10a

N-Methylbenzamide is a potent inhibitor of phosphodiesterase 10A (PDE10A) with demonstrated anti-cancer activity.

(R)-JAK2/STAT3-IN-10a is the R-isomer of JAK2/STAT3-IN-1.JAK2/STAT3-IN-1 is a GP130 D1 structural domain inhibitor with antitumor activity that inhibits the phosphorylation of JAK2 and STAT3. The KD value of (R)-JAK2/STAT3-IN-1 on GP130 protein is 3.8 μM.

9(R)-Δ6a,10a-THC is structurally similar to the known plant cannabinoids and may be an impurity or degradation product in Δ9-THC preparations.

ZLD10A is a highly potent and selective small molecule inhibitor of EZH2.

10alpha-Hydroxyepigambogic acid is a useful organic compound for research related to life sciences and the catalog number is T126303.

9R-10alpha-Hydroxyepigambogic acid is a useful organic compound for research related to life sciences and the catalog number is T126415.

ERD-12310A targets the estrogen receptor α (ERα) as a PROTAC with an ED50 value of 47 pM and possesses oral bioavailability.

PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.

ST7710AA1 is a PARP-1 inhibitor that acts by showing significant in vitro target inhibition and capability to substantially bypass the multidrug resistance mediated by Pgp.

PDE10A-IN-8 is a potent inhibitor of PDE10A.

SW2_110A is a cell-permeable, selective chromosome group 8 chromosome domain (CBX8 ChD) inhibitor with a Kd of 800 nM. In vitro, SW2_110A is 5-fold more selective for CBX8 ChD than all other CBX enantiomers.

SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD). SW2_110A acetate has a high affinity for CBX8N, inhibits the association between CBX8 and cell chromatin, and inhibits the proliferation of ML-AF9-induced THP1 leukemia cells.

(6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T67021 and the CAS number is 313369-26-5.

(6bR,10aS)-Ethyl 3-methyl-2-oxo-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T67022 and the CAS number is 313369-25-4.

(6bR,10aS)-3-Methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline is a useful organic compound for research related to life sciences. The catalog number is T67023 and the CAS number is 313368-85-3.

Anti-Mouse TCR V gamma 2 Antibody is an inhibitory IgG antibody derived from Armenian Hamster, targeting mouse TCR V gamma 2.

(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3), a palmitate derivative extracted from the root of Salvia miltiorrhiza, exhibits anti-cancer properties with DC50s of 25.5 μg mL against HeLa, 37.5 μg mL against HepG2, and 30.2 μg mL against OVCAR-3 human cancer cell lines [1].

GW759710A is a FLuc inhibitor (IC50: 0.73 μM) [1].

JC-010a is a selective allosteric inhibitor of SHP2 that inhibits the proliferation of cancer cells and can be utilized for cancer research [1].

Compound 8a (PDE10A-IN-3) serves as an inhibitor of phosphodiesterase 10A (PDE10A) and is utilized in schizophrenia research [1].

Anti-CCR8 Antibody (10A11) is a humanized IgG1 monoclonal antibody targeting CCR8.

Anti-Mouse TIGIT Antibody (10A7) is a monoclonal antibody of the mouse IgG2 subclass that targets TIGIT.

Cyclosporin A is a natural product and an active fungal metabolite, classified as a cyclic polypeptide immunosuppressant. It binds to cyclophilin and inhibits the activity of calcineurin (IC₅₀ = 7 nM) as well as CD11a/CD18 adhesion molecules. It is commonly used to induce uremia models.

Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner. Erastin has anti-tumor activity and acts selectively on tumor cells with RAS-carcinogenic mutations.