Search Result

Search Results for " p21 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T6839	FRAX1036		PAK
	FRAX-1036 is a effective and selective PAK1 inhibitor.		PAK
T16367	NVS-PAK1-1		PAK
	NVS-PAK1-1 is an effective and selective allosteric PAK1 inhibitor (IC50: 5 nM).		PAK
T6840	FRAX486		PAK
	FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.		PAK
T11342L	G-5555		PAK
	G-5555 is a potent inhibitor of p21-activated kinase 1 (PAK1) (Kis: 3.7 nM and 11 nM for PAK1 and PAK2, respectively).		PAK
T6546	IPA-3	IPA3,IPA 3	PAK
	IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).		PAK
T6014	FRAX597		PAK
	FRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM).		PAK
T16429	GNE 2861		PAK
	GNE 2861 inhibits PAK4, PAK5, and PAK6 (IC50s: 7.5, 36, 126 nM, respectively). GNE 2861 is a PAK inhibitor that shows group II selectivity.		PAK
T9698	UC2288		Mdm2 , p53
	UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 protein levels with minimal effect on p21 protein stability.		Mdm2 , p53
T7697	BIX-01294		Histone Methyltransferase , Autophagy
	BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).		Histone Methyltransferase , Autophagy
T7539	O6-Benzylguanine		Apoptosis , DNA Alkylation , DNA/RNA Synthesis
	O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.		Apoptosis , DNA Alkylation , DNA/RNA Synthesis
T11826	LCH-7749944	GNF-PF-2356	Apoptosis , PAK
	LCH-7749944 (GNF-PF-2356) effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. LCH-7749944 is a potent PAK4 inhibitor w...		Apoptosis , PAK
T1959	BIX-01294 trihydrochloride	BIX 01294	Histone Methyltransferase , Autophagy
	BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.		Histone Methyltransferase , Autophagy
T2539	Fingolimod hydrochloride	Fingolimod (FTY720) HCl,FTY720	TRP/TRPV Channel , S1P Receptor , PAK , LPL Receptor
	Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).		TRP/TRPV Channel , S1P Receptor , PAK , LPL Receptor
T12472	Pifithrin-α, p-Nitro, Cyclic	PFN-α	p53
	Pifithrin-α, p-Nitro, Cyclic (PFN-α) (PFN-α) is cell-permeable and active-form inhibitor of p53.		p53
T6626	PF-3758309	PF-309,PF-03758309,PF 3758309	Apoptosis , PAK
	PF-3758309 (PF-03758309) (IC50=1.3 nM), a pyrrolopyrazole inhibitor of PAK4, has effective ATP-competition.		Apoptosis , PAK
T4230	PF-3758309 hydrochloride	PF-03758309 hydrochloride	Apoptosis , PAK
	PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hyd...		Apoptosis , PAK
T3684	CP21R7	CP21	GSK-3 , PKC
	CP21R7 (CP21) is an effective and specific GSK3β inhibitor. It is used as an activator of stem cells prior to the induction of differentiation of stem cells to smooth muscle and endothelial cells. CP21R7 can be combined ...		GSK-3 , PKC
T41169	P21d hydrochloride
	P21d hydrochloride is a potent and selective breast tumor Ki nase (Brk) inhibitor (IC50 = 30 nM). Exhibits >650-fold selectively for Brk over Aurora B Ki nase and Lck. Downregulates SNAIL protein, restores E-cadherin exp...
TP2149L	NP213		Epigenetic Reader Domain
	NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane ...		Epigenetic Reader Domain
TP2149	NP213 TFA (942577-31-3 free base)	NP213 TFA	Others
	NP213 TFA is a rapidly acting and first-in-class synthetic antimicrobial peptide (AMP) with anti-fungal activity. It targets the fungal cytoplasmic membrane via membrane perturbation and disruption.		Others
T39772	BRK inhibitor P21d hydrochloride	BRK inhibitor P21d hydrochloride
	BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK/PTK6), displaying an IC50 of 30 nM. Additionally, it effectively suppresses p-SAM68 with an IC50 value of 52 nM. This compound, BR...
T36240	AP219
	AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an ...
T71870	CP21
	CP21 is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio. It is active against P. falciparum when used at concentrations of 10 and 100 µM. CP21 inhibits production of prostaglandin I2 induced by epinephri...
T62252	R-HP210
	R-HP210 inhibits LPS-induced transcription of several pro-inflammatory genes (IL-1β, IL-6 and COX-2). r-HP210 has an IC50 value of 3.80 μM for NF-κB-mediated bolus trans-suppression. r-HP210 does not induce trans-activat...
T62253	S-HP210
	S-HP210 is a selective and potent glucocorticoid receptor (GR) modulator that inhibits NF-κB transcription (IC50: 1.92 μM). S-HP210 is not toxic to mouse fibroblasts at effective doses of 3T3.
T73916	NP213 TFA
	NP213 TFA, a novel, first-in-class synthetic antimicrobial peptide (AMP) with rapid anti-fungal action, targets the fungal cytoplasmic membrane, resulting in perturbation and disruption. It has been demonstrated to be ef...
T78073	HP210		Glucocorticoid Receptor
	HP210, a selective glucocorticoid receptor modulator (SGRM), can suppress IL-1β and IL-6 mRNA expression, suggesting its utility in investigating inflammation-related diseases [1].		Glucocorticoid Receptor
T2454	Dacinostat	NVP-LAQ824,LAQ824	HDAC , Autophagy
	LAQ824 (Dacinostat (NVP-LAQ824)) is a novel HDAC inhibitor with IC50 of 32 nM and is an activator of the p21 promoter.		HDAC , Autophagy
T6840L	FRAX486 HCL(1232030-35-1 free base)		PAK
	FRAX486 HCL is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.		PAK
T8554	KCC-07		DNA Alkylator/Crosslinker
	KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenes...		DNA Alkylator/Crosslinker
T4321	Indisulam	E 7070	CDK , Carbonic Anhydrase
	Indisulam (E 7070) is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in th...		CDK , Carbonic Anhydrase
T0005	Aspirin	Acetylsalicylate,Acetylsalicylic Acid,ASA	Mitophagy , Virus Protease , COX , Autophagy
	Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cel...		Mitophagy , Virus Protease , COX , Autophagy
T3465	Vesnarinone	OPC-8212,Arkin,Piteranometozine	HIV Protease , PDE
	Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cel...		HIV Protease , PDE
T13349	WS-383		E1/E2/E3 Enzyme
	WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).		E1/E2/E3 Enzyme
T21806	HNHA		HDAC
	HNHA is an inhibitor of HDAC.		HDAC
T28733	SCH-53870
	SCH-53870 inhibits p21-hRas nucleotide exchange in vitro.
T26259	Tenovin-D3	TenovinD3
	Tenovin-D3 is a sirtuin SirT2 inhibitor. It acts by increasing p21 (CDKN1A) expression in a p53-independent manner.
T24274	KY-04031
	KY-04031 is an inhibitor of p21-activated kinase 4.
T70371	Xylarianaphthol-1
	Xylarianaphthol-1 is an activator of p21 promoter in a p53-independent manner.
T69243	AK963
	AK963, also known as 40708899, is a potent PAK1 (p21-activated kinase 1) inhibitor, which suppresses the proliferation of human gastric cancer cells significantly by downregulation of PAK1-NFκB-CyclinB1 pathway.
T62916	GEM144
	GEM144 is a potent, orally active dual inhibitor of DNA polymerase α (POLA1) and HDAC 11. GEM144 induces p53 acetylation, activates p21, blocks the cell cycle in G1/S phase and induces apoptosis.
T11342	G-5555 hydrochloride (1648863-90-4 free base)	G-5555 hydrochloride	PAK
	G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.		PAK
T62917	MIR002
	MIR002 is a potent, orally active dual inhibitor of DNA polymerase α (POLA1) and HDAC 11 with significant in vivo antitumor activity. p53 acetylation, p21 activation, cell cycle arrest in G1/S phase, and apoptosis induct...
T22490	2,3-DCPE hydrochloride		Others
	Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively.		Others
T15580	Inolitazone dihydrochloride	RS5444 dihydrochloride,CS-7017 dihydrochloride,Efatutazone dihydrochloride	PPAR
	Inolitazone dihydrochloride is an effective, high-affinity PPARγ agonist; its biological activity is dependent on PPARγ (IC50:0.8 nM) to inhibit cell growth. Inolitazone dihydrochloride enhances the role of cell cycle ki...		PPAR
T71034	Bizelesin
	Bizelesin is a synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. ...
T37026	Mesalamine impurity P
	Mesalamine impurity P is an impurity of Mesalamine . 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1]. [1]. Kyle Dammann, et al.PAK1 modulat...
T73792	(S)-(-)-Perillic acid
	(S)-(-)-Perillic acid, a terpenoid plant extract, exhibits antimicrobial and anticancer properties. This compound promotes cell apoptosis and cell cycle arrest while enhancing the levels of proteins such as Bax, Bcl2, p2...
T73579	YM-1
	YM-1, a stable and soluble analog of MKT-077, is an orally active inhibitor of Hsp70 that induces cell death in HeLa cells and elevates the levels of p53 and p21 proteins [1] [2].
T78805	AD4		Others
	AD4, an artemisinin derivative functioning as a proteolytic targeting chimera (PROTAC) for PCLAF, effectively degrades PCLAF in RS4;11 cells with an IC50 of 0.6 nM. This degradation activates the p21/Rb axis, resulting i...		Others

Compounds

Target: Histone Methyltransferase, Autophagy

O6-Benzylguanine

T7539

Synonym:

Target: Apoptosis, DNA Alkylation, DNA/RNA Synthesis

LCH-7749944

T11826

Synonym: GNF-PF-2356

Target: Apoptosis, PAK

BIX-01294 trihydrochloride

T1959

Synonym: BIX 01294

Target: Histone Methyltransferase, Autophagy

Fingolimod hydrochloride

T2539

Synonym: Fingolimod (FTY720) HCl,FTY720

Target: TRP/TRPV Channel, S1P Receptor, PAK, LPL Receptor

Pifithrin-α, p-Nitro, Cyclic

Synonym: PF-309,PF-03758309,PF 3758309

Target: Apoptosis, PAK

PF-3758309 hydrochloride

T4230

Synonym: PF-03758309 hydrochloride

Target: Apoptosis, PAK

Target: Epigenetic Reader Domain

NP213 TFA (942577-31-3 free base)

TP2149

Synonym: NP213 TFA

Target: Others

BRK inhibitor P21d hydrochloride

T39772

Synonym: BRK inhibitor P21d hydrochloride

Target: Glucocorticoid Receptor

Dacinostat

T2454

Synonym: NVP-LAQ824,LAQ824

Target: HDAC, Autophagy

FRAX486 HCL(1232030-35-1 free base)

Target: DNA Alkylator/Crosslinker

Indisulam

T4321

Synonym: E 7070

Target: CDK, Carbonic Anhydrase

Aspirin

T0005

Synonym: Acetylsalicylate,Acetylsalicylic Acid,ASA

Target: Mitophagy, Virus Protease, COX, Autophagy

Vesnarinone

T3465

Synonym: OPC-8212,Arkin,Piteranometozine

Target: HIV Protease, PDE

WS-383

T13349

Synonym:

Target: E1/E2/E3 Enzyme

G-5555 hydrochloride (1648863-90-4 free base)

T11342

Synonym: G-5555 hydrochloride

2,3-DCPE hydrochloride

T22490

Synonym:

Target: Others

Inolitazone dihydrochloride

T15580

Synonym: RS5444 dihydrochloride,CS-7017 dihydrochloride,Efatutazone dihydrochloride

Mesalamine impurity P

T37026

Synonym:

Target:

(S)-(-)-Perillic acid

Cat No.	Product Name	Synonyms	Targets
T8678	Naphthazarin	5,8-Dihydroxy-1,4-naphthoquinone,DHNQ	Apoptosis
	Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, inter...		Apoptosis
T0646	5-Aminosalicylic Acid	Mesalazine,5-ASA,Mesalamine	NF-κB , Lipoxygenase , COX , Glutathione Peroxidase , Endogenous Metabolite , PAK , PPAR
	5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE.
T1633	β-Carotene	Carotaben,Beta-Carotene,Provitamin A	Apoptosis , ROS , Endogenous Metabolite
	β-Carotene (Provitamin A) is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene...		Apoptosis , ROS , Endogenous Metabolite
T7939	Fingolimod	FTY-720A,FTY-720	S1P Receptor , PAK , LPL Receptor
	Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).		S1P Receptor , PAK , LPL Receptor
T5429	Theaflavin 3,3'-digallate	8-Gingerol,TFDG	Virus Protease , Antioxidant , HIV Protease , HSV
	Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregul...		Virus Protease , Antioxidant , HIV Protease , HSV
T6S1917	Schisandrol B	Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B	P450 , Reactive Oxygen Species , Autophagy
	1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a...		P450 , Reactive Oxygen Species , Autophagy
TN2080	Pinoresinol	(+)-Pinoresinol	Apoptosis , NF-κB , CDK , p53
	Pinoresinol ((+)-Pinoresinol) has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, to increase nitric oxide release and to reduce oxidative st...		Apoptosis , NF-κB , CDK , p53
T3314	Perillyl alcohol	Isocarveol,Perilla alcohol	Apoptosis , Endogenous Metabolite
	Perillyl Alcohol is a naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol (Isocarveol) inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-...		Apoptosis , Endogenous Metabolite
T16942	Sterigmatocystine		Others
	Sterigmatocystine is an inhibitor of G1 Phase and DNA synthesis and is used to inhibit p21 activity. Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versico...		Others
TN1354	Aaptamine		c-Myc , TNF , p53
	Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.		c-Myc , TNF , p53
TMA0918	Neochamaejasmine A		Caspase
	Neochamaejasmin A can inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells, it blocks cell cycle progression at the G1 phase by activating...		Caspase
T38243	Hygrolidin
	Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC...

Natural Products

Naphthazarin

T8678

Synonym: 5,8-Dihydroxy-1,4-naphthoquinone,DHNQ

Target: Apoptosis

5-Aminosalicylic Acid

T0646

Synonym: Mesalazine,5-ASA,Mesalamine

Target: NF-κB, Lipoxygenase, COX, Glutathione Peroxidase, Endogenous Metabolite, PAK, PPAR

β-Carotene

T1633

Synonym: Carotaben,Beta-Carotene,Provitamin A

Target: Apoptosis, ROS, Endogenous Metabolite

Fingolimod

T7939

Synonym: FTY-720A,FTY-720

Target: S1P Receptor, PAK, LPL Receptor

Theaflavin 3,3'-digallate

T5429

Synonym: 8-Gingerol,TFDG

Target: Virus Protease, Antioxidant, HIV Protease, HSV

Schisandrol B

T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Pinoresinol

TN2080

Synonym: (+)-Pinoresinol

Target: Apoptosis, NF-κB, CDK, p53

Perillyl alcohol

T3314

Synonym: Isocarveol,Perilla alcohol

Target: Apoptosis, Endogenous Metabolite

Target: c-Myc, TNF, p53

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04397	PAK-3 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	PAK3 is a member of PAK proteins, a family of serine/threonine p21-activating kinases, serve as effectors of small Rho GTPases Cdc42 and RAC and have been implicated in a wide range of biological activities. There are si...
TMPY-01187	Rac1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	RAC1 is a GTPase that belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal re...
TMPY-02439	Rac2 Protein, Human, Recombinant (His)	Human	E. coli
	Ras-related C3 botulinum toxin substrate 2 (Rac2) is a small G-protein belonging to the Ras subfamily of the GTPase family. Rac2 acts as an "on / off" switch for signal transduction cascades and motilities. When GDP is a...
TMPY-00499	TMP21 Protein, Human, Recombinant (mFc)	Human	HEK293
	TMED10 disrupts the complex formation between TGF-beta type I (also termed ALK5) and type II receptors (TbetaRII). Misexpression studies revealed that TMED10 attenuated TGF-beta-mediated signaling. A 20-amino acid-long r...
TMPH-02140	CYP21A2 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-d...
TMPH-00094	HSP21, chloroplastic Protein, Arabidopsis thaliana, Recombinant (His & Myc)	Arabidopsis thaliana	E. coli
	Chaperone protein required for seedling and chloroplast development under heat stress, probably by maintaining plastid-encoded RNA polymerase (PEP)-dependent transcription.
TMPH-01790	NUP210 Protein, Human, Recombinant (His)	Human	E. coli
	Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.
TMPH-02141	CYP21A2 Protein, Human, Recombinant (His)	Human	Yeast
	A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-d...
TMPY-05554	NUP210 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	NUP210 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells with GST tag. The predicted molecular weight is 31.7 kDa. Accession number: Q8TEM1-1
TMPH-03269	COMMD5 Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the ...
TMPK-01034	SEMA4B Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling p...
TMPH-01075	P53 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPY-02796	KIAA0101 Protein, Human, Recombinant (His)	Human	E. coli
	KIAA11, also known as p15(PAF), is a proliferating cell nuclear antigen-associated factor that interacts with proliferating cell nuclear antigen(PCNA). It was initially isolated in a yeast two-hybrid screen for PCNA bind...
TMPH-03264	P53 Protein, Rat, Recombinant (His)	Rat	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPH-02574	P53 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPY-04559	CDC42BPB Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	CDC42BPB is a member of the serine / threonine protein kinase family that contains a Cdc42 / Rsc-binding p21 binding domain similar to that of PAK kinase. The kinase domain of this protein is related to the myotonic dyst...
TMPY-03792	CHN1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	CHN1, also known as chimerin 1, is a TPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction me...
TMPY-04023	BCCIP Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ...
TMPY-00578	BCCIP Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ...
TMPY-02810	Ninjurin-1 Protein, Rat, Recombinant (hFc)	Rat	HEK293
	Ninjurin-1, also known as NINJ1, is a member of the Ninjurin family of transmembrane (TM) proteins. It is expressed in CD19(+) CD10(+) B-cell progenitor cells and higher levels in B-lineage acute lymphoblastic leukemia c...
TMPY-03700	S100A11 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of theS-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell pe...
TMPY-03793	CHN1 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	CHN1, also known as chimerin 1, is a TPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction me...
TMPY-01331	S100A11 Protein, Human, Recombinant	Human	E. coli
	Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of theS-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell pe...
TMPH-00842	P63 Protein, Human, Recombinant (His)	Human	E. coli
	Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specifi...
TMPY-03435	NCKIPSD Protein, Human, Recombinant (GST)	Human	E. coli
	NCKIPSD is localized exclusively in the cell nucleus. It plays a role in signal transduction and may function in the maintenance of sarcomeres and the assembly of myofibrils into sarcomeres. NCKIPSD also plays an importa...