Ferroptosis

Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically and biochemically distinct from other forms of regulated cell death such as apoptosis.

Cat No.	product name
T4309	CIL56	CIL56 is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation ...
T1644	Dopamine hydrochloride	Dopamine is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine b...
T0433	Artesunate	Artesunate is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore...
T6192	Alogliptin	Alogliptin(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9.
TQ0211	Brusatol	Brusatol is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.
T0191	Linagliptin	Linagliptin is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.
T6165	Bardoxolone Methyl	Bardoxolone Methyl, an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities.
T3116	Atorvastatin hemicalcium salt	Atorvastatin hemicalcium salt, an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication.
T0326	DL-Glutamine	DL-Glutamine, a non-essential amino acid, exists abundantly throughout the body and is participated in many metabolic processes. It is synthesized from glutamic ...
T16540	Piperazine Erastin	Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis.
T0477	Zileuton	Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the fo...
T2887	Trigonelline	Trigonelline, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
T1710	Trolox	Troloxa is a vitamin E analogue, used in reducing oxidative stress or damage.
T0326L	L-Glutamine	L-glutamine, a non-essential amino acid, is synthesized from glutamic acid and ammonia.
T0078L	Lapatinib ditosylate	Lapatinib is a tyrosine kinase receptor inhibitor used in the therapy of advanced breast cancer and other solid tumors. Lapatinib therapy is associated with tran...
T6235	Lapatinib Ditosylate	Lapatinib is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).
T6954	PRIMA-1	PRIMA-1 is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.
T2870	Matrine	Matrine, an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
T4414	Eprenetapopt	PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredox...
T5515	Hemin	Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer.
T0214	Pioglitazone	Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare i...
T7092	NADPH tetrasodium salt	NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate (NADP+) and acts as an electron donor in various ...
THS1455	DihydroarteMisinic acid	Dihydroartemisinic acid is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinal herb that is widely used to ...
T1637	Deferoxamine Mesylate	Deferoxamine is an iron-chelating agent that binds free iron in a stable complex. It also is an inhibitor of ferroptosis.
TJS2190	Nordihydroguaiaretic acid	Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) ...
T0877	Gallic acid	Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
T1765	Erastin	Erastin is a ferroptosis activator acting on mitochondrial VDAC. It induces ferroptotic cell death in vitro.
T1885	Siramesine hydrochloride	Siramesine (Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent antic...
TMA2394	DL-alpha-Tocopherol	Antioxidant.
T1297	Eugenol	Eugenol is a Standardized Chemical Allergen. The physiologic effect of eugenol is by means of Increased Histamine Release and Cell-mediated Immunity.
T5371	L-BUTHIONINE-(S,R)-SULFOXIMINE	L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cell...
T2796	Coenzyme Q10	Coenzyme Q10 (ubiquinone) is a naturally occurring compound, acting as the electron carrier in the mitochondrial respiratory chain.
T0672	Pravastatin sodium	Pravastatin sodium, an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.
T1487	Fluvastatin sodium	Fluvastatin sodium, a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.
T2O2733	L-Cystine	Not considered one of the 20 amino acids, Cystine is a sulfur-containing derivative obtained from oxidation of cysteine amino acid thiol side chains. It function...
T6871	L-Glutamic acid monosodium salt	L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor.
T6821	Dp44mT	Dp44mT, a effective iron chelator, has selective antitumor activity.
T7708	DL-Buthionine-(S,R)-sulfoximine	D,L-Buthionine-(S,R)-sulfoximine is an inhibitor of γ-glutamylcysteine synthetase for the treatment of solid tumors.
T2488	BAY 87-2243	BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
T3S1447	Arteannuin B	1. Arteannuin B has potent antimalarial activity.
T1847	Necrostatin-1	Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
T1622	Rosiglitazone maleate	Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity...
T1922	Pseudolaric Acid B	Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.
T6947	Piperlongumine	Piperlongumine is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).
T5364	TBHQ	Tert-butylhydroquinone (tBHQ) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.
T2401	Alogliptin Benzoate	Alogliptin Benzoate(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alogliptin may...
T0214L	Pioglitazone hydrochloride	Pioglitazone Hydrochloride is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
T0687	Simvastatin	Simvastatin is a HMG-CoA Reductase Inhibitor. The mechanism of action of simvastatin is as a Hydroxymethylglutaryl-CoA Reductase Inhibitor.
T1648	α-Vitamin E	(+)-α-Tocopherol is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
TQ0120	CDDO-Im	CDDO-Im is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).