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Results for "

aggregation

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    656
    TargetMol | Inhibitors_Agonists
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    2
    TargetMol | Compound_Libraries
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    45
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    TargetMol | Inhibitory_Antibodies
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    138
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    TargetMol | Inhibitors_Agonists
CYM50260
T150311355026-60-6In house
CYM50260 is a potent and highly selective agonist of the sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM), exhibiting no activity against S1P1-R, S1P2-R, S1P3-R, and S1P5-R.
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6-8 weeks
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Adenosine
D-Adenosine, Adenine riboside
T085358-61-7
Adenosine (D-Adenosine) is a natural product, a ribonucleoside consisting of adenine bound to ribose. Adenosine has vasodilatory, antiarrhythmic and analgesic effects.
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Trimethoprim
NSC-106568, NIH 204, BW 56-72
T1153738-70-5
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.
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Ozagrel
OKY-046, Domenan
T623682571-53-7
Ozagrel (Domenan) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.
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Prostaglandin E1
PGE1, Alprostadil
T1626745-65-3
Prostaglandin E1 (Alprostadil) is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Prostaglandin E1 is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP.
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NQTrp
T22118185351-19-3
NQTrp is an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects.
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7-10 days
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Skimmianine
Skimmianin, Skimmiamine, Chloroxylonine, beta-Fagarine
T2S210983-95-4
1. Skimmianine (Chloroxylonine) is a spasmolytic agent. 2. Skimmianine (Chloroxylonine) shows pharmacol. props. similar to 2-(Methylamino)-1-phenyl-1-propanol BCJ45-G.
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Neobavaisoflavone
T6S013941060-15-5
1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can significantly inhibit the production
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Sulfuretin
TN2244120-05-8
Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 through the Nrf2 ARE and JNK ERK signa
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Tau-aggregation and neuroinflammation-IN-1
T628992175953-98-5
Tau-aggregation and neuroinflammation-IN-1 is a potent inhibitor of tau protein aggregates, showing significant inhibitory activity against AcPHF6 and full-length tau protein aggregates. It has anti-inflammatory activity, reduces NO release, exhibits low cytotoxicity against LSP-stimulated BV2 cells, and reverses okadaic acid-induced memory impairment in rats.
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6-8 weeks
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TargetMol | Inhibitor Sale
aggregation-IN-1
T204182352525-91-8
aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.
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10-14 weeks
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α-syn aggregation inhibitor-1
T204680
α-syn aggregation inhibitor-1 (Compound 2e) acts as an inhibitor of α-syn aggregation. It is capable of inhibiting the cell viability of SH-SY5Y.
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Aβ/tau aggregation-IN-1
T397812252162-81-3
Aβ tau aggregation-IN-1 is a potent inhibitor of Aβ 1-42 β-sheet formation and tau aggregation, exhibiting K D values of 160 μM and 337 μM with Aβ 1-42 and tau, respectively. Additionally, Aβ tau aggregation-IN-1 efficiently penetrates the blood-brain barrier.
    7-10 days
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    Tau-aggregation-IN-1
    T634811619269-19-0
    Tau-aggregation-IN-1 is a dopamine D2 and D3 receptor agonist and an inhibitor of tau441 protein aggregation (IC50: 21 μM).
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    6-8 weeks
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    Aβ1–42 aggregation inhibitor 1
    T642382439107-75-0
    Aβ1-42 aggregation inhibitor 1 effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) with IC50 values of 2.64 μM and 1.29 μM, respectively. At 25 μM, it also reduces self-mediated Aβ1-42 aggregation by 51.29%, showcasing its potential for Alzheimer's disease research [1].
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    4-6 weeks
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    tau/aβ40 aggregation-in-1
    T74811
    Tau Aβ40 aggregation-IN-1 (Compound 20) functions as an inhibitor for tau and Aβ 40 aggregation, exhibiting IC50 values of 1.8 μM and 1.3 μM, respectively [1].
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    Aβ/tau aggregation-IN-3
    T781731210750-32-5
    Aβ tau aggregation-IN-3 is a potent inhibitor of amyloid protein aggregation, with an IC50 value of 0.85 µM in an Aβ-Thioflavin T (Aβ-ThT) functional aggregation assay, demonstrating anti-amyloid activity [1].
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    8-10 weeks
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    Tau protein aggregation-IN-1
    T79038916179-45-8
    Tau Protein Aggregation-IN-1 (Compound 0c) serves as an inhibitor of Tau protein aggregation, applicable in research related to protein folding disorders including Alzheimer's disease, dementia, Parkinson's disease, Huntington's disease, and prion-based spongiform encephalopathies [1].
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    6-8 weeks
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    Tau-aggregation-IN-3
    T874943032869-59-0
    Tau-aggregation-IN-3 (compound 9), a Tau protein aggregation inhibitor (TAI), demonstrates effectiveness in cell-based aggregation inhibition experiments with an EC50 of 4.816 μM. It is applicable in Alzheimer's disease research [1].
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    10-14 weeks
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    48740 rp
    RP-55778, RP-48740, RP 55779, RP 55778
    T1015993363-11-2In house
    48740 RP (RP 55779) is an antagonist of platelet-activating factor.
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    6-8 weeks
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    TargetMol | Inhibitor Hot
    Dehydrocorydaline
    Dehydrocorydalin, 13-Methylpalmatine
    T5S235830045-16-0
    1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins, thus resulting in MyoD activation and myoblast differentiation. 3. Dehydrocorydaline shows antiplatelet effects, it inhibits thrombin-induced platelet aggregation in a low dose ( IC50= 34.914 ug mL). 4. Dehydrocorydaline has anti-inflammatory and antinociceptive effects. 5. Dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax Bcl-2, activating caspases as well as cleaving PARP.
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    TargetMol | Inhibitor Hot
    Aglafoline
    Rocaglamide U, Aglafolin, (-)-Methyl rocaglate
    T10260143901-35-3In house
    Aglafoline inhibits in a concentration-dependent manner the aggregation and ATP release reaction induced in washed rabbit platelets by PAF (platelet-activating factor). The IC50 values of Aglafoline on PAF (3.6 nM)-induced platelet aggregation were about 50 μM.
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    3-6 months
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    Benzcyclane
    Benzcyclan, Bencyclane
    T105022179-37-5In house
    Benzcyclane (Benzcyclan) is an inhibitor of platelet aggregation and also a vasodilator that can be used in a variety of peripheral circulation disorders.
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    6-8 weeks
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    TargetMol | Inhibitor Sale
    LCB-2853
    T11825141335-10-6In house
    LCB-2853 is a potent thromboxane A2 prostaglandin H2 (TXA2 PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.
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    8-10 weeks
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