesis and malignance. Expression of WISP1 in some cells results in transformation and tumorigenesis. WISP1 acts to block cell death at a late stage in the p53-mediated apoptosis pathway. It was reported that WISP1 interacts with sulfated glycoconjugates, decorin and biglycan in the ECM of connective tissue, and possibly prevents their inhibitory activity in tumor cell proliferation.

Expression system: E. coli
Length: 26-360, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 32-361, Partial
Activity: Not Tested

Expression system: E. coli
Length: 25-349, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-486, partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-197, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-394, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-146, Partial
Activity: ELISA

Frizzled-1, also known as FZD1, belongs to theG-protein coupled receptor Fz Smo family. FZD1 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. FZD1 is expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. Frizzled is a family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol. Frizzled proteins and the genes encoding them have been identified in an array of animals, from sponges to humans. Frizzled proteins play key roles in governing cell polarity, embryonic development, formation of neural synapses, cell proliferation, and many other processes in developing and adult organisms. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.

Expression system: HEK293 Cells
Length: 35-355, Partial
Activity: ELISA

Expression system: E. coli
Length: 25-349, Full Length of Mature Protein
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 121-527, Partial
Activity: Enzyme activity