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Results for "

diabetic

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    333
    TargetMol | Inhibitors_Agonists
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    TargetMol | Compound_Libraries
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Rosiglitazone
BRL49653
T0334122320-73-4
Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer.
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Infliximab
T9921170277-31-3
Infliximab is a monoclonal antibody, a human-mouse chimeric monoclonal antibody that inhibits TNF-α and prevents TNF-α from interacting with TNFR1 and TNFR2. Infliximab can be used to treat Crohn's disease and rheumatoid arthritis.
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4-6 weeks
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Gatifloxacin hydrochloride
PD135432 (hydrochloride), BMS-206584 (hydrochloride), AM-1155 (hydrochloride)
T8384121577-32-0
Gatifloxacin hydrochloride (AM-1155 hydrochloride) is a fourth-generation fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV.
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Spironolactone
SC9420, Abbolactone
T0476
Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
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Rosiglitazone hydrochloride
Rosiglitazone HCl, BRL-49653 HCl
T6646302543-62-0
Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
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Antidiabetic agent 6
T89177
Compound 19, also known as Antidiabetic agent 6, is an antidiabetic compound. It stimulates the translocation of GLUT4 by activating the PI3K AKT-dependent signaling pathway. Furthermore, this compound reduces blood glucose levels in diabetic rats induced by streptozotocin.
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Antidiabetic agent 2
T79644
Compound 56 (Antidiabetic agent 2) is a glucose-uptake promoter that inhibits DPP-4, PTP-1B, α-amylase, and α-glucosidase, with IC50 values of 0.036, 0.042, 0.241, and 0.185 μM, respectively. This agent effectively decreases blood glucose levels [1].
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Antidiabetic agent 7
T205369
Antidiabetic agent 7 (Compound 5m) functions as a potent hyperglycemia inhibitor. It effectively stimulates GLUT4 translocation in skeletal muscle cells by activating the AMPK-dependent pathway. Additionally, this compound is capable of reducing blood glucose levels and exhibits favorable pharmacokinetic properties. Antidiabetic agent 7 is suitable for research related to antihyperglycemic treatments.
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Antidiabetic agent 5
T856782152667-21-3
Compound S1 (antidiabetic agent 5) is an antidiabetic agent that effectively inhibits the enzymes α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 µM and 8.89 µM, respectively. It reduces sugar levels and holds potential for type-II diabetes research [1].
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10-14 weeks
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Insulin (human)
Insulin(human), INSULIN
T822111061-68-0
Insulin (human) is a peptide hormone that promotes glycogen synthesis and regulates glucose levels in the blood. Insulin (human) has hypoglycemic activity and is used clinically to treat hyperglycemia in diabetic patients.
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dirlotapide
Slentrol, CP742033
T15006481658-94-0In house
Dirlotapide (CP742033) is an intestinal selective microsomal triglyceride transfer protein (MTP) inhibitor. It reduces body weight in diabetic dogs.Dirlotapide reduces food intake in a dose-dependent manner, possibly by increasing the release of peptide YY into the circulation.
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6-8 weeks
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Kamuvudine-8
T85346 In house
Kamuvudine-8 (K8) is a zidovudine (AZT) derivative that can be used to study diabetic macular edema.
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PPA-904
T1952530189-85-6In house
PPA-904, a specific phenothiazine photosensitizer, is used in photodynamic therapy (PDT).
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7-10 days
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P32/98 hemifumarate
P32 98 (hemifumarate)(136259-20-6 free base)
T21979251572-86-8In house
P32 98 hemifumarate is a dipeptidyl peptidase IV (DPP4) inhibitor with hypoglycemic properties that improves insulin sensitivity and β-cell responsiveness in the Zucker diabetic rat model, and may be useful in studies of type 2 diabetes and colitis.
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6-8 weeks
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α-NETA
αNETA, alpha-NETA
T61454115066-04-1In house
α-NETA is a potent choline acetyltransferase (ChA) inhibitor and an ALDH1A1 and chemokine-like receptor 1 (CMKLR1) antagonist.Anti-cancer activity,Cholinesterase and acetylcholinesterase (AChE) inhibition,Dose-dependent reduction of body weight and fasting blood glucose levels in STZ-induced diabetic mice,Significantly reduced expression of renal injury markers,May be CEP-9722 can be used for the study of diabetic nephropathy.
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6-8 weeks
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Raxofelast
IRFI016, IRFI-016, IRFI 016
T34268128232-14-4In house
Raxofelast (IRFI-016) is a hydrophilic, non-systemic, vitamin-like antioxidant that reduces ischemia-reperfusion injury in testis. Raxofelast is a good candidate compound for stopping oxidative stress after acute testicular torsion. Raxofelast has the potential to treat diabetic complications and atherosclerosis.
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6-8weeks
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16α-Bromoepiandrosterone
PPB2, HE-2000, HE2000, BEA, 16-Bromoepiandrosterone, 16alpha-Bromoepiandrosterone, 16a-Bromoepiandrosterone
T3205128507-02-0In house
16α-Bromoepiandrosterone (BEA) is a water-soluble synthetic sterol related to DHEA and is used in studies of type II diabetes and non-diabetic tuberculosis infections.
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6-8 weeks
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Ranirestat
SX-3030, SX3030, AS-3201, AS3201, AS 3201
T16723147254-64-6In house
Ranirestat (AS-3201) is an orally active and potent aldose reductase (AR) inhibitor with neuroprotective properties that ameliorates peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy.Ranirestat inhibits the inflammatory response of high glucose-exposed endothelial cells and may be useful for the study of diabetic sensory-motor polyneuropathy.
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8-10 weeks
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Coleneuramide
MCC-257
T67980204200-47-5In house
Coleneuramide (MCC-257) enhances the effect of nerve growth factor (NGF) on cell survival and can be used to study diabetic polyneuropathy.
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Minalrestat
ARI509, WAY-121509, WAY121509, WAYARI-509, ARI-509, WAY-ARI-509
T33389129688-50-2In house
Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.
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6-8weeks
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Apararenone
MT-3995
T14301945966-46-1In house
Apararenone (MT-3995) is a mineralocorticoid receptor antagonist indicated for the treatment of non-alcoholic steatohepatitis and diabetic nephropathy.
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Safotibant
LF220542, LF 220542, LF 22-0542, LF-220542, LF-22-0542, LF22-0542
T34485633698-99-4In house
Safotibant (LF-22-0542) is a bradykinin B1 receptor antagonist with anti-inflammatory and analgesic activity for the topical treatment of diabetic macular edema.
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6-8weeks
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AMG-1694
T142121361217-07-3In house
AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates GK translocation.
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6-8 weeks
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Sonedenoson
MRE-0094, MRE0094, MRE 0094
T34685131865-88-8In house
Sonedenoson (MRE0094) is an adenosine A(2A) receptor agonist and potential inhibitor potentially targeting SARS-CoV-2 coronavirus 2;-O-ribose methyltransferase, and may be used in the study of diabetic foot ulcers.
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6-8 weeks
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