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  • Inhibitors & Agonists
    785
    TargetMol | All_Pathways
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    45
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(-)-Epigallocatechin Gallate
Epigallocatechol Gallate, EGCG
T2988989-51-5
(-)-Epigallocatechin Gallate (EGCG) is a phenolic antioxidant polyphenol flavonoid found in plants such as green and black tea, which inhibits telomerase and DNA methyltransferase, blocks the activation of EGF receptors and HER-2 receptors, inhibits cellular oxidation, and prevents free radical damage to cells.
  • $43
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Paclitaxel
Taxol, NSC 125973
T096833069-62-4
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
  • $34
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TargetMol | Citations Cited
Cycloheximide
Naramycin A, CHX, Actidione
T122566-81-9
Cycloheximide (Naramycin A) is a natural product . Cycloheximide‘s IC50 values for protein synthesis and RNA synthesis in vivo are 532.5 nM and 2880 nM, respectively. Cycloheximide inhibits ferroptosis and autophagy and is an antifungal antibiotic.
  • $71
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TargetMol | Citations Cited
Rapamycin
Sirolimus, NSC-2260804, AY 22989
T153753123-88-9
Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
  • $30
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3-Methyladenine
NSC 66389, 3-MA
T18795142-23-4
3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50 = 60 μM) and class III VPS34 (IC50 = 25 μM). 3-Methyladenine inhibits autophagy.
  • $35
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TargetMol | Citations Cited
Brefeldin A
Decumbin, Cyanein, BFA, Ascotoxin
T606220350-15-6
Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activity.
  • $34
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TargetMol | Citations Cited
Trichostatin A
TSA
T627058880-19-6
Trichostatin A (TSA), a natural derivative of diene isohydroxamic acids, is a specific and reversible histone deacetylase inhibitor (IC50=1.8 nM) that induces hyperacetylation of core histones to regulate chromatin structure.
  • $86
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TargetMol | Citations Cited
G-418 disulfate
Geneticin sulfate, Geneticin, G418 Sulfate, Antibiotic G-418 sulfate
T6512108321-42-2
G-418 disulfate (Geneticin sulfate) is an aminoglycoside antibiotic that selectively inhibits eukaryotic protein synthesis by blocking peptide chain elongation.
  • $35
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Valproic Acid
VPA, Sodium valproate, Depakine, 2-Propylvaleric Acid, 2-Propylpentanoic Acid
T706499-66-1
Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that suppresses HDAC1 activity and induces HDAC2 degradation, exhibiting oral bioavailability. Valproic Acid activates Notch1 signalling and inhibits the proliferation of small cell lung carcinoma cells, making it applicable for research into epilepsy and bipolar disorder.
  • $50
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Anisylacetone
Fr12339104-20-1
Anisylacetone (Anisylacetone) is an effective lure for the male melon fly.
  • $29
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TargetMol | Inhibitor Sale
Ethyl 4-hydroxyphenylacetate
Fr1241517138-28-2
Ethyl 4-hydroxyphenylacetate is a selective inhibitor of monoamine oxidase A.
  • $30
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3-Methoxyphenylacetic acid
Fr138831798-09-0
3-Methoxyphenylacetic acid belongs to the class of organic compounds known as anisoles. 3-Methoxyphenylacetic acid is slightly soluble (in water) and a weakly acidic compound (based on its pKa).3-Methoxyphenylacetic acid (m-Methoxyphenylacetic acid), a m-hydroxyphenylacetic acid (m-OHPAA) derivative, is a phytotoxin in Rhizoctonia solani. 3-Methoxyphenylacetic acid is used to develop a toxin-mediated bioassay for resistance to rhizoctonia root rot
  • $29
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2'-Hydroxy-4'-methylacetophenone
Fr142986921-64-8
2'-Hydroxy-4'-methylacetophenone, a phenolic compound isolated from Angelicae koreana roots, possesses acaricidal properties and can be used in the preparation of 4'-methyl-2'-[(p-tolylsulfonyl)oxy]acetophenone.
  • $29
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4-Hydroxybenzyl cyanide
4-Hydroxyphenylacetonitrile
Fr1674514191-95-8
4-Hydroxybenzyl cyanide (4-Hydroxyphenylacetonitrile) shows strong antioxidative activity.
  • $29
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Bergenin
Cuscutin, Bengenin
T0122477-90-7
Bergenin (Bengenin) is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
  • $50
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TargetMol | Citations Cited
3,4-Dimethoxyphenylacetic acid
Homoveratrumic acid, homoveratric acid
T056893-40-3
3,4-Dimethoxyphenylacetic acid (Homoveratrumic acid) is the papaverine intermediate, used to synthesis cardiovascular drugs.
  • $29
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4-Pentynoic acid
Propargylacetic acid
T05806089-09-4
4-Pentynoic acid (Propargylacetic acid) reacts with 1-bromo-1-alkynes in the presence of a Pd catalyst to yield biologically active ynenol lactones and is used in the synthesis of a cytotoxic macrolide via ring-closing metathesis of a bis acetylene.
  • $29
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Dihydroartemisinin
β-Dihydroartemisinin, Dihydroqinghaosu, DHA, Artenimol
T060771939-50-9
Dihydroartemisinin (Artenimol) is an antimalarial drug.
  • $36
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TargetMol | Citations Cited
Phenyl acetate
Phenol acetate, Acetylphenol, Acetic acid phenyl ester
T0650122-79-2
Phenyl acetate (Acetic acid phenyl ester) is an aromatic fatty acid metabolite of phenylalanine with potential antineoplastic activity. Naturally occurring in mammals, phenylacetate induces differentiation, growth inhibition, and apoptosis in tumor cells.
  • $29
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Retinyl acetate
Vitamin A acetate, Retinyl (Retinol) Acetate, Retinol acetate
T0685127-47-9
Retinyl acetate (Vitamin A acetate) is a group of unsaturated nutritional hydrocarbons, that contains retinal, retinol, retinoic acid, and several provitamins A carotenoids, among which beta-carotene is the most important.
  • $30
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Isoliquiritigenin
Isoliquiritigen, ISL, GU17
T0725961-29-5
Isoliquiritigenin (ISL) is a flavonoid natural product that inhibits influenza virus replication (EC50=24.7 μM) and aldose reductase activity (IC50=320 nM). Isoliquiritigenin has antitumor activity.
  • $33
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TargetMol | Citations Cited
Tetracycline
Tetracyclinum, Tetracyclin, Deschlorobiomycin
T0912L60-54-8
Tetracycline is an orally active broad-spectrum antibiotic that exhibits inhibitory activity against various Gram-positive and Gram-negative bacteria, as well as Chlamydia, Mycoplasma, and Rickettsia. It is commonly used in anti-infection research and can also be used to induce tumor regression based on BCR-ABL gene silencing.
  • $30
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TargetMol | Citations Cited
D-α-Tocopherol acetate
Vitamin E Acetate, Tocopherol acetate
T101658-95-7
D-alpha-Tocopherol acetate (Vitamin E Acetate) is hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine.
  • $29
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TargetMol | Citations Cited
Capsaicin
Zostrix, Qutenza, 8-Methyl-N-vanillyl-trans-6-nonenamide, (E)-Capsaicin
T1062404-86-4
Capsaicin is an active natural component found in chili peppers and acts as a TRPV1 agonist (EC50 = 0.29 μM). It possesses multiple activities, including pain relief, antitumor, anti-inflammatory, antioxidant, and neuroprotective effects, as well as some neurotoxicity. Capsaicin can be used to establish itch models.
  • $50
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TargetMol | Citations Cited