10a

PDE10A-IN-8 is a potent inhibitor of PDE10A.

ZLD10A is a highly potent and selective small molecule inhibitor of EZH2.

9(R)-Δ6a,10a-THC is structurally similar to the known plant cannabinoids and may be an impurity or degradation product in Δ9-THC preparations.

N-Methylbenzamide is a potent inhibitor of phosphodiesterase 10A (PDE10A) with demonstrated anti-cancer activity.

PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.

(4E)-2-[4-(acetyloxy)-5-hydroxy-2-(2-hydroxypropan-2-yl)-7-methoxy-4a,10a-dimethyl-6,9-dioxo-2,3,4,4a,4b,5,6,9,10a,11,12,12a-dodecahydro-1,10-dioxatetraphen-8-yl]-4-methylhex-4-en-3-yl acetate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-(acetyloxy)-6-hydroxy-10a-methoxy-4,4,7,11b-tetramethyl-9-oxo-1H,2H,3H,4H,4aH,5H,6H,6aH,7H,9H,10aH,11H,11aH,11bH-phenanthro[3,2-b]furan-5-yl acetate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(4E)-2-[4-(acetyloxy)-6,9-dihydroxy-2-(2-hydroxypropan-2-yl)-4a,10a-dimethyl-5-oxo-2,3,4,4a,4b,5,10a,11,12,12a-decahydro-1,10-dioxatetraphen-8-yl]-4-methylhex-4-en-3-yl acetate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(4E)-2-[4-(acetyloxy)-5-hydroxy-2-(2-hydroxypropan-2-yl)-4a,10a-dimethyl-6,9-dioxo-2,3,4,4a,4b,5,6,9,10a,11,12,12a-dodecahydro-1,10-dioxatetraphen-8-yl]-4-methylhex-4-en-3-yl acetate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

5,6-bis(benzoyloxy)-3,4a-dihydroxy-10a-methoxy-4,7,11b-trimethyl-9-oxo-1H,2H,3H,4H,4aH,5H,6H,6aH,7H,9H,10aH,11H,11aH,11bH-phenanthro[3,2-b]furan-4-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).

Lumisterol 3 (9β,10α-Cholesta-5,7-dien-3β-ol) is a sterol metabolite and a photosensitised isomer derivative of vitamin D3. It activates Nrf2 and p53 and protects keratinocytes from UVB-induced damage.

Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C, with Kds of 2.7, 20, 0.14, and 6 nM, respectively.

(R)-JAK2/STAT3-IN-10a is the R-isomer of JAK2/STAT3-IN-1.JAK2/STAT3-IN-1 is a GP130 D1 structural domain inhibitor with antitumor activity that inhibits the phosphorylation of JAK2 and STAT3. The KD value of (R)-JAK2/STAT3-IN-1 on GP130 protein is 3.8 μM.

PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.

Compound 8a (PDE10A-IN-3) serves as an inhibitor of phosphodiesterase 10A (PDE10A) and is utilized in schizophrenia research [1].

9R-10alpha-Hydroxyepigambogic acid is a useful organic compound for research related to life sciences and the catalog number is T126415.

9-hydroxy-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2,6-dihydroxy-1,1,7-trimethyl-1,2,3,9,10,10a-hexahydrophenanthren-3-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

2-{4a,9,10a-trihydroxy-1-methyl-5,10-dioxo-1H,3H,4H,4aH,5H,10H,10aH-naphtho[2,3-c]pyran-3-yl}acetic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

methyl 2-{4a,6,10a-trihydroxy-1-methyl-5,10-dioxo-1H,3H,4H,4aH,5H,10H,10aH-naphtho[2,3-c]pyran-3-yl}acetate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

7-ethenyl-1,4a,7-trimethyl-1,2,3,4,4a,6,7,8,8a,9,10,10a-dodecahydrophenanthrene-1-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

7-ethenyl-1,4a,7-trimethyl-6-oxo-1,2,3,4,4a,6,7,8,8a,9,10,10a-dodecahydrophenanthrene-1-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

ERD-12310A targets the estrogen receptor α (ERα) as a PROTAC with an ED50 value of 47 pM and possesses oral bioavailability.