Search Result

Search Results for " mutant "

Targets

Dehydrogenase Isocitrate Dehydrogenase (IDH)

370

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T16161	Mutant IDH1 inhibitor		Dehydrogenase , Isocitrate Dehydrogenase (IDH)
	Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).		Dehydrogenase , Isocitrate Dehydrogenase (IDH)
T2705	Mutant EGFR inhibitor		EGFR
	Mutant EGFR inhibitor is a selective and potent Mutated EGFR inhibitor, inhibits L858R activating mutant, the Exonl9 deletion activating mutant and the T790M resistance mutant.		EGFR
T12128	Mutant IDH1-IN-2		Isocitrate Dehydrogenase (IDH)
	Mutant IDH1-IN-2 is a mutant Isocitrate dehydrogenase (IDH) proteins inhibitor		Isocitrate Dehydrogenase (IDH)
T2043	Mutant IDH1-IN-1	IDH1-IN-1	Dehydrogenase , Isocitrate Dehydrogenase (IDH)
	Mutant IDH1-IN-1 is a potent mutant IDH1 R132 h inhibitor with IC50 < 0.1 uM.		Dehydrogenase , Isocitrate Dehydrogenase (IDH)
T39716	Mutant IDH1-IN-6	Mutant IDH1-IN-6
	Mutant IDH1-IN-6 is an orally active compound that effectively inhibits mutant isocitrate dehydrogenase (IDH) enzymes. It demonstrates potency and selectivity, with IC50 values of 6.27, 3.71, 36.9, and 11.5 nM for IDH1 R...
T12129	Mutant IDH1-IN-4		Others
	Mutant IDH1-IN-4 is an mutant Isocitrate dehydrogenase 1 (IDH 1) inhibitor.		Others
T40272	KRAS mutant protein inhibitor 1
	KRAS mutant protein inhibitor 1 is a KRAS mutant protein inhibitor for potential treatment in cancer.
T11164	EGFR mutant-IN-1		EGFR
	EGFR mutant- in-1, A 5-methylpyrimidopyridone derivative are effective selective EGFRL858R/T790M/C797S mutant inhibitors with IC50 of 27.5 nM, which significantly weakened EGFRWT effect.		EGFR
T12685	RAF mutant-IN-1		Others
	RAF mutant-IN-1 is an inhibitor of RAF kinase(IC50 values of 21 nM, 30 nM and 392 nM for C-RAF 340D/Y341D, B-RAFV600E and B-RAFWT, respectively).		Others
T77805	KRAS G12C mutant protein inhibitor A-1

T64079	Mutant p53 modulator-1
	Mutant p53 modulator-1 is a mutant p53 modulator. mutant p53 modulator-1 is able to hinder the progression of cancers containing p53 mutations.
T9521	CHR-6494 TFA		Others
	CHR-6494 TFA is a potent haspin inhibitor, with an IC50 of 2 nM. It inhibits histone H3T3 phosphorylation. CHR-6494 TFA induces the apoptosis of cancer cells, including melanoma and breast cancer. CHR-6494 TFA can be use...		Others
T8485	THIQ		Melanocortin Receptor
	THIQ is a selective melanocortin-4 receptor (MC4R) agonist (hMC4R and rMC4R with IC50 of 1.2 nM and 0.6 nM , respectively).		Melanocortin Receptor
T16384	Olutasidenib	FT-2102	Dehydrogenase , Isocitrate Dehydrogenase (IDH)
	Olutasidenib (FT-2102) is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain penetrant, and selective inhibitor of the mutant Iso...		Dehydrogenase , Isocitrate Dehydrogenase (IDH)
T9246	JNJ-63576253		Androgen Receptor
	JNJ-63576253 is a Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).		Androgen Receptor
T16143	MRTX-1257		Ras
	MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX1257 demonstrated 31% bioavailability in the mouse, with fre...		Ras
T1921	Alpelisib	BYL-719	PI3K
	Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity. Alpelisib inhibits PI3Kβ/γ/δ with low activity (IC50=250/290/1200 nM). Alpelisib has antitumor activity and is targeted to P...		PI3K
T7414	ARS-853		Apoptosis , Raf , Ras
	ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells		Apoptosis , Raf , Ras
T9698	UC2288		Mdm2 , p53
	UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 protein levels with minimal effect on p21 protein stability.		Mdm2 , p53
T9303	MRTX1133		Ras
	MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors.		Ras
T13176	TNO155	Batoprotafib	Phosphatase
	TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 µM),with potential antineoplastic activity.		Phosphatase
T60076	Oritinib	SH-1028	EGFR
	Oritinib (SH-1028) is an inhibitor of EGFR with IC50s of 18, 0.7, 4, 0.1, 1.4 and 0.89 nM for EGFR (wt), EGFR (L858R), EGFR (L861Q), EGFR (L858R/T790M), EGFR (d746-750), EGFR (d746-750/T790M), respectively. Oritinib can ...		EGFR
T8369	Adagrasib	MRTX849	Ras
	Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Adagrasib ...		Ras
T8756	KRAS inhibitor-9	DUN09716	Apoptosis , Ras
	KRAS inhibitor-9 (DUN09716) is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS ...		Apoptosis , Ras
T1623	Lopinavir	ABT-378	SARS-CoV , HIV Protease
	Lopinavir (ABT-378) is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding to serum proteins than the structurally-related dr...		SARS-CoV , HIV Protease
T8872	(Rac)-JBJ-04-125-02	JBJ-04-125-02	EGFR
	(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.		EGFR
T9320	YK-3-237	B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid	Sirtuin
	YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells ca...		Sirtuin
T8933	JNJ-63576253 free base	TRC253,JNJ-63576253	Androgen Receptor
	JNJ-63576253 free base (TRC253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the re...		Androgen Receptor
T35343	MTI-31	MTI-31,LXI-15029	mTOR
	MTI-31 (LXI-15029) is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3CB and PIK3G with >5,000 fold selectivity in mTOR binding a...		mTOR
T3184	Kevetrin hydrochloride	Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride	Mdm2 , p53
	Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.		Mdm2 , p53
T4459	PK11000		DNA Alkylator/Crosslinker
	PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.		DNA Alkylator/Crosslinker
T2330	Rilpivirine	TMC278,R278474,DB08864	HIV Protease , Reverse Transcriptase
	Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infections.		HIV Protease , Reverse Transcriptase
T1952	MK-2206 dihydrochloride	MK-2206 2HCl	Apoptosis , Akt , Autophagy
	MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8/12/65 nM) with orally active, highly potent and selective potency. MK-2206 dihydrochloride exhibits antitumor a...		Apoptosis , Akt , Autophagy
T9997	GLL 398		Estrogen Receptor/ERR
	GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.		Estrogen Receptor/ERR
T9304	(S)-Sunvozertinib	N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide,DZD9008	EGFR , HER
	(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.		EGFR , HER
T6008	CNX-2006	CNX 2006,CNX2006	EGFR
	CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.		EGFR
T15617	JNJ-38877618	OMO-1	c-Met/HGFR
	JNJ-38877618 (OMO-1) is an effective and highly selective inhibitor of Met kinase (IC50s: 2 and 3 nM for wild type and mutant Met, respectively).		c-Met/HGFR
T3506	Nazartinib	EGF816,NVS-816	EGFR
	Nazartinib (EGF816) (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity...		EGFR
T8930	CID44216842	KUC103479N-02	CDK , Ras
	CID44216842 (KUC103479N-02) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT...		CDK , Ras
T23182	PPY A		Bcr-Abl
	PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinase (IC50 of 9 and 20 nM, respectively).PPY A also inhibits the growth of Bcr-Abl T315l mutant or wild-type Bcr-Abl genetically transformed cells.		Bcr-Abl
T6954	PRIMA-1	2,2-Bis(hydroxymethyl)-3-quinuclidinone,NSC-281668,PRIMA 1	Apoptosis , Others , Ferroptosis , Autophagy
	PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.		Apoptosis , Others , Ferroptosis , Autophagy
T10375	ARS-1323		Ras
	ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.		Ras
T6949	PLX7904	PB04	Raf
	PLX7904 (PB04), also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutan...		Raf
T3024	Avitinib	AC0010	EGFR , JAK , BTK
	Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administrat...		EGFR , JAK , BTK
T1928	Anacetrapib	MK-0859	CETP
	Anacetrapib (MK-0859) (MK0859) is an effective, specific, reversible rhCETP and mutant CETP(C13S) inhibitor (IC50: 7.9 nM and 11.8 nM). Anacetrapib reduces the transfer of cholesteryl ester from HDL to LDL and/or VLDL th...		CETP
T6918	Olmutinib	HM61713, BI 1482694,BI 1482694,HM61713	EGFR , BTK
	Olmutinib (HM61713, BI 1482694) is an orally available small molecule, a mutant-selective inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Olmutinib binds to and inhibits mutan...		EGFR , BTK
T72958	BCR-ABL-IN-7		Bcr-Abl
	BCR-ABL-IN-7 is a WT and T315I mutant ABL kinase inhibitor.BCR-ABL-IN-7 potently inhibits WT and T315I mutant ABL kinase activity.BCR-ABL-IN-7 can be used in chronic myelogenous leukemia (CML) research.		Bcr-Abl
T16162	Mutated EGFR-IN-1	Osimertinib analog	EGFR
	Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant, and T790M resistance mutant.		EGFR
T17257L	WR99210 hydrochloride(47326-86-3 free base)	WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine	Others
	WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target. It has subnanomolar potency for the wild type, double mutant and quadruple mut...		Others
T10534	BI-4020		EGFR
	BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase. BI-4020 exhibits activity agains the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines), the d...		EGFR

Compounds

Mutant IDH1 inhibitor

T16161

Synonym:

Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)

Mutant EGFR inhibitor

Target: Isocitrate Dehydrogenase (IDH)

Mutant IDH1-IN-1

T2043

Synonym: IDH1-IN-1

Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)

Mutant IDH1-IN-6

T39716

Synonym: Mutant IDH1-IN-6

KRAS mutant protein inhibitor 1

KRAS G12C mutant protein inhibitor A-1

T77805

Synonym:

Target:

Mutant p53 modulator-1

Target: Melanocortin Receptor

Olutasidenib

T16384

Synonym: FT-2102

Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)

JNJ-63576253

T9246

Synonym:

Target: Androgen Receptor

Target: Apoptosis, Raf, Ras

Synonym: Batoprotafib

Target: Apoptosis, Ras

Lopinavir

T1623

Synonym: ABT-378

Target: SARS-CoV, HIV Protease

(Rac)-JBJ-04-125-02

T8872

Synonym: JBJ-04-125-02

Target: EGFR

YK-3-237

T9320

Synonym: B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid

Target: Sirtuin

JNJ-63576253 free base

T8933

Synonym: TRC253,JNJ-63576253

Target: Androgen Receptor

MTI-31

T35343

Synonym: MTI-31,LXI-15029

Target: mTOR

Kevetrin hydrochloride

T3184

Synonym: Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride

Target: DNA Alkylator/Crosslinker

Rilpivirine

T2330

Synonym: TMC278,R278474,DB08864

Target: HIV Protease, Reverse Transcriptase

MK-2206 dihydrochloride

T1952

Synonym: MK-2206 2HCl

Target: Apoptosis, Akt, Autophagy

GLL 398

T9997

Synonym:

Target: Estrogen Receptor/ERR

(S)-Sunvozertinib

T9304

Synonym: N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide,DZD9008

Target: EGFR, HER

CNX-2006

T6008

Synonym: CNX 2006,CNX2006

Synonym: EGF816,NVS-816

Target: EGFR

CID44216842

T8930

Synonym: KUC103479N-02

Synonym: 2,2-Bis(hydroxymethyl)-3-quinuclidinone,NSC-281668,PRIMA 1

Target: Apoptosis, Others, Ferroptosis, Autophagy

Target: EGFR, JAK, BTK

Synonym: HM61713, BI 1482694,BI 1482694,HM61713

Synonym: Osimertinib analog

Target: EGFR

WR99210 hydrochloride(47326-86-3 free base)

T17257L

Synonym: WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine

Cat No.	Product Name	Synonyms	Targets
T1135	Vitamin D3	Cholecalciferol,Colecalciferol	Endogenous Metabolite
	Vitamin D3 (Cholecalciferol) , a naturally occurring form of vitamin D, activates an H305F/H397Y mutant vitamin D receptor (VDR).		Endogenous Metabolite
T7970	7-Ethoxycoumarin		Others
	7-Ethoxycoumarin, a typical human P450 substrate, is catalyzed by both wild-type and mutant forms of CYP102A1.		Others
TN1140	Onjisaponin B		AMPK , mTOR , Autophagy
	Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parki...		AMPK , mTOR , Autophagy
T1717	Alpha-Mangostin	α-Mangostin,Mangostin	Apoptosis , Virus Protease , Dehydrogenase , Reactive Oxygen Species , Antibacterial , Antifungal
	alpha-Mangostin (Mangostin) is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
TN5072	Strictosidine		Others
	Strictosidine has DNA damaging activity in yeast RS 188N mutant, assessed as drug level required to produce 12 mm zone of inhibition.		Others
TN5254	Wighteone	Erythrinin B,6-Isopentenylgenistein	Antifungal
	Wighteone (Erythrinin B) is a small molecule compound derived from Genista ephedroides with potential antifungal and anticancer activity against EGFR L858R/T790M mutant non-small cell lung cancer.		Antifungal
T83133	Alternaphenol B2		Isocitrate Dehydrogenase (IDH)
	Alternaphenol B2, a selective inhibitor of mutant isocitrate dehydrogenase 1 (IDH1m), is sourced from the coral-derived fungus Parengyodontium album SCSIO SX7W11. It exhibits inhibitory activity specifically against the ...		Isocitrate Dehydrogenase (IDH)

Natural Products

Vitamin D3

T1135

Synonym: Cholecalciferol,Colecalciferol

Target: Endogenous Metabolite

Target: AMPK, mTOR, Autophagy

alpha-Mangostin

T1717

Synonym: α-Mangostin,Mangostin

Target: Apoptosis, Virus Protease, Dehydrogenase, Reactive Oxygen Species, Antibacterial, Antifungal

Synonym: Erythrinin B,6-Isopentenylgenistein

Target: Isocitrate Dehydrogenase (IDH)

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-01464	IL-2 Superkine Protein, Human, Recombinant (L100F, R101D, L105V, I106V, I112F)	Human	Human Cells
	Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system，belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or m...
TMPY-03565	Mannan Binding Lectin/MBL2 Protein, Human, Recombinant	Human	CHO
	MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and dying host cells and is one of the four known mediators that initiate activation ...
TMPY-00748	Nectin-2 Protein, Human, Recombinant	Human	HEK293
	Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein a...
TMPY-02647	IFNAR1 Protein, Human, Recombinant (His)	Human	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPY-00747	Nectin-2 Protein, Human, Recombinant (His)	Human	HEK293
	Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein a...
TMPY-00395	Insulin Protein, Human, Recombinant	Human	Yeast
	INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsul...
TMPJ-01011	FGF-9 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine a...
TMPY-02558	IL-4 Protein, Mouse, Recombinant	Mouse	E. coli
	Interleukin-4, also known as IL4, is a secreted protein that belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. It e...
TMPY-04552	AKT1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to ...
TMPY-01862	IL-4 Protein, Human, Recombinant	Human	E. coli
	Interleukin-4, also known as IL4, is a secreted protein that belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. It e...
TMPY-01191	CD3 epsilon/CD3e Protein, Human, Recombinant (HEK293,His)	Human	HEK293
	T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delt...
TMPY-02701	CD3 epsilon/CD3e Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delt...
TMPY-00616	CD3 epsilon/CD3e Protein, Canine, Recombinant (hFc)	Canine	HEK293
	T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delt...
TMPY-00483	Parvalbumin/PVALB Protein, Human, Recombinant (His)	Human	E. coli
	Parvalbumins (PVALBs) are particularly abundant in the fast-contracting muscles and correlate positively with muscle relaxation speed in amphibians and fishes. The loss of PVALB plays a role in the pathogenesis of thyroi...
TMPH-00721	YgiS Protein, E. coli, Recombinant (His & SUMO)	E. coli	E. coli
	Probably part of a deoxycholate transport system. Its expression in the presence of deoxycholate in a ygiS deletion mutant increases intracellular deoxycholate levels and decreases cell growth; higher expression in the p...
TMPK-00113	Pentraxin 2/SAP Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Pentraxin-2 (PTX-2), also known as serum amyloid P component (SAP/APCS), is a constitutive, antiinflammatory, innate immune plasma protein whose circulating level is decreased in chronic human fibrotic recombinant human ...
TMPK-00690	EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled	Human	HEK293
	The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearran...
TMPY-05099	GBA/glucocerebrosidase Protein, Human, Recombinant (His)	Human	HEK293
	Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramida...
TMPK-00692	EGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearran...
TMPK-00689	EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled	Human	HEK293
	The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearran...
TMPY-03465	Flagellin Protein, Listeria monocytogenes, Recombinant (His)	Listeria monocytogenes	E. coli
	The role of flagella and motility in the attachment of the foodborne pathogen Listeria monocytogenes to various surfaces is mixed with some systems requiring flagella for an interaction and others needing only motility...
TMPK-00691	EGFRVIII Protein, Human, Recombinant (His & Avi)	Human	HEK293
	The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearran...
TMPK-00765	Pentraxin 2/SAP Protein, Human, Recombinant (hFc)	Human	HEK293
	Pentraxin-2 (PTX-2), also known as serum amyloid P component (SAP/APCS), is a constitutive, antiinflammatory, innate immune plasma protein whose circulating level is decreased in chronic human fibrotic recombinant human ...
TMPY-04152	RAB7A Protein, Rat, Recombinant (His)	Rat	E. coli
	RAB7A is a ubiquitous small GTPase, which controls transport to late endocytic compartments. Silencing or overexpression of wild type RAB7A changed the soluble/insoluble rate of peripherin indicating that RAB7A is import...
TMPY-02426	UBE2D1 Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-conjugating enzyme E2 D1 (UBE2D1), a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, which is short for stimulator of iron (Fe) transport. In other words, UbcH5A is significantly up...
TMPJ-00604	KIR2DL4 Protein, Human, Recombinant (His)	Human	Human Cells
	Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expres...
TMPJ-00125	TNF alpha Protein, Human, Recombinant (aa 57-233, His)	Human	E. coli
	Tumor Necrosis Factor-α (TNF-α) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF-α while cells that express CD8 secrete li...
TMPJ-00124	TNF alpha Protein, Human, Recombinant (aa 77-233, His)	Human	E. coli
	Tumor Necrosis Factor-α (TNF-α) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF-α while cells that express CD8 secrete li...
TMPY-04322	Mannan Binding Lectin/MBL2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and dying host cells and is one of the four known mediators that initiate activation ...
TMPY-00429	Mannan Binding Lectin/MBL2 Protein, Mouse, Recombinant (mFc)	Mouse	HEK293
	MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and dying host cells and is one of the four known mediators that initiate activation ...
TMPY-06383	Nectin-2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein a...
TMPK-01325	M-CSF/CSF1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of...
TMPY-06295	Nectin-2 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293
	Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein a...
TMPK-00322	M-CSF/CSF1 Protein, Human, Recombinant (aa 33-190)	Human	HEK293
	CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of...
TMPY-03652	KIR2DL4 Protein, Human, Recombinant	Human	CHO
	KIR2DL4, also known as CD158d, is a member of the killer cell Ig-like receptor (KIR) family. KIRs are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic an...
TMPY-03036	Nectin-2 Protein, Rat, Recombinant (His)	Rat	HEK293
	Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein a...
TMPY-02561	Nectin-2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein a...
TMPY-04254	IFNAR1 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPY-02634	IFNAR1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPY-00746	Nectin-2 Protein, Human, Recombinant (hFc)	Human	HEK293
	Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein a...
TMPY-01150	Nectin-2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein a...
TMPY-03651	KIR2DL4 Protein, Human, Recombinant (hFc)	Human	CHO
	KIR2DL4, also known as CD158d, is a member of the killer cell Ig-like receptor (KIR) family. KIRs are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic an...
TMPY-03829	IFNAR1 Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPY-01489	IFNAR1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPY-03991	DBI Protein, Human, Recombinant (His)	Human	E. coli
	The diazepam binding inhibitor (DBI), alternatively known as the acyl-CoA binding protein (ACBP), is involved in multiple biological actions. The polypeptide binds to the peripheral, or mitochondrial, benzodiazepine rece...
TMPY-03927	IFNAR1 Protein, Rhesus, Recombinant	Rhesus	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPJ-00869	GLB1 Protein, Human, Recombinant (His)	Human	Human Cells
	β Galactosidase is a lysosomal β Galactosidase that hydrolyzes the terminal β Galactose from Ganglioside and Keratan sulfate. In lysosome, the mature β Galactosidase protein associates with Cathepsin A and Neuraminidase ...
TMPY-02961	PANP/C12orf53 Protein, Human, Recombinant (hFc)	Human	HEK293
	C12orf53 is mainly expressed in adult brain and cerebellum. It also can be detected in fetal brain and virtually no expression in spleen, heart, kidney, liver and dorsal ganglion relative to brain. C12orf53 acts as a lig...
TMPY-02787	Aconitase 2 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	A homozygous missense mutation was identified in the ACO2 gene (c.1240T>G p.Phe414Val) that segregated with HSP complicated by intellectual disability and microcephaly. Lymphoblastoid cell lines of homozygous carrier pat...
TMPY-02545	Aconitase 2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	A homozygous missense mutation was identified in the ACO2 gene (c.1240T>G p.Phe414Val) that segregated with HSP complicated by intellectual disability and microcephaly. Lymphoblastoid cell lines of homozygous carrier pat...
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