T4309 |
CIL56
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CIL56 is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation ...
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T1644 |
Dopamine hydrochloride
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Dopamine is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine b...
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T0433 |
Artesunate
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Artesunate is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore...
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T6192 |
Alogliptin
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Alogliptin(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9.
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TQ0211 |
Brusatol
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Brusatol is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.
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T0191 |
Linagliptin
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Linagliptin is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.
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T6165 |
Bardoxolone Methyl
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Bardoxolone Methyl, an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities.
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T3116 |
Atorvastatin hemicalcium salt
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Atorvastatin hemicalcium salt, an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication.
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T0326 |
DL-Glutamine
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DL-Glutamine, a non-essential amino acid, exists abundantly throughout the body and is participated in many metabolic processes. It is synthesized from glutamic ...
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T16540 |
Piperazine Erastin
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Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis.
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T0477 |
Zileuton
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Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the fo...
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T2887 |
Trigonelline
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Trigonelline, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
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T1710 |
Trolox
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Troloxa is a vitamin E analogue, used in reducing oxidative stress or damage.
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T0326L |
L-Glutamine
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L-glutamine, a non-essential amino acid, is synthesized from glutamic acid and ammonia.
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T0078L |
Lapatinib ditosylate
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Lapatinib is a tyrosine kinase receptor inhibitor used in the therapy of advanced breast cancer and other solid tumors. Lapatinib therapy is associated with tran...
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T6235 |
Lapatinib Ditosylate
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Lapatinib is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).
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T6954 |
PRIMA-1
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PRIMA-1 is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.
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T2870 |
Matrine
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Matrine, an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
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T4414 |
Eprenetapopt
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PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredox...
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T5515 |
Hemin
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Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer.
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T0214 |
Pioglitazone
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Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare i...
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T7092 |
NADPH tetrasodium salt
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NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate (NADP+) and acts as an electron donor in various ...
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THS1455 |
DihydroarteMisinic acid
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Dihydroartemisinic acid is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinal herb that is widely used to ...
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T1637 |
Deferoxamine Mesylate
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Deferoxamine is an iron-chelating agent that binds free iron in a stable complex. It also is an inhibitor of ferroptosis.
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TJS2190 |
Nordihydroguaiaretic acid
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Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) ...
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T0877 |
Gallic acid
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Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
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T1765 |
Erastin
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Erastin is a ferroptosis activator acting on mitochondrial VDAC. It induces ferroptotic cell death in vitro.
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T1885 |
Siramesine hydrochloride
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Siramesine (Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent antic...
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TMA2394 |
DL-alpha-Tocopherol
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Antioxidant.
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T1297 |
Eugenol
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Eugenol is a Standardized Chemical Allergen. The physiologic effect of eugenol is by means of Increased Histamine Release and Cell-mediated Immunity.
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T5371 |
L-BUTHIONINE-(S,R)-SULFOXIMINE
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L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cell...
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T2796 |
Coenzyme Q10
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Coenzyme Q10 (ubiquinone) is a naturally occurring compound, acting as the electron carrier in the mitochondrial respiratory chain.
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T0672 |
Pravastatin sodium
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Pravastatin sodium, an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.
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T1487 |
Fluvastatin sodium
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Fluvastatin sodium, a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.
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T2O2733 |
L-Cystine
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Not considered one of the 20 amino acids, Cystine is a sulfur-containing derivative obtained from oxidation of cysteine amino acid thiol side chains. It function...
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T6871 |
L-Glutamic acid monosodium salt
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L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor.
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T6821 |
Dp44mT
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Dp44mT, a effective iron chelator, has selective antitumor activity.
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T7708 |
DL-Buthionine-(S,R)-sulfoximine
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D,L-Buthionine-(S,R)-sulfoximine is an inhibitor of γ-glutamylcysteine synthetase for the treatment of solid tumors.
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T2488 |
BAY 87-2243
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BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
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T3S1447 |
Arteannuin B
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1. Arteannuin B has potent antimalarial activity.
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T1847 |
Necrostatin-1
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Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
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T1622 |
Rosiglitazone maleate
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Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity...
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T1922 |
Pseudolaric Acid B
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Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.
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T6947 |
Piperlongumine
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Piperlongumine is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).
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T5364 |
TBHQ
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Tert-butylhydroquinone (tBHQ) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.
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T2401 |
Alogliptin Benzoate
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Alogliptin Benzoate(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alogliptin may...
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T0214L |
Pioglitazone hydrochloride
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Pioglitazone Hydrochloride is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
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T0687 |
Simvastatin
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Simvastatin is a HMG-CoA Reductase Inhibitor. The mechanism of action of simvastatin is as a Hydroxymethylglutaryl-CoA Reductase Inhibitor.
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T1648 |
α-Vitamin E
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(+)-α-Tocopherol is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
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TQ0120 |
CDDO-Im
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CDDO-Im is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
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