rho

Expression system: E. coli
Length: 1-419, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-348, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-36, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-36, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-36, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-36, Partial
Activity: Not Tested

Expression system: E. coli
Length: 2-204, Full Length of Mature Protein
Activity: Not Tested

Transforming protein RhoA, also known as Rho cDNA clone 12, Ras homolog gene family member A, RHOA and ARH12, is a cell membrane and cytoplasm protein that belongs to the small GTPase superfamily and Rho family. The Rho family of small GTPases plays a key role in the dynamic regulation of the actin cytoskeleton that underlies various important cellular functions such as shape changes, migration, and polarity. RHOA ARH12 is part of a larger family of related proteins known as the Ras superfamily; proteins involved in the regulation and timing of cell division. RHOA ARH12 is a small GTPase protein known to regulate the actin cytoskeleton in the formation of stress fibers. It acts upon two known effector proteins: ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 ( diaphanous homolog 1 (Drosophila) ). RHOA ARH12 regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. RHOA ARH12 serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. RHOA ARH12 may be an activator of PLCE1. It is activated by ARHGEF2, which promotes the exchange of GDP for GTP.

Expression system: E. coli
Length: 1-207, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 1-188, Full Length
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 1-136, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 24-146, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 149-166, Partial
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 1-234, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-384, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-136, Full Length
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 24-146, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 1-325, Full Length
Activity: Not Tested

PAK3 is a member of PAK proteins, a family of serine threonine p21-activating kinases, serve as effectors of small Rho GTPases Cdc42 and RAC and have been implicated in a wide range of biological activities. There are six mammalian PAKs which can be divided into two groups: group I PAKs (PAK1-3) and group II PAKs (PAK4-6). Although the two PAK groups are architecturally similar there are differences in their mode of regulation suggesting their cellular functions are likely to be different. Group I p21-activated kinases (PAK1 2 3) is demonstrated as ERK3 ERK4 activation loop kinases. It has been shown that group I PAKs phosphorylate ERK3 and ERK4 on Ser-189 and Ser-186, respectively, both in vitro and in vivo, and that expression of activated Rac1 augments this response. Besides regulation enzymatic activation of ERK3 ERK4, PAKs can also play roles in downstream activation of MAP kinase-activated protein kinase 5 (MK5) in vivo. Thus, the group I PAKs act as upstream activators of ERK3 and ERK4 and unravel a novel PAK-ERK3 ERK4-MK5 signaling pathway. In clinical, PAK has been proposed as a potential therapeutic target in schwannomas.

Expression system: E. coli
Length: 286-462, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-237, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 26-747, Partial
Activity: Not Tested

PRC1 (protein regulator of cytokinesis 1) is a key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. It is essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. PRC1 is required for KIF14 localization to the central spindle and midbody. It is also required to recruit PLK1 to the spindle. PRC1 stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. It is a homodimer and interacts with the C-terminal Rho-GAP domain and the basic region of RACGAP1. The interaction with RACGAP1 inhibits its GAP activity towards CDC42 in vitro, which may be required for maintaining normal spindle morphology. PRC1 also interacts separately via its N-terminal region with the C-terminus of CENPE, KIF4A and KIF23 during late mitosis. It interacts with KIF14, IF20A and PLK1.

Expression system: E. coli
Length: 1-163, Full Length
Activity: Not Tested