Analogue

Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.

3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.

Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).

Carboprost tromethamine, a synthetic 15-methyl analogue of prostaglandin F2α, effectively promotes uterine contractions and significantly reduces bleeding during and post-delivery.

D-(+)-Fucose is a non-metabolizable analog of l-arabinose and an inducer of β-methylgalactoside permease. It inhibits the induction of the l-arabinose manipulator and blocks the growth of Escherichia coli B r on mineral salts medium with l-arabinose.

Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.

Filgotinib analogue isa a structurally analogue of Filgotinib and can be used in life science related research.

Glufosinate ammonium is a phosphinic acid analog of glutamic acid and an herbicide with neurotoxic activity. It is converted by plant cells into PT (L-phosphinothricin).

VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)

Phentolamine Analogue 1 is a nonselective α-adrenergic antagonist, similar to phentolamine.

CPI-455 analogue (CPI-455 analogue) is an analogue of CPI-455 which is a KDM5 inhibitor.

Macitentan n-butyl analogue, a derivative of Macitentan, functions as an orally active dual antagonist targeting both endothelin ETA and ETB receptors. This compound shows promise for treating idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH), leveraging its non-peptide structure for potential therapeutic applications.

(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid, a constrained phenylalanine (Phe) analogue, can adopt beta-bend and helical structures, thereby facilitating a preferred side-chain orientation within the peptide.

Defactinib analogue-1 (Compound 7) serves as a ligand for the target protein FAK, and is utilized in the synthesis of PROTAC FAK degrader 1.

Bacilotetrin C analogue is a variant of Bacilotetrin C. It exhibits cytotoxicity against the triple-negative breast cancer cell line MDA-MB-231, with an IC50 of 0.48 μM. This compound induces autophagy (autophagy) in tumor cells and possesses antitumor activity.

Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor targeting PI3Kα δ γ.

Hymenialdisine Analogue #1 is the indole derivative of Hymenialdisine, a potent inhibitor of a variety of kinases including MEK-1, GSK-3Β, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations.

Rezivertinib analogue 1, a process impurity of osimertinib mesylate, serves as a research tool in the study of non-small cell lung cancer (NSCLC) [1].

Kadsurin A Analogue-1 (Compound 8), a lignan, can be extracted from Piper argyrophylum [1].

Exatecan Analogue 1 (Icp-3), a derivative of Exatecan, is instrumental in the synthesis of antibody-drug conjugates (ADCs) [1].

Napabucasin analogue, a PROTAC target protein ligand (Ligands for Target Protein for PROTACs), is utilized in synthesis. This compound serves as an essential component in the targeted degradation of proteins through the PROTAC technology.

SP100030 analogue 1 (compound 11) is a selective transcription activation (SITA) inhibitor within the SP100030 class, capable of inhibiting XPO1-dependent upregulation of IL2 in a Jurkat-based IL2-Luc reporter assay, with an EC50 of 137 nM.

Nucleoside Derivatives - 5-Modified pyrimidine nucleosides; Thio-nucleosides; Amino nucleosides; Protected nucleosides w NH2 OH open

Clozapine Analogues can be used to study neurological disorders.