HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product name	CAS No.	Purity
T11189	Emtricitabine S-oxide	152128-77-3	98%
T11189	Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection.Emtricitabine S-oxide (Emtricitabine sulfoxide) is a...
TN4675	Nortrachelogenin	34444-37-6	98%
TN4675	Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
TN3444	Aristolactam BII	53948-09-7	98%
TN3444	Aristolactam BII exhibits antimicrobial and antiinflammatory activity, it shows significant activity towards DPPH radical scavenging and potent inhibitory effect...
T13796	Nigranoic acid	39111-07-4	98%
T13796	Nigranoic acid is a natural product,and inhibits HIV-1 reverse transcriptase.
TN4934	Salaspermic acid	71247-78-4	98%
TN4934	Salaspermic acid is an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells.
T12420L	Pentosan Polysulfate Sodium (W/W 43%)	140207-93-8	98%
T12420L	Pentosan Polysulfate Sodium is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitia...
TMA1012	Ganoderiol F	114567-47-4	98%
TMA1012	Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency viru...
T10714	CCR5 antagonist 1	716354-86-8	98%
T10714	CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
TN4835	Przewalskin	119400-87-2	98%
TN4835	Przewalskin A and Przewalskin B showed modest anti-HIV-1 activity with EC50 = 41 and 30 microg/mL, respectively.
TN1852	Lancifodilactone F	850878-47-6	98%
TN1852	Lancifodilactone F exerts minimal cytotoxicity against C8166 cells (CC50 > 200 microg/mL) and shows anti-HIV activity with EC50 = 20.69 +/- 3.31 microg/mL and a ...
TN4264	Isoapetalic acid	34366-34-2	98%
TN4264	Isoapetalic acid and apetalic acid exhibit cytotoxic activities towards both cancer cell lines(human breast cancer (MCF-7) and human lung carcinoma (A-549) cell ...
TN1302	6,8-Diprenylorobol	66777-70-6	98%
TN1302	6,8-Diprenylorobol possesses weaker anti-H. pylori activity, it may be a useful chemopreventive agent for peptic ulcer or gastric cancer in H. pylori-infected in...
T16555	PNU-103017	166335-18-8	98%
T16555	PNU-103017 is an inhibitor of HIV protease.
TN5012	Shizukaol C	142279-41-2	98%
TN5012	1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. 2. Shizukaol C has significant cytotoxicit...
TN4911	Rhuscholide A	944804-58-4	98%
TN4911	Rhuscholide A possesses significant anti-HIV-1 activity with an EC50 value of 1.62 microM and a therapeutic index (TI) of 42.40.
T12420	Pentosan Polysulfate	37300-21-3	98%
T12420	Pentosan Polysulfate is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitial cysti...
TN1670	Ganodermanondiol	107900-76-5	98%
TN1670	Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
T16112	ML67-33	1443290-89-8	98%
T16112	ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activator ...
TN3777	Daurichromenic acid	82003-90-5	98%
TN3777	Daurichromenic acid is a terpenophenol with a potent anti-HIV activity.
T14559	BI 224436	1155419-89-8	98%
T14559	BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.