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SN-398

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Catalog No. T88266Cas No. 124623-00-3

SN-398, a derivative of Camptothecin, is an antitumor compound. It functions by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex to prevent DNA re-ligation, thereby inducing Topo I-mediated DNA breaks. In tests with Hela cells, SN-398 exhibits stronger antitumor activity than the original drug SN-38 (IC50=1.562 μM). SN-398 is applicable for research on the antiproliferative and growth-inhibitory effects of Topo I in cancer cells.

SN-398

SN-398

😃Good
Catalog No. T88266Cas No. 124623-00-3
SN-398, a derivative of Camptothecin, is an antitumor compound. It functions by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex to prevent DNA re-ligation, thereby inducing Topo I-mediated DNA breaks. In tests with Hela cells, SN-398 exhibits stronger antitumor activity than the original drug SN-38 (IC50=1.562 μM). SN-398 is applicable for research on the antiproliferative and growth-inhibitory effects of Topo I in cancer cells.
Pack SizePriceAvailabilityQuantity
25 mg$1,5202-4 weeks
50 mg$1,9802-4 weeks
100 mg$2,5002-4 weeks
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Product Introduction

Bioactivity
Description
SN-398, a derivative of Camptothecin, is an antitumor compound. It functions by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex to prevent DNA re-ligation, thereby inducing Topo I-mediated DNA breaks. In tests with Hela cells, SN-398 exhibits stronger antitumor activity than the original drug SN-38 (IC50=1.562 μM). SN-398 is applicable for research on the antiproliferative and growth-inhibitory effects of Topo I in cancer cells.
Chemical Properties
Molecular Weight410.40
FormulaC22H19FN2O5
Cas No.124623-00-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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