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Proteases/Proteasome MMP

MMP

Cat No. product name
TP1501L CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base) CTTHWGFTLC, CYCLIC acetate is an inhibitor for matrix metalloproteinases (MMP)-2 and MMP-9. It is also called type IV collagenase or gelatinase. Gelatinases are ...
T5S1026 Apigenin-7-glucuronide Apigenin-7-glucuronide possesses multiple activities, including antioxidant, anti-inflammatory, and aldose reductase inhibitory activities, it can inhibit MMP ac...
T2987 Epigallocatechin (-)-Epigallocatechin is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.
T4082 Astragaloside Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteas...
T7044 Norepinephrine Norepinephrine can stimulate apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. It can up-regulate the expression of vascula...
T4783 JNJ0966 JNJ0966 is a highly selective MMP-9 zymogen inhibitor (IC50: 440 nM).
T3850 Luteolin-7-glucuronide Luteolin-7-Glucuronide possesses antioxidant activities.
T6S0444 Salvianolic acid A Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.
T5361 T-26c T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor (IC50: 6.75 pM).
T5416 T-5224 T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription ...
T5680 ALOIN ALOIN Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells.
T2967 Stigmasterol Stigmasterol is found in the fats and oils of soybean, calabar bean and rape seed, as well as several other vegetables, legumes, nuts, seeds, and unpasteurized m...
T7449 1, 10-Phenanthroline monohydrate 1,10-Phenanthroline monohydrate is an inhibitor of metallopeptidases, inhibits zinc-dependent hydrolysis of Fa-Gly-Leu-NH2 by B. subtilis neutral protease and B....
TQ0129 L-​Alaninamide, N-​[2-​[2-​(hydroxyamino)​-​2-​oxoethyl]​-​4-​methyl-​1-​oxopentyl]​-​3-​methyl-​L-​valyl-​N-​(2-​aminoethyl)​- TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM).
T7522 GI 254023X GI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM) with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). GI254023X can r...
T8259 Doxycycline monohydrate Doxycycline monohydrate is an inhibitor of metalloproteinase (MMP)
TP1446 Histatin 5 (TFA)(115966-68-2,free) Histatin 5 TFA inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively.
T8310 MMP-9-IN-1 MMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9).
TN1093 Ginsenoside F4 Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the i...
TN1376 Alpha-Solanine Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut.
T2987 Epigallocatechin (-)-Epigallocatechin is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.
T3729 Ethyl gallate Ethyl gallate obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependen...
TN1615 Epitheaflagallin 3-O-gallate Epitheaflagallin 3-O-gallate is a promising functional food material with potential antiobesity and antiperiodontal disease activities, it suppresses tumor growt...
T2787 Picroside I Picroside I, a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B. It has antioxidant, and anti-inflammatory activities, it may...
T3813 Ginsenoside Rh2 Ginsenoside Rh2 is a minor stereoisomer of ginsenoside Rh2, possesses matrix metalloproteinase inhibitory.
T6011 Batimastat Batimastat (BB-94) is an effective, broad-spectrum matrix metalloprotease (MMP) inhibitor. Batimastat induces extracellular matrix degradation and inhibits angio...
T2743 Ilomastat Ilomastat (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.
T2750 Ginkgolide C Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.
T6885 Marimastat Marimastat (BB-2516) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor. MMP-9 (IC50=3 nM), MMP-1 (IC50=5 nM), MMP-2 (IC50=6 nM), MMP-14 (IC50=9 ...
T3472 CGS 27023A CGS 27023A is a non-peptidic, potent, and orally active stromelysin inhibitor.
T3388 Calycosin-7-O-beta-D-glucoside Calycosin 7-O-β-D-glucopyranoside possesses a protective effect on rat hepatocytes, an inhibitory effect on COX-2 activity. Calycosin 7-O-β-D-glucoside has ant...
T3414 Morroniside Morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice. It exhibits protective effects against diabetic renal ...
T2792 Glucosamine sulfate Extracted from synthetic product;Store the product in sealed, cool and dry condition
T2957 Arctigenin (-)-Arctigenin is found in burdock. (-)-Arctigenin is isolated from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD). Ar...
T2009 SB-3CT SB-3CT is a potent and specific gelatinase inhibitor for MMP-2(Ki=13.9 nM) and MMP-9(Ki=600 nM).
T0429 Glucosamine Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
T1402 Fenofibric acid Fenofibric Acid is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
T2834 Nobiletin Nobiletin is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (...
T3090 Abietic Acid Abietic Acid is the primary component of resin acid isolated from rosin.
T2893 Muscone Muscone is an organic compound that is the primary contributor to the odor of musk.
T1592 Acetohydroxamic acid Acetohydroxamic acid is an antagonist of the bacterial enzyme urease.
T1891 NSC 405020 NSC 405020 is a noncatalytic inhibitor of MT1-MMP.
TN1560 Dehydroeffusol Dehydroeffusol possesses anti-cancer, anxiolytic and sedative properties, it may antagonize the spasmogenic activity of various agents, and therefore, could be a...
TN1711 Gossypetin Gossypetin has anti-mutagenic, anti-atherosclerotic, antioxidant, as well as cytoprotective and antimicrobial effects, it inhibits bone resorption through down-r...
T4282 S-methyl-KE-298 S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from...
TN3616 Cedrelone Cedrelone exhibits antifeedant activity, it has insecticidal activity, it inhibits arval growth of P. saucia, and the molting of the milkweed bug, Oncopeltus fas...
T16966 S 3304 S 3304 is a novel matrix metalloproteinases inhibitor which is specific for MMP-2 and MMP-9.
T16986 Tanomastat Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 30...
T17201 UK 356618 UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).
T4S0181 Hinokiflavone Hinokiflavone is a novel modulator of pre-mRNA splicing activity in vitro and in cellulo. Hinokiflavone blocks splicing of pre-mRNA substrates by inhibiting spl...
TN2697 2,3-Dihydrohinokiflavone 2,3-Dihydrohinokiflavone is a suppressor of matrix metalloproteinases (MMPs) gene expression. It (IC50 =1.6uM) shows strong activity against Leishmania.
TN2775 2-Methoxystypandrone 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infla...
TN3016 4',6,7-Trimethoxyisoflavone 4',6,7-Trimethoxyisoflavone promotes wound healing through NOX2 induction, which leads to collective migration and MMP activation.
TN3587 Capillarisin Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN3691 Communic acid Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic...
T16137 MRS1177 MRS1177 is an effective and selective antagonist of the human Adenosine A3 receptor (hA3AR) (Ki: 0.3 nM).
TN4046 Excisanin A ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
TN4263 Isoangustone A Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
TN4394 Kobophenol A Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
TN4429 Leucodin Leucodin shows high anti-hypercholesterolemic potential. Leucodin may have anti-allergic activity, it shows a potent inhibitory activity upon the beta-hexosamini...
TN4437 Licorisoflavan A Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating ...
TN4978 Scutellarein-7-O-glucoside Scutellarein-7-O-glucoside inhibites MMP-2 activity.
TN5153 Torilin Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
TN5174 Trichosanatine Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatin...
T12539L Prinomastat Prinomastat inhibits MMP-2, MMP-3 and MMP-9 (Kis: 0.05 nM, 0.3 nM and 0.26 nM, respectively). Prinomastat crosses the blood-brain barrier. It also has antitumor ...
T13358 XL-784 XL-784 is a selective inhibitor of matrix metalloproteinases (MMP)(IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respecti...
TN1867 Licoricidin Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells.
T12511 PNU-248686A PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).
TN1879 Lucidenic acid A Lucidenic acid-A and -F are modulators of JNK and p38, respectively, they enhance LPS-induced immune responses in monocytic THP-1 cells possibly via the modulati...
TN1881 Lucidenic acid C Lucidenic acid C has anti-invasive effect, it shows significant inhibitory effects on PMA-induced MMP-9 activity and invasion of HepG(2 )cells.
TN1928 Methyl rosmarinate Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase.Methyl rosmari...
TN1998 Notoginsenoside T5 Total panax notoginsenosides (TPNS) are the main active ingredients in San-Chi, the root of(Burk) F.H. Chen, which belongs to the Araliaceae family and has been ...
TN2075 Pimaric acid Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced huma...
TN2316 Xanthyletin Xanthyletin has anti-inflammatory, anti-tumor and anti-bacterial activities, it also inhibits symbiotic fungus cultivated by leaf-cutting ants.
T12082 MMP3 inhibitor 1 MMP3 inhibitor 1 is a potent and highly selective inhibitor of MMP-3 (IC50 of 1 nM).
T12414 PF-00356231 hydrochloride PF-00356231 hydrochloride is an inhibitor of matrix metalloproteinase MMP-12 with IC50 of 1.4 μM.
T12539 Prinomastat hydrochloride Prinomastat hydrochloride is a orally active inhibitor of metalloproteinase (MMP)(MMP-1, MMP-3 and MMP-9 with IC50s of 79, 6.3 and 5.0 nM , respectively),with An...
T15574 Incyclinide Incyclinide is a matrix metalloproteinase (MMP) inhibitor. Thereby causing extracellular matrix degradation, tumor growth and invasion, and inhibiting angiogenes...
T14312 Apratastat Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) a...
T14322 ARP-100 ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-...
T14978 CL-82198 CL-82198 is a selective inhibitor of MMP-13 and it is a pharmacologic treatment for preventing osteoarthritis (OA) progression. CL-82198 binds to the entire S1...
T15055 DB04760 DB04760 is a highly selective, non-zinc-chelating inhibitor of MMP-13 (IC50: 8 nM). DB04760 obviously decreases paclitaxel neurotoxicity and has anticancer activ...
T12762 Ro 31-9790 Ro 31-9790 is a synthetic inhibitor of metalloproteinase (MMP).
T10461 Batimastat sodium salt Batimastat (BB-94) sodium salt is a broad-spectrum MMP inhibitor (IC50s: 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7, and MMP-3).
T10597 BR351 BR351 is a brain penetrant MMP inhibitor (IC50s: 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13).
T13249 UK-370106 UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-fibronecti...
T1140 Doxycycline hydrochloride Doxycycline hydrochloride is a synthetic tetracycline derivative with similar antimicrobial activity.
CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base)
TP1501LCAS TP1501L
CTTHWGFTLC, CYCLIC acetate is an inhibitor for matrix metalloproteinases (MMP)-2 and MMP-9. It is also called type IV collagenase or gelatinase. Gelatinases are ...
Apigenin-7-glucuronide
T5S1026CAS 29741-09-1
Apigenin-7-glucuronide possesses multiple activities, including antioxidant, anti-inflammatory, and aldose reductase inhibitory activities, it can inhibit MMP ac...
Epigallocatechin
T2987CAS 970-74-1
(-)-Epigallocatechin is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.
Astragaloside
T4082CAS T4082
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteas...
Norepinephrine
T7044CAS 51-41-2
Norepinephrine can stimulate apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. It can up-regulate the expression of vascula...
JNJ0966
T4783CAS 315705-75-0
JNJ0966 is a highly selective MMP-9 zymogen inhibitor (IC50: 440 nM).
Luteolin-7-glucuronide
T3850CAS 29741-10-4
Luteolin-7-Glucuronide possesses antioxidant activities.
Salvianolic acid A
T6S0444CAS 96574-01-5
Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.
T-26c
T5361CAS 869296-13-9
T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor (IC50: 6.75 pM).
T-5224
T5416CAS 530141-72-1
T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription ...
ALOIN
T5680CAS 8015-61-0
ALOIN Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells.
Stigmasterol
T2967CAS 83-48-7
Stigmasterol is found in the fats and oils of soybean, calabar bean and rape seed, as well as several other vegetables, legumes, nuts, seeds, and unpasteurized m...
1, 10-Phenanthroline monohydrate
T7449CAS 5144-89-8
1,10-Phenanthroline monohydrate is an inhibitor of metallopeptidases, inhibits zinc-dependent hydrolysis of Fa-Gly-Leu-NH2 by B. subtilis neutral protease and B....
L-​Alaninamide, N-​[2-​[2-​(hydroxyamino)​-​2-​oxoethyl]​-​4-​methyl-​1-​oxopentyl]​-​3-​methyl-​L-​valyl-​N-​(2-​aminoethyl)​-
TQ0129CAS 187034-31-7
TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM).
GI 254023X
T7522CAS 260264-93-5
GI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM) with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). GI254023X can r...
Doxycycline monohydrate
T8259CAS 17086-28-1
Doxycycline monohydrate is an inhibitor of metalloproteinase (MMP)
Histatin 5 (TFA)(115966-68-2,free)
TP1446CAS TP1446
Histatin 5 TFA inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively.
MMP-9-IN-1
T8310CAS 502887-71-0
MMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9).
Ginsenoside F4
TN1093CAS 181225-33-2
Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the i...
alpha-Solanine
TN1376CAS 20562-02-1
Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut.
Epigallocatechin
T2987CAS 970-74-1
(-)-Epigallocatechin is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.
Ethyl gallate
T3729CAS 831-61-8
Ethyl gallate obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependen...
Epitheaflagallin 3-O-gallate
TN1615CAS 102067-92-5
Epitheaflagallin 3-O-gallate is a promising functional food material with potential antiobesity and antiperiodontal disease activities, it suppresses tumor growt...
Picroside I
T2787CAS 27409-30-9
Picroside I, a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B. It has antioxidant, and anti-inflammatory activities, it may...
Ginsenoside Rh2
T3813CAS 112246-15-8
Ginsenoside Rh2 is a minor stereoisomer of ginsenoside Rh2, possesses matrix metalloproteinase inhibitory.
Batimastat
T6011CAS 130370-60-4
Batimastat (BB-94) is an effective, broad-spectrum matrix metalloprotease (MMP) inhibitor. Batimastat induces extracellular matrix degradation and inhibits angio...
Ilomastat
T2743CAS 142880-36-2
Ilomastat (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.
Ginkgolide C
T2750CAS 15291-76-6
Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.
Marimastat
T6885CAS 154039-60-8
Marimastat (BB-2516) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor. MMP-9 (IC50=3 nM), MMP-1 (IC50=5 nM), MMP-2 (IC50=6 nM), MMP-14 (IC50=9 ...
CGS 27023A
T3472CAS 161314-82-5
CGS 27023A is a non-peptidic, potent, and orally active stromelysin inhibitor.
Calycosin-7-O-beta-D-glucoside
T3388CAS 20633-67-4
Calycosin 7-O-β-D-glucopyranoside possesses a protective effect on rat hepatocytes, an inhibitory effect on COX-2 activity. Calycosin 7-O-β-D-glucoside has ant...
Morroniside
T3414CAS 25406-64-8
Morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice. It exhibits protective effects against diabetic renal ...
Glucosamine sulfate
T2792CAS 29031-19-4
Extracted from synthetic product;Store the product in sealed, cool and dry condition
Arctigenin
T2957CAS 7770-78-7
(-)-Arctigenin is found in burdock. (-)-Arctigenin is isolated from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD). Ar...
SB-3CT
T2009CAS 292605-14-2
SB-3CT is a potent and specific gelatinase inhibitor for MMP-2(Ki=13.9 nM) and MMP-9(Ki=600 nM).
Glucosamine
T0429CAS 3416-24-8
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
Fenofibric acid
T1402CAS 42017-89-0
Fenofibric Acid is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
Nobiletin
T2834CAS 478-01-3
Nobiletin is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (...
Abietic Acid
T3090CAS 514-10-3
Abietic Acid is the primary component of resin acid isolated from rosin.
Muscone
T2893CAS 541-91-3
Muscone is an organic compound that is the primary contributor to the odor of musk.
Acetohydroxamic acid
T1592CAS 546-88-3
Acetohydroxamic acid is an antagonist of the bacterial enzyme urease.
NSC 405020
T1891CAS 7497-07-6
NSC 405020 is a noncatalytic inhibitor of MT1-MMP.
Dehydroeffusol
TN1560CAS 137319-34-7
Dehydroeffusol possesses anti-cancer, anxiolytic and sedative properties, it may antagonize the spasmogenic activity of various agents, and therefore, could be a...
Gossypetin
TN1711CAS 489-35-0
Gossypetin has anti-mutagenic, anti-atherosclerotic, antioxidant, as well as cytoprotective and antimicrobial effects, it inhibits bone resorption through down-r...
S-methyl-KE-298
T4282CAS 143584-75-2
S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from...
Cedrelone
TN3616CAS 1254-85-9
Cedrelone exhibits antifeedant activity, it has insecticidal activity, it inhibits arval growth of P. saucia, and the molting of the milkweed bug, Oncopeltus fas...
S 3304
T16966CAS 203640-27-1
S 3304 is a novel matrix metalloproteinases inhibitor which is specific for MMP-2 and MMP-9.
Tanomastat
T16986CAS 179545-77-8
Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 30...
UK 356618
T17201CAS 230961-08-7
UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).
Hinokiflavone
T4S0181CAS 19202-36-9
Hinokiflavone is a novel modulator of pre-mRNA splicing activity in vitro and in cellulo. Hinokiflavone blocks splicing of pre-mRNA substrates by inhibiting spl...
2,3-Dihydrohinokiflavone
TN2697CAS 34292-87-0
2,3-Dihydrohinokiflavone is a suppressor of matrix metalloproteinases (MMPs) gene expression. It (IC50 =1.6uM) shows strong activity against Leishmania.
2-Methoxystypandrone
TN2775CAS 85122-21-0
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infla...
4',6,7-Trimethoxyisoflavone
TN3016CAS 798-61-8
4',6,7-Trimethoxyisoflavone promotes wound healing through NOX2 induction, which leads to collective migration and MMP activation.
Capillarisin
TN3587CAS 56365-38-9
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Communic acid
TN3691CAS 2761-77-5
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic...
MRS1177
T16137CAS 183721-13-3
MRS1177 is an effective and selective antagonist of the human Adenosine A3 receptor (hA3AR) (Ki: 0.3 nM).
Excisanin A
TN4046CAS 78536-37-5
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
Isoangustone A
TN4263CAS 129280-34-8
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
Kobophenol A
TN4394CAS 124027-58-3
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
Leucodin
TN4429CAS 17946-87-1
Leucodin shows high anti-hypercholesterolemic potential. Leucodin may have anti-allergic activity, it shows a potent inhibitory activity upon the beta-hexosamini...
Licorisoflavan A
TN4437CAS 129314-37-0
Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating ...
Scutellarein-7-O-glucoside
TN4978CAS 26046-94-6
Scutellarein-7-O-glucoside inhibites MMP-2 activity.
Torilin
TN5153CAS 13018-10-5
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
Trichosanatine
TN5174CAS 169626-16-8
Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatin...
Prinomastat
T12539LCAS 192329-42-3
Prinomastat inhibits MMP-2, MMP-3 and MMP-9 (Kis: 0.05 nM, 0.3 nM and 0.26 nM, respectively). Prinomastat crosses the blood-brain barrier. It also has antitumor ...
XL-784
T13358CAS 1224964-36-6
XL-784 is a selective inhibitor of matrix metalloproteinases (MMP)(IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respecti...
Licoricidin
TN1867CAS 30508-27-1
Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells.
PNU-248686A
T12511CAS 341498-89-3
PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).
Lucidenic acid A
TN1879CAS 95311-94-7
Lucidenic acid-A and -F are modulators of JNK and p38, respectively, they enhance LPS-induced immune responses in monocytic THP-1 cells possibly via the modulati...
Lucidenic acid C
TN1881CAS 95311-96-9
Lucidenic acid C has anti-invasive effect, it shows significant inhibitory effects on PMA-induced MMP-9 activity and invasion of HepG(2 )cells.
Methyl rosmarinate
TN1928CAS 99353-00-1
Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase.Methyl rosmari...
Notoginsenoside T5
TN1998CAS 769932-34-5
Total panax notoginsenosides (TPNS) are the main active ingredients in San-Chi, the root of(Burk) F.H. Chen, which belongs to the Araliaceae family and has been ...
Pimaric acid
TN2075CAS 127-27-5
Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced huma...
Xanthyletin
TN2316CAS 553-19-5
Xanthyletin has anti-inflammatory, anti-tumor and anti-bacterial activities, it also inhibits symbiotic fungus cultivated by leaf-cutting ants.
MMP3 inhibitor 1
T12082CAS 312930-75-9
MMP3 inhibitor 1 is a potent and highly selective inhibitor of MMP-3 (IC50 of 1 nM).
PF-00356231 hydrochloride
T12414CAS 820223-77-6
PF-00356231 hydrochloride is an inhibitor of matrix metalloproteinase MMP-12 with IC50 of 1.4 μM.
Prinomastat hydrochloride
T12539CAS 1435779-45-5
Prinomastat hydrochloride is a orally active inhibitor of metalloproteinase (MMP)(MMP-1, MMP-3 and MMP-9 with IC50s of 79, 6.3 and 5.0 nM , respectively),with An...
Incyclinide
T15574CAS 15866-90-7
Incyclinide is a matrix metalloproteinase (MMP) inhibitor. Thereby causing extracellular matrix degradation, tumor growth and invasion, and inhibiting angiogenes...
Apratastat
T14312CAS 287405-51-0
Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) a...
ARP-100
T14322CAS 704888-90-4
ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-...
CL-82198
T14978CAS 307002-71-7
CL-82198 is a selective inhibitor of MMP-13 and it is a pharmacologic treatment for preventing osteoarthritis (OA) progression. CL-82198 binds to the entire S1...
DB04760
T15055CAS 544678-85-5
DB04760 is a highly selective, non-zinc-chelating inhibitor of MMP-13 (IC50: 8 nM). DB04760 obviously decreases paclitaxel neurotoxicity and has anticancer activ...
Ro 31-9790
T12762CAS 145337-55-9
Ro 31-9790 is a synthetic inhibitor of metalloproteinase (MMP).
Batimastat sodium salt
T10461CAS 130464-84-5
Batimastat (BB-94) sodium salt is a broad-spectrum MMP inhibitor (IC50s: 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7, and MMP-3).
BR351
T10597CAS 960113-85-3
BR351 is a brain penetrant MMP inhibitor (IC50s: 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13).
UK-370106
T13249CAS 230961-21-4
UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-fibronecti...
Doxycycline hydrochloride
T1140CAS 10592-13-9
Doxycycline hydrochloride is a synthetic tetracycline derivative with similar antimicrobial activity.