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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TP1658L | Type A Allatostatin I acetate | Type A Allatostatin I acetate(123209-95-0 free base) | Others |
Type A Allatostatin I acetate is a tridecapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects. | |||
TP1658 | Type A Allatostatin I | ||
Type A Allatostatin I is a tridecapeptide that falls under the category of pleiotropic neuropeptides. These neuropeptides are known for their ability to inhibit the synthesis of juvenile hormone in insects. | |||
TP2188 | type I hair keratin fragment [Homo sapiens]/[Ovis aries]/[Rattus norvegicus] | Others | |
The human type I hair keratin subfamily comprises nine individual members, which can be subdivided into three groups. Group A (hHa1, hHa3-I, hHa3-II, hHa4) and B (hHa7, hHa8) each contains structurally related hair kerat... | |||
T1944 | LDN-214117 | ALK , TGF-beta/Smad | |
LDN-214117 is a potent and selective ALK2 inhibitor. | |||
TQ0155 | Miglustat hydrochloride | NB-DNJ hydrochloride,N-Butyldeoxynojirimycin hydrochloride,OGT918 hydrochloride | Transferase |
Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) is an inhibitor of glucosylceramide synthase and can be used for studies about Type I Gaucher disease. | |||
TP1878L | PACAP 1-38 acetate | PACAP | |
PACAP 1-38 acetate is a pituitary adenylate cyclase activating polypeptide (PACAP) analogue. PACAP 1-38 acetate binds to PACAP type I receptor(IC50 = 4 nM) and PACAP type II VIP2 receptor(IC50 = 1 nM) but not to PACAP ty... | |||
TQ0061 | CHZ868 | JAK | |
CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia. | |||
T16938 | ST034307 | Adenylyl cyclase | |
ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM). | |||
T6158 | LDN-193189 HCl | LDN193189 Hydrochloride | ALK |
LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor. | |||
T77432 | Anifrolumab | MDX-1333,MEDI-546 | IFNAR |
Anifrolumab(MEDI-546) is a potent type I interferon (IFN) receptor antagonist, a human monoclonal antibody that targets IFN.Anifrolumab inhibits the activity of type I interferon and is used for the prevention and treatm... | |||
T5197 | BIBF0775 | ALK , TGF-beta/Smad | |
BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM). | |||
T8330 | BIO-013077-01 | TGF-beta/Smad | |
BIO-013077-01 is a potent TGFbeta family type I receptors antagonist. | |||
TP1722L | PACAP (6-38), human, ovine, rat acetate | PACAP | |
PACAP (6-38), human, ovine, rat acetate is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively. | |||
T77502 | Wnt pathway inhibitor 3 | Wnt/beta-catenin , Adenylyl cyclase | |
Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studies to ameliorate osteoarthritis in a mouse model of experimenta... | |||
T72282 | Ebaresdax hydrochloride | Endogenous Metabolite | |
Ebaresdax hydrochloride has analgesic activity and is used in the study of painful diabetic neuropathy caused by type I or type II diabetes. | |||
TQ0060 | LY2857785 | Apoptosis , CDK | |
LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM). | |||
T67961 | Safironil | Others | |
safironil is a novel antifibrotic compound and a competitive inhibitor of collagen synthesis. safironil inhibited in vitro experiments on fibroblast activation monitored by collagen I mRNA or smooth muscle alpha-actin le... | |||
T68123 | Oxodipine | Calcium Channel | |
Oxodipine, a dihydropyridine-type calcium antagonist , inhibited KCl-induced aortic contraction in rabbits and reduced cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventri... | |||
T22840 | HexylHIBO | GluR | |
HexylHIBO is a type I mGluR antagonist that inhibits mGlu1a and mGlu5a, with Kb values of 140 and 110 μM, respectively.HexylHIBO decreases sEPSC in rats. | |||
T27643 | Izonsteride | LY-320236,LY320236,UNII-A5E8C36F34 | Reductase |
Izonsteride (LY320236) is a selective and potent 5alpha reductase inhibitor with dual action on the type I and type II isoforms of the enzyme.Izonsteride is used in the treatment of oncology and genitourinary disorders, ... | |||
T24088 | GGTI-2133 | GGTI2133,GGTI 2133 | Transferase |
GGTI-2133 is a potent mimetic peptidyl geranylgeranyltransferase type I inhibitor (GGTase I) with an IC50 value of 38 nM.GGTI-2133 inhibits the invasion of inflammatory cells into the airways in experimental asthma in mi... | |||
T2294 | BG45 | Apoptosis , HDAC | |
BG45 is an HDAC I type inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3/1/2/6 in cell-free assays, respectively. | |||
T2123 | LY2109761 | Autophagy , TGF-beta/Smad | |
LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2. | |||
T27034 | CL075 | 3M002,CL-075 | NF-κB , TLR , MyD88 |
CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to elicit the production of inflammatory cytokines and type I i... | |||
T2098 | A 77-01 | A77-01 | ALK , TGF-beta/Smad |
A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. | |||
T13683 | Epsilon-momfluorothrin | Momfluorothrin, (Z,1R,3R)- | Others |
Epsilon-momfluorothrin (Momfluorothrin, (Z,1R,3R)-), a type I synthetic pyrethroid insecticide, exerts its insecticidal properties and triggers activation of the constitutive androstane receptor (CAR). Notably, its admin... | |||
T5964 | Olmesartan | CS 088,RNH 6270 | RAAS |
Olmesartan (RNH 6270) is an Angiotensin II Type I receptor antagonist. Olmesartan is the active form of the antihypertensive drug olmesartan medoxomil,and has antihypertensive activity. | |||
T65133 | 3-Hydroxybutyric acid sodium | β-Hydroxybutyric acid sodium | |
3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite present in type I diabetic patients that has the property of regulating membrane lipids. | |||
T72617 | Nampt activator-2 | P450 , NAMPT | |
Nampt activator-2 is a NAMPT activator (EC50: 0.023 μM). Nampt activator-2 has an affinity for CYP2C9, 2D6, and 2C19 with affinity values of 0.060 μM, 0.41 μM, and 0.59 μM, respectively.Nampt activator-2 can be used in t... | |||
T6900 | MS023 | Histone Methyltransferase | |
MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively. | |||
T16708 | R-268712 | ALK , TGF-beta/Smad | |
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor. | |||
T4393 | MS049 2HCl (1502816-23-0(free base)) | Histone Methyltransferase | |
MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 μM for PRMT1, PRMT3, and PRMT8, respectively) and... | |||
T40996 | Coppersensor 1 | Coppersensor 1,CS1 | Others |
Coppersensor 1 (CS1) is a boron dipyrromethene-based fluorescent sensor for selective and sensitive detection of copper(I) ions (Cu + ) in biological samples. Coppersensor 1 can be imaged using any type of fluorescence m... | |||
T6549 | Isepamicin sulfate | Isepamicine (Isepamycin,Isepamicin Sulphate,Isepacin,sch21420) Sulphate | Antibacterial , Antibiotic |
Isepamicin sulfate (sch21420) Sulphate) , an aminoglycoside antibacterial with good activity against strains producing type I 6-acetyltransferase, inhibits bacterial protein synthesis by targeting the bacterial 30S ribos... | |||
T13613 | ChX710 | STING | |
ChX710 activates the type I interferon response to cytosolic DNA by priming specific Interferon-Stimulated Genes (ISGs), inducing the ISRE promoter sequence, and facilitating the phosphorylation of Interferon Regulatory ... | |||
T1977 | Dorsomorphin | Compound C,BML-275 | AMPK , Autophagy , TGF-beta/Smad |
Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive. Dorsomorphin inhibits the BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin induces autophagy, and possesses antitumor ... | |||
T1726 | SB-431542 | SB 431542 | ALK , TGF-beta/Smad |
SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective. SB 431542 also has inhibitory activity against ALK4 and ALK7 but not other proteins. SB 431542 can be used for induced differentiatio... | |||
T19675 | SM360320 | CL-087,SM 360320,CL 087,1V136,SM-360320,CL087 | TLR |
SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for ... | |||
T36113 | Cobaltic Protoporphyrin IX chloride | Protoporphyrin IX cobaltic chloride | Autophagy |
Cobaltic Protoporphyrin IX chloride (CoPP) is a potent heme oxygenase 1 (HO-1) inducer with antiviral activity that inhibits influenza A virus (IAV) infection by inducing a type I IFN response. mTOR inhibitor-8 is a pote... | |||
T6273 | Vadimezan | DMXAA,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404 | Influenza Virus , VDA , STING , IFNAR |
Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without aff... | |||
T35348 | LDN-193189 2HCl | LDN-193189 2HCl,DM-3189 2HCl | ALK , TGF-beta/Smad |
LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively, in kinase assays.LDN-193189 2HCl inhibited ... | |||
T1900 | LDN-212854 | LDN212854,BMP Inhibitor III | ALK , TGF-beta/Smad |
LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors. | |||
T11500L | GSK3368715 dihydrochloride | EPZ019997 dihydrochloride,GSK3368715 2HCl,EPZ019997 2HCl | Histone Methyltransferase |
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active and potent inhibitor of type I protein arginine methyltransferases (PRMTs) with anticancer and antitumor activity, inhibiting PRMT1, PRMT3, PRMT4... | |||
T77513 | 2-Chlorophenylboronic acid | FAAH | |
2-Chlorophenylboronic acid is a monohalogenated phenylboronic acid, which is an important pharmaceutical intermediate and is widely used in the synthesis of new drugs.2-Chlorophenylboronic acid has an inhibitory effect o... | |||
T60248 | 4-Aminobenzamidine dihydrochloride | p-Aminobenzamidine dihydrochloride | Serine Protease |
4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) is a strong trypsin inhibitor and a relatively weak inhibitor of urokinase type plasminogen activator (uPA) (K i =82 μM). 4-Aminobenzamidine can inh... | |||
T61338 | MS023 dihydrochloride | MS023 2HCl | Histone Methyltransferase |
MS023 dihydrochloride (MS023 2HCl) is a selective, cytosolic and highly potent inhibitor of human type I protein arginine methyltransferases (PRMTs) with antitumour activity, inhibits PRMT1, PRMT3, PRMT4, PRMT6, and PRMT... | |||
T77484 | Atibuclimab | TNF | |
Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region. Atibuclimab can be used to treat amyotrophic lateral sclerosis. Atibuclimab reduces LPS-indu... | |||
T3031 | A 83-01 | ALK5 Inhibitor IV,A8301 | ALK , TGF-beta/Smad |
A 83-01 (ALK5 Inhibitor IV) is an inhibitor of the TGF-β type I receptors ALK5, ALK4, and ALK7 (IC50=12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse fibroblasts into iPSCs. A 83-01 can be used in organoid cult... | |||
T21979 | P32/98 (hemifumarate) | ||
P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a K i value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model. P32... | |||
T8785 | HALOFUGINONE LACTATE | DNA/RNA Synthesis , TGF-beta/Smad | |
HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner ... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T64812 | Collagenase Type I | Collagenase I,Collagenase Type I (From microorganisms) | Others |
Collagenase Type I is a proteolytic enzyme that breaks down the peptide bonds in collagen, the main structural protein of connective tissue. Collagenase has been explored as a potential treatment option to break down her... | |||
T1135 | Vitamin D3 | Cholecalciferol,Colecalciferol | Endogenous Metabolite |
Vitamin D3 (Cholecalciferol) , a naturally occurring form of vitamin D, activates an H305F/H397Y mutant vitamin D receptor (VDR). | |||
T12039 | Miglustat | N-Butyldeoxynojirimycin,OGT918,NB-DNJ | Others |
Miglustat (NB-DNJ) is an alkylated product of imino sugar deoxynojirimycin.It is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1). | |||
T6856 | Halofuginone | Tempostatin,empostatin,RU-19110 | Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad |
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal. | |||
T3524 | Halofuginone hydrobromide | Tempostatin,RU-19110 (hydrobromide),Stenorol | Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad |
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce... | |||
T2862 | Desaminotyrosine | Phloretate,3-(4-Hydroxyphenyl)propanoic acid,Hydro-p-coumaric acid,3-(4-Hydroxyphenyl)propionic acid,Phloretic acid | Others , Influenza Virus , Endogenous Metabolite |
Desaminotyrosine (3-(4-Hydroxyphenyl)propionic acid) is a microbially associated metabolite. Desaminotyrosine protects from influenza through augmentation of type I interferon signaling. | |||
T19340 | Glutarylcarnitine | O-glutaroyl-L-carnitine | Endogenous Metabolite |
Glutarylcarnitine (O-glutaroyl-L-carnitine) is a diagnostic metabolite for malonic aciduria and glutaric aciduria type I monitored in most tandem mass spectrometry newborn screening programmes. | |||
T6293 | Mycophenolate Mofetil | TM-MMF,RS 61443 | Apoptosis , Dehydrogenase , Drug Metabolite |
Mycophenolate Mofetil (TM-MMF), an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrogenase (IMPDH). | |||
TN2100 | Pratensein | Others , NF-κB | |
Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells. | |||
T6975 | Sarcosine | Sarcosinic acid,Methylaminoacetic acid,Sarcosin,Methylglycine,N-Methylaminoacetic acid,N-methylglycine | Others , GlyT , Endogenous Metabolite |
Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist. | |||
T1521 | (±)-10-Hydroxycamptothecin | Hydroxy Camptothecine,10-Hydroxycamptothecin | Topoisomerase |
(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. S... | |||
TN1088 | 3,5,6,7,8,3',4'-Heptemthoxyflavone | 3,3',4',5,6,7,8-heptamethoxyflavone | Others |
3,5,6,7,8,3',4'-Heptemthoxyflavone has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotective effects; it inhibits collagenase activity and induces type I pro... | |||
T5273 | 2-Hydroxy-3-methylbutanoic acid | 2-Hydroxy-3-methylbutyric acid,2-Hydroxyisovaleric Acid,(±)-2-Hydroxyisopentanoic Acid | Others , Endogenous Metabolite |
2-Hydroxy-3-methylbutanoic acid ((±)-2-Hydroxyisopentanoic Acid) is a metabolite found in the urine of patients with phenylketonuria, methylmalonic acidemia, propionic acidemia, 3-ketothiolase deficiency, isovaleric acid... | |||
T2S1792 | Lycobetaine | Ungeremine | Antibacterial |
1. Lycobetaine (Ungeremine) is a potential biofungicide against Penicillium roqueforti and Aspergillus niger.2. Lycobetaine have strong antibacterial activity against Flavobacterium columnare . 3. Lycobetaine effectively... | |||
T5267 | N-Acetyl-L-glutamic acid | Ac-L-Glu-OH,N-Acetylglutamic acid | Others , Endogenous Metabolite |
N-Acetyl-L-glutamic acid (Ac-L-Glu-OH) (NAcGlu) is an acetylated amino acid. NAcGlu is biosynthesized from glutamic acid and acetyl-CoA by the enzyme N-acetyl glutamate synthase (NAGS). NAcGlu activates carbamoyl phospha... | |||
T2830 | Betulinic acid | ALS-357,Lupatic acid,Betulic acid | Apoptosis , Mitophagy , NF-κB , HIV Protease , Topoisomerase , Endogenous Metabolite , Aminopeptidase , Autophagy |
Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretroviral, antimalarial, and anti-inflammatory propert... | |||
T13544 | Altertoxin I | Dihydroalterperylenol | Others |
Altertoxin I (Dihydroalterperylenol) is a quinone-type mycotoxin produced by Alternaria alternata fungi. It is mutagenic and cytotoxic and can weakly disrupt metabolic communication. | |||
T31382 | Deoxypyridinoline | Lysylpyridinoline | |
Deoxypyridinoline is one of two pyridinium cross-links that provide structural stiffness to type I collagen found in bones. It is excreted unmetabolized in urine and is a specific marker of bone resorption and osteoclast... | |||
TN5447 | Apigenin 7-O-methylglucuronide | Apigenin-7-O-β-D-glucuronide methyl ester | |
Apigenin 7-O-methylglucuronide did not affect GAG level or secretion, may potentially be used in osteogenesis imperfecta (OI) type I pharmacotherapy in patients with normal GAG content. Apigenin 7-O-methylglucuronide whi... | |||
T75540 | Ipomoeassin F | ||
Ipomoeassin F, a selective and potent inhibitor of endoplasmic reticulum (ER) protein translocation, targets the Sec61 complex's pore-forming subunit (Sec61α) at the ER membrane. It inhibits the ER membrane translocation... | |||
T73717 | CGAMP diammonium | ||
cGAMP (Cyclic GMP-AMPP) diammonium serves as an intrinsic second messenger in metazoans, initiating the production of interferons upon cytosolic DNA detection. It activates the stimulator of interferon genes (STING), sub... | |||
TN4456 | Lucidadiol | AChR , HSV | |
Lucidadiol exhibits butyrylcholinesterase-inhibitory activity at concentrations up to 200 uM, it also possesses inhibitory activity against acetylcholinesterase (AChE) with the percentage inhibition at 100 uM. Lucidadiol... | |||
T13606L | CGAMP disodium | ||
cGAMP disodium is a cyclic dinucleotide (CDN) found in bacteria that acts as an endogenous second messenger affecting interferon production in response to cytoplasmic DNA. cGAMP disodium cascades signals from type I inte... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04774 | ALK-2/ACVR1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been... | |||
TMPY-01047 | IL-1R1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro... | |||
TMPY-01168 | ALK-1 Protein, Human, Recombinant (His) | Human | HEK293 |
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. ... | |||
TMPY-03157 | ALK-2/ACVR1 Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been... | |||
TMPY-03706 | ALK-2/ACVR1 Protein, Canine, Recombinant (hFc) | Canine | HEK293 |
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been... | |||
TMPY-02059 | IL-1R1 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro... | |||
TMPY-03688 | IL-1R1 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro... | |||
TMPY-03744 | IL-1R1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro... | |||
TMPY-03707 | ALK-2/ACVR1 Protein, Canine, Recombinant (His) | Canine | HEK293 |
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been... | |||
TMPY-03247 | ALK-2/ACVR1 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been... | |||
TMPY-02142 | IL-1R1 Protein, Rat, Recombinant (His & mFc) | Rat | HEK293 |
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro... | |||
TMPJ-01142 | CDO1 Protein, Human, Recombinant (His) | Human | E. coli |
Cysteine Dioxygenase Type 1 (CDO1) is a mammalian non-heme iron enzyme that belongs to the cysteine dioxygenase family. CDO1 is highly expressed in the liver and placenta, and has a low expression in heart, brain and pan... | |||
TMPH-03469 | 3-dehydroquinase Protein, Salmonella typhi, Recombinant (His) | Salmonella typhi | Yeast |
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ... | |||
TMPJ-01117 | INPP5A Protein, Human, Recombinant (His) | Human | Human Cells |
Type I inositol 1,4,5-trisphosphate 5-phosphatase is a 412 amino acids protein that belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family. Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme ... | |||
TMPH-02524 | Arginase-1/ARG1 Protein, Mouse, Recombinant (His) | Mouse | Yeast |
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell ... | |||
TMPH-02525 | Arginase-1/ARG1 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell ... | |||
TMPK-01239 | THSD7A Protein, Human, Recombinant (His) | Human | HEK293 |
Thrombospondin type I domain-containing 7A (THSD7A), is a specific autoantigen of adult idiopathic membranous nephropathy (IMN), whose circulating antibody (THSD7A-AB) represents a promising biomarker for diagnosis of IM... | |||
TMPK-00687 | Keratin, type I cytoskeletal 19 (310-399) Protein, Canine, Recombinant (His) | Canine | E. coli |
Keratin 19 (K19) belongs to the keratin family of proteins, which maintains structural integrity of epithelia. In cancer, K19 is highly expressed in several types where it serves as a diagnostic marker. | |||
TMPJ-01178 | TGFBR1 Protein, Mouse, Recombinant (hFc) | Mouse | Human Cells |
TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Pho... | |||
TMPY-01096 | ALK-2/ACVR1 Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 |
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been... | |||
TMPY-02729 | IL-1R1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro... | |||
TMPY-02341 | IL-1R1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro... | |||
TMPY-05207 | PRKAR1A Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
PRKAR1A, also known as PRKAR1 and PKR1, is one of the regulatory subunits of cAMP-dependent protein kinase A (PKA). PKA can be activated by cAMP. cAMP is a signaling molecule important for a variety of cellular functions... | |||
TMPH-01025 | CALCA Protein, Human, Recombinant (GST) | Human | E. coli |
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevate... | |||
TMPY-00658 | ALK-2/ACVR1 Protein, Human, Recombinant (His & hFc) | Human | HEK293 |
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been... | |||
TMPJ-00240 | CAMK1 Protein, Human, Recombinant (His) | Human | Human Cells |
Calcium/Calmodulin-Dependent Protein Kinase Type 1 (CAMK1) belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, and CaMK subfamily. CAMK1 contains one protein kinase domain and widely expressed.... | |||
TMPJ-00304 | ALK-1 Protein, Mouse, Recombinant (hFc) | Mouse | Human Cells |
Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angi... | |||
TMPY-02648 | PACAP receptor/ADCYAP1R1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Pituitary adenylate cyclase activating polypeptide (PACAP, Adcyap1) activation of PAC1 receptors ( Adcyap1r1) significantly increases excitability of guinea pig cardiac neurons. This modulation of excitability is mediate... | |||
TMPJ-00280 | TNF R1 Protein, Mouse, Recombinant | Mouse | E. coli |
Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a) is a member of the tumor necrosis factor receptor superfamily. Tnfrsf1a is one of the major receptors for the tumor necrosis factor-alpha. It can activate t... | |||
TMPY-01048 | IL-1R1 Protein, Human, Recombinant (His) | Human | HEK293 |
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro... | |||
TMPY-03426 | IL-1R1 Protein, Human, Recombinant | Human | HEK293 |
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This pro... | |||
TMPJ-01158 | ALK-2/ACVR1 Protein, Human, Recombinant (hFc) | Human | Human Cells |
Activin RIA, also known as ALK-2, TSK-7L, SKR1, TSR-I, and ACTR-I, is a glycosylated 65 kDa type I receptor in the TGF-beta serine/threonine kinase receptor family. Binding of TGF-beta superfamily ligands induces formati... | |||
TMPY-00650 | ALK-1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. ... | |||
TMPY-03656 | PRKAR1A Protein, Human, Recombinant (His) | Human | HEK293 |
PRKAR1A, also known as PRKAR1 and PKR1, is one of the regulatory subunits of cAMP-dependent protein kinase A (PKA). PKA can be activated by cAMP. cAMP is a signaling molecule important for a variety of cellular functions... | |||
TMPJ-01086 | CD244 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Natural killer cell receptor 2B4 (2B4/CD244)is a 66 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 protein family. SLAM family proteins have an extracellular domain (ECD) with two or four Ig-like d... | |||
TMPY-01907 | VSIG4 Protein, Human, Recombinant (His) | Human | HEK293 |
VSIG4 (V-set and immunoglobulin domain containing 4), also known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig, is a type I transmembrane glycoprotein. It is a B7 family-related protein and an... | |||
TMPY-03072 | IFN-omega Protein, Human, Recombinant (His) | Human | HEK293 |
IFNs are a large family of proteins having antiviral, antiproliferative, and immunomodulatory effects, and are divided into two major classes, type I and type II, based on differences in receptor binding and nucleotide s... | |||
TMPY-02237 | KIR2DL3 Protein, Human, Recombinant (His) | Human | HEK293 |
Killer cell immunoglobulin-like receptor 2DL3, also known as CD158 antigen-like family member B2, KIR-23GB, Killer inhibitory receptor cl 2-3, MHC class I NK cell receptor, NKAT2a, NKAT2b, Natural killer-associated trans... | |||
TMPY-05442 | KIR2DL3 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Killer cell immunoglobulin-like receptor 2DL3, also known as CD158 antigen-like family member B2, KIR-23GB, Killer inhibitory receptor cl 2-3, MHC class I NK cell receptor, NKAT2a, NKAT2b, Natural killer-associated trans... | |||
TMPJ-01430 | NovoNectin Protein, Human, Recombinant | Human | E. coli |
Fibronectin1(FN1) is a secreted protein and contains 12 fibronectin type-I domains,fibronectin type-II domains and 16 fibronectin type-III domains.Recombinant human fibronectin fragment, is a protein of ~63 kDa containin... | |||
TMPY-05511 | NKp46/NCR1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
NCR1, also known as NK-p46 and CD335, is a natural cytotoxicity receptor(NCR). NCRs are type I transmembrane proteins with 1-2 extracellular immunoglobulin domains, a transmembrane domain containing a positively charged ... | |||
TMPJ-00387 | IL-4R alpha Protein, Mouse, Recombinant (hFc) | Mouse | Human Cells |
Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions a... | |||
TMPY-01009 | TGFBI Protein, Human, Recombinant (His) | Human | HEK293 |
TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several ... | |||
TMPJ-00261 | TGF beta 2 Protein, Mouse/Rat, Recombinant | Mouse,Rat | Human Cells |
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofaci... | |||
TMPJ-00113 | CD79B Protein, Human, Recombinant (hFc) | Human | Human Cells |
CD79B is a single-pass type I membrane protein. CD79B contains one Ig-like V-type domain and one ITAM domain. CD79B is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the... | |||
TMPY-00265 | Interferon alpha 2/IFNA2 Protein, Human, Recombinant | Human | Yeast |
IFNA2 (Interferon Alpha 2) is a Protein Coding gene. This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Type I Interfero... | |||
TMPY-01934 | IL-21R Protein, Human, Recombinant (His) | Human | HEK293 |
Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R, and NILR, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 4 subfamil... | |||
TMPY-03758 | Vaccinia Virus B18R/B19R Protein (His) | VACV | Baculovirus-Insect Cells |
B18R is a type I interferon (IFN)-binding protein, which is encoded by the B18R open reading frame in the WR (Western Reserve) strain of vaccinia virus. It is also known as B19R in the Copenhagen strain of Vaccinia. ... | |||
TMPY-00007 | Interferon alpha 2/IFNA2 Protein, Mouse, Recombinant | Mouse | Yeast |
IFNA2 (Interferon Alpha 2) is a Protein Coding gene. This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Type I Interfero... | |||
TMPY-04799 | IFNAR2 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 |
Interferon-alpha/beta receptor beta chain (IFNAR2) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protei... | |||
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Cat No. | Product Name | ||
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L4100 | TGF-beta/Smad Compound Library | 185 compounds | |
A unique collection of 185 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening; |