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Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T14545 Berberine chloride hydrate 68030-18-2 98.94%
Berberine chloride hydrate
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid commonly used as an antibiotic.Berberine chloride hydrate has antitumor activity, ...
T78067 Stobadine 85202-17-1 98%
Stobadine
Stobadine, a potent antioxidant, safeguards endoplasmic reticulum (ER) membrane fluidity against free radical-induced changes. It shows promise in the developmen...
T78229 Aminoguanidine hemisulfate 996-19-0 98%
Aminoguanidine hemisulfate
Aminoguanidine hemisulfate, an inhibitor of nitric oxide synthases (NOS) and reactive oxygen species (ROS), effectively suppresses ANE-induced ROS production in ...
T78517 Dapsone hydroxylamine 32695-27-5 98%
Dapsone hydroxylamine
Dapsone hydroxylamine (DDS-NOH) promotes methemoglobinemia, impedes catalase (CAT) activity, and suppresses the generation of reactive oxygen species, while also...
T78549 Ethylene glycol dimethacrylate 97-90-5 98%
Ethylene glycol dimethacrylate
Ethylene glycol dimethacrylate, a methacrylate monomer, demonstrates cytotoxic and genotoxic impacts on human gingival fibroblasts (HGFs), elevating intracellula...
T78616 Glutathione ethyl ester 92614-59-0 98%
Glutathione ethyl ester
Glutathione ethyl ester, a cell-permeable GSH donor, enhances the in vitro production of embryos by bolstering antioxidative defense, thereby ensuring an effecti...
T78623 Cobalt protoporphyrin IX 14325-03-2 98%
Cobalt protoporphyrin IX
Cobalt Protoporphyrin IX serves as a potent, specific inducer of heme oxygenase-1 (HO-1) and demonstrates broad-spectrum antiviral effects against Influenza A vi...
T78624 OPC-163493 1644467-84-4 98%
OPC-163493
OPC-163493 is an orally active, liver-targeted mitochondrial uncoupling agent that diminishes Δψ (delta psi) and mitochondrial ROS (reactive oxygen species) prod...
T78887 ROS-IN-2 98%
ROS-IN-2
ROS-IN-2 (compound 85), a seco-lupane triterpenoid derivative, inhibits reactive oxygen species (ROS) production and shields mitochondria from oxidative damage b...
T79252 Apoptosis inducer 13 98%
Apoptosis inducer 13
Apoptosis Inducer 13 (Compound Ru4) promotes apoptosis in cancer cells while also suppressing their migration and invasion. Additionally, it facilitates the conv...
T79260 MCI 98%
MCI
MCI, a chemical compound demonstrating significant anti-inflammatory effects, particularly in collagen-induced arthritis (CIA) models, modulates inflammation thr...
T79287 SB-1295 98%
SB-1295
SB-1295, an orally active CDK9/T1 inhibitor with an IC50 of 0.17 μM, exhibits antiproliferative effects on HCT 116 and MIA PaCa-2 cells. It promotes cell death i...
T79333 LZWL02003 1371564-45-2 98%
LZWL02003
LZWL02003, an anti-neuroinflammatory agent, demonstrates a protective effect on MPP+-induced neuronal damage and reduces ROS expression. Additionally, it enhance...
T79388 Anticancer agent 154 98%
Anticancer agent 154
Anticancer agent 154 (Compound 8h) enhances reactive oxygen species production, causing mitochondrial damage, and promotes cell apoptosis and DNA damage. It trig...
T79480 Anti-inflammatory agent 47 2925288-12-4 98%
Anti-inflammatory agent 47
Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) and nitric oxide (NO) while inhibiting neur...
T79517 ROS inducer 2 2921602-19-7 98%
ROS inducer 2
Compound I16 (ROS inducer 2) is a potent inducer of Reactive Oxygen Species (ROS) with an effective concentration (EC 50) of 3.43 μg/mL demonstrated in vitro. It...
T79518 ROS inducer 3 2921602-09-5 98%
ROS inducer 3
Compound I6 (ROS inducer 3) is a potent ROS inducer with robust in vitro bioactivity, demonstrated by an EC50 of 2.86 μg/mL. It exhibits significant protective a...
T79946 Isorabaichromone 194669-79-9 98%
Isorabaichromone
Isorabaichromone exhibits potent antioxidative properties, including DPPH radical and superoxide anion scavenging activities [1].
T79951 Piperkadsin A 895543-36-9 98%
Piperkadsin A
Piperkadsin A effectively inhibits reactive oxygen species (ROS) production, specifically targeting PMA-induced ROS in human polymorphonuclear neutrophils, exhib...
T80026 AHK 126828-32-8 98%
AHK
AHK, a bioactive peptide known for its antioxidant properties, has been employed as a cosmetic ingredient [1].
Berberine chloride hydrate
T14545
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid commonly used as an antibiotic.Berberine chloride hydrate has antitumor activity, ...
Stobadine
T78067
Stobadine, a potent antioxidant, safeguards endoplasmic reticulum (ER) membrane fluidity against free radical-induced changes. It shows promise in the developmen...
Aminoguanidine hemisulfate
T78229
Aminoguanidine hemisulfate, an inhibitor of nitric oxide synthases (NOS) and reactive oxygen species (ROS), effectively suppresses ANE-induced ROS production in ...
Dapsone hydroxylamine
T78517
Dapsone hydroxylamine (DDS-NOH) promotes methemoglobinemia, impedes catalase (CAT) activity, and suppresses the generation of reactive oxygen species, while also...
Ethylene glycol dimethacrylate
T78549
Ethylene glycol dimethacrylate, a methacrylate monomer, demonstrates cytotoxic and genotoxic impacts on human gingival fibroblasts (HGFs), elevating intracellula...
Glutathione ethyl ester
T78616
Glutathione ethyl ester, a cell-permeable GSH donor, enhances the in vitro production of embryos by bolstering antioxidative defense, thereby ensuring an effecti...
Cobalt protoporphyrin IX
T78623
Cobalt Protoporphyrin IX serves as a potent, specific inducer of heme oxygenase-1 (HO-1) and demonstrates broad-spectrum antiviral effects against Influenza A vi...
OPC-163493
T78624
OPC-163493 is an orally active, liver-targeted mitochondrial uncoupling agent that diminishes Δψ (delta psi) and mitochondrial ROS (reactive oxygen species) prod...
ROS-IN-2
T78887
ROS-IN-2 (compound 85), a seco-lupane triterpenoid derivative, inhibits reactive oxygen species (ROS) production and shields mitochondria from oxidative damage b...
Apoptosis inducer 13
T79252
Apoptosis Inducer 13 (Compound Ru4) promotes apoptosis in cancer cells while also suppressing their migration and invasion. Additionally, it facilitates the conv...
MCI
T79260
MCI, a chemical compound demonstrating significant anti-inflammatory effects, particularly in collagen-induced arthritis (CIA) models, modulates inflammation thr...
SB-1295
T79287
SB-1295, an orally active CDK9/T1 inhibitor with an IC50 of 0.17 μM, exhibits antiproliferative effects on HCT 116 and MIA PaCa-2 cells. It promotes cell death i...
LZWL02003
T79333
LZWL02003, an anti-neuroinflammatory agent, demonstrates a protective effect on MPP+-induced neuronal damage and reduces ROS expression. Additionally, it enhance...
Anticancer agent 154
T79388
Anticancer agent 154 (Compound 8h) enhances reactive oxygen species production, causing mitochondrial damage, and promotes cell apoptosis and DNA damage. It trig...
Anti-inflammatory agent 47
T79480
Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) and nitric oxide (NO) while inhibiting neur...
ROS inducer 2
T79517
Compound I16 (ROS inducer 2) is a potent inducer of Reactive Oxygen Species (ROS) with an effective concentration (EC 50) of 3.43 μg/mL demonstrated in vitro. It...
ROS inducer 3
T79518
Compound I6 (ROS inducer 3) is a potent ROS inducer with robust in vitro bioactivity, demonstrated by an EC50 of 2.86 μg/mL. It exhibits significant protective a...
Isorabaichromone
T79946
Isorabaichromone exhibits potent antioxidative properties, including DPPH radical and superoxide anion scavenging activities [1].
Piperkadsin A
T79951
Piperkadsin A effectively inhibits reactive oxygen species (ROS) production, specifically targeting PMA-induced ROS in human polymorphonuclear neutrophils, exhib...
AHK
T80026
AHK, a bioactive peptide known for its antioxidant properties, has been employed as a cosmetic ingredient [1].
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TargetMol