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Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.
Cat. No. Product name CAS No. Purity Chemical Structure
TN4923 Rubicordifolin 849699-55-4 98%
Rubicordifolin exhibits potent cytotoxic and antitumor activities.
TN4107 Ganoderic acid X 86377-53-9 98%
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
TQ0134 Podocarpusflavone A 22136-74-9 98%
Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.
T14945 CH-0793076 534605-78-2 98%
CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast ca...
TN1169 1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside 1415729-43-9 98%
1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside may have DNA topoisomerases I and II inhibitory activity and cytotoxicity.
T15586 Intoplicine 125974-72-3 98%
Intoplicine is an inhibitor of DNA topoisomerase I and II.
TN4422 Lauterine 28200-65-9 98%
Lauterine is a DNA topoisomerase inhibitor.
TN4283 Isodiospyrin 20175-84-2 98%
Isodiospyrin is a novel human DNA topoisomerase I inhibitor, it exhibits cytotoxic activity to tumor cell lines. Isodiospyrin has antibacterial activity, the min...
TN2953 3-Hydroxysarpagine 857297-90-6 98%
Standard reference
TN5133 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone 125537-92-0 98%
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...
T15054 Daun02 290304-24-4 98%
Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
T14953 Chloroquinoxaline sulfonamide 97919-22-7 98%
Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
T16286 Nelonemdaz 640290-67-1 98%
Neu2000 is an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptor.
T14703 Karenitecin 203923-89-1 98%
Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
TN5190 Tryprostatin A 171864-80-5 98%
Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mamm...
TN1889 Lupalbigenin 76754-24-0 98%
Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
TN4173 Guajadial C 1529775-02-7 98%
Guajadial C acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. It shows cytotoxicity against five human cancer cell lines.
TN2464 Eleutherin 478-36-4 98%
Eleutherin is a natural product from Eleutherine americana
T15200 Edotecarin 174402-32-5 98%
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
TN4172 Guajadial B 1414455-03-0 98%
Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines,...
Rubicordifolin
TN4923
Rubicordifolin exhibits potent cytotoxic and antitumor activities.
Ganoderic acid X
TN4107
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
Podocarpusflavone A
TQ0134
Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.
CH-0793076
T14945
CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast ca...
1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside
TN1169
1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside may have DNA topoisomerases I and II inhibitory activity and cytotoxicity.
Intoplicine
T15586
Intoplicine is an inhibitor of DNA topoisomerase I and II.
Lauterine
TN4422
Lauterine is a DNA topoisomerase inhibitor.
Isodiospyrin
TN4283
Isodiospyrin is a novel human DNA topoisomerase I inhibitor, it exhibits cytotoxic activity to tumor cell lines. Isodiospyrin has antibacterial activity, the min...
3-Hydroxysarpagine
TN2953
Standard reference
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
TN5133
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...
Daun02
T15054
Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
Chloroquinoxaline sulfonamide
T14953
Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
Nelonemdaz
T16286
Neu2000 is an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptor.
Karenitecin
T14703
Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
Tryprostatin A
TN5190
Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mamm...
Lupalbigenin
TN1889
Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
Guajadial C
TN4173
Guajadial C acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. It shows cytotoxicity against five human cancer cell lines.
Eleutherin
TN2464
Eleutherin is a natural product from Eleutherine americana
Edotecarin
T15200
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
Guajadial B
TN4172
Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines,...
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