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Ferroptosis

Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically and biochemically distinct from other forms of regulated cell death such as apoptosis.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T79359 Anticancer agent 147 2241283-11-2 98%
Anticancer agent 147
Compound 6j (Anticancer agent 147), a sophoridine derivative and ferroptosis inducer, promotes intracellular accumulation of Fe2+, reactive oxygen species (ROS),...
T79639 Lepadin H 412328-25-7 98%
Lepadin H
Lepadin H, a marine alkaloid and ferroptosis inducer, exhibits significant cytotoxicity by promoting p53 expression, escalating ROS production, and enhancing lip...
T79777 GPX4-IN-7 98%
GPX4-IN-7
GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment. Exhibiting potent antitumor properties, it inhibits ...
T79945 Ferroptosis-IN-1 98%
Ferroptosis-IN-1
Ferroptosis-IN-1, a diterpene derived from A. campylantha, functions as a ferroptosis inhibitor with an EC50 of 10 μM and is utilized in the study of neuroinflam...
T82408 Ferroptosis-IN-3 98%
Ferroptosis-IN-3
Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM). It ...
T1565 Deferiprone 30652-11-0 99.97%
Deferiprone
Deferiprone (Deferidone) is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity.
T0877 Gallic acid 149-91-7 99.95%
Gallic acid
Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
T0687 Simvastatin 79902-63-9 99.95%
Simvastatin
Simvastatin (MK 733) is a HMG-CoA Reductase Inhibitor. The mechanism of action of simvastatin is as a Hydroxymethylglutaryl-CoA Reductase Inhibitor.
T6468 D-glutamine 5959-95-5 99.92%
D-glutamine
D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.
T0433 Artesunate 88495-63-0 99.91%
Artesunate
Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and m...
T4309 CIL56 300802-28-2 99.91%
CIL56
CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumul...
T3116 Atorvastatin hemicalcium salt 134523-03-8 99.89%
Atorvastatin hemicalcium salt
Atorvastatin hemicalcium salt (Atorvastatin Calcium), an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication.
T0078 Lapatinib 231277-92-2 99.89%
Lapatinib
Lapatinib (GW572016) is a dual inhibitor of Lapatinib is a dual ErbB2/EGFR (IC50: 9.2/10.8 nM) inhibitor
T1457 Deferasirox 201530-41-8 99.89%
Deferasirox
Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.
T8662 UAMC-3203 hydrochloride 2271358-65-5 99.87%
UAMC-3203 hydrochloride
UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM.
T9073 SRS16-86 1793052-96-6 99.85%
SRS16-86
SRS16-86 is a novel third-generation ferrostatin, is an inhibitor of ferroptosis.
T60168 NCOA4 - 9a 2650557-72-3 99.84%
NCOA4 - 9a
NCOA4 - 9a is a ferroptosis inhibitor.
TQ0211 Brusatol 14907-98-3 99.82%
Brusatol
Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.
T3S1447 Arteannuin B 50906-56-4 99.8%
Arteannuin B
1. Arteannuin B has potent antimalarial activity.
T1637 Deferoxamine Mesylate 138-14-7 99.8%
Deferoxamine Mesylate
Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulat...
Anticancer agent 147
T79359
Compound 6j (Anticancer agent 147), a sophoridine derivative and ferroptosis inducer, promotes intracellular accumulation of Fe2+, reactive oxygen species (ROS),...
Lepadin H
T79639
Lepadin H, a marine alkaloid and ferroptosis inducer, exhibits significant cytotoxicity by promoting p53 expression, escalating ROS production, and enhancing lip...
GPX4-IN-7
T79777
GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment. Exhibiting potent antitumor properties, it inhibits ...
Ferroptosis-IN-1
T79945
Ferroptosis-IN-1, a diterpene derived from A. campylantha, functions as a ferroptosis inhibitor with an EC50 of 10 μM and is utilized in the study of neuroinflam...
Ferroptosis-IN-3
T82408
Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM). It ...
Deferiprone
T1565
Deferiprone (Deferidone) is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity.
Gallic acid
T0877
Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
Simvastatin
T0687
Simvastatin (MK 733) is a HMG-CoA Reductase Inhibitor. The mechanism of action of simvastatin is as a Hydroxymethylglutaryl-CoA Reductase Inhibitor.
D-glutamine
T6468
D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.
Artesunate
T0433
Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and m...
CIL56
T4309
CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumul...
Atorvastatin hemicalcium salt
T3116
Atorvastatin hemicalcium salt (Atorvastatin Calcium), an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication.
Lapatinib
T0078
Lapatinib (GW572016) is a dual inhibitor of Lapatinib is a dual ErbB2/EGFR (IC50: 9.2/10.8 nM) inhibitor
Deferasirox
T1457
Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.
UAMC-3203 hydrochloride
T8662
UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM.
SRS16-86
T9073
SRS16-86 is a novel third-generation ferrostatin, is an inhibitor of ferroptosis.
NCOA4 - 9a
T60168
NCOA4 - 9a is a ferroptosis inhibitor.
Brusatol
TQ0211
Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.
Arteannuin B
T3S1447
1. Arteannuin B has potent antimalarial activity.
Deferoxamine Mesylate
T1637
Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulat...
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TargetMol