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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8345 | Carbutamide | Others | |
Carbutamide is a sulfonylurea antidiabetic agent with hypoglycemic activity. | |||
T7042 | 1,5-Isoquinolinediol | PARP | |
1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol... | |||
T9921 | Infliximab | TNF | |
Infliximab is a humanized antibody against tumor necrosis factor α TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis. | |||
T16724 | Razuprotafib | AKB-9778 | Phosphatase , Others |
Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor (IC50: 50 nM). Razuprotafib is effective for the activation of Tie-2 and is protective against acute kidney injury. | |||
T7704 | KY-226 | Phosphatase | |
KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM,) | |||
T7502L | PF 05089771 | PF-05089771,PF05089771 | Sodium Channel |
PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent. | |||
T2058 | Palosuran | ACT-058362 | GPR |
Palosuran (ACT-058362) (ACT-058362) is a new potent and specific antagonist of the human UT receptor. | |||
T21902 | ML351 | Lipoxygenase | |
ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM). | |||
T6237 | Trelagliptin | SYR-472 | Proteasome , DPP-4 |
Trelagliptin (SYR-472) is a highly specific and long-acting DPP-4 inhibitor. | |||
T7502 | PF 05089771 tosylate | Sodium Channel | |
PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8... | |||
T1129 | Benfotiamine | Benzoylthiamine monophosphate,S-Benzoylthiamine O-monophosphate | Others |
Benfotiamine (S-Benzoylthiamine O-monophosphate) is a synthetic S-acyl derivative of thiamine (vitamin B1), used as an antioxidant dietary supplement. | |||
T3100 | GSK-J4 | GSK J4 HCl | Apoptosis , Histone Demethylase |
GSK-J4 (GSK J4 HCl) is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX wit... | |||
T25340 | Diprotin A | Ile-Pro-Ile | DPP-4 |
Diprotin A (Ile-Pro-Ile) (Ile-Pro-Ile) is a dipeptidyl peptidase IV (DPP-IV) inhibitor. | |||
T8408 | GKT136901 | AK120765 | NADPH-oxidase , NADPH |
GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite | |||
T0476 | Spironolactone | SC9420,Abbolactone | Glucocorticoid Receptor , Androgen Receptor , Autophagy |
Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist. | |||
T35317 | Zopolrestat | CP 73850,CP73850,CP-73850,Zopolrestatum | Reductase |
Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM). | |||
T2316 | Omarigliptin | MK-3102 | Proteasome , DPP-4 |
Omarigliptin (MK-3102) has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency. | |||
T8405 | Vardenafil hydrochloride | PDE | |
Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes | |||
T0096 | Vardenafil | Vivanza,Levitra,Vardenafil hydrochloride | PDE |
Vardenafil (Vivanza) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemod... | |||
T4691 | Asimadoline hydrochloride | EMD-61753 hydrochloride | Opioid Receptor |
Asimadoline hydrochloride (EMD-61753 hydrochloride) is a κ-opioid receptor agonist potentially for the treatment of pruritus. Asimadoline hydrochloride has also been shown to be used in the treatment of irritable bowel s... | |||
T0334 | Rosiglitazone | BRL49653 | Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy |
Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer. | |||
T6587 | Mitiglinide Calcium | KAD-1229,S21403 | ATPase , Potassium Channel |
Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells. | |||
T6542 | Imidapril hydrochloride | Novaloc,Imidapril HCl,Tanapril,TA-6366 | RAAS |
Imidapril hydrochloride (Tanapril) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension. | |||
T2296 | Trelagliptin succinate | SYR-472 succinate,SYR472 | Proteasome , DPP-4 |
Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (T2D). | |||
T1615 | Irbesartan | SR-47436,BMS-186295 | Apoptosis , RAAS |
Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist. | |||
T4097 | Vardenafil hydrochloride trihydrate | Vardenafil HCl Trihydrate,BAY38-9456 | PDE |
Vardenafil hydrochloride trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. | |||
T4383 | GSK-J4 Hydrochloride | GSK J4 HCl,GSK J4 HCl (1373423-53-0 free base) | Histone Demethylase |
GSK-J4 Hydrochloride (GSK J4 HCl) is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with an IC50 value greater than 50 μM in vitro. | |||
T1530 | Mitiglinide calcium hydrate | KAD-1229 calcium hydrate,Mitiglinide calcium,S-21403 calcium hydrate | Potassium Channel |
Mitiglinide calcium hydrate (S-21403 calcium hydrate) is a drug for the treatment of type 2 diabetes. Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) K(ATP) channels in pancreatic ... | |||
T6646 | Rosiglitazone hydrochloride | BRL-49653 HCl,Rosiglitazone HCl | Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy |
Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells. | |||
T1293 | Gatifloxacin | BMS 206584-01,PD 135432,CG5501,BMS-206584,AM-1155 | Topoisomerase , Antibacterial , Antibiotic |
Gatifloxacin (CG5501) is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. | |||
T4633 | Asimadoline | EMD-61753 | Opioid Receptor |
Asimadoline (EMD-61753) is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany. Asimadoline was originally developed to treat peripheral pain such as arthritis. Asimadoline... | |||
T4480 | Vardenafil dihydrochloride | Levitra,Vardenafil Hydrochloride | PDE |
Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. | |||
T79644 | Antidiabetic agent 2 | Glucosidase | |
Compound 56 (Antidiabetic agent 2) is a glucose-uptake promoter that inhibits DPP-4, PTP-1B, α-amylase, and α-glucosidase, with IC50 values of 0.036, 0.042, 0.241, and 0.185 μM, respectively. This agent effectively decre... | |||
T37890L | GLP-1(28-36)amide acetate | GLP-1(28-36)amide acetate(1225021-13-5 Free base) | Antioxidant , Glucagon Receptor |
GLP-1(28-36)amide acetate inhibits mitochondrial permeability transition with antioxidant, anti-diabetic and cardioprotection activities. | |||
T28360 | PF-00489791 | PF-4634817,PF 4634817,PF00489791,PF 00489791,PF4634817 | PDE |
PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy. | |||
T34485 | Safotibant | LF220542,LF 220542,LF 22-0542,LF-220542,LF-22-0542,LF22-0542 | Bradykinin Receptor |
Safotibant (LF-22-0542) is a bradykinin B1 receptor antagonist with anti-inflammatory and analgesic activity for the topical treatment of diabetic macular edema. | |||
T33389 | Minalrestat | ARI509,WAY-121509,WAY121509,WAYARI-509,ARI-509,WAY-ARI-509 | Reductase |
Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients. | |||
T7298 | FT011 | Others | |
FT011, a direct anti-fibrotic agent,attenuates cardiac remodelling and dysfunction in experimental diabetic cardiomyopathy. | |||
T11877 | LR-90 | Others | |
LR-90, an advanced glycation end product (AGE) inhibitor, is utilized in diabetic animal model research. This compound effectively suppresses inflammatory responses in human monocytes. | |||
T6486 | Enalapril Maleate | MK-421 Maleate,Renitec Maleate,Glioten Maleate,MK-421 (maleate),Vasotec Maleate | RAAS |
Enalapril Maleate (MK-421 Maleate), an angiotensin-converting enzyme (ACE) inhibitor, is utilized in the treatment of hypertension, chronic heart failure , and diabetic nephropathy. | |||
T0358 | Aminoguanidine hydrochloride | Imino semicarbazide,Pimagedine hydrochloride,CP-12009-18 tartrate,Hydrazinecarboximidamide,Guanyl hydrazine,Pimagedine | NOS , NO Synthase |
Aminoguanidine hydrochloride (Hydrazinecarboximidamide) is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy. | |||
T67980 | Coleneuramide | MCC-257 | Others |
Coleneuramide (MCC-257) enhances the effect of nerve growth factor (NGF) on cell survival and can be used to study diabetic polyneuropathy. | |||
T16910 | Sorbinil | Reductase | |
Sorbinil is an Aldose reductase inhibitor. Sorbinil plays a therapeutic role in treating diabetes and diabetic complications decreases AR activity and inhibit the polyol pathway. | |||
T72282 | Ebaresdax hydrochloride | Endogenous Metabolite | |
Ebaresdax hydrochloride has analgesic activity and is used in the study of painful diabetic neuropathy caused by type I or type II diabetes. | |||
TP1761L | Handle region peptide, rat acetate | Handle region peptide, rat acetate(749227-53-0 free base) | Others |
Handle region peptide, rat acetate is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye. | |||
T8679 | Epidermal Growth Factor | EGFR | |
Epidermal Growth Factor binds to epidermal growth factor receptor (EGFR) and stimulates cell growth and proliferation. It is approved for the treatment of diabetic foot ulcers. | |||
T24626 | PF-249 | PF-06685249,PF 06685249,PF06685249 | AMPK |
PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy. | |||
T65133 | 3-Hydroxybutyric acid sodium | β-Hydroxybutyric acid sodium | |
3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite present in type I diabetic patients that has the property of regulating membrane lipids. | |||
T22276 | Bis(maltolato)oxovanadium(IV) | BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV) | Phosphatase , Others |
Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent i... | |||
TP1978L | NFAT inhibitor, Cell Permeable aceate | Others | |
NFAT inhibitor, Cell Permeable aceate is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. It can be used for the research of podocyte and diabetic nephropathy. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8158 | Tilianin | Others | |
Tilianin is a flavonoid glycoside of Dragocephalum moldavicum L. | |||
TN1644 | Flavanomarein | Others | |
Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells trea... | |||
T3S1591 | Notoginsenoside Fc | Others , Autophagy | |
1. Notoginsenoside Fc has perfect anti-platelet aggregatory effect. | |||
TN6490 | Regaloside C | Others | |
Regaloside C is a glycerol glucoside isolated from Lilium genus with anti-inflammatory properties. | |||
T7912 | (−)-Myrtenal | (1R)-(−)-Myrtenal | Others |
(−)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats. | |||
T3803 | Specnuezhenide | Nuzhenide,Nuezhenide | Others , NF-κB , Wnt/beta-catenin |
Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect t... | |||
TN1686 | Ginsenoside Rg4 | Antibacterial | |
Ginsenoside Rg4 is a natural product | |||
T2755 | Rhoifolin | Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside | Others , p38 MAPK , NF-κB , transporter , IGF-1R , Autophagy |
Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves. | |||
TN7108 | Urolithin C | Apoptosis , Calcium Channel , Reactive Oxygen Species , IGF-1R , Endogenous Metabolite | |
Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway. | |||
TN2111 | Prunin | Naringenin 7-0-glucoside | Phosphatase , Anti-infection , Virus Protease |
Prunin (Naringenin 7-0-glucoside) possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells; it also can... | |||
T7792 | Hispidin | Endogenous Metabolite , PKC | |
Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective properties | |||
TN6774 | Emodin 6-O-β-D-glucoside | Glucoemodin | Others |
Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside ... | |||
TN1471 | Cassiaside C | Toralactone 9-O-β-D-gentiobioside | Others , Endogenous Metabolite |
Cassiaside C (Toralactone 9-O-β-D-gentiobioside), a naphthopyrone extracted from Cassia tora seeds, exhibits in vitro inhibitory activity against the formation of advanced glycation end products (AGE). | |||
T2S1158 | 4,5-Dicaffeoylquinic acid | 3,4-Dicaffeoylquinic acid,Isochlorogenic acid C | Others , HBV , Endogenous Metabolite |
1. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) has antiviral activity, including anti-HIV-1 integrase activity. 2. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) shows anti-hepatotoxic activity. | |||
T8384 | Gatifloxacin hydrochloride | AM-1155 (hydrochloride),BMS-206584 (hydrochloride),PD135432 (hydrochloride) | Topoisomerase , Antibacterial , Antibiotic |
Gatifloxacin hydrochloride (AM-1155 hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, which can inhibit the bacterial enzyme DNA rotase and topoisomerase IV. | |||
T6S1917 | Schisandrol B | Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B | P450 , Reactive Oxygen Species , Autophagy |
1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a... | |||
T7026 | KukoaMine B | Antioxidant | |
Kukoamine B, as a constituent of Lycii Cortex, exhibits anti-acute inflammatory, anti-oxidant, and anti-diabetic characteristics. | |||
T7986 | Methyl tetracosanoate | Others | |
Methyl tetracosanoate is a natural product, with anti-diabetic activity. | |||
T4396 | Officinalisinin I | Others | |
Officinalisinin I can effectively reduce the blood glucose and protect nerve injuryin diabetic mice. | |||
T10183 | 6-Methoxytricin | Others | |
6-Methoxytricin is a flavonoid isolated from Artemisia iwayomogi. It is an inhibitor on aldose reductase (AR) and advanced glycation endproduct (AGE) formation activities (IC50s: 30.29 μM and 134.88 μM). 6-Methoxytricin ... | |||
T5S0669 | Bergamottin | 5-Geranoxypsoralen,Bergamotine,Bergaptin | P450 |
1. Bergamottin (5-Geranoxypsoralen) can significantly reduce blood glucose and increase glucose tolerance and insulin sensitivity in KK-A<sup>y</sup>diabetic mice. | |||
T2741 | Glycyrrhizic acid | Glycyrrhizin | Virus Protease , Dehydrogenase , MAO |
Glycyrrhizic acid (Glycyrrhizin) is a triterpenoid saponinl with anti-tumor and anti-diabetic activities. | |||
T6S1367 | Procyanidin B2 | Proanthocyanidin B2 | Reactive Oxygen Species , NOD |
Procyanidin B2 (Proanthocyanidin B2) has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression ... | |||
T4S0295 | Apigenin 7-glucoside | Cosmetin,Cosmosiin,Cosmosioside,Apigenin-7-O-β-D-glucopyranoside,Thalictiin,Apigetrin | Reactive Oxygen Species , HIV Protease |
1. Apigenin 7-glucoside (Cosmosiin) is a anti-HIV agent. 2. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 tr... | |||
TN1308 | 6-Hydroxyflavanone | Others , Lipoxygenase , COX , GABA Receptor | |
6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A r... | |||
TN2130 | Manghaslin | Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside | AChE , Glucosidase |
Manghaslin (Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside) has considerable α-glucosidase inhibitory activity, illustrating the anti-diabetic potential of phenolic-rich litchi pulp extracts. Manghaslin also shows inhibito... | |||
T4854 | Acetoacetic acid lithium salt | LithoTab acetoacetate,Lithium acetoacetate,Lithium 3-Oxobutyrate | Others , Endogenous Metabolite |
Acetoacetic acid lithium salt (Lithium 3-Oxobutyrate) is a weak organic acid that can be produced in the human liver under certain conditions of poor Metabolism leading to excessive fatty acid breakdown (diabetes mellitu... | |||
T2740 | Trans-Cinnamic acid | Isocinnamic acid,Cinnamic acid,trans-3-Phenylacrylic acid,Phenylacrylic acid,Cinnamylic acid,3-Phenylacrylic acid,Myricitrine | Endogenous Metabolite , Antibacterial |
trans-Cinnamic acid (Myricitrine) exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro. | |||
T5708 | LUPENONE | Phosphatase , Parasite | |
Lupenone is a natural product isolated from Rhizoma Musae and has good anti-diabetic activity,and has anti-inflammatory activity.lupenone were potent PTP1B inhibitors with IC50 values of 15.11±1.23μM. | |||
T2212 | Geniposide | Beta Amyloid , Influenza Virus | |
Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation... | |||
T3S0381 | Chrysophanol 8-O-glucoside | Serine Protease | |
Chrysophanol 8-O-glucoside and chrysophanol have mild cytotoxicity and anti-diabetic properties and can play metabolic roles in the insulin-stimulated glucose transport pathway | |||
TN1406 | Dihydrokaempferol | Aromadendrin | Apoptosis , BCL |
Dihydrokaempferol (Aromadendrin) is a natural product. It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression, possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory ... | |||
TN2165 | Rubrofusarin gentiobioside | Rubrofusarin-6-O-beta-D-gentiobioside | ERK , NF-κB , TGF-beta/Smad |
Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that it has potential as a preventive... | |||
T3823 | D-Pinitol | Pinitol,Inzitol,D-(+)-Pinitol,Methylinositol,3-O-Methyl-D-chiro-inositol | Others , Influenza Virus |
D-Pinitol (Methylinositol) has anti-inflammatory activity. D-Pinitol(Methylinositol) exerts insulin-like activity, used for many diabetic associated conditions. D-Pinitol(Methylinositol) is a safe nutrient to reduce calo... | |||
T5S1632 | Barlerin | 8-O-Acetylshanzhiside methyl ester,ND01 | VEGFR , TNF , NF-κB , Akt , Caspase |
Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ e... | |||
T7600 | Fucoxanthin | all-trans-Fucoxanthin | Others |
Fucoxanthin (all-trans-Fucoxanthin) is a carotenoid that occurs naturally in certain algae. It is found as an accessory pigment in the chloroplasts of brown algae and most other heterokonts, giving them a brown or olive-... | |||
T8184 | Fucosterol | PARP , Endogenous Metabolite , PPAR | |
Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and C/EBPα expression. | |||
TN1134 | Euscaphic acid | Apoptosis , LDL , PI3K , DNA/RNA Synthesis , NO Synthase , Prostaglandin Receptor | |
Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of... | |||
T5S2129 | Sciadopitysin | TNF , NF-κB | |
Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effects on antimycin A-induced toxicity in o... | |||
TN1020 | Monomelittoside | Danmelittoside | Others |
Monomelittoside (Danmelittoside), a compound extracted from the venom of the Chinese honeybee, is a flavonoid glycoside that has been found to have anti-inflammatory, anti-tumor and anti-diabetic properties. It has also ... | |||
TL0001 | Dencichine | L-Dencichin,ODAP,Dencichin | Others , HIF/HIF Prolyl-Hydroxylase |
Dencichine (ODAP) is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation and fibrinolytic system. It has renoprotective effec... | |||
T2P2919 | (2S,3R,4S)-4-Hydroxyisoleucine | (4S)-4-Hydroxy-L-isoleucine,Hydroxyisoleucine | PI3K |
(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid. HIL stimulates glucose-dependent insulin secr... | |||
T5S0384 | Rhapontin | Ponticin,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside | Apoptosis , Others |
1. Rhapontin (Ponticin) can alleviate liver steatosis and improve blood glucose and lipid profiles in KK/Ay diabetic mice, indicates that rhaponticin has a noticeable antidiabetic effect and could be potentially used as ... | |||
T4S0969 | Obtusifolin | Antioxidant , NF-κB | |
1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be... | |||
T5813 | BYAKANGELICIN | Reductase | |
BYAKANGELICIN,a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor,and is effective for the treatment of sugar cataracts and diabetic neuropathy and hence might be useful as a lea... | |||
TN1911 | Marein | transporter , Akt , HDAC , AMPK | |
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for ... | |||
T3414 | Morroniside | Apoptosis , MMP , Pyroptosis | |
Morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice. It exhibits protective effects against diabetic renal damage and human umbilical vein endothelial cells, by inhib... | |||
T5S0661 | Koumine | Others | |
1. Koumine can treat the diabetic neuropathy. 2. Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent. 3. Koumine has a significant analgesic effect in rodent behavioral models of infla... | |||
T3849 | Kinsenoside | (+)-Kinsenoside | Apoptosis , Nrf2 |
Kinsenoside ((+)-Kinsenoside) shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury as well as improving its function, it cou... | |||
TN1042 | Chebulic acid | Others | |
Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, has potent anti-oxidant activity,which breaks the cross-links of proteins induced by advanced glycation end-products (AGEs) and inhibits t... | |||
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Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00639 | EPO/Erythropoietin Protein, Human, Recombinant (hFc) | Human | HEK293 |
Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting... | |||
TMPY-00443 | EPO/Erythropoietin Protein, Mouse, Recombinant | Mouse | HEK293 |
Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting... | |||
TMPY-00853 | IL-1RA Protein, Human, Recombinant | Human | E. coli |
Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A), and interleukin 1, beta (IL1B), and mo... | |||
TMPJ-00071 | EPO/Erythropoietin Protein, Human, Recombinant (His) | Human | Human Cells |
Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoi... | |||
TMPY-02361 | VEGFR2/KDR Protein, Human, Recombinant (His) | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-05556 | Adiponectin Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Adiponectin (ADIPOQ), or 30 kDa adipocyte complement-related protein (Acrp30) is a protein secreted by adipose tissue, which acts to reduce insulin resistance and atherogenic damage, but it also exerts actions in other t... | |||
TMPY-02848 | Adiponectin Protein, Human, Recombinant (hFc) | Human | HEK293 |
Adiponectin (ADIPOQ), or 30 kDa adipocyte complement-related protein (Acrp30) is a protein secreted by adipose tissue, which acts to reduce insulin resistance and atherogenic damage, but it also exerts actions in other t... | |||
TMPY-01278 | Apolipoprotein H/APOH Protein, Human, Recombinant (His) | Human | HEK293 |
Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, Activated protein C-binding protein, B2GPI, and B2G1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipop... | |||
TMPY-02986 | EPO/Erythropoietin Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting... | |||
TMPK-01128 | LRG1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Diabetic nephropathy (DN) is an important public health concern of increasing proportions and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the most common long-term microvascular... | |||
TMPK-00526 | LRG1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Diabetic nephropathy (DN) is an important public health concern of increasing proportions and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the most common long-term microvascular... | |||
TMPY-00462 | EPO/Erythropoietin Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting... | |||
TMPY-02073 | EPO/Erythropoietin Protein, Rat, Recombinant (His) | Rat | Baculovirus-Insect Cells |
Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting... | |||
TMPY-05837 | IL-1RA Protein, Rat, Recombinant (His) | Rat | E. coli |
Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A), and interleukin 1, beta (IL1B), and mo... | |||
TMPY-00852 | IL-1RA Protein, Human, Recombinant (hFc) | Human | HEK293 |
Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A), and interleukin 1, beta (IL1B), and mo... | |||
TMPY-05845 | IL-1RA Protein, Cynomolgus, Recombinant (His) | Cynomolgus | E. coli |
Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A), and interleukin 1, beta (IL1B), and mo... | |||
TMPY-03081 | IL-1RA Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A), and interleukin 1, beta (IL1B), and mo... | |||
TMPK-00891 | GIP Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial. Initial interest in the therapeutic... | |||
TMPK-00036 | GIP Protein, Human, Recombinant (His) | Human | HEK293 |
The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial. Initial interest in the therapeutic... | |||
TMPK-00890 | GIP Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial. Initial interest in the therapeutic... | |||
TMPK-01122 | SG3/Secretogranin 3 Protein, Human, Recombinant (aa 20-468, His) | Human | HEK293 |
Secretogranin III (Scg3) is a member of the granin protein family that regulates the biogenesis of secretory granules. Scg3 was recently discovered as an angiogenic factor, expanding its functional role to extrinsic regu... | |||
TMPK-00673 | SG3/Secretogranin 3 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Secretogranin III (Scg3) is a member of the granin protein family that regulates the biogenesis of secretory granules. Scg3 was recently discovered as an angiogenic factor, expanding its functional role to extrinsic regu... | |||
TMPY-02100 | TEM7 Protein, Human, Recombinant (His) | Human | HEK293 |
Plexin domain-containing protein 1, also known as tumor endothelial marker 3, tumor endothelial marker 7 and PLXDC1 and TEM3, is a secreted, cytoplasm and single-pass type I membrane protein that belongs to the plexin fa... | |||
TMPK-00367 | MMP-9 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demon... | |||
TMPK-00503 | MMP-9 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demon... | |||
TMPK-00368 | MMP-9 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demon... | |||
TMPY-00719 | CNDP1 Protein, Human, Recombinant (His) | Human | HEK293 |
CNDP1, also known as carnosine dipeptidase 1, glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), is a member of the M20 metalloprotease family. The CNDP1 gene contains trinucleotide (CTG) repeat l... | |||
TMPY-02733 | CNDP1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
CNDP1, also known as carnosine dipeptidase 1, glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), is a member of the M20 metalloprotease family. The CNDP1 gene contains trinucleotide (CTG) repeat l... | |||
TMPK-00139 | Adiponectin Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Adiponectin, also known as Acrp30, is an adipocyte-derived protein with wide ranging paracrine and endocrine effects on metabolism and inflammation.Important adipokine involved in the control of fat metabolism and insuli... | |||
TMPK-00554 | Adiponectin Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Adiponectin, also known as Acrp30, is an adipocyte-derived protein with wide ranging paracrine and endocrine effects on metabolism and inflammation.Important adipokine involved in the control of fat metabolism and insuli... | |||
TMPY-00146 | RKIP/PEBP1 Protein, Human, Recombinant | Human | E. coli |
Phosphatidylethanolamine-binding protein 1 (PEBP1), also known as Raf kinase inhibitor protein, belongs to PEBP family of proteins. It is known to interact with many proteins that are mainly involved in pathways that mon... | |||
TMPY-05657 | VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-02678 | VEGFR2/KDR Protein, Rat, Recombinant (His) | Rat | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-04794 | VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc) | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-03202 | VEGFR2/KDR Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-01044 | VEGFR2/KDR Protein, Human, Recombinant (hFc) | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-04795 | VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, His) | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-04530 | VEGFR2/KDR Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-02736 | VEGFR2/KDR Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-02858 | VEGFR2/KDR Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-04796 | VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, His) | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-05382 | VEGFR2/KDR Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-04924 | VEGFR2/KDR Protein, Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-04802 | VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc) | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-05610 | VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-04940 | VEGFR2/KDR Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-03499 | CARHSP1 Protein, Human, Recombinant (His) | Human | E. coli |
CARHSP1 is a biomarker for diabetic complications. Adenovirus-mediated CARHSP1 overexpression and siRNA-mediated knockdown experiments were performed to characterize the role of CARHSP1 in the regulation of gluconeogen... | |||
TMPJ-01451 | Asprosin Protein, Human, Recombinant (His) | Human | Human Cells |
Asprosin is a protein hormone that is produced by white adipose tissue in mammals (and potentially by other tissues), which is then transported to the liver and stimulates it to release glucose into the blood stream. In ... | |||
TMPH-03760 | NAMPT Protein, Mouse, Recombinant | Mouse | E. coli |
The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low lev... | |||
TMPJ-00022 | LGALS7 Protein, Human, Recombinant | Human | E. coli |
The Galectin family of proteins, with specificity for Nacetyllactosamine containing glycoproteins, consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs).They also poss... | |||
------------------------ More ------------------------ |
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L1900 | Anti-Diabetic Compound Library | 690 compounds | |
A unique collection of 690 diabetes related compounds; | |||
L4800 | Angiogenesis related Compound Library | 1370 compounds | |
A unique collection of 1370 proangiogenic and antiangiogenic compounds for new targets identification, research in mechanisms of angiogenesis, and high throughput screening (HTS) and high content screening (HCS); | |||
L9700 | Endoplasmic Reticulum Stress Compound Library | 193 compounds | |
A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS); |