Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPRelated productsBioactivityChemical infoStorage&SolubilityCalculator

AMG410 diTFA

Copy Product Info
🥰Excellent

Synonyms:

Catalog No. T217880 Copy Product Info
🥰Excellent
AMG410 diTFA is a non-covalent selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D. It exhibits over 100-fold selectivity for HRAS and NRAS. AMG410 diTFA is a dual inhibitor of both GTP (active) and GDP (inactive) states, with Kd values of 1 nM for the GDP state and 22 nM for the GTP state. The compound effectively blocks KRAS signaling without dependence on the cycling state and inhibits the proliferation of tumor cells with wild-type KRAS amplification. It is applicable for research in colorectal, pancreatic, and lung cancers.

AMG410 diTFA

Cas No. 3040175-18-3
Other Forms of AMG410 diTFA:
AMG410T2040833040175-17-2
In Stock
View details
Pack SizePriceUSA StockGlobal StockQuantity
10 mgInquiryInquiryInquiry
50 mgInquiryInquiryInquiry
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Quotation
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
Questions
TargetMol
View More

Resource Download

Product Introduction

Bioactivity
Description
AMG410 diTFA is a non-covalent selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D. It exhibits over 100-fold selectivity for HRAS and NRAS. AMG410 diTFA is a dual inhibitor of both GTP (active) and GDP (inactive) states, with Kd values of 1 nM for the GDP state and 22 nM for the GTP state. The compound effectively blocks KRAS signaling without dependence on the cycling state and inhibits the proliferation of tumor cells with wild-type KRAS amplification. It is applicable for research in colorectal, pancreatic, and lung cancers.
Targets & IC50
KRas (G12D):1-4 nM
In vitro
AMG410 diTFA exhibits potent antiproliferative activity in KRAS mutant cells (median IC 50 = 12 nM). Importantly, AMG410 diTFA does not show antiproliferative activity in non-KRAS transformed cells (median IC 50 > 5 µM).
In vivo
AMG410 diTFA demonstrates significant in vivo efficacy by consistently reducing phosphorylated ERK levels throughout the dosing period. It causes tumor stasis or regression in various cell-derived xenograft (CDX) and patient-derived xenograft (PDX) models originating from colorectal, pancreatic, and lung cancer cell lines harboring multiple KRAS mutant alleles, such as G12D, G12V, G12C, and G13D.
Chemical Properties
Molecular Weight884.13
FormulaC35H34ClF8N7O9
Cas No.3040175-18-3
SmilesOC(C(F)(F)F)=O.FC1=C2C3=CN=C1C4=C(CCCOC(O[C@@]5([H])CN(CCOC5)C3=NC(OC[C@@]67N(CCC7)C[C@@H](C6)F)=N2)=O)C(Cl)=CC8=C4C=NN8.OC(C(F)(F)F)=O
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 µL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
µL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: AMG410 diTFA in vivo | AMG410 diTFA in vitro | AMG410 diTFA formula | AMG410 diTFA molecular weight
TargetMol | Logo

Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.