d13

D13 is an acylhydrazone antifungal.1 It is active against C. neoformans in vitro (MIC80 = 0.06 μg/ml). D13 (20 mg/kg per day, p.o.) increases survival in mouse models of C. neoformans, C. albicans, or A. fumigatus infection. |1. Lazzarini, C., Haranahalli, K., Rieger, R., et al. Acylhydrazones as antifungal agents targeting the synthesis of fungal sphingolipids. Antimicrob. Agents Chemother. 62(5), e00156-00118 (2018).

Palmitoleic Acid-D13 (Standard) is a reference standard of Palmitoleic Acid-D13 intended for quantitative analysis, quality control, and related biochemical research applications. Palmitoleic acid-d13 is the deuterated form of Palmitoleic acid. Palmitoleic acid, a component of fatty acids, has the potential to prevent death from cerebrovascular diseases in SHRSP rats.

Lusutrombopag-D13 is a deuterated compound of Lusutrombopag. Lusutrombopag (TQ0223) has a CAS number of 1110766-97-6. Lusutrombopag (TQ0223) is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist for chronic liver disease (CLD) patients with thrombocytopenia prior to elective invasive surgery.

Alachlo-D13 (2,6-diethylphenyl-D13) is a deuterated compound of Alachlo.

Acetylcholine-[D13] Bromide (N,N,N-Trimethyl-D9; 1,1,2,2-D4) (Standard) is a reference standard of Acetylcholine-[D13] Bromide (N,N,N-Trimethyl-D9; 1,1,2,2-D4) intended for quantitative analysis, quality control, and related biochemical research applications.

Heptanoic-D13 Acid (Standard) is a reference standard of Heptanoic-D13 Acid intended for quantitative analysis, quality control, and related biochemical research applications.

Colfosceril miristate-D13 (DMPC-D13) is the deuterated form of Colfosceril miristate. Colfosceril miristate (T9525) (DMPC) is a synthetic phospholipid utilized in the study of liposomes and lipid bilayers. It is employed for research on lipid monolayers and bilayers.

Choline-D13 Bromide (N,N,N-trimethyl-D9; 1,1,2,2-D4) is a deuterated compound of Choline Bromide. Choline Bromide (TYD-01307) has a CAS number of 1927-06-6.

Guanosine-D13 is the deuterated form of Guanosine. Guanosine (T6523) (DL-Guanosine) is a type of nucleoside composed of guanine linked to a ribose ring through a β-N9-glycosidic bond. It exhibits activity against HSV (herpes simplex virus).

MES-D13 is the deuterated form of MES. MES (2-Morpholinoethanesulphonic acid) serves as a zwitterionic buffer with an effective buffering range of pH 5.5-7.0. As a Good's buffer, MES is extensively used in biochemistry and molecular biology experiments, including cell culture, enzyme activity assays, electrophoresis, and protein research.

1,2-Distearoyl-sn-glycero-3-phosphorylcholine-D13 is the deuterated variant of 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (T9510) (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a lipid utilized in liposome synthesis and serves as a lipid component in lipid nanoparticle (LNP) systems.

Choline-D13 chloride is a deuterated form of Choline chloride (T1039). Choline chloride, an organic compound and a quaternary ammonium salt, acts as both a substrate for acyl receptors and choline acetyltransferase. It serves as a photosynthesis enhancer in plants and is also used as a feed additive for poultry and livestock to boost egg and offspring production.

Thymol-D13 is the deuterated analog of Thymol. Thymol (T3S0717) is a major monoterpenol found in essential oils derived from plants belonging to the Lamiaceae family, as well as other families such as Verbenaceae, Scrophulariaceae, and Ranunculaceae. It exhibits antioxidant, anti-inflammatory, antibacterial, and antifungal properties.

Palmitoleic acid-D13 is the deuterated form of Palmitoleic acid (T4872). Palmitoleic acid, a component of fatty acids, has the potential to prevent death from cerebrovascular diseases in SHRSP rats.

Acetylcholine-D13 bromide is the deuterated form of Acetylcholine bromide (T20344).

Adenosine-D13 is a deuterium-labeled form of Adenosine. Adenosine (T0853) (Adenine riboside) is a widely present endogenous secretion that exerts effects via four G-protein-coupled receptors (A1, A2A, A2B, and A3). It influences nearly all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

2'-Deoxyguanosine-D13 is a deuterium-labeled form of 2'-Deoxyguanosine (T22218) (Deoxyguanosine), also known as guanine deoxyriboside.

TD139 is a small molecule inhibitor of inhaled galectin-3 (Gal-3) with potential anti-fibrotic activity, commonly used in the study of idiopathic pulmonary fibrosis.

MD13 is a macrophage migration inhibitor (MIF) oriented PROTAC (Ki value: 71 nM). MD13 can be used to study cancer.

The KD values of D13-9001 in Escherichia coli and Pseudomonas aeruginosa were 1.15μM and 3.57μM, respectively. D13-9001 has antibiotic activity. It is an effective AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor.

CD13-IN-1 (Compound 5f) is a CD13 inhibitor with an IC50 value of 1.71 μM. It effectively suppresses the proliferation of various tumor cells, demonstrating antitumor activity.

SD133 (Sd-133) is a cadherin-11 inhibitor for studying tumors overexpressing cadherin-11.

AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes.

ZDLD13 is a β-carboline that exhibits potent anti-HCT116 activity inclusive of inhibition of invasion and migration, inhibition of colony formation, inducing of apoptosis as well as arresting of G1 phase in cell cycle. ZDLD13 is an orally active and selective inhibitor of CDK4/CycD3 (IC 50 = 0.38 μM) which exhibits significant inhibition of tumor growth in HCT116 tumor xenograft model [1].