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DNA Damage/DNA Repair Topoisomerase

Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.
Cat No. product name
T1020 Doxorubicin hydrochlorideHOT Doxorubicin intercalation between base pairs in the DNA helix, thereby preventing DNA replication. It also inhibits topoisomerase II.
T0132 EtoposideHOT Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50: 60.3 μM).
T9088 Topovale Topovale is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM ...
T0425 Pefloxacin Mesylate Pefloxacin mesylate is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.
T1121 Podophyllotoxin Podophyllotoxin is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, ...
T1166 Ellipticine Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.49±...
T3181 SW044248 SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.
T0125 Epirubicin hydrochloride Epirubicin hydrochloride is an antineoplastic agent which can inhibit Topoisomerase.
T6010 Idarubicin HCl Idarubicin HCl, a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).
T1521 Hydroxy Camptothecine Hydroxy Camptothecine is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzym...
T6588 Mitoxantrone Mitoxantrone is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA rep...
T3339 Sophoridine Sophoridine, a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and ev...
T6336 Amonafide Amonafide(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA c...
T1306 Norfloxacin Norfloxacin(Norxacin) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
T2830 Betulinic acid Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretrov...
T0158 Mitoxantrone hydrochloride Mitoxantrone Hydrochloride is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor.
T6628 Pirarubicin Pirarubicin is an anthracycline antibiotic. It is also a DNA/RNA synthesis inhibitor that intercalates into DNA and interacts with topoisomerase II, utilized as ...
T0717L Enoxacin Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
T3481 Bimolane Bimolane is a topoisomerase II inhibitor.
T1123 (S)-(+)-Camptothecin (S)-(+)-Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I), isolated from Camptotheca acuminata.
T1294 Fleroxacin Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.
T0902 Ofloxacin Ofloxacin is a fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzym...
T0717 Enoxacin Sesquihydrate Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
T1640 Ciprofloxacin Ciprofloxacin, a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram-p...
T1703 SN38 SN-38 is an active metabolite of CPT-11.
T0250 Ciprofloxacin hydrochloride Ciprofloxacin hydrochloride is a broad-spectrum antimicrobial carboxyfluoroquinoline.
T1206 Amsacrine Amsacrine (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells. Amsacrine also expresses topoisomerase inhibitor activity, specifica...
T0909 Nalidixic acid Nalidixic acid is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA ...
T1060 Flumequine Flumequine is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II ...
T6467 Dexrazoxane HCl Dexrazoxane HCl is a cardio-protective drug.
T6567 Levofloxacin Levofloxacin is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdo...
T1095 Sparfloxacin Sparfloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.
T1293 Gatifloxacin Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase ...
T3117 Marbofloxacin Marbofloxacin is an effective, broad-spectrum antibiotic of bacterial, which inhibits DNA replication.
T1174 Topotecan hydrochloride Topotecan hydrochloride is an antineoplastic agent used to treat ovarian cancer.
T2160 Suramin Sodium Salt Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various gro...
T0486 Irinotecan hydrochloride trihydrate Irinotecan HCl-trihydrate keeps DNA from unwinding by inhibiting topoisomerase 1.
T1451 Levofloxacin Hemihydrate Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxaci...
T2394 Pixantrone dimaleate Pixantrone dimaleate (BBR 2778 dimaleate) is an experimental antineoplastic drug.
T0974 Novobiocin Sodium Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveu...
T0425L Pefloxacin Mesylate Dihydrate Pefloxacin mesylate dehydrate, an antibacterial agent, restrains bacterial DNA replication by inhibiting DNA gyrase (topoisomerase).
T1444 Lomefloxacin Lomefloxacin is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.
T3186 NU2058 NU2058 is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
T1620 Pazufloxacin Mesylate Pazufloxacin (INN) is a fluoroquinolone antibiotic.
T6724 Voreloxin Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
T0331 Moxifloxacin hydrochloride Moxifloxacin is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria as well as atypical pathogens. Moxifloxacin has been li...
T2764 10-Hydroxycamptothecin 10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.
T1492 Gemifloxacin mesylate Gemifloxacin mesylate inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. Gemifloxacin Me...
T1456 Doxorubicin Doxorubicin is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
T0274 Cinoxacin Cinoxacin, an older synthetic antimicrobial, was related to the quinolone class of antibiotics. Its activity was similar to oxolinic acid and nalidixic acid.
T1523 Teniposide Teniposide, a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.
T0909L Nalidixic acid sodium salt Nalidixic acid sodium salt is an antimicrobial agent with a limited bacteriocidal spectrum.
T6228 Irinotecan Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the actio...
T1625 Lomefloxacin hydrochloride Lomefloxacin hydrochloride inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhi...
T8747 Levofloxacin hydrochloride Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxac...
T22456 Voreloxin hydrochloride Voreloxin hydrochloride is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.
T14953 Chloroquinoxaline sulfonamide Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
T15054 Daun02 Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
T11249L Dxd Dxd (Exatecan derivative for ADC) is a potent inhibitor of DNA topoisomerase I (IC50: 0.31 μM). It is used as a conjugated drug of HER2-targeting ADC.
T15200 Edotecarin Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
T13231 Trovafloxacin Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.
T15578 Indotecan Indotecan is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).
T11090L Aldoxorubicin Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubi...
T15586 Intoplicine Intoplicine is an inhibitor of DNA topoisomerase I and II.
T16286 Neu2000 Neu2000 is an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptor.
T16726 Rebeccamycin Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase...
TN2464 Eleutherin Eleutherin is a natural product from Eleutherine americana
T14703 Karenitecin Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
TN2953 3-Hydroxysarpagine Standard reference
TN4107 Ganoderic acid X Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
TN4172 Guajadial B Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines,...
TN4173 Guajadial C Guajadial C acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. It shows cytotoxicity against five human cancer cell lines.
TN4283 Isodiospyrin Isodiospyrin is a novel human DNA topoisomerase I inhibitor, it exhibits cytotoxic activity to tumor cell lines. Isodiospyrin has antibacterial activity, the min...
TN4422 Lauterine Lauterine is a DNA topoisomerase inhibitor.
TN4660 Niranthin Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitiv...
TN4923 Rubicordifolin Rubicordifolin exhibits potent cytotoxic and antitumor activities.
TN5133 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone 5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it s...
TN5190 Tryprostatin A Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mamm...
T8333 Aurintricarboxylic acid Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing ...
T14945 CH-0793076 CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast ca...
TN2105 Proscillaridin A Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
T4047 Bisantrene Bisantrene is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA sing...
T7551 Belotecan hydrochloride Belotecan hydrochloride is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity
T7048 1,4-Naphthoquinone 1, 4-Naphthoquinone was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities[2]. It was also used to inhibit the acetyltransferase...
T4614 Ellipticine hydrochloride Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
T4952 10-Hydroxycampothecin 10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.
T5394 Prulifloxacin Prulifloxacin is a broad-spectrum fluoroquinolone antibiotic. It Inhibits bacterial DNA synthesis by inhibiting the activity of bacterial DNA topoisomerase II an...
T5784 Topotecan Topotecan is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.
T5S1952 9-Methoxycamptothecin 9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.
T5820 Amsacrine hydrochloride Amsacrine hydrochloride  is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.
T5853 Rubitecan Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentrat...
T7309 TAS-103 (dihydrochloride) TAS-103 (dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.
T7187 Genz-644282 Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.
TQ0049 MC-DOXHZN hydrochloride MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin. Doxorubicin is a DNA topoisomerase II inhibitor.
TN2105 Proscillaridin A Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
TQ0063 Zoliflodacin Zoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-posit...
TQ0088 Exatecan Mesylate Exatecan Mesylate is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).
TQ0134 Podocarpusflavone A Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.
T3S1957 9-Aminocamptothecin 9-Aminocamptothecin is an inhibitor of topoisomerase I with potent anticancer activity.
TN1037 Groenlandicine Groenlandicine is a protoberberine alkaloid from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human reco...
TN1169 1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside 1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside may have DNA topoisomerases I and II inhibitory activity and cytotoxicity.
TN1375 Alpha-Lapachone alpha-Lapachone has antineoplastic activity, it shows an approximately trypanocidal activity against Trypanosoma cruzi.
TN1734 Heveaflavone Heveaflavone has anti-proliferation effects, it shows moderate Topoisomerase I inhibitory activity. It also possesses a good antioxidant activity via its DPPH fr...
TN1886 Lucidin 3-O-primeveroside Lucidin-3-O- primeveroside, a food pigment, shows effective antifeedant against the carpet beetle. It is reported to be carcinogenic in the kidney and liver of r...
TN1889 Lupalbigenin Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
TN1917 Mauritianin Mauritianin and (+)-syringaresinol as new topoisomerase I inhibitors. Mauritianin has statistically significant cytoprotective activity similar to that of silyma...
T0486L Irinotecan Hydrochloride Irinotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active me...
Doxorubicin hydrochloride HOT
T1020CAS 25316-40-9
Doxorubicin intercalation between base pairs in the DNA helix, thereby preventing DNA replication. It also inhibits topoisomerase II.
Etoposide HOT
T0132CAS 33419-42-0
Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50: 60.3 μM).
Topovale
T9088CAS 500214-53-9
Topovale is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM ...
Pefloxacin Mesylate
T0425CAS 70458-95-6
Pefloxacin mesylate is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.
Podophyllotoxin
T1121CAS 518-28-5
Podophyllotoxin is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, ...
Ellipticine
T1166CAS 519-23-3
Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.49±...
SW044248
T3181CAS 522650-83-5
SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.
Epirubicin hydrochloride
T0125CAS 56390-09-1
Epirubicin hydrochloride is an antineoplastic agent which can inhibit Topoisomerase.
Idarubicin HCl
T6010CAS 57852-57-0
Idarubicin HCl, a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).
Hydroxy Camptothecine
T1521CAS 64439-81-2
Hydroxy Camptothecine is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzym...
Mitoxantrone
T6588CAS 65271-80-9
Mitoxantrone is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA rep...
Sophoridine
T3339CAS 6882-68-4
Sophoridine, a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and ev...
Amonafide
T6336CAS 69408-81-7
Amonafide(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA c...
Norfloxacin
T1306CAS 70458-96-7
Norfloxacin(Norxacin) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
Betulinic acid
T2830CAS 472-15-1
Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretrov...
Mitoxantrone hydrochloride
T0158CAS 70476-82-3
Mitoxantrone Hydrochloride is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor.
Pirarubicin
T6628CAS 72496-41-4
Pirarubicin is an anthracycline antibiotic. It is also a DNA/RNA synthesis inhibitor that intercalates into DNA and interacts with topoisomerase II, utilized as ...
Enoxacin
T0717LCAS 74011-58-8
Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
Bimolane
T3481CAS 74550-97-3
Bimolane is a topoisomerase II inhibitor.
(S)-(+)-Camptothecin
T1123CAS 7689-03-4
(S)-(+)-Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I), isolated from Camptotheca acuminata.
Fleroxacin
T1294CAS 79660-72-3
Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.
Ofloxacin
T0902CAS 82419-36-1
Ofloxacin is a fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzym...
Enoxacin Sesquihydrate
T0717CAS 84294-96-2
Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
Ciprofloxacin
T1640CAS 85721-33-1
Ciprofloxacin, a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram-p...
SN38
T1703CAS 86639-52-3
SN-38 is an active metabolite of CPT-11.
Ciprofloxacin hydrochloride
T0250CAS 93107-08-5
Ciprofloxacin hydrochloride is a broad-spectrum antimicrobial carboxyfluoroquinoline.
Amsacrine
T1206CAS 51264-14-3
Amsacrine (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells. Amsacrine also expresses topoisomerase inhibitor activity, specifica...
Nalidixic acid
T0909CAS 389-08-2
Nalidixic acid is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA ...
Flumequine
T1060CAS 42835-25-6
Flumequine is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II ...
Dexrazoxane HCl
T6467CAS 149003-01-0
Dexrazoxane HCl is a cardio-protective drug.
Levofloxacin
T6567CAS 100986-85-4
Levofloxacin is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdo...
Sparfloxacin
T1095CAS 110871-86-8
Sparfloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.
Gatifloxacin
T1293CAS 112811-59-3
Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase ...
Marbofloxacin
T3117CAS 115550-35-1
Marbofloxacin is an effective, broad-spectrum antibiotic of bacterial, which inhibits DNA replication.
Topotecan hydrochloride
T1174CAS 119413-54-6
Topotecan hydrochloride is an antineoplastic agent used to treat ovarian cancer.
Suramin Sodium Salt
T2160CAS 129-46-4
Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various gro...
Irinotecan hydrochloride trihydrate
T0486CAS 136572-09-3
Irinotecan HCl-trihydrate keeps DNA from unwinding by inhibiting topoisomerase 1.
Levofloxacin Hemihydrate
T1451CAS 138199-71-0
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxaci...
Pixantrone dimaleate
T2394CAS 144675-97-8
Pixantrone dimaleate (BBR 2778 dimaleate) is an experimental antineoplastic drug.
Novobiocin Sodium
T0974CAS 1476-53-5
Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveu...
Pefloxacin Mesylate Dihydrate
T0425LCAS 149676-40-4
Pefloxacin mesylate dehydrate, an antibacterial agent, restrains bacterial DNA replication by inhibiting DNA gyrase (topoisomerase).
Lomefloxacin
T1444CAS 98079-51-7
Lomefloxacin is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.
NU2058
T3186CAS 161058-83-9
NU2058 is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
Pazufloxacin Mesylate
T1620CAS 163680-77-1
Pazufloxacin (INN) is a fluoroquinolone antibiotic.
Voreloxin
T6724CAS 175414-77-4
Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
Moxifloxacin hydrochloride
T0331CAS 186826-86-8
Moxifloxacin is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria as well as atypical pathogens. Moxifloxacin has been li...
10-Hydroxycamptothecin
T2764CAS 19685-09-7
10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.
Gemifloxacin mesylate
T1492CAS 210353-53-0
Gemifloxacin mesylate inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. Gemifloxacin Me...
Doxorubicin
T1456CAS 23214-92-8
Doxorubicin is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
Cinoxacin
T0274CAS 28657-80-9
Cinoxacin, an older synthetic antimicrobial, was related to the quinolone class of antibiotics. Its activity was similar to oxolinic acid and nalidixic acid.
Teniposide
T1523CAS 29767-20-2
Teniposide, a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.
Nalidixic acid sodium salt
T0909LCAS 3374-05-8
Nalidixic acid sodium salt is an antimicrobial agent with a limited bacteriocidal spectrum.
Irinotecan
T6228CAS 97682-44-5
Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the actio...
Lomefloxacin hydrochloride
T1625CAS 98079-52-8
Lomefloxacin hydrochloride inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhi...
Levofloxacin hydrochloride
T8747CAS 177325-13-2
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxac...
Voreloxin hydrochloride
T22456CAS 175519-16-1
Voreloxin hydrochloride is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.
Chloroquinoxaline sulfonamide
T14953CAS 97919-22-7
Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
Daun02
T15054CAS 290304-24-4
Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
Dxd
T11249LCAS 1599440-33-1
Dxd (Exatecan derivative for ADC) is a potent inhibitor of DNA topoisomerase I (IC50: 0.31 μM). It is used as a conjugated drug of HER2-targeting ADC.
Edotecarin
T15200CAS 174402-32-5
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
Trovafloxacin
T13231CAS 147059-72-1
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.
Indotecan
T15578CAS 915303-09-2
Indotecan is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).
Aldoxorubicin
T11090LCAS 1361644-26-9
Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubi...
Intoplicine
T15586CAS 125974-72-3
Intoplicine is an inhibitor of DNA topoisomerase I and II.
Neu2000
T16286CAS 640290-67-1
Neu2000 is an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptor.
Rebeccamycin
T16726CAS 93908-02-2
Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase...
Eleutherin
TN2464CAS 478-36-4
Eleutherin is a natural product from Eleutherine americana
Karenitecin
T14703CAS 203923-89-1
Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
3-Hydroxysarpagine
TN2953CAS 857297-90-6
Standard reference
Ganoderic acid X
TN4107CAS 86377-53-9
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
Guajadial B
TN4172CAS 1414455-03-0
Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines,...
Guajadial C
TN4173CAS 1529775-02-7
Guajadial C acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. It shows cytotoxicity against five human cancer cell lines.
Isodiospyrin
TN4283CAS 20175-84-2
Isodiospyrin is a novel human DNA topoisomerase I inhibitor, it exhibits cytotoxic activity to tumor cell lines. Isodiospyrin has antibacterial activity, the min...
Lauterine
TN4422CAS 28200-65-9
Lauterine is a DNA topoisomerase inhibitor.
Niranthin
TN4660CAS 50656-77-4
Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitiv...
Rubicordifolin
TN4923CAS 849699-55-4
Rubicordifolin exhibits potent cytotoxic and antitumor activities.
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
TN5133CAS 125537-92-0
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it s...
Tryprostatin A
TN5190CAS 171864-80-5
Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mamm...
Aurintricarboxylic acid
T8333CAS 4431-00-9
Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing ...
CH-0793076
T14945CAS 534605-78-2
CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast ca...
Proscillaridin A
TN2105CAS 466-06-8
Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
Bisantrene
T4047CAS 78186-34-2
Bisantrene is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA sing...
Belotecan hydrochloride
T7551CAS 213819-48-8
Belotecan hydrochloride is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity
1,4-Naphthoquinone
T7048CAS 130-15-4
1, 4-Naphthoquinone was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities[2]. It was also used to inhibit the acetyltransferase...
Ellipticine hydrochloride
T4614CAS 5081-48-1
Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
10-Hydroxycampothecin
T4952CAS 67656-30-8
10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.
Prulifloxacin
T5394CAS 123447-62-1
Prulifloxacin is a broad-spectrum fluoroquinolone antibiotic. It Inhibits bacterial DNA synthesis by inhibiting the activity of bacterial DNA topoisomerase II an...
Topotecan
T5784CAS 123948-87-8
Topotecan is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.
9-Methoxycamptothecin
T5S1952CAS 39026-92-1
9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.
Amsacrine hydrochloride
T5820CAS 54301-15-4
Amsacrine hydrochloride  is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.
Rubitecan
T5853CAS 91421-42-0
Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentrat...
TAS-103 (dihydrochloride)
T7309CAS 174634-09-4
TAS-103 (dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.
Genz-644282
T7187CAS 529488-28-6
Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.
MC-DOXHZN hydrochloride
TQ0049CAS 480998-12-7
MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin. Doxorubicin is a DNA topoisomerase II inhibitor.
Proscillaridin A
TN2105CAS 466-06-8
Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
Zoliflodacin
TQ0063CAS 1620458-09-4
Zoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-posit...
Exatecan Mesylate
TQ0088CAS 169869-90-3
Exatecan Mesylate is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).
Podocarpusflavone A
TQ0134CAS 22136-74-9
Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.
9-Aminocamptothecin
T3S1957CAS 91421-43-1
9-Aminocamptothecin is an inhibitor of topoisomerase I with potent anticancer activity.
Groenlandicine
TN1037CAS 38691-95-1
Groenlandicine is a protoberberine alkaloid from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human reco...
1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside
TN1169CAS 1415729-43-9
1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside may have DNA topoisomerases I and II inhibitory activity and cytotoxicity.
alpha-Lapachone
TN1375CAS 4707-33-9
alpha-Lapachone has antineoplastic activity, it shows an approximately trypanocidal activity against Trypanosoma cruzi.
Heveaflavone
TN1734CAS 23132-13-0
Heveaflavone has anti-proliferation effects, it shows moderate Topoisomerase I inhibitory activity. It also possesses a good antioxidant activity via its DPPH fr...
Lucidin 3-O-primeveroside
TN1886CAS 29706-59-0
Lucidin-3-O- primeveroside, a food pigment, shows effective antifeedant against the carpet beetle. It is reported to be carcinogenic in the kidney and liver of r...
Lupalbigenin
TN1889CAS 76754-24-0
Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
Mauritianin
TN1917CAS 109008-28-8
Mauritianin and (+)-syringaresinol as new topoisomerase I inhibitors. Mauritianin has statistically significant cytoprotective activity similar to that of silyma...
Irinotecan Hydrochloride
T0486LCAS 100286-90-6
Irinotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active me...