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Decuroside I

Name: Decuroside I
Brand: TargetMol
SKU: TN6536
Rating: 4.5 (1 reviews)

Catalog No. TN6536 Copy Product Info

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Decuroside I shows weak inhibiting activity against the primary and secondary wave aggregation of human platelet.

Decuroside I

Copy Product Info

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Catalog No. TN6536

Decuroside I shows weak inhibiting activity against the primary and secondary wave aggregation of human platelet.

Cas No. 96638-79-8

Pack Size	Price	USA Stock	Global Stock	Quantity
5 mg	$550	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description

Decuroside I shows weak inhibiting activity against the primary and secondary wave aggregation of human platelet.

In vitro

METHODS AND RESULTS:Three kinds of new coumarin-glycosides, Decuroside I (1), Decuroside II (2), Decuroside III (3), which were isolated from the N-butanol extracts of the crude drug Zi-Hua Qian-Hu, the root of PEUCEDANUM DECURSIVUM Maxim. (Umbelliferae), were elucidated to be nodakenetin-4′- O-β-gentiobiose, nodakenetin-4′- Oβ-isomaltose and nodakenetin-4′- O-β-maltose, respectively, by the methods of chemical and spectral analysis. These three new compounds as well as Decuroside IV (4), decuroside V (5) and nodakenin (6) which were also isolated from Zi-Hua Qian-Hu were tested on human platelet aggregation induced by 2 μM ADP. CONCLUSIONS:Among these coumarin-glycosides, 3 and 4, showed the strongest inhibiting activity against the primary and secondary wave aggregation of human platelet. 1 and 2 had a less inhibiting effect or none at all, and 5 was rather promotive against the primary wave aggregation.

Chemical Properties

Molecular Weight	570.544
Formula	C₂₆H₃₄O₁₄
Cas No.	96638-79-8
Smiles	CC(C)(OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C1Cc2cc3ccc(=O)oc3cc2O1
Relative Density.	1.61 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Decuroside I