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Search Results for " ccr "

Targets

53

Compounds

3

Natural Products

13

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T25214 CCR-11 CCR11,CCR 11 Antibiotic
CCR-11 is a tannin-containing derivative with antimicrobial activity. CCR-11 inhibits the proliferation of B. subtilis and HeLa cells. CCR-11 inhibits bacterial proliferation and bacterial cytoplasmic division by inhibit...
T14688 BMS CCR2 22 CCR
BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.
T10715 CCR6 inhibitor 1 CCR
CCR6 inhibitor 1 is an effective and selective inhibitor of CCR6 (IC50 of monkey and human CCR6 was 0.45 nM and 6 nM, respectively). CCR6 is associated with both autoimmune and non-autoimmune diseases, so CCR6 inhibitor ...
T10708 CCR1 antagonist 6 CCR
CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM).
T11481 GSK2239633A CCR
GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.
T10156 CCR3 antagonist 1 CCR
CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.
T13114 CCR2 antagonist 4 Teijin compound 1 CCR
CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM).
TQ0103 INCB3344 CCR
INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8 nM (mCCR2) and in 3.8 nM (hCCR2) antagonism of chemotaxis act...
T4300 AZD2098 CCR
AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.
TQ0283 RS102895 CCR
RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.
T5384 RS 504393 CCR
RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).
T14900 CCR2-RA-[R] CCR
CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).
T10712 CCR2 antagonist 3 AZD-2927,AZD2927 CCR
CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.
T4674 SB297006 SB 297006 CCR
SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of ...
T24700 R243 R 243,R-243 CCR
R243 is CCR8 signaling and chemotaxis inhibitor.
T10425 AZ084 CCR
AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.
T16111 ML604086 CCR
ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations. ML604086 is a selective inhibitor of CCR8. It also inhibiting CCL1 binding to CCR8 on circulating T-cells.
T16091 MK-0812 Succinate Others , CCR
MK-0812 Succinate is an effective and selective CCR2 antagonist. It also has a high affinity at CCR2.
T11699 J-113863 CCR
J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptor...
T3430 PF-4136309 INCB8761,PF 4136309 CCR
PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.
T4584 BMS-813160 BMS 813160 CCR
BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.
T12773 RS102895 hydrochloride Others , 5-HT Receptor , CCR
RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).
T2375 BX471 BX 471,BX-471,ZK-811752 CCR
BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.
T10639 C-021 dihydrochloride CCR
C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.
T7499 TAK-779 Takeda 779 HIV Protease , CXCR , CCR
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
T30258 AZD-4818 CCR1 antagonist CCR
AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.
T27682 CCR2 antagonist 5 JNJ-41443532,JNJ-41443532 Free Base,JNJ 41443532,JNJ41443532 CCR
CCR2 antagonist 5 (JNJ-41443532) is a selective and orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM).JNJ-41443532 binds mCCR2 with a Ki of 9.6...
T7624 DAPTA DAPTA(TFA),D-Ala-peptide T-amide,Adaptavir HIV Protease , CCR
DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.
T6016 Maraviroc Celsentri,UK-427857,Selzentry HIV Protease , CCR
Maraviroc (Selzentry) is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits HIV-1 entry via CCR5 coreceptor interaction.
TQ0297 Cenicriviroc TAK-652,TBR-652 HIV Protease , CCR
Cenicriviroc (TAK-652) is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory activity.
T17225 Vercirnon CCX282-B,GSK-1605786,Traficet-EN CCR
Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.
T10714 CCR5 antagonist 1 HIV Protease , CCR
CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
T10713 CCR4 antagonist 2 Calcium Channel
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the n...
T10710 CCR1 antagonist 9 CCR
CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).
T14899 CCR1 antagonist 8 CCR
CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).
T10711 CCR2 antagonist 1 CCR
CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
T10709 CCR1 antagonist 7 CCR
CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].
T21870 C-021 4-​Quinazolinamine, 2-​[1,​4'-​bipiperidin]​-​1'-​yl-​N-​cycloheptyl-​6,​7-​dimethoxy- CCR
C 021 dihydrochloride is a potent CCR4 antagonist. C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s ...
T39661 CCR4 antagonist 3 CCR4 antagonist 3
CCR4 antagonist 3 is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC 50 s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4 antago...
T39662 CCR4 antagonist 3 hydrochloride
CCR4 antagonist 3 hydrochloride is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC 50 s of 22 nM and 50 nM in the calcium flux and CTX assa...
T2386 Pirfenidone S-7701,AMR-69,S-7701,AMR69 CCR , TGF-beta/Smad
Pirfenidone (AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tum...
T3435 Vicriviroc maleate SCH-D (maleate),SCH-417690 (maleate) HIV Protease , CCR
Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in clinical development for the treatment...
T10716 CCR7 Ligand 1 CCR7-Cmp2105 Others
CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activat...
T19230 CCR2 antagonist 4 hydrochloride Teijin compound 1 hydrochloride Others
CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM).
T60145 CCR6 antagonist 1 CCR
CCR6 antagonist 1, a chemical compound acting as a CCR6 antagonist, effectively inhibits the CCL20/CCR6 axis. Its utility lies in research focused on autoimmune-mediated inflammatory diseases, including inflammatory bowe...
T60336 CCR4 antagonist 3-1 CCR
CCR4 antagonist 3-1 is a less active chemokine receptor 4 (CCR4) antagonist that inhibits [125I]TARC (thymus and activation-regulated chemokine) with an IC50 value of 1.7 μM. CCR4 antagonist 3-1 inhibits the binding of r...
T9983 CCR8 antagonist 1 LUN04765 CCR
CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.
T77349 CCR1/5/8 activator 1 Phospholipase
CCR1/5/8 activator 1 is a cytoplasmic phospholipase A inhibitor with antifungal activity.
T62944 CCR8 antagonist 2
CCR8 antagonist 2 is a potent antagonist of CCR8 that inhibits the activity of CCR8 (C-C Motif chemokine receptor 8), which is predominantly expressed on Treg and Th2 cells, and not on Th1 cells. CCR8 antagonist 2 can be...
T64242 CCR1 antagonist 11 hydrochloride
CCR1 antagonist 11 hydrochloride (A1B1) is an orally active CCR1 antagonist that acts on hCCR1 (IC50: 0/.03 μM), mCCR1 (IC50: 0.58 μM), rCCR1 (IC50: 0.32 μM). 11 hydrochloride can be used to study rheumatoid arthritis an...

Compounds

CCR-11
T25214
Synonym: CCR11,CCR 11
Target: Antibiotic
BMS CCR2 22
T14688
Synonym:
Target: CCR
CCR6 inhibitor 1
T10715
Synonym:
Target: CCR
CCR1 antagonist 6
T10708
Synonym:
Target: CCR
GSK2239633A
T11481
Synonym:
Target: CCR
CCR3 antagonist 1
T10156
Synonym:
Target: CCR
CCR2 antagonist 4
T13114
Synonym: Teijin compound 1
Target: CCR
INCB3344
TQ0103
Synonym:
Target: CCR
AZD2098
T4300
Synonym:
Target: CCR
RS102895
TQ0283
Synonym:
Target: CCR
RS 504393
T5384
Synonym:
Target: CCR
CCR2-RA-[R]
T14900
Synonym:
Target: CCR
CCR2 antagonist 3
T10712
Synonym: AZD-2927,AZD2927
Target: CCR
SB297006
T4674
Synonym: SB 297006
Target: CCR
R243
T24700
Synonym: R 243,R-243
Target: CCR
AZ084
T10425
Synonym:
Target: CCR
ML604086
T16111
Synonym:
Target: CCR
MK-0812 Succinate
T16091
Synonym:
Target: Others, CCR
J-113863
T11699
Synonym:
Target: CCR
PF-4136309
T3430
Synonym: INCB8761,PF 4136309
Target: CCR
BMS-813160
T4584
Synonym: BMS 813160
Target: CCR
RS102895 hydrochloride
T12773
Synonym:
Target: Others, 5-HT Receptor, CCR
BX471
T2375
Synonym: BX 471,BX-471,ZK-811752
Target: CCR
C-021 dihydrochloride
T10639
Synonym:
Target: CCR
TAK-779
T7499
Synonym: Takeda 779
Target: HIV Protease, CXCR, CCR
AZD-4818
T30258
Synonym: CCR1 antagonist
Target: CCR
CCR2 antagonist 5
T27682
Synonym: JNJ-41443532,JNJ-41443532 Free Base,JNJ 41443532,JNJ41443532
Target: CCR
DAPTA
T7624
Synonym: DAPTA(TFA),D-Ala-peptide T-amide,Adaptavir
Target: HIV Protease, CCR
Maraviroc
T6016
Synonym: Celsentri,UK-427857,Selzentry
Target: HIV Protease, CCR
Cenicriviroc
TQ0297
Synonym: TAK-652,TBR-652
Target: HIV Protease, CCR
Vercirnon
T17225
Synonym: CCX282-B,GSK-1605786,Traficet-EN
Target: CCR
CCR5 antagonist 1
T10714
Synonym:
Target: HIV Protease, CCR
CCR4 antagonist 2
T10713
Synonym:
Target: Calcium Channel
CCR1 antagonist 9
T10710
Synonym:
Target: CCR
CCR1 antagonist 8
T14899
Synonym:
Target: CCR
CCR2 antagonist 1
T10711
Synonym:
Target: CCR
CCR1 antagonist 7
T10709
Synonym:
Target: CCR
C-021
T21870
Synonym: 4-​Quinazolinamine, 2-​[1,​4'-​bipiperidin]​-​1'-​yl-​N-​cycloheptyl-​6,​7-​dimethoxy-
Target: CCR
CCR4 antagonist 3
T39661
Synonym: CCR4 antagonist 3
Target:
CCR4 antagonist 3 hydrochloride
T39662
Synonym:
Target:
Pirfenidone
T2386
Synonym: S-7701,AMR-69,S-7701,AMR69
Target: CCR, TGF-beta/Smad
Vicriviroc maleate
T3435
Synonym: SCH-D (maleate),SCH-417690 (maleate)
Target: HIV Protease, CCR
CCR7 Ligand 1
T10716
Synonym: CCR7-Cmp2105
Target: Others
CCR2 antagonist 4 hydrochloride
T19230
Synonym: Teijin compound 1 hydrochloride
Target: Others
CCR6 antagonist 1
T60145
Synonym:
Target: CCR
CCR4 antagonist 3-1
T60336
Synonym:
Target: CCR
CCR8 antagonist 1
T9983
Synonym: LUN04765
Target: CCR
CCR1/5/8 activator 1
T77349
Synonym:
Target: Phospholipase
CCR8 antagonist 2
T62944
Synonym:
Target:
CCR1 antagonist 11 hydrochloride
T64242
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T6413 Bindarit AF2838 CCR
Bindarit (AF2838) displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
TN1273 7,4'-Dihydroxyflavone 4',7-Dihydroxyflavone NF-κB , COX , HDAC , CCR , NOD
7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
TN2951 3-(hydroxymethyl)cyclopentanone CCR
3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the preparation of HIV chemokine CCR-5 receptor antagonists.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPK-00879 CCR2b Protein-VLP, Human, Recombinant Human HEK293 Cells
The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammator...
TMPK-00897 CCR8 Protein, Human, Recombinant (mFc) Human HEK293 Cells
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and ...
TMPK-00896 CCR8 Protein, Human, Recombinant (hFc) Human HEK293 Cells
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and ...
TMPK-01316 CCR8 Protein, Cynomolgus, Recombinant (mFc) Cynomolgus HEK293 Cells
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and ...
TMPH-01064 CCR4 Protein, Human, Recombinant (His & SUMO) Human E. coli
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger...
TMPH-01065 CCR4 Protein-VLP, Human, Recombinant (His) Human HEK293 Cells
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger...
TMPH-01066 CCR6 Protein, Human, Recombinant (His & Myc) Human E. coli
CCR6 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 12.9 kDa and the accession number is P51684.
TMPY-00856 TCCR Protein, Human, Recombinant (hFc) Human HEK293 Cells
TCCR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 79 kDa and the accession number is Q6UWB1.
TMPK-00356 IL-27RA/TCCR Protein, Human, Recombinant (His) Human HEK293 Cells
IL-27Ra (also known as TCCR and WSX1) as a gene whose expression can induce the transformation of hematopoietic cells. IL-27Ra (IL-27R) is a type I cytokine receptor that functions as the ligand binding component of the ...
TMPY-05543 TCCR Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
TCCR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.6 kDa and the accession number is AAC40121.1.
TMPY-06792 TCCR Protein, Mouse, Recombinant (His & Avi), Biotinylated Mouse HEK293 Cells
TCCR Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 56.37 kDa and the accession number is AAC40121.1.
TMPK-00009 CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated Human E. coli
The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited n...
TMPK-00008 CCL5 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited n...
Cat No. Product Name
L7600 Chemokine Inhibitor Library

59 compounds
A unique collection of 59 chemokines or chemokine receptors targeted compounds for high throughput and high content screening;
TargetMol