serine protease

Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the activity of Cathepsin B, Cathepsin H, and Cathepsin L, and blocks fusion of amphipathic lysosomes. Leupeptin hemisulfate also has anti-inflammatory activity.

Alpha-Amyrin (alpha-Amyrine) is an inhibitor of trypsin and chymotrypsin with antineoplastic effects. alpha-Amyrin can be used in studies about acting as a hepatomodulatory.

erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether is a compound extracted from Brazilian rubber seed hulls and is an inhibitory activity against human leukocyte elastase (IC50 : 171 umol/L).

Trypsin Inhibitor, soybean is a trypsin inhibitor extracted from leguminous plants.

Chymotrypsin (Chymotrypsin A) is a serine protease synthesized by the pancreas, which cleaves protein chains on the carboxyl side of aromatic amino acids.

Trypsin is a serine protease that can be isolated from fish to hydrolyze lysine or arginine carboxy-side proteins. With the anti-inflammatory activity, Trypsin could induce the cell membrane fusion of PDCoV-infected cells through the interaction between the S glycoprotein of PDCoV and pAPN, activate PAR2 and PAR4, and promote cell proliferation and differentiation. Trypsin can be used to promote wound healing and study neurogenic inflammation.

Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells.

Bradykinin is an inflammatory mediator. It is a peptide that causes blood vessels to dilate (enlarge) via the release of prostacyclin, nitric oxide, and Endothelium-Derived Hyperpolarizing Factor. Bradykinin is a physiologically and pharmacologically active peptide of the kinin group of proteins, consisting of nine amino acids.

Chrysophanol 8-O-glucoside and chrysophanol have mild cytotoxicity and anti-diabetic properties and can play metabolic roles in the insulin-stimulated glucose transport pathway

Rivulariapeptolides 1155 is a potent serine protease inhibitor with inhibitory concentrations (IC50s) of 41.84 nM, 4.94 nM, and 56.54 nM against chymotrypsin, elastase, and proteinase K, respectively [1].

Rivulariapeptolides 1185, a highly potent and selective serine protease inhibitor, exhibits IC50 values of 13.17 nM for chymotrypsin, 23.59 nM for elastase, and 55.26 nM for proteinase K [1].

Rivulariapeptolides 1121 is a potent and selective serine protease inhibitor, demonstrating IC50 values of 35.52 nM for chymotrypsin, 13.24 nM for elastase, and 48.05 nM for proteinase K [1].

Rivulariapeptolides 988 demonstrates significant potency and selectivity as a serine protease inhibitor, exhibiting IC50 values of 95.46 nM for chymotrypsin, 15.29 nM for elastase, and 85.50 nM for proteinase K [1].

Secologanoside shows anti-complementary, allelopathic, and anti-elastase activities.

Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of ce

Aristololactam IIIa demonstrates substantial inhibition of superoxide anion generation and elastase release, exhibiting IC50 values of 0.12 and 0.20 μg mL, respectively [1].

Nostosin G, a linear peptide, comprises three subunits: 4-hydroxyphenyllactic acid (Hpla), homotyrosine (Hty), and argininal. It exhibits a potent trypsin inhibitory effect, demonstrated by an IC 50 value of 0.1 μM [1].

Rennin (Chymosin) is a proteolytic enzyme related to pepsin, produced in the stomachs of certain animals, that effectively coagulates liquid milk into a semi-solid form, prolonging its retention in the stomach. It specifically targets K-casein, cleaving the peptide bond between the amino acid residues phenylalanine and methionine (105 and 106), and plays a crucial role in cheese production [1].

Laccaridione B inhibits the activity of serine proteases. It exhibits inhibitory effects on trypsin, papain, thermolysin, collagenase, and zinc metalloprotease with IC50 values of 10.9 μg/mL, 5.1 μg/mL, 8.4 μg/mL, 5.7 μg/mL, and 3.0 μg/mL, respectively. Additionally, Laccaridione B shows significant antiproliferative activity against L-929, K-562, and HeLa cells, with IC50 values of 2.4 μg/mL, 1.8 μg/mL, and 13.9 μg/mL, respectively.

Bacithrocin C is a thrombin inhibitor that suppresses the activity of thrombin, factor Xa, trypsin, and papain, with IC50 values of 80 μM, 15 μM, 1.3 μM, and 0.02 μM, respectively.

Bacithrocin B is a thrombin inhibitor that suppresses the activity of thrombin, Factor Xa, trypsin, and papain, with IC50 values of 84 μM, 17 μM, 1.7 μM, and 0.02 μM, respectively.

Bacithrocin C is a thrombin inhibitor that also suppresses factor Xa, trypsin, and papain, with IC50 values of 48 μM, 13 μM, 0.65 μM, and 0.02 μM, respectively.

19 alpha-Hydroxyasiatic acid shows significant anticoagulant effect on the extrinsic pathway.

Pyracrenic acid is a potent elastase inhibitor with an IC50 value of 1.5 mg/mL. Pyracrenic acid shows DPPH radical scavenging activity. It also shows significant cytotoxic activities against human cancer cells COLO 205 and AGS.