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Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Cat. No. Product name CAS No. Purity Chemical Structure
TN1058 Pelargonidin chloride 134-04-3 98%
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
T8306 Epiberberine chloride 889665-86-5 98%
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07...
T4902 ISOQUERCITRIN 21637-25-2 98%
Isoquercitrin is an effective antioxidant and an eosinophilic inflammation suppressor.
T33701 NM-3 181427-78-1 98%
NM-3 is an orally available anti-angiogenic inhibitor with anti-tumour activity.NM-3 is used as a radiation modulator in vitro and in vivo.NM-3 inhibits vascular...
T37688 Cyfluthrin 68359-37-5 98%
Cyfluthrin is a pyrethroid insecticide and a modulator of voltage-gated sodium channels (Nav).1,2It slowly activates rat recombinant Nav1.8 channels, delays inac...
TN7108 Urolithin C 165393-06-6 98%
Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
T41242 Uric acid sodium 1198-77-2 98%
Uric acid sodium, scavengers of oxygen radicals, is a potent and common antioxidant that helps maintain stable blood pressure and resist oxidative stress. Uric a...
T67498 3-Amino-1,2,4-triazole 61-82-5 98%
3-Amino-1,2,4-triazole is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves ...
T20578 Maclurin 519-34-6 98%
Maclurin is a phenolic component of mulberry twigs, exerts anti-metastatic effects. Maclurin effectively protects against OH-induced damages to DNA and MSCs and ...
T38155 N-Acetyl-D-cysteine 26117-28-2 98%
N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway[1]...
T17155 Trabectedin 114899-77-3 98%
Trabectedin a tetrahydroisoquinoline alkaloid. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbon...
T75342 MitoSOX Red 1003197-00-9 98%
MitoSOX Red is a novel fluorescent probe that is specific and cell membrane-permeable and targets mitochondria in living cells.MitoSOX Red is oxidized by superox...
TN1403 Arjunolic acid 465-00-9 98%
Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
T12059L Mitoquinone mesylate 845959-50-4 98%
Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant to protect against oxidative damage.
T8033 Sodium Thiocyanate 540-72-7 98%
Sodium Thiocyanate, one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals.
T8193 α-Thujone 546-80-5 98%
Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
T7703 PK11007 874146-69-7 98%
PK11007 is an anti-p53 drug.
T30087 Antroquinonol 1010081-09-0 98%
Antroquinonol is a ubiquinone derivative from Antrodia camphorata with anti-inflammatory and anticancer activities.Antroquinonol reduces oxidative stress and inh...
T2S0007 Ferulic acid sodium 24276-84-4 98%
Sodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular disease...
T6674 L-Ascorbic acid sodium salt 134-03-2 98%
Sodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
Pelargonidin chloride
TN1058
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
Epiberberine chloride
T8306
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07...
ISOQUERCITRIN
T4902
Isoquercitrin is an effective antioxidant and an eosinophilic inflammation suppressor.
NM-3
T33701
NM-3 is an orally available anti-angiogenic inhibitor with anti-tumour activity.NM-3 is used as a radiation modulator in vitro and in vivo.NM-3 inhibits vascular...
Cyfluthrin
T37688
Cyfluthrin is a pyrethroid insecticide and a modulator of voltage-gated sodium channels (Nav).1,2It slowly activates rat recombinant Nav1.8 channels, delays inac...
Urolithin C
TN7108
Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
Uric acid sodium
T41242
Uric acid sodium, scavengers of oxygen radicals, is a potent and common antioxidant that helps maintain stable blood pressure and resist oxidative stress. Uric a...
3-Amino-1,2,4-triazole
T67498
3-Amino-1,2,4-triazole is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves ...
Maclurin
T20578
Maclurin is a phenolic component of mulberry twigs, exerts anti-metastatic effects. Maclurin effectively protects against OH-induced damages to DNA and MSCs and ...
N-Acetyl-D-cysteine
T38155
N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway[1]...
Trabectedin
T17155
Trabectedin a tetrahydroisoquinoline alkaloid. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbon...
MitoSOX Red
T75342
MitoSOX Red is a novel fluorescent probe that is specific and cell membrane-permeable and targets mitochondria in living cells.MitoSOX Red is oxidized by superox...
Arjunolic acid
TN1403
Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
Mitoquinone mesylate
T12059L
Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant to protect against oxidative damage.
Sodium Thiocyanate
T8033
Sodium Thiocyanate, one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals.
α-Thujone
T8193
Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
PK11007
T7703
PK11007 is an anti-p53 drug.
Antroquinonol
T30087
Antroquinonol is a ubiquinone derivative from Antrodia camphorata with anti-inflammatory and anticancer activities.Antroquinonol reduces oxidative stress and inh...
Ferulic acid sodium
T2S0007
Sodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular disease...
L-Ascorbic acid sodium salt
T6674
Sodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
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