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microtubule

" in TargetMol Product Catalog
  • Inhibitors & Agonists
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Paclitaxel
Taxol, NSC 125973
T096833069-62-4
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
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Colchicine
Colcin, Colchisol, Colchineos
T032064-86-8
Colchicine (Colcin) is a natural product that is an inhibitor of microtubule polymerization (IC50=3 nM) and blocks microtubule polymerization by binding to microtubule proteins. Colchicine can be used in the treatment of ventilation and rheumatic diseases.
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Docetaxel
RP-56976, NSC 628503
T1034114977-28-5
Docetaxel (RP-56976), a semi-synthetic analog of paclitaxel, is a microtubule depolymerization inhibitor (IC50=0.2 μM) that attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing, anti-tumor activity.
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Vincristine sulfate
Leurocristine sulfate, Leurocristine, 22-Oxovincaleukoblastine sulfate
T12702068-78-2
Vincristine sulfate is an alkaloidal natural product that binds to microtubule proteins and inhibits the formation of microtubules, thereby inhibiting mitosis in tumor cells. Vincristine sulfate is used as a microtubule destabilizing agent in research studies for the treatment of hematologic neoplasms such as leukemias and lymphomas, as well as in studies related to sarcomas in children.
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Ansamitocin p-3
NSC292222, Maytansinol isobutyrate, Antibiotic C 15003P3
T2226266584-72-3
Ansamitocin p-3 (Maytansinol isobutyrate) is an inhibitor of microtubule with IC50 of 3.4 μM for tubulin polymerization.
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7-10 days
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Taccalonolide B
TN2256108885-69-4
Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM.
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L-Clausenamide
(-)-Clausenamide
T32614201529-58-0In house
L-Clausenamide is an alkaloid extracted from the leaves of the yellow bark (Clausena lansium (Lour) skeels) and can be used to improve cognitive function. L-Clausenamide inhibits beta-amyloid (Aβ) toxicity and prevents the formation of neurofibrillary tangles by inhibiting tau phosphorylation. L-Clausenamide has neuroprotective activity and can be used to modulate stimuli triggered by Aβ25-35. L-Clausenamide can be used to study neurological disorders like Alzheimer's disease.
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6-8 weeks
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Podofilox
Podophyllotoxin, (+)-Shikonin
T1121518-28-5
Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
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Mebendazole
Vermox, Telmin, Pantelmin, Mebenvet
T115531431-39-7
Mebendazole (Mebenvet) is a hedgehog inhibitor, used as an antihelminthic.
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Griseofulvin
Fulvicin, Amudane, Grisactin
T1382126-07-8
Griseofulvin (Fulvicin) is an antifungal agent used in the treatment of TINEA infections.
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Cabazitaxel
XRP6258, TXD 258, taxoid XRP6258, RPR-116258A
T2543183133-96-2
Cabazitaxel (taxoid XRP6258) is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docetaxel.
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4'-Demethylepipodophyllotoxin
DMEP, 4'-DMEP, 4-Demethylepipodophyllotoxin, 4'-O-demethylepipodophyllotoxin
T29376559-91-7
4'-Demethylepipodophyllotoxin (DMEP) is a potent inhibitor of microtubule assembly.
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Combretastatin A4
CRC 87-09, CA4
T6212117048-59-6
Combretastatin A4 (CA4) is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).
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Jasplakinolide
Jaspamide, NSC-613009
T11712102396-24-7
Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits antifungal and antitumor activity and stabilizes pre-existing actin filaments. Jasplakinolide competitively binds to F-actin with the ghost pen cyclic peptide and has a Kd value of 15 nM for F-actin.
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Vinblastine sulfate
NSC49842, Vincaleukoblastine sulfate salt
T1668143-67-9
Vinblastine sulfate (Vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).
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2-Methoxyestradiol
NSC-659853, 2-MeOE2, 2-ME2
T2220362-07-2
2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis.
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Ceratamine A
T10763634151-15-8
Ceratamine A, an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., functions as a microtubule-stabilizing agent with cytotoxic effects against human cancer cell lines.
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Cytochalasin A
T1092814110-64-6
Cytochalasin A, a cell-permeable fungal toxin and oxidized derivative of cytochalasin B, is an inhibitor of HIV-1 protease (IC50 = 3 μM). It inhibits actin polymerization, interferes with microtubule assembly by reacting with sulfhydryl groups, and serves as an antibiotic and bactericidal active agent.
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Tubulysin D
T13228309935-57-7
Tubulysin D is a tetrapeptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and displays potent antitumor activity.
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Colcemid
NSC-3096, Kolchicin, Demecolcine, C-12669, C12669, C 12669
T19720477-30-5
Colcemid (NSC-3096) is an inhibitor of microtubule polymerization. It used to study embryonic cloning.
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7-10 days
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Maytansine
NSC-153858, NSC153858, Maitansina, NSC 153858, Maitansine
T2135135846-53-8
Maytansine (NSC-153858), an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.
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Cephalomannine
Baccatin III
T221771610-00-9
Cephalomannine (Baccatin III) is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.
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Vindoline
T27732182-14-1
Vindoline is an indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly.
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Santalol
T2S179711031-45-1
1. Santalol has good antibacterial, anti-oxidation and anti-tumor activities. 2. α-Santalol is a potent antimitotic agent induced by interference with microtubule assembly. 3. α-Santalol shows a significant antifungal effect against a dermatophytic fungus
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7-10 days
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