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Mitochondrial Metabolism

Mitochondrial metabolism encompasses pathways that generate ATP to drive intracellular unfavorable energetic reactions and produce the building blocks necessary for macromolecule synthesis.

FilterSignaling PathwaysMetabolismMitochondrial Metabolism
  • Imeglimin hydrochloride
    T7486775351-61-6
    Imeglimin hydrochloride (EMD 387008 hydrochloride) prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.
    • $34
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    TargetMol | Inhibitor Hot
  • MPP+ iodide
    T916936913-39-0
    MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA)
    • $33
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    TargetMol | Inhibitor Hot
  • Lipoic acid
    T222351200-22-2
    Lipoic acid (R-(+)-Thioctic acid) is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism.
    • $57
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  • TT01001
    T249051022367-69-6
    TT01001 (Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate) is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 can be used in studies about the treatment of type II diabetes.
    • $119
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  • 4-methyl-6-phenyl-2H-pyranone
    TN24364467-30-5
    4-methyl-6-phenyl-2H-pyranone is derived from Scutellaria baicalensis Georgi and improves mitochondrial functionality to protect astrocytes against hydrogen peroxide-induced toxicity.
    • $50
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  • McN3716
    T1197869207-52-9In house
    McN3716 is a carnitine palmitoyltransferase I (CPT-1) inhibitor for the study of metabolic diseases.
    • $350
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  • VK-28
    T9956312611-92-0
    VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.
    • $195
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    TargetMol | Inhibitor Sale
  • ND-011992
    T776152446880-46-0
    ND-011992 is a reversible and selective quinazoline inhibitor targeting quinone reductases and quinol oxidases.ND-011992 inhibits E. coli BL21*Δcyo respiratory complex I. ND-011992 inhibits bo3 oxidase, bd-I oxidases and bd-II oxidases, ND-011992 inhibits E. coli BL21*Δcyo respiratory complex I, bo3 oxidase, bd-I oxidases, and bd-II oxidases with IC50s of 0.12, 2.47, 0.63, and 1.3 μM, respectively.ND-011992 can be used in the study of tuberculosis.
    • $195
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    TargetMol | Inhibitor Sale
  • Tebufenpyrad
    T4446119168-77-3
    Tebufenpyrad (Comanche) (mitochondrial complex-1 inhibitors) is an agro-chemically important acaricide that functions like the known mitochondrial toxicant rotenone.
    • $77
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  • (S)-Coriolic acid
    T3797429623-28-7In house
    (S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid inhibits the adhesion of tumor cells to the vascular endothelium and down-regulates the expression of IRGpIIb/IIIa receptors at around 1 μM. (S)-Coriolic acid is a metabolite of 15-lipoxygenase (15-LOX), which often acts as an endogenous ligand to activate PPARγ. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial damage.
    • $389
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  • Glibenclamide
    T163410238-21-8
    Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
    • $45
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    TargetMol | Citations Cited
  • Mito-TEMPO
    T194281334850-99-5
    Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic. Mito-TEMPO scavenges superoxide and alkyl radicals and prevents mitochondrial oxidation, necrosis and apoptosis.
    • $51
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    TargetMol | Citations Cited
  • FCCP
    T6834370-86-5
    FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. FCCP is often used as an apoptosis inducer.
    • $36
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    TargetMol | Citations Cited
  • CCCP
    T7081555-60-2
    CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules TBK1 and IRF3.
    • $41
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    TargetMol | Citations Cited
  • THP104c
    T9777877792-12-6
    THP104c is an inhibitor of mitochondrial fission.
    • $119
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  • Speract
    T748776901-59-2
    Speract, a peptide from sea urchin eggs, regulates sperm motility and stimulates sperm mitochondrial metabolism.
    • $70
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  • FGIN-1-43
    T22783145040-29-5
    FGIN-1-43 is a potent and specific ligand for the mitochondrial DBI receptor.
    • $41
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  • Z16078526
    T77621852222-94-7
    Z16078526 enhances thermogenesis in mice by inducing endogenous Ucp1 expression, promoting p38 MAPK phosphorylation, and stimulating lipolysis in primary mouse brown adipocytes. Additionally, it activates thermogenic gene expression and mitochondrial activity, specifically uncoupled respiration, in these cells.
    • $48
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  • D-Histidine
    T9372351-50-8
    D-Histidine is an enantiomer of L-histidine. L-Histidine is an inhibitor of mitochondrial glutamine transport and also an essential amino acid for infants.
    • $30
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  • NDH-1 inhibitor-1
    T67928173964-49-3
    NDH-1 inhibitor-1 is an effective NDH-1 inhibitor, which can inhibit bovine SMP (mitochondrial granules), potato SMP and Escherichia coli, with pI50 values of <4, 5.40, 6.15 µM, respectively.
    • $47
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  • MitoSOX Red
    T753421003197-00-9
    MitoSOX Red is a novel fluorescent probe that is specific and cell membrane-permeable and targets mitochondria in living cells.MitoSOX Red is oxidized by superoxide upon entry into the mitochondria and is not oxidized by other ROS or RNS-generating systems.MitoSOX Red then binds to nucleic acids in the mitochondrion and produces a strong red fluorescence.MitoSOX Red can be used as a fluorescent indicator for the specific detection of superoxide.MitoSOX Red can be used as a fluorescent indicator for the specific detection of superoxide. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. Superoxide dismutase (SOD) prevents the oxidation of MitoSOX Red.
    • $396
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  • Tricarballylic acid
    T556499-14-9
    Tricarballylic acid (Carballylic acid) is an inhibitor of aconitase.
    • $41
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  • SCAL-255
    T794762798953-61-2
    SCAL-255 is a mitochondrial complex I (CI) inhibitor, exhibiting potent inhibition with an IC50 of 1.14 μM. It impedes mitochondrial function by blocking oxygen consumption rate (OCR), inducing reactive oxygen species (ROS) production, and diminishing mitochondrial membrane potential (MMP). Furthermore, SCAL-255 significantly hampers the proliferation of cancer cells reliant on oxidative phosphorylation (OXPHOS) [1].
    • $1,520
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  • CTPI-2
    T873268003-38-3
    CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 μM). CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 exhibits anti-tumor activity.CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet.
    • $47
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  • Imeglimin
    T22860775351-65-0
    Imeglimin (EMD 387008) is an orally available antidiabetic compound that enhances mitochondrial function, enhances insulin secretion, promotes β-cell proliferation and improves pancreatic β-cell survival in mice.
    • $35
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  • Mitochondrial fusion promoter M1
    T9232219315-22-7
    Mitochondrial fusion promoter M1, a modulator of mitochondrial dynamics, enhances mitochondrial function and cellular respiration, and has shown efficacy in reducing brain and cardiac damage in rats suffering from cardiac ischemia/reperfusion injury.
    • $43
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  • L-Histidine
    T2A253271-00-1
    L-Histidine (L-(-)-Histidine) is a semi-essential amino acid (children should obtain it from food) needed in humans for growth and tissue repair, L-Histidine is important for maintenance of myelin sheaths that protect nerve cells and is metabolized to the neurotransmitter histamine. Histamines play many roles in immunity, gastric secretion, and sexual functions. L-Histidine is also required for blood cell manufacture and protects tissues against damage caused by radiation and heavy metals.
    • $41
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  • L-2-Hydroxyglutaric acid disodium
    T1374863512-50-5
    L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity(Km and Ki of 2.52 mM and 11.13 mM, respectively).
    • $45
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  • GW604714X
    T9235853953-65-8
    GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) were found to be potent inhibitors of mitochondrial respiration supported by pyruvate
    • $116
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  • α-Lipoic Acid
    T02001077-28-7
    α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
    • $29
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  • Nerol
    T5645106-25-2
    Nerol (Neryl alcohol) is a monoterpene found in many essential oils, such as lemon balm and hop.Nerol can lessened the severity of ouabain-triggered arrhythmias in mammalian heart.
    • $39
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  • Schaftoside
    T389851938-32-0
    Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.
    • $40
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    TargetMol | Citations Cited
  • Glutamate dehydrogenase (NAD(P))
    T736169029-12-3
    Glutamate dehydrogenase NAD(P) (GLDH) is a mitochondrial enzyme widely found in organisms that catalyzes the reversible oxidative deamination of glutamate to produce α-ketoglutarate (α-KG), which is used in the study of diseases caused by abnormalities in glutamate metabolism.
    • $50
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  • VLX600
    T8500327031-55-0
    VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells.
    • $48
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  • CCI-006
    T10706292053-42-0
    CCI-006, a selective inhibitor and chemosensitizer for MLL-rearranged leukemia cells, disrupts mitochondrial respiration. This action leads to irreversible mitochondrial depolarization and triggers a pro-apoptotic unfolded protein response in specific MLL-r leukemia cells.
    • $98
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  • Perhexiline maleate
    T124086724-53-4
    Perhexiline maleate is an orally active inhibitor of CPT1 and CPT2 that reduces fatty acid metabolism. The IC50 values of perhexiline maleate against rat heart and liver CPT 1 were 77 and 148 μM, respectively.
    • $51
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  • ER-000444793
    T15241792957-74-5
    ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).
    • $70
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  • 7ACC2
    T17681472624-85-3
    7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells.
    • $31
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  • Azemiglitazone
    T46391133819-87-0
    Azemiglitazone (MSDC 0602) is an insulin sensitizer potentially for the treatment of diabetes.
    • $52
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  • Gboxin
    T153732101315-36-8
    Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity.
    • $55
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  • Mito-LND
    T92112361564-49-8
    Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
    • $135
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  • Genistein 8-c-glucoside
    T1370166026-80-0
    Genistein 8-c-glucoside (G8CG) induces mitochondrial membrane depolarization and induces apoptosis. Genistein 8-c-glucoside (G8CG) is a natural glucoside isolated from flowers of Lupinus luteus L.
    • $141
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  • Fumarate hydratase-IN-1
    T113371644060-37-6
    Fumarate hydratase-IN-1 is a cell-permeable fumarate hydratase inhibitor with antiproliferative activity and can be used to study cellular activity.
    • $91
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  • Dihydrorotenone
    TN15866659-45-6
    Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome.
    • $115
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  • IMT1
    T88412304621-31-4
    IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.
    • $74
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  • Lonidamine
    T023950264-69-2
    Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).
    • $33
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    TargetMol | Citations Cited
  • BI-6C9
    T5827791835-21-7
    BI-6C9 is an inhibitor of tBid (Kd = 20 µM).BI-6c9 prevented MOMP and mitochondrial fission, and protected the cells from cell death.
    • $60
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  • MCU-i4
    T9031371924-24-2
    MCU-i4 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.
    • $37
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  • Kresoxim-Methyl
    T7922143390-89-0
    Kresoxim-methyl is a strobilurin fungicide,inhibits conidial germination of V. inaequalis isolates from apple orchards .
    • $50
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  • UK-5099
    T444156396-35-1
    UK-5099 (PF-1005023) is a specific and potent inhibitor of MPC carrier activity [1]. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50: 50 nM) [1].
    • $31
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