Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Cat. No.	Product name	CAS No.	Purity
TN1058	Pelargonidin chloride	134-04-3	98%
TN1058	Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
T8306	Epiberberine chloride	889665-86-5	98%
T8306	Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07...
T4902	ISOQUERCITRIN	21637-25-2	98%
T4902	Isoquercitrin is an effective antioxidant and an eosinophilic inflammation suppressor.
T33701	NM-3	181427-78-1	98%
T33701	NM-3 is an orally available anti-angiogenic inhibitor with anti-tumour activity.NM-3 is used as a radiation modulator in vitro and in vivo.NM-3 inhibits vascular...
T37688	Cyfluthrin	68359-37-5	98%
T37688	Cyfluthrin is a pyrethroid insecticide and a modulator of voltage-gated sodium channels (Nav).1,2It slowly activates rat recombinant Nav1.8 channels, delays inac...
TN7108	Urolithin C	165393-06-6	98%
TN7108	Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
T41242	Uric acid sodium	1198-77-2	98%
T41242	Uric acid sodium, scavengers of oxygen radicals, is a potent and common antioxidant that helps maintain stable blood pressure and resist oxidative stress. Uric a...
T67498	3-Amino-1,2,4-triazole	61-82-5	98%
T67498	3-Amino-1,2,4-triazole is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves ...
T20578	Maclurin	519-34-6	98%
T20578	Maclurin is a phenolic component of mulberry twigs, exerts anti-metastatic effects. Maclurin effectively protects against OH-induced damages to DNA and MSCs and ...
T38155	N-Acetyl-D-cysteine	26117-28-2	98%
T38155	N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway[1]...
T17155	Trabectedin	114899-77-3	98%
T17155	Trabectedin a tetrahydroisoquinoline alkaloid. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbon...
T75342	MitoSOX Red	1003197-00-9	98%
T75342	MitoSOX Red is a novel fluorescent probe that is specific and cell membrane-permeable and targets mitochondria in living cells.MitoSOX Red is oxidized by superox...
TN1403	Arjunolic acid	465-00-9	98%
TN1403	Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
T12059L	Mitoquinone mesylate	845959-50-4	98%
T12059L	Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant to protect against oxidative damage.
T8033	Sodium Thiocyanate	540-72-7	98%
T8033	Sodium Thiocyanate, one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals.
T8193	α-Thujone	546-80-5	98%
T8193	Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
T7703	PK11007	874146-69-7	98%
T7703	PK11007 is an anti-p53 drug.
T30087	Antroquinonol	1010081-09-0	98%
T30087	Antroquinonol is a ubiquinone derivative from Antrodia camphorata with anti-inflammatory and anticancer activities.Antroquinonol reduces oxidative stress and inh...
T2S0007	Ferulic acid sodium	24276-84-4	98%
T2S0007	Sodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular disease...
T6674	L-Ascorbic acid sodium salt	134-03-2	98%
T6674	Sodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.