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Search Result

Search Results for " ache "

Targets

AChE NO Synthase AChE

206

Compounds

112

Natural Products

5

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T40335 AChE-IN-3 NO Synthase , AChE
AChE-IN-3 had inhibitory effect on AChE and stronger inhibitory effect on NO, with EC50 of 0.57 μM.
Fr12799 AChE-IN-23
AChE-IN-23 (compound 3h) is an inhibitor of acetylcholinesterase (AChE) with an IC 50 value of 48.3 μM [1].
T77758 AChE/BuChE-IN-4 AChE
AChE/BuChE-IN-4 is a multi-target AChE/BuChE inhibitor with oral activity and blood-brain barrier permeability, with IC50 values of 2.08 and 7.41 μM for AChE and BuChE, respectively.
T9989 AChE-IN-27 Others
AChE-IN-27 is a small molecule used for high-throughput assays.
T62360 AChE-IN-26 AChE
AChE-IN-26 (compound 4a) is an AChE (acetylcholinesterase) inhibitor (IC50: 0.42 μM).
T77352 ACHE Inhibitor 12
ACHE Inhibitor 12 inhibited acetylcholinesterase with an IC50 value of 0.38 µM.
T61969 AChE/BChE-IN-10 AChR , AChE
AChE/BChE-IN-10 is a potent dual inhibitor of AChE and BChE with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 exhibits good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation...
T80671 ACHE-IN-38 5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one Antifungal
ACHE-IN-38 is a potent Acetylcholinesterase inhibitor that can be used for the synthesis of compounds with anti-inflammatory, anti-tumor, and antibacterial activities.
T60891 AChE/BChE/MAO-B-IN-1 MAO , AChE
AChE/BChE/MAO-B-IN-1 is a reversible, non-time-dependent inhibitor of AChE, BChE and MAO-B that crosses the blood-brain barrier and exhibits inhibitory effects on hAChE, hBChE and hMAO-B with IC50s of 7.31, 0.56 and 26.1...
T79553 AChE-IN-34
AChE-IN-34 (compound 5l) is a potent, selective AChE inhibitor exhibiting an IC50 of 3.98 µM and negligible BChE inhibition. It demonstrates mixed-mode inhibition of AChE with a Ki of 0.044 µM using acetylthiocholine sub...
T62728 AChE-IN-24
AChE-IN-24 is a potent inhibitor of AChE that crosses the blood-brain barrier. hAChE is strongly inhibited by AChE-IN-24 (IC50: 0.053 μM). aChE-IN-24 can be used to study Alzheimer's disease (AD).
T61049 AChE-IN-11
AChE-IN-11 (compound 5C) can be used in the Alzheimer's disease research with neuroprotective effects and good antioxidant activity (ORAC = 2.5 eq). AChE-IN-11 is a good multifunctional agent with IC 50 values of 7.9 μM...
T63628 AChE-IN-19
AChE-IN-19 is a potent inhibitor of AChE (IC50: 0.56 μM) and also exhibits inhibition of Aβ aggregation. aChE-IN-19 exhibits neuroprotective effects and is virtually non-toxic to SH-SY5Y cells. aChE-IN-19 can be used to ...
T61845 AChE-IN-21
AChE-IN-21 (Compound I-8) is a highly potent and selective orally active inhibitor of acetylcholinesterase (AChE). It exhibits an impressive inhibitory concentration (IC50) of 2.66 nM. Additionally, AChE-IN-21 demonstrat...
T83186 AChE-IN-42
Compound AChE-IN-42, also known as Compound 28, is an acetylcholinesterase (AChE) inhibitor with an inhibition constant (K i) of 0.44 μM [1].
T83185 AChE-IN-43
AChE-IN-43 is a potent, selective AChE inhibitor with a K i of 0.41 μM, applicable in the study of neurological diseases [1].
T74382 AChE-IN-4
AChE-IN-4 is an acetylcholine esterase inhibitor (AChEI) with an IC50 value of 24.1 μM.
T63307 AChE-IN-6
AChE-IN-6 is an optimal multifunctional ligand that significantly inhibits AChE activity with IC50 values of 0.20 μM and 37.02 nM for EeAChE and HuAChE, respectively, and has anti-Aβ activity (IC50= 1.92 μM for self-indu...
T79583 AChE-IN-36
AChE-IN-36 (compound A4) is an acetylcholinesterase inhibitor with an IC50 of 0.04 μM, influencing ROS levels and modulating the gene expression of NRF2 [1].
T62538 AChE-IN-15
AChE-IN-15 (Compound 3d) is a reversible inhibitor of human acetylcholinesterase (huAChE) and human butyrylcholinesterase (huBChE) with IC50 values of 6.8 μM and 16.1 μM for huAChE and huBChE, respectively, with signific...
T79584 AChE-IN-37
AChE-IN-37 (compound A2) is an acetylcholinesterase inhibitor with an inhibitory concentration (IC50) of 0.23 µM. It alters reactive oxygen species (ROS) levels and modulates the gene expression of nuclear factor erythro...
T83187 AChE-IN-41
AChE-IN-41 (Compound 2), a Galantamine-Memantine hybrid, possesses cholinesterase inhibitory capabilities. This compound demonstrates enhanced plasma stability and similar microsomal stability in vitro but has a reduced ...
T78905 AChE-IN-29
AChE-IN-29, a 3-OH pyrrolidine derivative, acts as a cholinesterase (ChE) inhibitor with potent activity against human acetylcholinesterase (hAChE), electric eel acetylcholinesterase (eeAChE), and equine butyrylcholinest...
T80011 AChE-IN-46
AChE-IN-46 (compound 4), a β-cyclocostunolide, functions as an acetylcholinesterase (AChE) inhibitor [1].
T62590 AChE-IN-25
AChE-IN-25 is a selective, potent, non-competitive inhibitor of acetylcholinesterase (AChE) with an IC50 value of 2.95 μM. AChE-IN-25 can be used to study Alzheimer's disease.
T63938 AChE-IN-20
AChE-IN-20 is a potent inhibitor of AChE (IC50: 397.32 nM, Ki: 335.76 nM). AChE-IN-20 inhibits hCA-I (IC50: 84.14 nM, Ki: 97,86 nM), hCA-II (IC50: 69.24 nM, Ki: 76.23 nM) and α GLY (IC50: 52.08 nM, Ki: 57.93 nM).
T64162 AChE-IN-5
AChE-IN-5 (compound 5) is an orally active, blood-brain barrier-transparent substance with significant in vitro biological activity against AChE/5-HT1A/SERT. IC50: 2.29 nM).
T79251 AChE-IN-30
AChE-IN-30 is an acetylcholinesterase (AChE) inhibitor exhibiting neuroprotective effects with an inhibitory concentration (IC 50) of 4.4 μM. It prevents hydrogen peroxide (H 2 O 2)-induced apoptosis by inhibiting the ac...
T62441 AChE-IN-14
AChE-IN-14 is a potent cholinesterase inhibitor, acting on electric eel acetylcholinesterase (eeAChE) (IC50: 0.46 μM), human recombinant acetylcholinesterase (hAChE) (IC50: 0.48 μM) and equine serum butyrylcholinesterase...
T79554 AChE-IN-35
AChE-IN-35 (compound 5g) serves as an acetylcholinesterase inhibitor, exhibiting an inhibitory concentration 50 (IC50) value of 5.88 μM [1].
T62743 AChE-IN-10
AChE-IN-10 (Compound 24r) is a potent inhibitor of AChE with an IC50 value of 2.4 nM. AChE-IN-10 decreases amyloid aggregation in the presence of AChE. AChE-IN-10 exhibited a potent inhibitory effect on AChE, reducing ta...
T83184 AChE-IN-44
AChE-IN-44 (Compound Tap4), an AChE inhibitor, is convertible into its thiazole salt form known as Tat2 [1].
T62541 AChE-IN-22
AChE-IN-22 (compound 10q) is a selective inhibitor of acetylcholinesterase (AChE) that acts on both AChE (IC50: 0.88 μM) and BuChE (IC50: 10 μM). AChE-IN-22 binds to both the CAS (catalytic active site) and PAS (peripher...
T63990 AChE-IN-12
AChE-IN-12 is a potent inhibitor of acetylcholinesterase (AChE) that crosses the blood-brain barrier (BBB) and acts on rat AChE (IC50: 0.41 μM) and electric eel AChE (IC50: 1.88 μM). AChE-IN-12 significantly inhibited Cu...
T78939 AChE-IN-31
AChE-IN-31 (compound 1), a non-competitive acetylcholinesterase (AChE) inhibitor, exhibits potential for Alzheimer's disease research [1].
T79691 AChE-IN-40
AChE-IN-40 (Compound 5C), with an inhibitory concentration 50 (IC50) of 120 nM, is an acetylcholinesterase (AChE) inhibitor suitable for Alzheimer's disease research [1].
T61648 AChE-IN-8
AChE-IN-8 (Compound 19) is a highly potent inhibitor of acetylcholinesterase (AChE), exhibiting an IC50 value of 1.95 μM. This compound shows promise for further investigation in the research of Alzheimer's disease [1].
T83183 AChE-IN-45
AChE-IN-45 (Compound 14) is an acetylcholinesterase (AChE) inhibitor exhibiting an IC50 value of 11.57±0.45 nM, and it demonstrates both antioxidant and neuroprotective activities [1].
T73245 AChE-IN-9
AChE-IN-9, a Tacrine glycoconjugate connected to acetylated β-Glucose, acts as an AChE inhibitor, demonstrating an IC 50 value of 0.4 μM and exhibiting reduced hepatotoxicity in healthy cells. This compound finds use in ...
T61936 AChE-IN-7
AChE-IN-7 (Compound 16) is a selective and effective acetylcholinesterase inhibitor with IC50 of 0.045 μM and 19.68 μ M for eeAChE and eeBuChE, respectively. AChE-IN-7 has high permeability of blood-brain barrier. AChE-I...
T78817 AChE-IN-39
AChE-IN-39 (Compound 7c), with an IC50 value of 0.058 μM, is an acetylcholinesterase (AChE) inhibitor known for its DPPH scavenging activity and potential to ameliorate cognitive impairments in an aluminum chloride (AlCl...
T60721 AChE/BChE-IN-5
AChE/BChE-IN-5 (BMC-16) is an AChE and BChE dual inhibitor that can cross the BBB. The IC 50 values of AChE/BChE-IN-5 for human AChE (hAChE) and human BChE (hBChE) are 266 nM and 10.6 nM , respectively [1].
T72874 SEH/AChE-IN-2
sEH/AChE-IN-2 and acetylcholinesterase ( AChE ). sEH/AChE-IN-2 provides cumulative effects against neuroinflammation and memory impairment. sEH/AChE-IN-2 has the potential for the research of Alzheimer's disease (AD) .
T60529 AChE/BChE-IN-3
AChE/BChE-IN-3 (BMC-1) is an AChE and BChE dual inhibitor with IC 50 values of 6.08 μM for electric eel AChE (elAChE) and 0.383 μM for equine serum BChE (eqBChE), respectively [1].
T72892 AChE/MAO-IN-1
AChE/MAO-IN-1 is a potent inhibitor of human acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), and monoamine oxidase B (MAO-B), demonstrating inhibitory concentrations (IC50) of 0.0248 μM, 0.0409 μM, and 0.1108 μ...
T61620 AChE/PDE4-IN-1
AChE/PDE4-IN-1 (compound 12c) is a highly effective and specific dual inhibitor of PDE4 and AChE, with IC50 values of 0.28 μM and 1.88 μM for AChE and PDE4D, respectively. This compound demonstrates notable potential in ...
T79548 AChE/BChE-IN-13
AChE/BChE-IN-13 (compound 5j) serves as a potent dual inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting half-maximal inhibitory concentrations (IC50) of 20.89 μM for AChE and 17.3...
T72875 SEH/AChE-IN-3
sEH/AChE-IN-3 (15) serves as a dual inhibitor targeting both soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE), demonstrating potent activity and the ability to cross the blood-brain barrier (BBB). It exhib...
T79966 AChE/BChE-IN-14
AChE/BChE-IN-14 (compound 13), a benzylisoquinoline alkaloid extracted from Fissistigma polyanthum roots, demonstrates inhibitory effects on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), coupled with...
T72763 AChE/BuChE-IN-1
AChE/BuChE-IN-1, a selective butyrylcholinesterase (BuChE) inhibitor derived from chrysin, exhibits a potent efficacy with an IC50 of 0.48 μM against BuChE and a lesser inhibitory effect on acetylcholinesterase (AChE) wi...

Compounds

AChE-IN-3
T40335
Synonym:
Target: NO Synthase, AChE
AChE-IN-23
Fr12799
Synonym:
Target:
AChE/BuChE-IN-4
T77758
Synonym:
Target: AChE
AChE-IN-27
T9989
Synonym:
Target: Others
AChE-IN-26
T62360
Synonym:
Target: AChE
ACHE Inhibitor 12
T77352
Synonym:
Target:
AChE/BChE-IN-10
T61969
Synonym:
Target: AChR, AChE
ACHE-IN-38
T80671
Synonym: 5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one
Target: Antifungal
AChE/BChE/MAO-B-IN-1
T60891
Synonym:
Target: MAO, AChE
AChE-IN-34
T79553
Synonym:
Target:
AChE-IN-24
T62728
Synonym:
Target:
AChE-IN-11
T61049
Synonym:
Target:
AChE-IN-19
T63628
Synonym:
Target:
AChE-IN-21
T61845
Synonym:
Target:
AChE-IN-42
T83186
Synonym:
Target:
AChE-IN-43
T83185
Synonym:
Target:
AChE-IN-4
T74382
Synonym:
Target:
AChE-IN-6
T63307
Synonym:
Target:
AChE-IN-36
T79583
Synonym:
Target:
AChE-IN-15
T62538
Synonym:
Target:
AChE-IN-37
T79584
Synonym:
Target:
AChE-IN-41
T83187
Synonym:
Target:
AChE-IN-29
T78905
Synonym:
Target:
AChE-IN-46
T80011
Synonym:
Target:
AChE-IN-25
T62590
Synonym:
Target:
AChE-IN-20
T63938
Synonym:
Target:
AChE-IN-5
T64162
Synonym:
Target:
AChE-IN-30
T79251
Synonym:
Target:
AChE-IN-14
T62441
Synonym:
Target:
AChE-IN-35
T79554
Synonym:
Target:
AChE-IN-10
T62743
Synonym:
Target:
AChE-IN-44
T83184
Synonym:
Target:
AChE-IN-22
T62541
Synonym:
Target:
AChE-IN-12
T63990
Synonym:
Target:
AChE-IN-31
T78939
Synonym:
Target:
AChE-IN-40
T79691
Synonym:
Target:
AChE-IN-8
T61648
Synonym:
Target:
AChE-IN-45
T83183
Synonym:
Target:
AChE-IN-9
T73245
Synonym:
Target:
AChE-IN-7
T61936
Synonym:
Target:
AChE-IN-39
T78817
Synonym:
Target:
AChE/BChE-IN-5
T60721
Synonym:
Target:
sEH/AChE-IN-2
T72874
Synonym:
Target:
AChE/BChE-IN-3
T60529
Synonym:
Target:
AChE/MAO-IN-1
T72892
Synonym:
Target:
AChE/PDE4-IN-1
T61620
Synonym:
Target:
AChE/BChE-IN-13
T79548
Synonym:
Target:
sEH/AChE-IN-3
T72875
Synonym:
Target:
AChE/BChE-IN-14
T79966
Synonym:
Target:
AChE/BuChE-IN-1
T72763
Synonym:
Target:
1 2 3 4 5
Cat No. Product Name Synonyms Targets
T75544 AChE/BChE-IN-11
AChE/BChE-IN-11 (compound 1), a natural product derived from artichoke leaves, is a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 70 μM for AChE and 71 μM for BChE, re...
TN1899 Lycoramine AChE
Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
TN1858 Leptomerine AChE
Leptomerine (IC50 = 2.5 mM) shows potent anticholinesterasic activity.
Fr14127 Coumaran 2,3-Dihydrobenzofuran Endogenous Metabolite , AChE
Coumaran (2,3-Dihydrobenzofuran) is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L. camara. Coumaran(2,3-Dihydrobenzofuran) can be used as a biopesticide. 2,3-dihydrobenzofuran is a member of the clas...
TN3500 Beta-Amyrone β-Amyron COX , AChR , PPAR , Antifection
beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM. beta-Amyrone has anti-inflammatory activity through inhibiting the expression of COX-2. beta-Amyrone exhibits a...
T2S1200 Sinapine Antioxidant , P-gp , AChE
1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities.
TN2298 Vincosamide AChE
Vincosamide is an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity. Vincosamide can effect relaxation of the supercoiled pBR322 plasmid DNA in ...
T3392 Sinapine thiocyanate P-gp , AChE
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-o...
T4852 Trimyristin Trimyristoylglycerol,Tritetradecanoin,Glyceryl trimyristate,1,2,3-Tritetradecanoylglycerol Phosphatase , Endogenous Metabolite , AChE
Trimyristin (Tritetradecanoin) is primarily located in the membrane (predicted from logP) and adiposome. glyceryl trimyristate exists in all eukaryotes, ranging from yeast to humans. In humans, glyceryl trimyristate is i...
TN1653 Fustin ERK , Beta Amyloid , AChR
Fustin is the phytogenic flavanol component of the plant Rhus verniciflua Stokes. Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
TN4675 Nortrachelogenin (-)-Wikstromol,(-)-Nortrachelogenin Apoptosis , Antifungal
Nortrachelogenin ((-)-Wikstromol), which can be extracted from Partrinia scabiosaefolia, has antifungal activity and induces membrane disruption and cysteinyl asparagin-dependent apoptosis.
TC0014 Trachelanthine Others
Trachelanthine is a natural product from Eupatorium fortunei.
TN4673 (+)-Nortrachelogenin Wikstromol Apoptosis , HIV Protease , PI3K , Antifection
(+)-Nortrachelogenin is a lignan isolated from Wikstroemia indica C.A. Meyer (Thymelaeaceae). (+)-Nortrachelogenin possesses antileukemic activity.
T3855 Tracheloside Estrogen Receptor/ERR , Phosphorylase
Tracheloside significantly decreases the activity of alkaline phosphatase (IC50: 0.31 μg/ml), a level of inhibition comparable to that of tamoxifen (IC50: 0.43 μg/ml).
TN4674 Nortrachelogenin-8'-O-beta-glucoside Others
Nortrachelogenin-8'-O-beta-glucoside is a lignan with a diarylhydroxybutyrolactone skeleton which isolated from the leaves and stems of Trachelospermum jasminoides (Lindl.) Lem.
TN6508 Trachelogenin (-)-Trachelogenin Virus Protease , c-Myc , HCV Protease , Wnt/beta-catenin
Trachelogenin ((-)-Trachelogenin), isolated from Combretum fruticosum, is an HCV entry inhibitor with anti-proliferative effects. Its mechanism is related to affecting the phosphorylation of key proteins such as β-Cateni...
TN7058 Dihydrolapachenole 6-methoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene Others
Dihydrolapachenole (6-methoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene) can be isolated from T. chrysantha.
TN3974 Epinortrachelogenin Others
Epinortrachelogenin is a natural product of Cephalotaxus, Cephalotaxaceae. The catalog number is TN3974 and the CAS number is 125072-69-7. Epinortrachelogenin can be used as a reference standard.
TN6543 Trachelogenin 4'-O-beta-gentiobioside
Trachelogenin 4'-O-beta-gentiobioside is a natural product for research related to life sciences. The catalog number is TN6543 and the CAS number is 106647-13-6.
TN5158 Trachelanthamine Others
Trachelanthamine is a natural product from Eupatorium fortunei.
TN5159 Trachelosiaside Others
Trachelosiaside shows moderate activity against lipoxygenase.
T40810 Rachelmycin NSC298223,CC-1065
Rachelmycin (CC-1065; NSC 298223) is a potent naturally antibiotic isolated from Streptomyces zelensis . Rachelmycin binds non-covalently and covalently (N-3 adenine adduct) in the minor groove of B-form DNA. Rachelmycin...
TMA1065 Nortracheloside Others
Nortracheloside is a natural product of Trachelospermum, Apocynaceae. The catalog number is TMA1065 and the CAS number is 33464-78-7. Nortracheloside can be used as a reference standard.
TN3513 Bis-5,5-nortrachelogenin Others
Bis-5,5-nortrachelogenin has anti-allergic activity, it inhibited NO production with IC50 value of 48.6 microM.
T81650 Nortrachelogenin 4'-O-β-gentiobioside
Nortrachelogenin 4'-O-β-gentiobioside (compound 20) is a lignan extracted from the aerial components of Trachelospermum [1].
T83286 5-Methoxytracheloside
5-Methoxytracheloside, a lignan lactone, is isolated from the stems and leaves of Trachelospermum jasminoides [1].
TN6509 Nortrachelogenin-5'-C-beta-glucoside
Nortrachelogenin-5'-C-beta-glucoside is a natural product of Trachelospermum, Apocynaceae. The catalog number is TN6509 and the CAS number is 858127-39-6. Nortrachelogenin-5'-C-beta-glucoside can be used as a reference s...
TN6786 O-Desmethyl Galanthamine Sanguinine AChE
O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid and it is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM.
T9862 Pseudocoptisine chloride Isocoptisine chloride AChE
Pseudocoptisine chloride (Isocoptisine chloride) is isolated from Corydalis Tuber with anti-inflammatory and anti-amnestic properties. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity (IC50 = 12.8 μ...
TN1527 (-)-Corynoxidine Corynoxidine Antibacterial , AChE , Antifection
(-)-Corynoxidine is an AChE inhibitor derived from tubers of Stephania succifera. Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus strains in di...
T4S1725 Galanthamine Galantamine Apoptosis , AChE
Galanthamine (Galantamine) is an acetylcholinesterase (AChE)inhibitor(IC50 : 500 nM), can reduce brain damage induced by hypoxia-ischemia.
T0086 Galanthamine hydrobromide Galantamine hydrobromide,Galanthamine HBr AChR , AChE
Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
T2846 Isoimperatorin Antibacterial , AChE
Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE).
T13301 Violanthin AChE
Violanthin is a natural product isolated from the aerial parts of Piper bavinum and inhibits acetylcholinesterase (AChE) (IC50: 79.80 μM). It has potent antioxidant and antibacterial activities.
TN6783 Corysamine chloride CORYSAMINE CHLORIDE(RG) AChE
Corysamine chloride (CORYSAMINE CHLORIDE(RG)) was identified to inhibit the activity of ACHE.
TN1030 N-p-trans-Coumaroyltyramine AChE , Parasite
N-p-trans-Coumaroyltyramine is a natural product, is an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC50 of 13.3 μM for T. bruc...
T5S1025 Picfeltarraenin IA Picfeltarraenin A AChE
1. Picfeltarraenin IA (Picfeltarraenin A), IB, IV, X, XI are stronger AChE inhibitions than the known AChE inhibitor Tacrine.
T11351 Galanthamine N-Oxide AChE
Galanthamine N-Oxide, an alkaloid extracted from Zephyranthes concolor bulbs, effectively inhibits acetylcholinesterase (AChE) from electric eel with an EC50 of 26.2 μM. It acts as a significant inhibitor of substrate ac...
TN1799 Isorubrofusarin-6-O-β-gentiobioside Isorubrofusarin 10-gentiobioside BACE , AChR
Isorubrofusarin-6-O-β-gentiobioside is derived from from Cassia obtusifolia Linn seeds and shows promising inhibitory activity against AChE and BACE1.
TN2443 Chikusetsusaponin Ib Chikusetsu saponin Ib AChE
Chikusetsusaponin Ib (Chikusetsu saponin Ib) is an inhibitor of AChE and can be used in studies about anti-Alzheimer's diseases.
TN1589 Dihydrowithaferin A AChE
Dihydrowithaferin A is a withanolide isolated from Withania somnifera with activity against acetylcholinesterase (AChE). Dihydrowithaferin A in the diet may prevent or decrease the growth of tumors.
T5721 Dehydroevodiamine hydrochloride AChE
Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.
TN2130 Manghaslin Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside AChE , Glucosidase
Manghaslin (Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside) has considerable α-glucosidase inhibitory activity, illustrating the anti-diabetic potential of phenolic-rich litchi pulp extracts. Manghaslin also shows inhibito...
T13681 Epi-galantamine AChE
Epi-galantamine, a diastereomer of galantamine, is an alkaloid extracted from the bulbs and flowers of the Caucasian snowdrop (Galanthus woronowii). It acts as an AChE inhibitor, featuring an EC50 of 45.7 μM.
T3026 (-)-Huperzine A HupA,Huperzine A Apoptosis , AChR , AChE , iGluR
(-)-Huperzine A (HupA) , an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the tr...
TN1673 Garcinone C ATM/ATR , CDK , STAT , AChR , Antifection
Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcinone C is an AChE inhibitor and has potential cytotoxic effe...
Fr16605 Lupinine AChR , AChE
Lupinine is an alkaloid capable of counteracting ethanol anesthesia. Lupinine is an AChE and BChE inhibitor and potential CD69 activator found in species of Loranthus, Calia, and Lupinus. It may also inhibit heparin.
T11366 Garcinol Apoptosis , Endogenous Metabolite , Histone Acetyltransferase , AChR , AChE
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone...
TN6919 Methyl tridecanoate Beta Amyloid , AChE
Methyl tridecanoate is a natural product.
T22464 1,2-Dimyristoyl-sn-glycerol 1,2-DMG Others , PKC
1,2-Dimyristoyl-sn-glycerol (1,2-DMG) is able to increase AChE activity by 35-40% at concentrations of 25 micrograms/ml in the parasite S. mansoni..
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Natural Products

AChE/BChE-IN-11
T75544
Synonym:
Target:
Lycoramine
TN1899
Synonym:
Target: AChE
Leptomerine
TN1858
Synonym:
Target: AChE
Coumaran
Fr14127
Synonym: 2,3-Dihydrobenzofuran
Target: Endogenous Metabolite, AChE
beta-Amyrone
TN3500
Synonym: β-Amyron
Target: COX, AChR, PPAR, Antifection
Sinapine
T2S1200
Synonym:
Target: Antioxidant, P-gp, AChE
Vincosamide
TN2298
Synonym:
Target: AChE
Sinapine thiocyanate
T3392
Synonym:
Target: P-gp, AChE
Trimyristin
T4852
Synonym: Trimyristoylglycerol,Tritetradecanoin,Glyceryl trimyristate,1,2,3-Tritetradecanoylglycerol
Target: Phosphatase, Endogenous Metabolite, AChE
Fustin
TN1653
Synonym:
Target: ERK, Beta Amyloid, AChR
Nortrachelogenin
TN4675
Synonym: (-)-Wikstromol,(-)-Nortrachelogenin
Target: Apoptosis, Antifungal
Trachelanthine
TC0014
Synonym:
Target: Others
(+)-Nortrachelogenin
TN4673
Synonym: Wikstromol
Target: Apoptosis, HIV Protease, PI3K, Antifection
Tracheloside
T3855
Synonym:
Target: Estrogen Receptor/ERR, Phosphorylase
Nortrachelogenin-8'-O-beta-glucoside
TN4674
Synonym:
Target: Others
Trachelogenin
TN6508
Synonym: (-)-Trachelogenin
Target: Virus Protease, c-Myc, HCV Protease, Wnt/beta-catenin
Dihydrolapachenole
TN7058
Synonym: 6-methoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene
Target: Others
Epinortrachelogenin
TN3974
Synonym:
Target: Others
Trachelogenin 4'-O-beta-gentiobioside
TN6543
Synonym:
Target:
Trachelanthamine
TN5158
Synonym:
Target: Others
Trachelosiaside
TN5159
Synonym:
Target: Others
Rachelmycin
T40810
Synonym: NSC298223,CC-1065
Target:
Nortracheloside
TMA1065
Synonym:
Target: Others
Bis-5,5-nortrachelogenin
TN3513
Synonym:
Target: Others
Nortrachelogenin 4'-O-β-gentiobioside
T81650
Synonym:
Target:
5-Methoxytracheloside
T83286
Synonym:
Target:
Nortrachelogenin-5'-C-beta-glucoside
TN6509
Synonym:
Target:
O-Desmethyl Galanthamine
TN6786
Synonym: Sanguinine
Target: AChE
Pseudocoptisine chloride
T9862
Synonym: Isocoptisine chloride
Target: AChE
(-)-Corynoxidine
TN1527
Synonym: Corynoxidine
Target: Antibacterial, AChE, Antifection
Galanthamine
T4S1725
Synonym: Galantamine
Target: Apoptosis, AChE
Galanthamine hydrobromide
T0086
Synonym: Galantamine hydrobromide,Galanthamine HBr
Target: AChR, AChE
Isoimperatorin
T2846
Synonym:
Target: Antibacterial, AChE
Violanthin
T13301
Synonym:
Target: AChE
Corysamine chloride
TN6783
Synonym: CORYSAMINE CHLORIDE(RG)
Target: AChE
N-p-trans-Coumaroyltyramine
TN1030
Synonym:
Target: AChE, Parasite
Picfeltarraenin IA
T5S1025
Synonym: Picfeltarraenin A
Target: AChE
Galanthamine N-Oxide
T11351
Synonym:
Target: AChE
Isorubrofusarin-6-O-β-gentiobioside
TN1799
Synonym: Isorubrofusarin 10-gentiobioside
Target: BACE, AChR
Chikusetsusaponin Ib
TN2443
Synonym: Chikusetsu saponin Ib
Target: AChE
Dihydrowithaferin A
TN1589
Synonym:
Target: AChE
Dehydroevodiamine hydrochloride
T5721
Synonym:
Target: AChE
Manghaslin
TN2130
Synonym: Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside
Target: AChE, Glucosidase
Epi-galantamine
T13681
Synonym:
Target: AChE
(-)-Huperzine A
T3026
Synonym: HupA,Huperzine A
Target: Apoptosis, AChR, AChE, iGluR
Garcinone C
TN1673
Synonym:
Target: ATM/ATR, CDK, STAT, AChR, Antifection
Lupinine
Fr16605
Synonym:
Target: AChR, AChE
Garcinol
T11366
Synonym:
Target: Apoptosis, Endogenous Metabolite, Histone Acetyltransferase, AChR, AChE
Methyl tridecanoate
TN6919
Synonym:
Target: Beta Amyloid, AChE
1,2-Dimyristoyl-sn-glycerol
T22464
Synonym: 1,2-DMG
Target: Others, PKC
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Recombinant Proteins

Species：
Human (2)
Mouse (1)
Rat (1)
cockroaches (1)
Expression System：
E. coli (3)
HEK293 (1)
P. pastoris (1)
Tag：
C-6His (1)
His (1)
N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged (1)
N-terminal 6xHis-tagged (1)
Tag Free (1)
Cat No. Product Name Species Expression System
TMPH-03234 Acetylcholinesterase Protein, Rat, Recombinant (His) Rat E. coli
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
TMPY-06677 Bla g 4 Protein, cockroaches, Recombinant cockroaches P. pastoris
TMPY-01742 Acetylcholinesterase Protein, Mouse, Recombinant (His) Mouse HEK293
Acetylcholinesterase, also known as ACHE, is an enzyme that degrades (through its hydrolytic activity) the neurotransmitter acetylcholine, producing choline and an acetate group. Acetylcholinesterase plays a crucial role...
TMPJ-00695 CuTA Protein, Human, Recombinant (His) Human E. coli
Protein CutA (CUTA) posseses a signal peptide and is widely expressed in brain. CUTA mayforms part of a complex of membrane proteins attached to acetylcholinesterase (AChE). CUTA takes part in cellular tolerance to a bro...
TMPH-01282 ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO) Human E. coli
RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in th...
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