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Ras

Ras is a family of related proteins which is expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1931 6H05 1469338-01-9 99.02%
6H05
6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
T10374 ARS-1323-alkyne 2436544-27-1 98.00%
ARS-1323-alkyne
ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
T78651 Glecirasib 2657613-87-9 98%
Glecirasib
Glecirasib (KRAS G12C inhibitor 36) is a potent inhibitor targeting the oncogenic KRAS G12C mutation, a key signaling molecule within the Ras protein family that...
T78661 TH-Z835 2766209-50-9 98%
TH-Z835
TH-Z835 is a selective inhibitor for the KRAS (G12D) mutation, demonstrating an inhibitory concentration (IC50) of 1.6 μM. It effectively hampers both mantGMPPNP...
T79057 KRAS G12C inhibitor 58 2915599-52-7 98%
KRAS G12C inhibitor 58
KRAS G12C inhibitor 58 is utilized in cancer research as an inhibitor of the KRAS G12C mutation [1].
T79072 KRAS G12D modulator-1 2883034-05-5 98%
KRAS G12D modulator-1
KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and is ...
T79092 TH-Z827 2847881-81-4 98%
TH-Z827
TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C). Addition...
T79148 PROTAC KRAS G12C degrader-3 2768099-51-8 98%
PROTAC KRAS G12C degrader-3
PROTAC KRAS G12C Degrader-3 (Comp 283) serves as a potent degrader of KRAS G12C, utilized in cancer research [1].
T79150 KRAS G12C inhibitor 59 2914919-88-1 98%
KRAS G12C inhibitor 59
KRAS G12C Inhibitor 59 is a compound with anticancer properties.
T79162 SOS1/KRAS-IN-1 2836330-34-6 98%
SOS1/KRAS-IN-1
SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].
T79166 KRAS G12C inhibitor 60 98%
KRAS G12C inhibitor 60
KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, and pancreati...
T79183 SOS1-IN-16 2930763-85-0 98%
SOS1-IN-16
SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 of ...
T79673 LUNA18 2676177-63-0 98%
LUNA18
LUNA18 is an orally active inhibitor targeting KRAS, exhibiting potent activity with an IC50 value of less than 2 nM against the KRAS G12D-SOS mutation. It is ut...
T79799 Pan-KRAS-IN-4 2885961-55-5 98%
pan-KRAS-IN-4
Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].
T79800 Pan-KRAS-IN-2 2882825-14-9 98%
pan-KRAS-IN-2
Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D,...
T79814 Pan-KRAS-IN-3 2875116-29-1 98%
pan-KRAS-IN-3
Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].
T79869 Rac1-IN-3 380470-06-4 98%
Rac1-IN-3
Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].
T79870 RMC-4998 2642037-07-6 98%
RMC-4998
RMC-4998 is a molecular glue compound exhibiting potent antitumor activity, capable of forming a ternary complex with CYPA and an activated KRAS G12C mutation. B...
TN1953 Morusinol 62949-93-3 98%
Morusinol
Morusinol is a flavonoid extracted from the root bark of Morus alba. Morusinol has antiplatelet and anticancer activities, inhibits arterial thrombosis in vivo, ...
T11776 KRas G12C inhibitor 1 2158297-28-8 98%
KRas G12C inhibitor 1
KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.
6H05
T1931
6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
ARS-1323-alkyne
T10374
ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
Glecirasib
T78651
Glecirasib (KRAS G12C inhibitor 36) is a potent inhibitor targeting the oncogenic KRAS G12C mutation, a key signaling molecule within the Ras protein family that...
TH-Z835
T78661
TH-Z835 is a selective inhibitor for the KRAS (G12D) mutation, demonstrating an inhibitory concentration (IC50) of 1.6 μM. It effectively hampers both mantGMPPNP...
KRAS G12C inhibitor 58
T79057
KRAS G12C inhibitor 58 is utilized in cancer research as an inhibitor of the KRAS G12C mutation [1].
KRAS G12D modulator-1
T79072
KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and is ...
TH-Z827
T79092
TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C). Addition...
PROTAC KRAS G12C degrader-3
T79148
PROTAC KRAS G12C Degrader-3 (Comp 283) serves as a potent degrader of KRAS G12C, utilized in cancer research [1].
KRAS G12C inhibitor 59
T79150
KRAS G12C Inhibitor 59 is a compound with anticancer properties.
SOS1/KRAS-IN-1
T79162
SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].
KRAS G12C inhibitor 60
T79166
KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, and pancreati...
SOS1-IN-16
T79183
SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 of ...
LUNA18
T79673
LUNA18 is an orally active inhibitor targeting KRAS, exhibiting potent activity with an IC50 value of less than 2 nM against the KRAS G12D-SOS mutation. It is ut...
pan-KRAS-IN-4
T79799
Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].
pan-KRAS-IN-2
T79800
Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D,...
pan-KRAS-IN-3
T79814
Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].
Rac1-IN-3
T79869
Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].
RMC-4998
T79870
RMC-4998 is a molecular glue compound exhibiting potent antitumor activity, capable of forming a ternary complex with CYPA and an activated KRAS G12C mutation. B...
Morusinol
TN1953
Morusinol is a flavonoid extracted from the root bark of Morus alba. Morusinol has antiplatelet and anticancer activities, inhibits arterial thrombosis in vivo, ...
KRas G12C inhibitor 1
T11776
KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.
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TargetMol