Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.

Cat. No.	Product name	CAS No.	Purity
TN4923	Rubicordifolin	849699-55-4	98%
Rubicordifolin exhibits potent cytotoxic and antitumor activities.
TN4107	Ganoderic acid X	86377-53-9	98%
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
TQ0134	Podocarpusflavone A	22136-74-9	98%
Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.
T14945	CH-0793076	534605-78-2	98%
CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast ca...
TN1169	1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside	1415729-43-9	98%
1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside may have DNA topoisomerases I and II inhibitory activity and cytotoxicity.
T15586	Intoplicine	125974-72-3	98%
Intoplicine is an inhibitor of DNA topoisomerase I and II.
TN4422	Lauterine	28200-65-9	98%
Lauterine is a DNA topoisomerase inhibitor.
TN4283	Isodiospyrin	20175-84-2	98%
Isodiospyrin is a novel human DNA topoisomerase I inhibitor, it exhibits cytotoxic activity to tumor cell lines. Isodiospyrin has antibacterial activity, the min...
TN2953	3-Hydroxysarpagine	857297-90-6	98%
Standard reference
TN5133	3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone	125537-92-0	98%
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...
T15054	Daun02	290304-24-4	98%
Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
T14953	Chloroquinoxaline sulfonamide	97919-22-7	98%
Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
T16286	Nelonemdaz	640290-67-1	98%
Neu2000 is an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptor.
T14703	Karenitecin	203923-89-1	98%
Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
TN5190	Tryprostatin A	171864-80-5	98%
Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mamm...
TN1889	Lupalbigenin	76754-24-0	98%
Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
TN4173	Guajadial C	1529775-02-7	98%
Guajadial C acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. It shows cytotoxicity against five human cancer cell lines.
TN2464	Eleutherin	478-36-4	98%
Eleutherin is a natural product from Eleutherine americana
T15200	Edotecarin	174402-32-5	98%
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
TN4172	Guajadial B	1414455-03-0	98%
Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines,...

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

TN4923

Rubicordifolin

849699-55-4

98%

Rubicordifolin exhibits potent cytotoxic and antitumor activities.

TN4107

Ganoderic acid X

86377-53-9

98%

Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.

TQ0134

Podocarpusflavone A

22136-74-9

98%

Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.

T14945

CH-0793076

534605-78-2

98%

CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast ca...

TN1169

1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside

1415729-43-9

98%

1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside may have DNA topoisomerases I and II inhibitory activity and cytotoxicity.

T15586

Intoplicine

125974-72-3

98%

Intoplicine is an inhibitor of DNA topoisomerase I and II.

TN4422

Lauterine

28200-65-9

98%

Lauterine is a DNA topoisomerase inhibitor.

TN4283

Isodiospyrin

20175-84-2

98%

Isodiospyrin is a novel human DNA topoisomerase I inhibitor, it exhibits cytotoxic activity to tumor cell lines. Isodiospyrin has antibacterial activity, the min...

TN2953

3-Hydroxysarpagine

857297-90-6

98%

Standard reference

TN5133

3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone

125537-92-0

98%

5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...

T15054

Daun02

290304-24-4

98%

Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.

T14953

Chloroquinoxaline sulfonamide

97919-22-7

98%

Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.

T16286

Nelonemdaz

640290-67-1

98%

Neu2000 is an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptor.

T14703

Karenitecin

203923-89-1

98%

Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.

TN5190

Tryprostatin A

171864-80-5

98%

Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mamm...

TN1889

Lupalbigenin

76754-24-0

98%

Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.

TN4173

Guajadial C

1529775-02-7

98%

Guajadial C acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. It shows cytotoxicity against five human cancer cell lines.

TN2464

Eleutherin

478-36-4

98%

Eleutherin is a natural product from Eleutherine americana

T15200

Edotecarin

174402-32-5

98%

Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).

TN4172

Guajadial B

1414455-03-0

98%

Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines,...