ATPase

DHQ (2,3-dihydroxy-quinoxalin) is an inducer of ATPase activity that of Herpes Simplex Virus thymidine kinase.

FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. FCCP is often used as an apoptosis inducer.

Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit

Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.

Licoflavone B has schistosomicidal activity, it showed high S. mansoni ATPase (IC50 of 23.78 μM) and ADPase (IC50 of 31.50 μM) inhibitory activities.

3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs), it inhibits osteoclastogenesis via nuclear factor of activ

Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.

Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.

Thevetin B is a cardiac glycoside and an inhibitor of Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) from Thevetia peruviana.

ATPase-IN-3 is an ATPase (ATPase) inhibitor that can be used in the study of metabolism-related diseases.

Tamoxifen (ICI47699) is a selective and orally effective estrogen receptor modulator (SERM). Tamoxifen has both inhibitory (e.g., mammary cells) and activating (e.g., bone, liver, and uterine cells) activity against estrogens.

Bacopaside II is a potential anti-angiogenic agent, it can reduce endothelial cell migration and tubulogenesis and induce apoptosis.

Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways involved in lipid disorders and carci

Asebogenin is a compound fractionated from Salvia miltiorrhiza with antifungal activity, inhibition of GPVI-induced platelet reactions, and inhibition of NET formation induced by pro-inflammatory stimuli.

Chalepensin, a furanocoumarin isolated from the rutaceae plant Ruta chalepensis L., is a selective CYP2A6 inhibitor, inhibiting CYP1A1, CYP1A2, CYP2A13, CYP2C9, CYP2D6, CYP2E1, and CYP3A4.Chalepensin exhibits Chalepensin j has antiprotozoal activity and inhibits methicillin-resistant Staphylococcus aureus (MRSA) with MIC values in the range of 32-128 μg mL.

8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-car is a H+ K+ ATPase inhibitor with IC50 of 0.38μM.

V-ATPase-IN-1 (Compound 3b-03) is an inhibitor of Vacuolar-type H+-ATPases (V-ATPase), exhibiting an inhibition constant (IC50) of 194.80 μM and effectively targeting the V-ATPase subunit A with a dissociation constant (Kd) of 0.803 μM. This compound demonstrates insecticidal activity against M. separata (LC50 = 2.64 mM), aiding in the development of chemical insecticides.

ATPase-IN-5 (compound 11) is an effective inhibitor of Pma1p-ATPase, with an IC50 value of 12.7 μM. It plays a significant role in antifungal research.

ATPase-IN-2 is a compound that acts as an inhibitor of ATPase, with an IC50 value of 0.9 μM. It also inhibits the glycohydrolase activity of C. difficile toxin B (TcdB) with an AC50 value of 30.91 μM. ATPase-IN-2 is commonly utilized in ATP-related research [1].

RUVBL1 2 ATPase-IN-1 is an effective RUVBL1 2 ATPase inhibitor with IC50 values of 6.0 and 7.7 μM, respectively. RUVBL1 2 ATPase-IN-1 can be used in cancer disease studies.

Compound MS1 (ATPase-IN-4) effectively inhibits the ATPase activity of EHD4, demonstrating an IC 50 of 0.92 μM. It also suppresses the enzymatic activity of EHD2.

Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activity.

PF 03716556 (PF-3716556) , an effective and specific P-CAB (potassium-competitive acid blocker), is utilized for the treatment of gastroesophageal reflux disease.

(S)-PF-03716556 can be used as an acid pump inhibitor for the treatment of disease conditions mediated by acid pump inhibitory activity.