serine protease

Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the activity of Cathepsin B, Cathepsin H, and Cathepsin L, and blocks fusion of amphipathic lysosomes. Leupeptin hemisulfate also has anti-inflammatory activity.

Trypsin Inhibitor, soybean is a trypsin inhibitor extracted from leguminous plants.

Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells.

Alpha-Amyrin (alpha-Amyrine) is an inhibitor of trypsin and chymotrypsin with antineoplastic effects. alpha-Amyrin can be used in studies about acting as a hepatomodulatory.

Chrysophanol 8-O-glucoside and chrysophanol have mild cytotoxicity and anti-diabetic properties and can play metabolic roles in the insulin-stimulated glucose transport pathway

erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether is a compound extracted from Brazilian rubber seed hulls and is an inhibitory activity against human leukocyte elastase (IC50 : 171 umol L).

Secologanoside shows anti-complementary, allelopathic, and anti-elastase activities.

β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase protease inhibitors for broad spectrum inhibition. It functions as an organic phosphate donor

L-Serine (serine) is a non-essential amino acid in humans, L-Serine is present and functionally important in many proteins.L-Serine is also found at the active site of the serine protease enzyme class that includes trypsin and chymotrypsin.

Chymotrypsin (Chymotrypsin A) is a serine protease synthesized by the pancreas, which cleaves protein chains on the carboxyl side of aromatic amino acids.

Trypsin is a serine protease that can be isolated from fish to hydrolyze lysine or arginine carboxy-side proteins. With the anti-inflammatory activity, Trypsin could induce the cell membrane fusion of PDCoV-infected cells through the interaction between the S glycoprotein of PDCoV and pAPN, activate PAR2 and PAR4, and promote cell proliferation and differentiation. Trypsin can be used to promote wound healing and study neurogenic inflammation.

Bradykinin is an inflammatory mediator. It is a peptide that causes blood vessels to dilate (enlarge) via the release of prostacyclin, nitric oxide, and Endothelium-Derived Hyperpolarizing Factor. Bradykinin is a physiologically and pharmacologically active peptide of the kinin group of proteins, consisting of nine amino acids.

Rivulariapeptolides 1185, a highly potent and selective serine protease inhibitor, exhibits IC50 values of 13.17 nM for chymotrypsin, 23.59 nM for elastase, and 55.26 nM for proteinase K [1].

Molassamide B, a serine protease inhibitor, exhibits potent inhibitory activity, as evidenced by its IC50 values of 24.65 nM against chymotrypsin, 11.69 nM against elastase, and 5.42 nM against proteinase K [1].

Rivulariapeptolides 1121 is a potent and selective serine protease inhibitor, demonstrating IC50 values of 35.52 nM for chymotrypsin, 13.24 nM for elastase, and 48.05 nM for proteinase K [1].

Rivulariapeptolides 988 demonstrates significant potency and selectivity as a serine protease inhibitor, exhibiting IC50 values of 95.46 nM for chymotrypsin, 15.29 nM for elastase, and 85.50 nM for proteinase K [1].

Myriocin (Thermozymocidin), a metabolite derived from Myriococcum albomyces, is a serine-palmitoyltransferase (SPT) inhibitor with potential antitumour, anticancer, and antiparasitic activities.Myriocin inhibits tumour growth by regulating macrophage polarisation and function through the PI3K Akt mTOR pathway.Myriocin inhibits HCV infection and can be used in the study of neurological diseases. Myriocin inhibits HCV infection and can be used to study neuropathy and fungal infections.

Rivulariapeptolides 1155 is a potent serine protease inhibitor with inhibitory concentrations (IC50s) of 41.84 nM, 4.94 nM, and 56.54 nM against chymotrypsin, elastase, and proteinase K, respectively [1].

Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of ce