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    TargetMol | Inhibitors_Agonists
Tween 80
T139479005-65-6
Tween 80 is a nonionic surfactant and emulsifier that reduces bacterial adherence and inhibits biofilm formation. Tween 80 is widely used as a co-solvent in pharmacology experiments because of its ability to enhance the solubility of compounds in the aqueous phase.
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TargetMol | Inhibitor Hot
TAK-137
TAK137
T708801358749-55-9In house
TAK-137 is an AMPA receptor enhancer with antidepressant effects. TAK-137 has the ability to improve cognition and could be used to study schizophrenia.
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6-8 weeks
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TargetMol | Inhibitor Hot
Dazostinag disodium
T724822553413-93-5In house
Dazostinag disodium (TAK-676) is a synthetic novel interferon gene (STING) agonist that triggers STING signaling pathway activation and type I interferon activation. Dazostinag disodium (TAK-676) is also a highly effective immune system modulator with complete resolution and lasting memory of T cell immunity and the ability to promote lasting interferon-dependent anti-tumor immune responses.
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10-14 weeks
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TargetMol | Inhibitor Hot
Pembrolizumab
Pembrolizumab(anti-PD-1)
T99081374853-91-4
Pembrolizumab (MK-3475) is a humanized monoclonal antibody inhibiting the PD-1 receptor and the first in the class of agents called the HER2 dimerization inhibitors that impairs the ability of HER2 to bind to other members of the HER family.
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TargetMol | Inhibitor Hot
Thapsigargin
TQ030267526-95-8
Thapsigargin is a natural product, an inhibitor of sarcoplasmic endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking the ability of cells to pump calcium into the sarcoplasmic and endoplasmic reticulum.
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TargetMol | Inhibitor Hot
Cletoquine hydrochloride
Cletoquine hydrochloride( 4298-15-1 Free base)
T10835L1159358-29-9In house
Cletoquine hydrochloride is a major active metabolite of Hydroxychloroquine. Cletoquine hydrochloride is a Chloroquine derivative and exhibits the ability to against the chikungunya virus (CHIKV). Cletoquine hydrochloride exhibits antimalarial effects.
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PACMA 31
T412771401089-31-3In house
PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.
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Praeruptorin B
Praeruptorin D
T4S142173069-28-0In house
Praeruptorin B (Praeruptorin D), a compound found in the roots of Peuced, is an inhibitor of sterol regulatory element-binding proteins (SREBPs) that attenuates the metastatic ability of human renal cancer cells by targeting CTSC and CTSV expression, and can be used in the study of osteoporosis.
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7-10 days
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MC-1-F2
T696592376894-10-7In house
MC-1-F2 is a direct FOXC2 inhibitor with anticancer activity, inhibits cancer stem cell (CSC) characteristics, and reduces the invasive ability of castration-resistant prostate cancer (CRPC) cell lines. MC-1-F2 can be used to study prostate cancer.
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4-6 weeks
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KKII5
T772886381-55-1In house
KKII5 is a potent inhibitor of the lipoxygenase LOX-1 with an IC50 of 19 μM.KKII5 inhibits lipid peroxidation and enhances the ability of the active centers of some compounds to receive electrons.
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TV 3279
T77332209394-29-6In house
TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apoptotic enzyme glyceraldehyde phosphate dehydrogenase in PC-12 and neuroblastoma cells.
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JI130
T95882234271-86-2In house
JI130 is able to impair the ability of Hes1 to repress transcription. JI130 treatment significantly reduced tumor volume in a murine pancreatic tumor xenograft model.
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PD-1/PD-L1-IN-9
T96512628506-54-5In house
PD-1 PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1 PD-L1 interaction. It enhances the immune cells' ability to kill tumor cells and demonstrates significant antitumor activity in vivo in a CT26 mouse model.
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Diammonium Glycyrrhizinate
Diammonium Glycyrrhizin
T052279165-06-3
Diammonium Glycyrrhizinate (Glycyrrhizin) , an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inhibits 11-β-hydroxysteroid dehydrogenase and other enzymes involved in the metabolism of corticosteroids. Therefore, glycyrrhizic acid, the main and sweet component of licorice, has been studied for its ability to cause hypermineralocorticoidism with potassium loss and sodium retention, edema, increased blood pressure, as well as inhibited the renin-angiotensin-aldosterone system.
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Azelaic acid
Nonanedioic acid, Finacea, Azelex, Anchoic acid
T0926123-99-9
Azelaic acid (Anchoic acid) is a component of hair and skin conditioners and is produced by the ozonolysis of oleic acid. Azelaic acid has bacteriostatic activity against Propionibacterium acnes and Staphylococcus epidermidis by inhibiting protoprotein synthesis in microbial cells. Azelaic acid also has the ability to inhibit pigmentation due to its free radical scavenging action.
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Chitosan oligosaccharide
COS
T10789148411-57-8
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine that activates AMPK while inhibiting inflammatory signaling pathways, including NF-κB and MAPK.
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DPPH
2,2-Diphenyl-1-picrylhydrazyl
T110931898-66-4
DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a cell-permeable, stable free radical commonly used to evaluate the free radical scavenging ability, hydrogen donation capacity of compounds, and to measure the antioxidant activity of tissue extracts.
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3-Chloropropiophenone
T1342936-59-4
3-Chloropropiophenone (CPP) is a synthetic compound that is used in the synthesis of organic reagents, pharmaceuticals, and other products. It has the ability to inhibit certain enzymes (e.g. cytochrome P450) and inhibit the growth of certain tumor cells.
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Dicaprylyl carbonate
Dimethyl carbonate
T192781680-31-5
Dicaprylyl carbonate (Dimethyl carbonate) is a solid fat derived from plants and a dry emollient. Dimethyl carbonate has good skin compatibility and comprehensive properties, such as a sunscreen filter with the ability to dissolve and disperse.
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Malic acid disodium hydrate
Hydroxybutanedioic acid disodium hydrate, E 296 disodium hydrate, Disodium DL-malate hydrate
T20029663474-37-3
Malic acid disodium hydrate is commonly used as a food additive, buffering agent and nutritional supplement with the ability to enhance food flavor, improve texture and regulate acidity. Hydroxybutanedioic acid disodium hydrate can also be used as a dietary supplement to help increase energy production, reduce fatigue and enhance athletic performance.
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Limonin
Obaculactone, Dictamnolactone, Limonoic acid 3,19:16,17 dilactone, Citrolimonin
T27281180-71-8
Limonin (Citrolimonin) is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.
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(-)-Epigallocatechin
l-Epigallocatechin, Epigallocatechin, EGC
T2987970-74-1
(-)-Epigallocatechin, the predominant flavonoid in green tea, possesses the unique ability to attach to unfolded native polypeptides, thereby inhibiting their transformation into amyloid fibrils.
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Laurocapram
Tranzone, N-Lauryl caprolactam, N-Dodecylcaprolactam, N-0252, Azone
T2A250959227-89-3
Laurocapram (N-Lauryl caprolactam) is a percutaneous enhancer. Upon application to the skin, laurocapram interacts with lipids in the stratum corneum and may enhance the ability of the skin to absorb a hydrophilic chemical.
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γ-Oryzanol
Oliver, Gammariza, Gamma-Oryzanol
T360611042-64-1
γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the destruction of free radicals in the skin. It has recently been researched for its ability to slow the progress of melanin pigmentation by intercepting the ultraviolet rays at the skin's surface and hindering their transmission.
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