HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product name	CAS No.	Purity
T16555	PNU-103017	166335-18-8	98%
T16555	PNU-103017 is an inhibitor of HIV protease.
TN3567	Calanolide E	142566-61-8	98%
TN3567	Calanolide E2 has anti-HIV activity.
T60742	HIV-1 integrase inhibitor 8	1568-80-5	98%
T60742	HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor.
TN2284	Triptonine B	168009-85-6	98%
TN2284	Triptonine B demonstrates potent anti-HIV activity with an EC(50) value of <0.10 microg/mL and an in vitro therapeutic index value of >1000.
T0742	Papaverine hydrochloride	61-25-6	98%
T0742	Papaverine hydrochloride can used in an effective manner in the management of renal colic pain in patients unresponsive to commonly used conventional agents. Pap...
T6589	MK-2048	869901-69-9	98%
T6589	MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.
TN5011	Shizukaol B	142279-40-1	98%
TN5011	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
T12420L	Pentosan Polysulfate Sodium (W/W 43%)	140207-93-8	98%
T12420L	Pentosan Polysulfate Sodium is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitia...
T16112	ML67-33	1443290-89-8	98%
T16112	ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activator ...
T6418	BMS-378806	357263-13-9	98%
T6418	BMS-378806 selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.
T10928	Cytochalasin A	14110-64-6	98%
T10928	Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), ...
TN3152	6-Acetonyldihydrochelerythrine	22864-92-2	98%
TN3152	6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
TN1708	Gomisin M2	82425-45-4	98%
TN1708	Gomisin M2 is an anti-HIV agent.
T10658	CA inhibitor 1	2189684-45-3	98%
T10658	CA inhibitor 1 (GS-6207 analog) is a potent inhibitor of the HIV capsid.
TN2186	Schisantherin D	64917-82-4	98%
TN2186	Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
T16829	(S)-BI-1001	957889-73-5	98%
T16829	(S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).
T5S0983	Absinthin	1362-42-1	98%
T5S0983	1. Absinthiin is a weak HIV-1 protease inhibitor.
TN1866	Licoricesaponin G2	118441-84-2	98%
TN1866	Licoricesaponin G2 has the anti-inflammatory effects as NF-κB inhibitors, it has anti-HIV activity via significantly interacted with R15K.
TN4585	Moronic acid	6713-27-5	98%
TN4585	Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. It also shows significant anti-HIV activity (EC(50) 186)...
TN2839	2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid	176983-21-4	98%
TN2839	2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen (...