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Cat No. | Product Name | Synonyms | Targets |
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T39781 | Aβ/tau aggregation-IN-1 | ||
Aβ/tau aggregation-IN-1 is a potent inhibitor of Aβ 1-42 β-sheet formation and tau aggregation. It exhibits K D values of 160 μM and 337 μM with Aβ 1-42 and tau, respectively. Additionally, Aβ/tau aggregation-IN-1 can pe... | |||
T62899 | Tau-aggregation and neuroinflammation-IN-1 | Microtubule Associated , NO Synthase | |
Tau-aggregation and neuroinflammation-IN-1 is a potent inhibitor of tau protein aggregates, showing significant inhibitory activity against AcPHF6 and full-length tau protein aggregates. Tau-aggregation and neuroinflamma... | |||
T63481 | Tau-aggregation-IN-1 | ||
Tau-aggregation-IN-1 is a dopamine D2 and D3 receptor agonist and an inhibitor of tau441 protein aggregation (IC50: 21 μM). | |||
T78173 | Aβ/tau aggregation-IN-3 | ||
Aβ/tau aggregation-IN-3 is a potent inhibitor of amyloid protein aggregation, exhibiting an IC50 value of 0.85 µM in an Aβ-Thioflavin T (Aβ-ThT) functional aggregation assay. This compound demonstrates anti-amyloid activ... | |||
T74811 | Tau/Aβ40 aggregation-IN-1 | ||
Tau/Aβ40 aggregation-IN-1 (Compound 20) functions as an inhibitor for tau and Aβ 40 aggregation, exhibiting IC50 values of 1.8 μM and 1.3 μM, respectively [1]. | |||
T64238 | Aβ1–42 aggregation inhibitor 1 | ||
Aβ1-42 aggregation inhibitor 1 effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), demonstrating IC50 values of 2.64 μM and 1.29 μM, respectively. At a concentration of 25 μM, it also redu... | |||
T79038 | Tau protein aggregation-IN-1 | ||
Tau Protein Aggregation-IN-1 (Compound 0c) serves as an inhibitor of Tau protein aggregation, applicable in research related to protein folding disorders including Alzheimer's disease, dementia, Parkinson's disease, Hunt... | |||
T5036 | Cangrelor tetrasodium | GPR , P2Y Receptor | |
Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects. | |||
T14965 | Ciliobrevin D | ATPase , Hedgehog/Smoothened | |
Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibits dynein-dependent microtubule gliding and ATPase activity ... | |||
T3536 | AZD1283 | P2Y Receptor | |
AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithromboti... | |||
T5460 | Mofezolac | COX | |
Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000 | |||
T6594 | MNS | Syk , Src , p97 | |
MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. | |||
T2065 | Bioymifi | DR5 Activator | Apoptosis , TNF |
Bioymifi (DR5 Activator) is a novel and potent small-molecule activator of the TRAIL receptor DR5 in human cancer cells. | |||
T2629 | UNC2881 | TAM Receptor | |
UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively. | |||
T15031 | CYM50260 | Others , LPL Receptor | |
CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R. | |||
T6236 | Ozagrel | OKY-046,Domenan | Thrombin , Prostaglandin Receptor |
Ozagrel (Domenan) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral isch... | |||
T15047 | Dacisteine | N,S-Diacetyl-L-cysteine | Others |
Dacisteine (N,S-Diacetyl-L-cysteine) is an inhibitor of New Delhi metallo-beta-lactamase-1 (NDM-1, IC50 = 1000 μM). | |||
T8719 | SC99 | Apoptosis , JAK , STAT | |
SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activiti... | |||
T13554 | Arimoclomol maleate | BRX-220 | HSP |
Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer. | |||
T1893 | Parmodulin 2 | ML 161 | Protease-activated Receptor |
Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thromb... | |||
T4190 | Ticlopidine | PCR 5332,Ticlid | ATPase , Adiponectin receptor |
Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. | |||
T6625 | Ozagrel hydrochloride | Ozagrel HCl,OKY-046 HCl | Thrombin , Prostaglandin Receptor |
Ozagrel hydrochloride (OKY-046 HCl) is a selective thromboxane A(2) synthetase inhibitor used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia. | |||
T0230 | Prasugrel | LY640315,CS-747,PCR 4099 | P2Y Receptor |
Prasugrel (CS-747) is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANGINA and MYOCARDIAL INFARCTION, as well as in those... | |||
T16164 | MY-5445 | N-(3-chlorophenyl)-4-phenylphthalazin-1-amine | PDE |
MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM). | |||
T13553 | Arimoclomol | BRX-220 free base | HSP |
Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (ALS). | |||
T2569 | Chlorotrianisene | tris(p-methoxyphenyl)chloroethylene,CTA,tri-p-anisylchloroethylene,TACE | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , COX |
Chlorotrianisene (tri-p-anisylchloroethylene) is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), with predominantly estrogenic but... | |||
T22118 | NQTrp | Microtubule Associated | |
NQTrp is an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. | |||
T0182L | Clopidogrel hydrogen sulfate | (S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel | P450 , P2Y Receptor |
Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets and platelet adhesion and aggregation. | |||
T6952 | Prasugrel Hydrochloride | LY 640315,PCR 4099 (hydrochloride),Effient Hydrochloride,LY 640315 Hydrochloride,Prasugrel HCl | P2Y Receptor |
Prasugrel Hydrochloride (LY 640315 Hydrochloride) is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome. | |||
T7003 | Leucomethylene blue mesylate | TRx0237 mesylate,TRx0237 (LMTX) mesylate,Methylene blue leuco base mesylate salt,Leucomethylene Blue Dimesylate | Beta Amyloid , Microtubule Associated |
Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. | |||
T15757 | Limaprost | 17α,20-dimethyl-δ2-PGE1,OP1206,ONO1206 | PGE Synthase |
Limaprost (17α,20-dimethyl-δ2-PGE1) is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency.It is a potent and orally active vasodilator. Limaprost increases blood... | |||
T3757 | NQ301 | Thrombin , Platelet aggregation | |
NQ301, an antithrombotic agent, inhibits collagen-challenged rabbit platelet aggregation (IC50: 10 mg/mL). | |||
T12596 | (4E)-SUN9221 | 5-HT Receptor , Adrenergic Receptor | |
(4E)-SUN9221 is a potent dual α1-adrenergic receptor and 5-HT2 receptor antagonist that shows antihypertensive and antiplatelet aggregation activity in hypertensive rats. | |||
T1618 | Dipyridamole | Persantin,Dypyridamole,Dipyridamol,NSC-515776,Dipyudamine | PDE |
Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation. | |||
T35161 | Xemilofiban | SC-54684A,SC54684A,SC 54684A | Others |
Xemilofiban (SC 54684A) interrupts platelet aggregation, promotes thrombosis, and is used in the study of unstable angina. | |||
T19892 | BSBM7 | Beta Amyloid | |
BSBM7 is an inhibitor of Aβ aggregation and neuronal toxicity. | |||
T6182 | Tirofiban | L700462,Aggrastat,MK383 | Integrin |
Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM. | |||
T12857 | SC-52012 | Others | |
SC-52012 is a novel and potent fibrinogen receptor antagonist, an RGD mimetic, which inhibits platelet aggregation. | |||
T13368 | YLF-466D | C24 | AMPK |
YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation. | |||
T8575 | ENFENAMIC ACID | Platelet aggregation | |
Enfenamic acid is a platelet aggregation inhibitor and with antirheumatic. | |||
T22932L | LPYFD-NH2 acetate | LPYFD-NH2 acetate (700361-48-4 free base) | Beta Amyloid |
LPYFD-NH2 acetate shows some inhibitory effect on the aggregation of Abeta(1-42). | |||
T63208L | Aβ-IN-1 TFA | Aβ-IN-1 TFA(2766509-32-2 Free base) | |
Aβ-IN-1 TFA inhibits and reverses different types of protein aggregation. | |||
T4077 | PE859 | Beta Amyloid , Gamma-secretase , Microtubule Associated | |
PE859 is a potent inhibitor of both tau and Aβ aggregation. | |||
T0362 | Ticlopidine hydrochloride | Ticlodone,Ticlopidine HCl,Ticlodix | Adenosine Receptor |
Ticlopidine hydrochloride (Ticlodix) is an effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES. | |||
T3608 | Carbasalate calcium | Rheomin,Omegin,Alcacyl,Iromin,Solupsan,Carbasalate Calcium | Platelet aggregation |
Carbasalate calcium (Rheomin) is an analgesic, antipyretic, and anti-inflammatory drug, as well as a platelet aggregation inhibitor. | |||
T9887 | Ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate | Platelet aggregation | |
ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate is a platelet aggregation inhibitor. | |||
TQ0026 | MDR-1339 | DWK-1339 | Beta Amyloid , Gamma-secretase |
MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation. | |||
T25635 | Lateritin | Bassiatin | Acyltransferase |
Lateritin (Bassiatin) is An Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor and a platelet aggregation inhibitor from the mycelial cake of Gibberella lateritium. Bassiatin is the (3S,6R) isomer. | |||
T24542 | NP-313 | NP 313,NSC 4264,NSC-4264,NSC4264 | |
NP-313 (NSC-4264) is a potent antithrombotic agent that inhibits platelet aggregation and activation by inhibiting thromboxane A 2 synthesis and selectively inhibiting SOCC-mediated Ca2+ efflux. | |||
T0182 | Clopidogrel | (S)-Clopidogrel,SR-25990C | P2Y Receptor |
Clopidogrel (SR-25990C), a P2Y12 receptor antagonist, decreases platelet aggregation. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN6919 | Methyl tridecanoate | Beta Amyloid , AChE | |
Methyl tridecanoate is a natural product. | |||
T6S0139 | Neobavaisoflavone | Apoptosis , DNA/RNA Synthesis | |
1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si... | |||
T3781 | Jujuboside B | Others | |
Jujuboside B has potent inhibitory effects on collagen-, thrombin-, AA-, and ADP-induced aggregation, and also exhibits superior protection on the thromboembolic model. | |||
T3S1591 | Notoginsenoside Fc | Others , Autophagy | |
1. Notoginsenoside Fc has perfect anti-platelet aggregatory effect. | |||
T0853 | Adenosine | D-Adenosine,Adenine riboside | Apoptosis , Nucleoside Antimetabolite/Analog , Endogenous Metabolite , Autophagy |
Adenosine (D-Adenosine) is a ribonucleoside comprised of adenine bound to ribose, with vasodilatory, antiarrhythmic and analgesic activities. | |||
TN2244 | Sulfuretin | NF-κB , Autophagy | |
Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 thr... | |||
T2S2109 | Skimmianine | beta-Fagarine,Skimmianin,Chloroxylonine,Skimmiamine | Others |
1. Skimmianine (Chloroxylonine) is a spasmolytic agent. 2. Skimmianine (Chloroxylonine) shows pharmacol. props. similar to 2-(Methylamino)-1-phenyl-1-propanol BCJ45-G. | |||
T5548 | Verbenone | 2-Pinen-4-one,(-)-Verbenone | Others |
(-)-Verbenone ((-)-Verbenone) is an important component of the essential oil from rosemary. It is also an insect pheromone with a spicy odor and camphoraceous fragrance. | |||
T2230 | Paeoniflorin | Peoniflorin | HSP , COX |
Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall. | |||
T1626 | Prostaglandin E1 | PGE1,Alprostadil | Endogenous Metabolite , Prostaglandin Receptor |
Prostaglandin E1 (Alprostadil) is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Prostaglandin E1 is a potent vasodilator agent that increases peripheral blood flow, in... | |||
T1153 | Trimethoprim | NIH 204,BW 56-72,NSC-106568 | DHFR , DNA/RNA Synthesis , Antifolate , Antibacterial , Antibiotic |
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Tra... | |||
T3839 | Cycloolivil | Isoolivil | Free radical scavengers , Others , Platelet aggregation |
Cycloolivil (Isoolivil) is a natural polyphenolic compound with a significant radical scavenging activity present in olive trees. Cycloolivil has antioxidant activity, it may prevent thrombotic complications associated t... | |||
TN4222 | Homoeriodictyol 7-O-β-D-glucoside | Homoeriodictyol 7-O-glucoside | Others , Platelet aggregation |
Homoeriodictyol 7-O-β-D-glucoside (Homoeriodictyol 7-O-glucoside) is a natural product from Viscum coloratum(Kom.)Nakai. Homoeriodictyol 7-O-β-D-glucoside is an antagonist of platelet-activating factor (PAF). | |||
TN6924 | Anhydrosafflor yellow B | (2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,AHSYB | Others |
Anhydrosafflor yellow B ((2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,... | |||
T3817 | Darutigenol | Others | |
Darutigenol has obvious antithrombotic effect, its mechanism may be related to inhibition of platelet aggregation and adhesion. | |||
TN2343 | Pseudojervine | Jervin-3-glucoside,O-beta-D-Glucopyranosyljervine | Platelet aggregation |
Pseudojervine (O-beta-D-Glucopyranosyljervine) is derived from Veratrum nigrum L. Pseudojervine exhibits feeble inhibition activity against platelet aggregation. | |||
TQ0036 | Anemarrhenasaponin I | Others | |
Anemarrhenasaponin I shows the remarkable inhibiting effect on platelet aggregation. | |||
T12164 | N6-(4-Hydroxybenzyl)adenosine | Para-topolin riboside | P2Y Receptor |
N6-(4-Hydroxybenzyl)adenosine (Para-topolin riboside) is a platelet aggregation inhibitor. | |||
TN1626 | Eugenin | Others | |
Eugenin is a chromone isolated from Peucedanum japonicum.Eugenin potent antiplatelet aggregation activity | |||
TN1057 | Veratrosine | Veratramine 3-glycoside,Veratramine-beta-D-glucoside | Platelet aggregation |
Veratrosine (Veratramine-beta-D-glucoside) is an alkaloid isolated from the herbs of Veratrum nigrum. Veratrosine exhibits feeble inhibition activity against platelet aggregation. | |||
TN2086 | Piperlotine A | Antibacterial | |
Piperlotine A is an alkaloid that can be extracted from Piperonyssinus rolfsii and has antiplatelet aggregation activity.Piperlotine A showed inhibition of Mycobacterium tuberculosis in an in vitro assay with a MIC value... | |||
TN1643 | Ferulamide | 4-Hydroxy-3-methoxycinnamide | PAFR , AChR |
Ferulamide (4-Hydroxy-3-methoxycinnamide), a Ferulic acid derivative, shows potent inhibitory activity against arachidonic acid-induced platelet aggregation. | |||
T3734 | 3',4'-Dihydroxyacetophenone | Qingxintong,4-Acetylpyrocatechol | Tyrosinase , Platelet aggregation |
3',4'-Dihydroxyacetophenone (Qingxintong) is an active constituent of Chinese medicine. It is platelet aggregation Inhibitor and also has anti-arrhythmia activity. | |||
TN2027 | Oxysanguinarine | 8-Oxosanguinarine,Hydroxysanguinarine | Parasite |
Oxysanguinarine (Hydroxysanguinarine) possesses antiplatelet aggregation activity, it has potential inhibitory properties against the dengue virus. | |||
T11012 | Dextran | Dextran 40 | Platelet aggregation |
Dextran (Dextran 40) (Dextran 40) has an inhibitory effect on platelet aggregation and coagulation factors, and is used as an agent for increasing plasma volume. | |||
T2898 | Andrographolide | Andrographis | SARS-CoV , Influenza Virus , NF-κB , Autophagy |
Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential antineoplastic. | |||
TN6710 | Methyl acetylsalicylate | ACETYLSALICYLIC ACID METHYL ESTER | Others |
Methyl acetylsalicylate (ACETYLSALICYLIC ACID METHYL ESTER) is a natural product isolated from Pisum sativum. Inhibition of collagen-induced human platelet rich plasma aggregation | |||
T3429 | Protopine | Macleyine,Hypercorine,Corydinine,Biflorine,Fumarine | Reactive Oxygen Species , Platelet aggregation , Histamine Receptor |
Protopine (Fumarine) is a benzylisoquinoline alkaloid. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic. | |||
TN2315 | Xanthopurpurin | Platelet aggregation , Antifection | |
Xanthopurpurin shows antiviral activity. Xanthopurpurin can effectively inhibit rotavirus multiplication by promoting virus-induced apoptosis in MA-104 cells. Xanthopurpurin shows mainly strong inhibition of collagen-ind... | |||
TN1254 | 3'-Methoxydaidzein | Sodium Channel | |
3'-Methoxydaidzein is a dual isoflavone and Sodium Channel inhibitor. 3'-Methoxydaidzein inhibited NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM and 505 nM, respectively. 3'-Methoxydaidzein was specific for colla... | |||
T3408 | Syringin | Lilacin,Syringoside,eleutheroside-b,Methoxyconiferine | NOS , Autophagy |
Syringin (eleutheroside-b) is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects. | |||
T1723 | Adenosine 5'-diphosphate | Adenosine diphosphate,adenosine pyrophosphate,ADP | Endogenous Metabolite |
Adenosine 5'-diphosphate (ADP) induces human platelet aggregation and non-competitively blocks the stimulated human platelet adenylate cyclase. | |||
T5810 | TABERSONINE HYDROCHLORIDE | Beta Amyloid | |
TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity. | |||
T4S1658 | Benzoyloxypaeoniflorin | Benzoyloxypeoniflorin | NF-κB , Tyrosinase |
Benzoyloxypaeoniflorin (Benzoyloxypeoniflorin) is a natural product,contributes to improving blood circulation through their inhibitory effects on both platelet aggregation and blood coagulation. | |||
T2S1749 | Protogracillin | Others | |
Protogracillin may have inhibitions on platelet aggregation (PAG) and thrombosis. | |||
T2745 | 18α-Glycyrrhetinic acid | Enoxolone,Glycyrrhetinic acid | Apoptosis , NF-κB , Proteasome |
18α-Glycyrrhetinic acid (Enoxolone) is an inhibitor of NF-kB and an activator of the proteasome, and functions as a longevity-promoting and anti-aggregation factor in multicellular organisms. It induces apoptosis. | |||
T2727 | Salvianolic acid B | Others | |
Salvianolic acid B (Dan Shen Suan B) is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant, and antithrombotic effect | |||
T5725 | Salvianolic acid B | lithospermic acid B,Dan Shen Suan B | Sirtuin , Autophagy |
Salvianolic acid B (Dan Shen Suan B) is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant, and antithrombotic effect | |||
T0131 | Cepharanthine | NSC-623442 | Apoptosis , TNF , HIV Protease , Autophagy |
Cepharanthine (NSC-623442), a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and inhibits cytokine production. | |||
TN1341 | 8-Deoxygartanin | Beta Amyloid , NF-κB , Parasite | |
8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α2-amyloid (Aα2) aggregation, it has multifunctional activities against Alzheimer's disease (AD) a... | |||
TL0001 | Dencichine | L-Dencichin,ODAP,Dencichin | Others , HIF/HIF Prolyl-Hydroxylase |
Dencichine (ODAP) is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation and fibrinolytic system. It has renoprotective effec... | |||
T0070 | Pentoxifylline | Oxpentifylline,PTX,BL-191 | HIV Protease , PDE , Adenosine Receptor , Autophagy |
Pentoxifylline (PTX) modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It also inhibits platelet ... | |||
T3S0645 | N-trans-Feruloyltyramine | Feruloyltyramine,N-Feruloyltyramine,Moupinamide | Others , COX |
1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s... | |||
T7030 | Anemarsaponin B | p38 MAPK , NF-κB , MEK , COX , NO Synthase | |
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B c... | |||
TN6975 | Cirsiumaldehyde | 5,5’-oxydimethylenebis(2-furfural) | Platelet aggregation |
Cirsiumaldehyde is a compound isolated from the mature fruits of Lobelia chinensis, Cornus officinalis, and the fruits of Hippophae rhamnoides.Cirsiumaldehyde in the presence of collagen inhibited U46619-induced (1~5 uM)... | |||
TN1170 | 1-Cinnamoylpyrrolidine | Platelet aggregation | |
1-Cinnamoylpyrrolidine, a natural product prepared from Piper caninum, can be used as a DNA strand breaking agent, inducing the relaxation of the plasmid pBR322 DNA superhelix in the presence of Cu2+. 1-Cinnamoylpyrrolid... | |||
TN1622 | Ermanin | NOS , Influenza Virus , COX , HIV Protease , Antibacterial , Antibiotic | |
Ermanin is a flavonoid isolated from Tanacetum microphyllum.Ermanin inhibits platelet aggregation and has anti-tuberculosis and anti-viral/bacterial properties.Ermanin has anti-inflammatory activity by inhibiting the exp... | |||
T3427 | Polydatin | Piceid,Polydotin Peceid | Apoptosis , Mitophagy , NF-κB , Autophagy |
Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th... | |||
TN1873 | Lirinidine | Others | |
(+)-Lirinidine has antioxidative activity, and it can significantly inhibit the proliferation of melanoma cells; it also shows potent inhibition of melanogenesis. Lirinidine exhibits significant inhibition of collagen, a... | |||
T5S0896 | Loureirin A | Akt , PI3K | |
Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen, collagen-related pept... | |||
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Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00624 | PEAR1 Protein, Rat, Recombinant (His) | Rat | Baculovirus-Insect Cells |
Platelet endothelial aggregation receptor-1 (PEAR1), an epidermal growth factor repeat-containing transmembrane receptor, is known to participate in platelet contact-induced activation. Platelet endothelial aggregation r... | |||
TMPH-00213 | Disintegrin batroxostatin Protein, Bothrops atrox, Recombinant (His & Myc) | Bothrops atrox | E. coli |
Inhibits fibrinogen interaction with platelets. Acts by binding to the glycoprotein IIb-IIIa receptor (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor a... | |||
TMPY-00545 | Dermcidin Protein, Human, Recombinant (hFc) | Human | HEK293 |
Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths due to its often late stage diagnosis, and dermcidin (DCD) may have the potential to be used as a serum biomarker for HCC for more timely dia... | |||
TMPY-01012 | P4HB Protein, Human, Recombinant (His) | Human | HEK293 |
Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase famil... | |||
TMPY-00939 | Thrombopoietin Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver a... | |||
TMPY-01126 | CD39 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
CD39, also known as ENTPD1, belongs to the GDA1/CD39 NTPase family. It is expressed primarily on activated lymphoid cells and can also be detected in endothelial tissues. The vascular isoform and the placental isoform II... | |||
TMPY-05151 | CD39 Protein, Cynomolgus, Rhesus, Recombinant (His) | Cynomolgus,Rhesus | Baculovirus-Insect Cells |
CD39, also known as ENTPD1, belongs to the GDA1/CD39 NTPase family. It is expressed primarily on activated lymphoid cells and can also be detected in endothelial tissues. The vascular isoform and the placental isoform II... | |||
TMPY-02808 | CD39 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
CD39, also known as ENTPD1, belongs to the GDA1/CD39 NTPase family. It is expressed primarily on activated lymphoid cells and can also be detected in endothelial tissues. The vascular isoform and the placental isoform II... | |||
TMPY-02778 | ENPP2 Protein, Human, Recombinant (His) | Human | HEK293 |
ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen... | |||
TMPY-00463 | ENPP2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen... | |||
TMPY-04330 | Mer Protein, Human, Recombinant | Human | HEK293 |
Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li... | |||
TMPY-00716 | CD89 Protein, Human, Recombinant (His) | Human | HEK293 |
FCAR, also called FcαRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This recep... | |||
TMPY-04830 | GAS6 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin ... | |||
TMPY-01578 | CD166/ALCAM Protein, Human, Recombinant (His) | Human | HEK293 |
Activated leukocyte cell adhesion molecule (ALCAM)/Cluster of differentiation (CD166) is a type I transmembrane cell adhesion molecule belonging to the Ig superfamily and a ligand for CD6 that is expressed on T lymphocyt... | |||
TMPY-00882 | Mer Protein, Human, Recombinant (His & hFc) | Human | HEK293 |
Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li... | |||
TMPY-02521 | HIST3H2A Protein, Human, Recombinant | Human | E. coli |
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident ... | |||
TMPY-01278 | Apolipoprotein H/APOH Protein, Human, Recombinant (His) | Human | HEK293 |
Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, Activated protein C-binding protein, B2GPI, and B2G1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipop... | |||
TMPH-00323 | Snaclec rhodocytin subunit beta Protein, Calloselasma rhodostoma, Recombinant (His & Myc) | Calloselasma rhodostoma | E. coli |
Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen ... | |||
TMPH-00320 | Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodostoma, Recombinant (His) | Calloselasma rhodostoma | Yeast |
Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen ... | |||
TMPH-00322 | Snaclec rhodocytin subunit beta Protein, Calloselasma rhodostoma, Recombinant (His) | Calloselasma rhodostoma | Yeast |
Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen ... | |||
TMPH-00321 | Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodostoma, Recombinant (His & SUMO) | Calloselasma rhodostoma | E. coli |
Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen ... | |||
TMPH-00216 | SVMP Protein, Bothrops jararaca, Recombinant (His & KSI) | Bothrops jararaca | E. coli |
Metalloproteinase that binds to von Willebrand factor (VWF) and induces its interaction with GPIb (GP1BA), resulting in platelet aggregation. | |||
TMPH-00083 | Dehydrin ERD14 Protein, Arabidopsis thaliana, Recombinant (His & Myc) | Arabidopsis thaliana | E. coli |
Intrinsically disordered protein acting as a chaperone. Prevents heat-induced aggregation and/or inactivation of various substrates. Binds to acidic phospholipid vesicles without affecting membrane fluidity. | |||
TMPH-02851 | PDIA2 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded protei... | |||
TMPH-01822 | P2Y1 Protein, Human, Recombinant (His) | Human | E. coli |
Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately p... | |||
TMPH-01603 | Lanosterol synthase/LSS Protein, Human, Recombinant (His) | Human | E. coli |
Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens prote... | |||
TMPH-03121 | CXCL4 Protein, Pig, Recombinant (His & Myc) | Sus scrofa (Pig) | E. coli |
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophil... | |||
TMPH-00215 | SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc) | Bothrops jararaca | E. coli |
Thrombin-like snake venom serine protease that clots fibrinogen by releasing fibrinopeptide A from the alpha chain of fibrinogen (FGA), induces platelet aggregation through its interaction with GPIb (GP1BA/GP1BB), and ac... | |||
TMPH-03283 | CD39 Protein, Rat, Recombinant (His) | Rat | Baculovirus |
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP.... | |||
TMPJ-01124 | PDIA6 Protein, Human, Recombinant (His) | Human | Human Cells |
Protein Disulfide-Isomerase A6 (PDIA6) is a 48.5kDa protein that belongs to the protein disulfide isomerase family (PDI). PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes which catalyzes the formation and br... | |||
TMPH-03284 | CD39 Protein, Rat, Recombinant (E. coli, His) | Rat | E. coli |
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP.... | |||
TMPH-03600 | Glucosyltransferase-SI Protein, S. mutans serotype c, Recombinant (His & Myc) | Streptococcus mutans | E. coli |
Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and fo... | |||
TMPJ-00734 | KNG1 Protein, Human, Recombinant (His) | Human | Human Cells |
Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role ... | |||
TMPH-02571 | CD9 Protein, Mouse, Recombinant (His) | Mouse | in vitro E. coli expression system |
Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays... | |||
TMPH-00217 | SVMP Protein, Bothrops leucurus, Recombinant (His & Myc) | Bothrops leucurus | E. coli |
Non-hemorrhagic metalloproteinase that hydrolyzes the alpha chains of fibrinogen, as well as fibrin, fibronectin and casein. Beta and gamma chains are also hydrolyzed, but more slowly. Thrombolytic activity is also obser... | |||
TMPH-02997 | Dps Protein, Mycobacterium smegmatis, Recombinant (His & SUMO) | Mycobacterium smegmatis | E. coli |
Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical produ... | |||
TMPH-00331 | ALS3 Protein, Candida albicans, Recombinant (B2M & His & Myc) | Candida albicans | E. coli |
Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans... | |||
TMPJ-00754 | CRYAA Protein, Human, Recombinant (His) | Human | E. coli |
Alpha-Crystallin A Chain (CRYAA) belongs to the small heat shock protein (HSP20) family and can be induced by heat shock. The expression of CRYAA is preferentially restricted to the lens cell. CRYAA may contribute to the... | |||
TMPH-00214 | SVMP Protein, Bothrops atrox, Recombinant (His & Myc) | Bothrops atrox | E. coli |
Snake venom zinc metalloproteinase that acts on fibrinogen, fibrin, fibronectin (FN1), type I collagen, type IV collagen, integrin alpha-7/beta-1 (ITGA7/ITGB1) and integrin alpha-1/beta-1 (ITGA1/ITGB1). Binds to fibronec... | |||
TMPH-03163 | SVTLE Protein, Protobothrops flavoviridis, Recombinant (His & Myc) | Protobothrops flavoviridis | E. coli |
Thrombin-like snake venom serine protease that clots fibrinogen (FGA) by releasing fibrinopeptide A. According to PubMed:8585090, only cleaves rabbit fibrinogen, whereas no specificity is described in PubMed:3910643 (tes... | |||
TMPJ-00766 | ANXA1 Protein, Human, Recombinant | Human | E. coli |
Annexin A1 is the first characterized member of the annexin family of proteins and is able to bind to cellular membranes in a calcium-dependent manner, promoting membrane fusion and endocytosis. Annexin A1 has anti-infla... | |||
TMPJ-01420 | CD40 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | Human Cells |
CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, va... | |||
TMPJ-00634 | CD40 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | Human Cells |
CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, va... | |||
TMPJ-00915 | HSP40 Protein, Human, Recombinant (His) | Human | E. coli |
DnaJ Homolog Subfamily B Member 1 (DNAJB1) is a member of the heat shock protein family. Heat shock proteins (HSPs) are a highly conserved family of stress response proteins. HSPs function primarily as molecular chaperon... | |||
TMPY-04336 | Orange fluorescent protein Protein, Discosoma sp, Recombinant (His) | Discosoma sp | E. coli |
OFPSparkTM is a red (orange) fluorescent protein (excitation/emission maxima are 549 and 566 nm, respectively) derived from DsRed. Possessing high photostability and pH stability, OFPSparkTM is more than twice brighter t... | |||
TMPY-01795 | P4HB Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase famil... | |||
TMPY-01609 | Thrombopoietin Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver a... | |||
TMPH-00026 | Catechol 1,2-dioxygenase Protein, Acinetobacter baylyi, Recombinant (His) | Actinia equina | E. coli |
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphin... | |||
TMPY-03161 | JAM-A Protein, Rat, Recombinant (His) | Rat | HEK293 |
Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as... | |||
TMPY-01035 | JAM-A Protein, Human, Recombinant (His) | Human | HEK293 |
Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as... | |||
------------------------ More ------------------------ |
Cat No. | Product Name | ||
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L5400 | Anti-Cardiovascular Disease Compound Library | 1428 compounds | |
A unique collection of 1428 cardiovascular diseases related compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L8710 | Cuproptosis Compound Library | 411 compounds | |
TargetMol’s Cuproptosis Compound Library is a collection of 411 compounds related to copper-dependent death that can be used to study its mechanism and related diseases. |