b 9

STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.

Dermaseptin-B9, an antimicrobial peptide, has been isolated from the Phyllomedusinae subfamily of frogs [1].

Blumenol B 9-O-glucoside is a natural product for research related to life sciences. The catalog number is TN6251 and the CAS number is 114226-08-3.

Folic acid is an orally active essential nutrient involved in the synthesis of DNA/RNA and the production and maintenance of new cells. It exhibits antidepressant-like effects and can reduce the risk of neural tube defects in newborns. Folate deficiency can cause megaloblastic anemia, macrocytic anemia, neural tube closure defects, tumors, and aging-related diseases. Folic acid is also commonly used in research on folate deficiency-related conditions and to induce acute kidney injury models.

Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxidase in neurons, thereby blocking the production of superoxide, which reduces ischemic injury in the acute phase after stroke.

Tat-NR2B9c TFA is a 20-aa peptide, and acts as an inhibitor of postsynaptic density-95 (PSD-95)(EC50 of 6.7 nM for PSD-95d2), and possesses neuroprotective efficacy.

Tat-NR2B9c acetate (NA-1 acetate) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c acetate disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c acetate also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy.

Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R is a useful organic compound for research related to life sciences and the catalog number is T64611.

Tat-HA-NR2B9, comprising an HIV-1 Tat transduction domain fragment, an influenza virus hemagglutinin (HA) epitope-tag, and the C-terminal 9 amino acids of NR2B (NR2B9c), has demonstrated efficacy in reducing infarct size and enhancing neurological function following ischemia-induced cerebral injury in rats [1].

Folic acid disodium is a water-soluble and essential B-complex vitamin for the human body, playing a key role in DNA synthesis and cell division. It is used to treat anaemia and foetal neural tube defects (NTDs) caused by folate deficiency.

BA6b9 is an allosteric inhibitor targeting the SK4 channel via the CaM-PIP2 binding domain. It interacts with two critical residues, Arg191 and His192, located in the S4-S5 linker to inhibit the SK4 channel, with an IC50 of 8.6 μM (WT SK4). BA6b9 significantly prolongs the effective refractory period (ERP) of the atria and atrioventricular node in isolated rat hearts, reducing the induction of atrial fibrillation (AF), highlighting its potential for arrhythmia research.

Apetalumoside B9 is a natural product that can be used in related research in the field of life sciences. Its product number is TN8615.

123B9 is a tumor-homing agent characterized as a potent and selective agonist for EphA2 with a dissociation constant (Kd) of 4.0 μM. It specifically targets the ligand-binding domain of the EphA2 tyrosine kinase receptor. Notably, 123B9 does not significantly inhibit the ligand-binding domains of closely related receptors EphA3 and EphA4.

(123B9)2-Motif is a selective agonist of the EphA2 receptor with a dissociation constant (Kd) of 4.9 μM and does not bind to EphA4. It functions by inducing phosphorylation and oligomerization of the EphA2 receptor, promoting receptor activation and internalization. (123B9)2-Motif is primarily used in research on targeted drug delivery for cancers overexpressing EphA2, such as breast cancer, to reduce circulating tumor cells and inhibit metastasis.

(123B9)2-L2-PTX is an EphA2 agonist peptide-drug conjugate (PDC). It consists of dimer 123B9 and Paclitaxel. This compound significantly reduces circulating tumor cells and inhibits lung metastasis in a breast cancer metastasis mouse model. (123B9)2-L2-PTX is applicable in cancer research, including studies on melanoma, ovarian cancer, and breast cancer.

mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTOR inhibitor 9b possesses anticancer activity and can be used to study leukemia, skin, breast, lung and colon cancers.

AalphaC (2-Amino-alpha-carboline) is a potential carcinogen.

9'-Methyllithospermate B is a natural extract obtained from Cynoglossum columnae.

9'-Methyl lithospermate B is a phenolic compound extracted from Radix Salvia miltiorrhizae.

MAO-B-IN-9 is a monoamine oxidase B MAO-B inhibitor (IC50: 0.18 μM) that crosses the blood-brain barrier with potency, selectivity and time-dependence. MAO-B-IN-9 has neuroprotective effects against Aβ1-42-induced neuronal cell death, which may be related to the anti-aggregation effect of Aβ1-42.

B-Raf IN 9 (compound 8b) is an effective B-Raf inhibitor (IC50=24.79 nM) that blocks the cell cycle at the G2/M phase, induces apoptosis, and exhibits potent anti-tumor activity on human prostate cancer PC-3 cells (IC50=7.83 μM).

(S)-9-((tert-Butyldimethylsilyl)oxy)-4,11-diethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione is a useful organic compound for research related to life sciences and the catalog number is T64821.

NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dual resveratrol units that strongly inhibit NF-κB signaling. This compound demonstrates notable anti-tumor properties and pronounced sonocytotoxicity against cancer cells, maintaining biosafety in xenograft mouse models.

Cbl-b-IN-9 (Compound 300) is a potent inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, with half-maximal inhibitory concentrations (IC50s) of 5.6 nM and 4.7 nM, respectively [1].