erk — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T36675	ERK Inhibitor
	ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-speci...
T9141	ERK-IN-3	ASN007 free base	ERK
	ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driven by RAS mutations.		ERK
T11224	Rineterkib	ERK-IN-1	ERK , Raf
	Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.		ERK , Raf
T11225	ERK-IN-2		ERK
	ERK-IN-2, an ERK2 inhibitor, exhibits an IC50 value of 1.8 nM. At doses greater than 10 μM, it may induce off-target toxicity and/or activity [1].		ERK
T39453	ERK-IN-3 benzenesulfonate
	ERK-IN-3 benzenesulfonate is a potent and orally active inhibitor of ERK . ERK-IN-3 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC 50 values. ERK-IN-3 benzenesulfonate can be used for the research of cancer...
T3166	VX-11e	Vertex-11e,VTX-11e,TCS ERK 11e	ERK , GSK-3 , FLT , CDK , Aurora Kinase
	VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.		ERK , GSK-3 , FLT , CDK , Aurora Kinase
T74997	ERK-IN-6
	ERK-IN-6 (compound 6g) serves as a potent anti-proliferative agent against esophageal squamous cell carcinoma (ESCC), inducing apoptosis through the ERK pathway. This compound has potential applications in ESCC research ...
T82443	ERK-CLIPTAC		PROTACs
	ERK-CLIPTAC is a PROTAC (PROteolysis TArgeting Chimera) molecule designed to induce the degradation of Extracellular signal-Regulated Kinase (ERK) [1].		PROTACs
T71316	ERK Inhibitor II (Negative control)
	ERK Inhibitor II (Negative control) effectively blocks extracellular signal-regulated kinase (ERK) and interferes with insulin receptor activation, serving as a useful tool in diabetes research.
T72517	ERK-IN-2 free base
	ERK-IN-2 free base, an inhibitor of ERK2, demonstrates potent efficacy with an IC50 value of 1.8 nM. However, doses exceeding 10 μM may result in off-target toxicity and/or activity.
T5184	ERK5-IN-1		ERK
	ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).		ERK
T5535	ERK5-IN-2		ERK
	ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.		ERK
T80543	STE-MEK1(13)	ERK Activation Inhibitor Peptide,Ste-MPKKKPTPIQLNP-NH₂	ERK
	STE-MEK1(13), a cell-permeable ERK1/2 inhibitor with IC50 values ranging from 13 to 30 μM, impedes the phosphorylation of ERK1/2, as demonstrated in studies [1] [2].		ERK
TN2346	Mogrol		ERK , AMPK , STAT
	Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.		ERK , AMPK , STAT
T6S0655	Corynoxeine		ERK
	1. Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation and may be useful in the prevention and treatment of vascular diseases and restenosis after angioplasty.		ERK
T8472	ERK1/2 inhibitor 2	ASTX-029,ASTX029	ERK
	ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable extracellular signal-regulated kinases 1 and 2 (ERK 1/2) inhibitor, with potential antineoplastic activity.		ERK
T11226	ERK1/2 inhibitor 1		ERK
	ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.		ERK
T5358	Longdaysin		ERK , Casein Kinase , CDK
	Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 µM). It also can inhibit ERK2 (IC50: 52 µM).		ERK , Casein Kinase , CDK
T4091	Temuterkib	LY3214996	ERK
	Temuterkib (LY3214996) is a potent and selective, orally available inhibitor of the extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity.		ERK
T3856	Tenuifoliside A		ERK , Others
	Tenuifoliside A has anti-apoptotic , neuroprotective activity. And tenuifoliside A has anti-inflammatory effect, which is mediated by the inhibition of the NF-κB and MAPK pathways.		ERK , Others