Search Result

Search Results for " mtor "

Targets

226

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T36316	mTOR inhibitor-8	mTOR-IN-8	mTOR , Autophagy
	mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, which can be used to study non-small cell lung cancer.		mTOR , Autophagy
T63399L	mTOR/HDAC-IN-1 HCl	mTOR/HDAC-IN-1 HCl（2815286-02-1 Free base)	HDAC , mTOR
	mTOR/HDAC-IN-1 HCl is a potent dual inhibitor of mTOR and HDAC with potential anti-inflammatory, anti-proliferative, autophagy and apoptosis-inducing effects for cancer research.		HDAC , mTOR
T12123	mTOR inhibitor-3		mTOR
	mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.		mTOR
T5338	mTOR inhibitor-1		mTOR , Autophagy
	C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.		mTOR , Autophagy
T12589	PI3Kα/mTOR-IN-1		PI3K , mTOR
	PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR. PI3Kα/mTOR-IN-1 shows an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 12.5 nM and 10.6 nM for mTOR and PI3Kα in a cell free assay , respectively.		PI3K , mTOR
T12459	PI3K/mTOR Inhibitor-2		PI3K , mTOR
	PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16,1 and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR. PI3K/mTOR Inhibitor-2 has antitumor activity.		PI3K , mTOR
T67703	mTOR inhibitor 9b		mTOR
	mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTOR inhibitor 9b possesses anticancer activity and can be used to ...		mTOR
T67705	mTOR inhibitor 9a
	mTOR inhibitor 9a inhibited the growth of human LNCap cells with an ic50 of 80 nm. 1-methyl-3 -{4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl}urea may have antitumor activity.
T67702	mTOR inhibitor 9d		PI3K , mTOR
	mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia, skin cancer, breast cancer, lung cancer and colon cancer.		PI3K , mTOR
T67704	mTOR inhibitor 9e		PI3K , mTOR
	mTOR inhibitor 9e is a selective mTOR inhibitor with IC50 of 0.68nM and 1359nM for mTOR and PI3Kα, respectively.		PI3K , mTOR
T67701	mTOR inhibitor 9f		PI3K , mTOR
	mTOR inhibitor 9f is a selective mTOR inhibitor with IC50 of 1.25nM and 82nM for mTOR and PI3Kα, respectively.		PI3K , mTOR
T67706	mTOR inhibitor 9c		PI3K , mTOR
	mTOR inhibitor 9c is a selective mTOR inhibitor with IC50 of 0.7nM and 825nM for mTOR and PI3Kα, respectively.		PI3K , mTOR
T9310	mTOR inhibitor 13		PI3K , mTOR
	mTOR inhibitor 13 is a selective mTOR inhibitor with IC50 of 0.29nM and 119nM for mTOR and PI3Kα, respectively.		PI3K , mTOR
T60564	PI3K/Akt/mTOR-IN-2		Apoptosis , Akt , PI3K , mTOR
	PI3K/Akt/mTOR-IN-2 is a potent PI3K/AKT/mTOR inhibitor.PI3K/Akt/mTOR-IN-2 has anticancer effects and is selective for MDA-MB-231 cells with an IC50 of 2.29 μM.PI3K/Akt/mTOR-IN-2 exhibits anticancer activity and induces c...		Apoptosis , Akt , PI3K , mTOR
T12124	mTOR inhibitor-2		mTOR
	mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).		mTOR
T12460	PI3K/mTOR Inhibitor-1		PI3K
	PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)		PI3K
T11544	HDACs/mTOR Inhibitor 1		HDAC
	HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1.2 nM, and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα).		HDAC
T9309	mTOR inhibitor 11
	mTOR inhibitor 11 is a useful organic compound for research related to life sciences. The catalog number is T9309 and the CAS number is 1195785-35-3.
T79211	mTOR inhibitor-11		mTOR
	mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6. It also exhibits inhibitory activity against pCHK1 and PDE4D with IC50 values of 17.2 μM and 17.0 μM,...		mTOR
T81744	mTOR inhibitor-14		mTOR
	mTOR Inhibitor-14 (compound 14c) is a potent inhibitor of mTOR with minimal inhibition of CYP2C8 and has demonstrated the capability to inhibit tumor growth [1].		mTOR
T79212	mTOR inhibitor-12		mTOR
	mTOR inhibitor-12 (Compound 11), a selective, brain-penetrant mTOR inhibitor, exhibits no genotoxicity risk and is utilized in research pertaining to central nervous system (CNS) diseases [1].		mTOR
T64041	PI3K/mTOR Inhibitor-7
	PI3K/mTOR Inhibitor-7 is a potent dual PI3K/mTOR inhibitor. PI3K/mTOR Inhibitor-7 is 4.7-fold more potent than gedatolisib, with IC50 values of 1.4 μM and 0.3 μM, respectively. 10 μM of PI3K/mTOR Inhibitor-7 is able to s...
T63470	PI3K/mTOR Inhibitor-8
	PI3K/mTOR Inhibitor-8 is a dual inhibitor of PI3K (PI3Kα IC50: 0.46 nM) and mTOR (mTOR IC50: 12 nM). PI3K/mTOR Inhibitor-8 blocks the cell cycle of HCT-116 cells in G1/S phase and induces apoptosis. apoptosis).
T72408	PI3K/mTOR Inhibitor-5
	PI3K/mTOR Inhibitor-5 is a potent dual inhibitor of PI3K and mTOR, displaying IC50 values of 86.9 nM (for PI3K) and 14.6 nM (for mTOR), respectively.
T62438	PI3K/mTOR Inhibitor-9
	PI3K/mTOR Inhibitor-9 (Compound 1) is a potent inhibitor of both mTOR and PI3K, acting on mTOR (IC50: 38 nM), PI3Kα (IC50: 6.6 nM), PI3Kγ (IC50: 6.6 nM) and PI3Kδ (IC50: 0.8 nM).
T72374	PI3K/mTOR Inhibitor-12		PI3K
	PI3K/mTOR Inhibitor-12, a potent and selective orally active inhibitor, exhibits IC50 values of 0.06 nM for PI3Kα and 3.12 nM for mTOR, indicating significant antitumor activity with reduced liver toxicity [1].		PI3K
T63770	PI3K/mTOR Inhibitor-4
	PI3K/mTOR Inhibitor-4 is an orally active pan-I PI3K/mTOR inhibitor. PI3K/mTOR Inhibitor-4 is an enzyme inhibitor that acts on PI3Kα (IC50: 0.63 nM), PI3Kγ (IC50: 22 nM), PI3Kδ (IC50: 9.2 nM) and mTOR (IC50: 13.85 nM). P...
T72780	HSP90/mTOR-IN-1
	HSP90/mTOR-IN-1 is an effective and orally administrable inhibitor targeting both Hsp90 and mTOR, displaying IC50 values of 69 nM and 29 nM, respectively. This compound inhibits the proliferation of SW780 cells by overly...
T63399	mTOR/HDAC-IN-1
	mTOR/HDAC-IN-1 (Compound 50) is a dual inhibitor targeting both mTOR and HDAC with respective IC50 values of 0.49 nM and 0.91 nM. It holds potential as an anti-cancer agent [1].
T72380	PI3K/mTOR Inhibitor-13
	PI3K/mTOR Inhibitor-13, an orally active dual inhibitor targeting phosphoinositol 3-kinase (PI3K) and mTOR kinase, holds potential for treating sexual diseases, solid tumors, and idiopathic pulmonary fibrosis (IPF).
T64219	PI3K/mTOR Inhibitor-6
	PI3K/mTOR Inhibitor-6 (Compound 19c) is a potent dual PI3K/mTOR inhibitor that is more stable than gedatolisib in artificial gastric fluid. 10 μM of PI3K/mTOR Inhibitor-6 significantly inhibits the PI3K/Akt/mTOR signalli...
T61888	mTOR/HDAC6-IN-1
	mTOR/HDAC6-IN-1 is an effective dual inhibitor of histone deacetylase (HDAC6) and mammalian rapamycin (mTOR). The IC50 values for HDAC6 and mTOR are 56 nM and 133.7 nM respectively. MTOR/HDAC6-IN-1 can significantly indu...
T61516	PI3K/mTOR Inhibitor-3
	PI3K/mTOR Inhibitor-3 (compound 12) is an imidazoline compound with potent dual inhibitory effects on PI3K and mTOR. This compound exhibits notable anti-cancer activity [1].
T81470	PI3K/mTOR Inhibitor-14		PI3K
	PI3K/mTOR Inhibitor-14 (compound Y-2) serves as a dual inhibitor of PI3K and mTOR, exhibiting IC50 values of 171.4 nM and 10.1 nM , respectively, and demonstrates antitumor activities [1].		PI3K
T63455	PI3K/Akt/mTOR-IN-3
	PI3K/Akt/mTOR-IN-3 is a potent inhibitor of PI3K/Akt/mTOR. PI3K/Akt/mTOR-IN-3 inhibits the migration of MCF-7 cells (IC50: 0.77 μM), HeLa cells (IC50: 1.23 μM) and HepG2 cells (IC50: 4.57 μM). PI3K/Akt/mTOR-IN-3 inhibite...
T35343	MTI-31	MTI-31,LXI-15029	mTOR
	MTI-31 (LXI-15029) is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3CB and PIK3G with >5,000 fold selectivity in mTOR binding a...		mTOR
T14033	3BDO		Apoptosis , mTOR , Autophagy
	3BDO is an activator of mTOR. It can also inhibit autophagy..		Apoptosis , mTOR , Autophagy
T6045	Torin 1		DNA-PK , PI3K , mTOR , Autophagy
	Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.		DNA-PK , PI3K , mTOR , Autophagy
T6030	XL388		P450 , PI3K , mTOR
	XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.		P450 , PI3K , mTOR
T40351	MHY-1685		mTOR
	MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.		mTOR
T1859	AZD-8055		Apoptosis , mTOR , Autophagy
	AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.		Apoptosis , mTOR , Autophagy
T3514	CZ415		mTOR
	CZ415 is a potent and highly selective mTOR inhibitor.		mTOR
T2475	KU-0063794		mTOR
	KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.		mTOR
T12270	NV-5138		mTOR
	NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.		mTOR
T5472	PQR620		mTOR
	PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.		mTOR
T6100	Torin 2		Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy
	Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 2...		Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy
T7166	GNE-493		PI3K , mTOR
	GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR,respectively.		PI3K , mTOR
T7343	PF-04979064		PI3K , mTOR
	PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).		PI3K , mTOR
T16355	NSC781406		PI3K , mTOR
	NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).		PI3K , mTOR
T1961	Vistusertib	AZD2014	Apoptosis , Akt , PI3K , S6 Kinase , mTOR , Autophagy
	Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.		Apoptosis , Akt , PI3K , S6 Kinase , mTOR , Autophagy

Compounds

mTOR inhibitor-8

T36316

Synonym: mTOR-IN-8

Target: mTOR, Autophagy

mTOR/HDAC-IN-1 HCl

T63399L

Synonym: mTOR/HDAC-IN-1 HCl（2815286-02-1 Free base)

Target: mTOR, Autophagy

PI3K/mTOR Inhibitor-2

Target: Apoptosis, Akt, PI3K, mTOR

PI3K/mTOR Inhibitor-1

T12460

Synonym:

Target: PI3K

HDACs/mTOR Inhibitor 1

PI3K/mTOR Inhibitor-7

T64041

Synonym:

Target:

PI3K/mTOR Inhibitor-8

T63470

Synonym:

Target:

PI3K/mTOR Inhibitor-5

T72408

Synonym:

Target:

PI3K/mTOR Inhibitor-9

T62438

Synonym:

Target:

PI3K/mTOR Inhibitor-12

T72374

Synonym:

Target: PI3K

PI3K/mTOR Inhibitor-4

PI3K/mTOR Inhibitor-13

T72380

Synonym:

Target:

PI3K/mTOR Inhibitor-6

PI3K/mTOR Inhibitor-3

T61516

Synonym:

Target:

PI3K/mTOR Inhibitor-14

Synonym: MTI-31,LXI-15029

Target: Apoptosis, mTOR, Autophagy

Torin 1

T6045

Synonym:

Target: DNA-PK, PI3K, mTOR, Autophagy

XL388

T6030

Synonym:

Target: P450, PI3K, mTOR

Target: Apoptosis, mTOR, Autophagy

Target: Apoptosis, ATM/ATR, DNA-PK, mTOR, Autophagy

Target: Apoptosis, Akt, PI3K, S6 Kinase, mTOR, Autophagy

Cat No.	Product Name	Synonyms	Targets
TN1891	Lupiwighteone		Apoptosis , BCL , PARP , Caspase
	Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.		Apoptosis , BCL , PARP , Caspase
T5S0658	Corynoxine		Autophagy
	Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.		Autophagy
T2717	Salidroside	Rhodioloside	Apoptosis , mTOR
	Salidroside (Rhodioloside) is a bioactive phenolic glycoside compound isolated from Rhodiola crenulata. It is a prolyl endopeptidase Inhibitor.		Apoptosis , mTOR
T2998	Dihydromyricetin	Ampelopsin,Ampeloptin	Influenza Virus , GABA Receptor , DNA/RNA Synthesis , mTOR , Autophagy
	Dihydromyricetin (Ampelopsin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyricetin can activate autophagy...
T3O2749	L-Leucine	(S)-Leucine,Leu	mTOR
	L-Leucine ((S)-Leucine) is one of nine essential amino acids in humans (provided by food), L-Leucine is important for protein synthesis and many metabolic functions. L-Leucine contributes to regulation of blood-sugar lev...		mTOR
T5S0506	Rotundic acid	Rutundic acid	Apoptosis , Others , p38 MAPK , Akt , mTOR
	Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) c...		Apoptosis , Others , p38 MAPK , Akt , mTOR
T3895	Polyphyllin I		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
	Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha...		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
TN4761	Phellamurin		P-gp
	Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadmini...		P-gp
TN1405	Arnicolide D		Akt , Caspase , PI3K , STAT , mTOR
	Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling path...		Akt , Caspase , PI3K , STAT , mTOR
T6354	(+)-Usnic acid	D-Usnic Acid,(+)-Usniacin	Antiviral , Antibacterial , mTOR
	(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.		Antiviral , Antibacterial , mTOR
T2974	Cyclovirobuxine D	CVB-D,Bebuxine,Cyclovirobuxin D	Apoptosis , Others , Akt , mTOR , Autophagy
	Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.		Apoptosis , Others , Akt , mTOR , Autophagy
T5740	25(R,S)-Ruscogenin	(25RS)-Ruscogenin	Others , HIF
	25(R,S)-Ruscogenin is a natual product.		Others , HIF
T3981	Acacetin	4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin	Apoptosis , IAP , COX , Autophagy
	Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.		Apoptosis , IAP , COX , Autophagy
T2P2806	Hederacolchiside A1	Raddeanoside R13	Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR
	Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacol...		Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR
T1537	Rapamycin	Sirolimus,AY 22989,NSC-2260804	Others , Endogenous Metabolite , Antibiotic , mTOR , Autophagy , Antifungal
	Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
T2851	Daphnetin	7,8-Dihydroxycoumarin,Daphnetol	EGFR , PKA , PKC , Parasite , Autophagy
	Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-...		EGFR , PKA , PKC , Parasite , Autophagy
T2995	Chrysophanol	3-Methylchrysazin,Chrysophanic Acid,Turkey Rhubarb	EGFR
	Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.		EGFR
T8200	Ginkgolide K		AMPK , Autophagy
	Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.		AMPK , Autophagy
T2S0410	Euphorbia factor L1	Euphorbiasteroid	Apoptosis , P-gp
	Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, ant...		Apoptosis , P-gp
TN6735	Bigelovin		Apoptosis , Reactive Oxygen Species , Retinoid Receptor , Autophagy , RAR/RXR
	Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a pote...
TN1140	Onjisaponin B		AMPK , mTOR , Autophagy
	Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parki...		AMPK , mTOR , Autophagy
T2S2382	3'-Hydroxypterostilbene	3'-HPT	Apoptosis , Autophagy
	3'-Hydroxypterostilbene (3'-HPT), a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 μM for COLO 205, HCT-116, and HT-29 cells, respectively, b...		Apoptosis , Autophagy
T4672	Brevilin A		Apoptosis , Anti-infection , JAK , STAT , Autophagy
	Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si...		Apoptosis , Anti-infection , JAK , STAT , Autophagy
TN2085	Piperlonguminine		Anti-infection , Antibacterial , Antifungal
	Piperlonguminine is an alkaloid amide isolated from the Piper species. Piperlonguminine shows anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, antifungal and antibacterial activities.Piperl...		Anti-infection , Antibacterial , Antifungal
T6S0659	Rhynchophylline	Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin	Calcium Channel , NF-κB
	1. Rhynchophylline (Mitrinermine) can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in c...		Calcium Channel , NF-κB
T3318	Wogonoside	Glychionide B,Wogonin 7-O-glucuronide,Oroxindin	GABA Receptor , Autophagy
	Wogonoside (Wogonin 7-O-glucuronide) acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.		GABA Receptor , Autophagy
T3800	Typhaneoside	Aervitrin	Others , Autophagy
	Typhaneoside (Aervitrin) is a flavonoid glycoside plant extract with potential ability to treat primary dysmenorrhea through the Shaofu Zhuyu decoction.		Others , Autophagy
T5497	AMAROGENTIN		Apoptosis , AMPK
	Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell cycle and apoptosis		Apoptosis , AMPK
TN7226	2-Hydroxy-3-methoxy chalcone
	2-Hydroxy-3-methoxy chalcone has anticancer activity and inhibits colon cancer.
T6S1784	Brazilin	Natural Red 24,Braziletto,Brasilin,Superbresiline	Apoptosis , Others , AMPK , Autophagy
	1. Brazilin (Braziletto) exhibits anti-hepatotoxic, antiplatelet effects. 2. Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell death through a c-Fos-mediated and tumor cell specific sign...		Apoptosis , Others , AMPK , Autophagy
TN1163	2'-Hydroxychalcone		Others
	2'-Hydroxychalcone is a drug synthesis intermediate for the synthesis of flavonoids. 2'-Hydroxychalcone loaded in nanoemulsion showed fungicidal activity against Coccidioides parapsilosis in Danio rerio model.2'-Hydroxyc...		Others
T72904	Norswertianin
	Norswertianin, a xanthone-based compound, acts as a potent anti-glioma agent. It promotes differentiation of GBM cells via oxidative stress and autophagy dependent on Akt/mTOR signaling.
TN4788	Pierreione B		mTOR
	Pierreione B is an inhibitor of mTOR signaling with strong anticancer activity. Pierreione A and Pierreione B demonstrate solid tumor selectivity with minimal cytotoxicity.		mTOR
T27305	Fascaplysin chloride	NSC622398,NSC 622398,Fascaplysin,NSC-622398
	Fascaplysin is a cyclin D kinase 4/ cyclin D1 inhibitor (IC50 = 0.35 μM). Fascaplysin induces caspase mediated crosstalk between autophagy and apoptosis through the inhibition of PI3K/AKT/mTOR signaling cascade in human ...
TN4356	Jolkinolide A		Akt , STAT , mTOR
	Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly inhibited the proliferation and migration of HUVECs.		Akt , STAT , mTOR
TN6591	Cannabisin B
	Cannabisin B possesses considerable antiproliferative activity and that it may be utilised as a promising chemopreventive agent against hepatoblastoma disease. It induces autophagic cell death by inhibiting the AKT/mTOR ...
T75438	Corynoxine hydrochloride
	Corynoxine hydrochloride, a tetracyclic oxindole alkaloid extracted from the hooks of Uncaria macrophylla, functions as a natural autophagy enhancer. It facilitates the removal of alpha-synuclein by activating the Akt/mT...
TN2328	Zeylenone		Apoptosis , ERK , MAPK , Akt , PI3K , mTOR
	Zeylenone, a cyclohexene oxide from Uvaria grandiflora, has antitumour and antiproliferative activity, inhibiting cervical cancer cell proliferation and inducing apoptosis through the PI3K/AKT/mTOR and MAPK/ERK signallin...		Apoptosis , ERK , MAPK , Akt , PI3K , mTOR
TN3310	9,9'-Di-O-(E)-feruloylsecoisolariciresinol		mTOR
	1,4-O-Diferuloylsecoisolariciresinol(9,9'-Di-O-(E)-feruloylsecoisolariciresinol),and pierreione B, two novel inhibitors of mTOR signaling, have strong anticancer activity. (+)-9,9'-O-Diferuloylsecoisolariciresinol has si...		mTOR
T40483	8-Aminoadenosine	8-NH2-Ado
	8-Aminoadenosine (8-NH2-Ado) is an RNA-directed nucleoside analogue that effectively diminishes cellular ATP levels and impedes mRNA synthesis. Furthermore, it effectively obstructs Akt/mTOR signaling, inducing autophagy...
T16165	Myriocin	ISP-I,Thermozymocidin	HCV Protease , Antifungal
	Myriocin (Thermozymocidin), a metabolite derived from Myriococcum albomyces, is a serine-palmitoyltransferase (SPT) inhibitor with potential antitumour, anticancer, and antiparasitic activities.Myriocin inhibits tumour g...		HCV Protease , Antifungal
TN5050	Sprengerinin C		NADPH-oxidase , VEGFR , p38 MAPK , ROS , Akt , PI3K , mTOR , p53
	Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can strongly suppress tumor angiogenesis in human umbilical vein ...
TN2095	Pomiferin		NOS , NF-κB , PDE
	Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has anti-inflammatory and neuroprotective activities.		NOS , NF-κB , PDE

Natural Products

Lupiwighteone

TN1891

Synonym:

Target: Apoptosis, BCL, PARP, Caspase

Synonym: Rhodioloside

Target: Apoptosis, mTOR

Dihydromyricetin

T2998

Synonym: Ampelopsin,Ampeloptin

Target: Influenza Virus, GABA Receptor, DNA/RNA Synthesis, mTOR, Autophagy

L-Leucine

T3O2749

Synonym: (S)-Leucine,Leu

Target: mTOR

Rotundic acid

T5S0506

Synonym: Rutundic acid

Target: Apoptosis, Others, p38 MAPK, Akt, mTOR

Polyphyllin I

T3895

Synonym:

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

Target: Akt, Caspase, PI3K, STAT, mTOR

(+)-Usnic acid

T6354

Synonym: D-Usnic Acid,(+)-Usniacin

Target: Antiviral, Antibacterial, mTOR

Cyclovirobuxine D

T2974

Synonym: CVB-D,Bebuxine,Cyclovirobuxin D

Target: Apoptosis, Others, Akt, mTOR, Autophagy

25(R,S)-Ruscogenin

T5740

Synonym: (25RS)-Ruscogenin

Target: Others, HIF

Acacetin

T3981

Synonym: 4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin

Target: Apoptosis, IAP, COX, Autophagy

Hederacolchiside A1

T2P2806

Synonym: Raddeanoside R13

Target: Apoptosis, ERK, MEK, Akt, PI3K, Parasite, mTOR

Rapamycin

T1537

Synonym: Sirolimus,AY 22989,NSC-2260804

Target: Others, Endogenous Metabolite, Antibiotic, mTOR, Autophagy, Antifungal

Daphnetin

T2851

Synonym: 7,8-Dihydroxycoumarin,Daphnetol

Target: EGFR, PKA, PKC, Parasite, Autophagy

Chrysophanol

T2995

Synonym: 3-Methylchrysazin,Chrysophanic Acid,Turkey Rhubarb

Target: AMPK, Autophagy

Euphorbia factor L1

T2S0410

Synonym: Euphorbiasteroid

Target: Apoptosis, P-gp

Bigelovin

TN6735

Synonym:

Target: Apoptosis, Reactive Oxygen Species, Retinoid Receptor, Autophagy, RAR/RXR

Onjisaponin B

TN1140

Synonym:

Target: AMPK, mTOR, Autophagy

3'-Hydroxypterostilbene

T2S2382

Synonym: 3'-HPT

Target: Apoptosis, Autophagy

Brevilin A

T4672

Synonym:

Target: Apoptosis, Anti-infection, JAK, STAT, Autophagy

Piperlonguminine

TN2085

Synonym:

Target: Anti-infection, Antibacterial, Antifungal

Rhynchophylline

T6S0659

Synonym: Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin

Target: Calcium Channel, NF-κB

Wogonoside

T3318

Synonym: Glychionide B,Wogonin 7-O-glucuronide,Oroxindin

Target: GABA Receptor, Autophagy

Typhaneoside

T3800

Synonym: Aervitrin

Target: Others, Autophagy

AMAROGENTIN

T5497

Synonym:

Target: Apoptosis, AMPK

2-Hydroxy-3-methoxy chalcone

Synonym: Natural Red 24,Braziletto,Brasilin,Superbresiline

Target: Apoptosis, Others, AMPK, Autophagy

Synonym: NSC622398,NSC 622398,Fascaplysin,NSC-622398

Target: Akt, STAT, mTOR

Corynoxine hydrochloride

Target: Apoptosis, ERK, MAPK, Akt, PI3K, mTOR

9,9'-Di-O-(E)-feruloylsecoisolariciresinol

Synonym: ISP-I,Thermozymocidin

Target: HCV Protease, Antifungal

Sprengerinin C

TN5050

Synonym:

Target: NADPH-oxidase, VEGFR, p38 MAPK, ROS, Akt, PI3K, mTOR, p53

Pomiferin

TN2095

Synonym:

Target: NOS, NF-κB, PDE

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-02089	mTOR Protein, Human, Recombinant (His & Myc)	Human	E. coli
	mTOR Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPY-02252	LAMTOR2 Protein, Human, Recombinant (His)	Human	E. coli
	Ragulator complex protein LAMTOR2, also known as Endosomal adaptor protein p14, Late endosomal/lysosomal Mp1-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-...
TMPJ-01378	Mp1 Protein, Human, Recombinant (His)	Human	E. coli
	Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding pro...
TMPH-01996	LAMTOR1 Protein, Human, Recombinant (His)	Human	E. coli
	LAMTOR1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPK-00283	CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi)	Human	HEK293
	CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tu...
TMPK-00524	CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tu...
TMPY-04540	S6K1/RPS6KB1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase...
TMPK-00523	FLT3 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
	The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2 (fetal liver kinase) and Stk-1(stem cell tyrosine kinase) is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the re...
TMPK-00416	FLT3 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	CHO
	The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2 (fetal liver kinase) and Stk-1(stem cell tyrosine kinase) is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the re...
TMPY-06821	THRB Protein, Human, Recombinant (His)	Human	E. coli
	Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone/ligand-bin...
TMPY-02113	14-3-3 sigma Protein, Mouse, Recombinant	Mouse	E. coli
	14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the 14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells....
TMPY-01263	14-3-3 sigma Protein, Human, Recombinant (GST)	Human	E. coli
	14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the 14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells....
TMPY-01275	14-3-3 sigma Protein, Human, Recombinant	Human	E. coli
	14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the 14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells....
TMPH-02855	PML Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and vi...
TMPH-01710	Mucolipin-1/MCOLN1 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to t...

mTOR Protein, Human, Recombinant (His & Myc)

TMPH-02089

Species: Human

Expression System: E. coli

LAMTOR2 Protein, Human, Recombinant (His)

TMPY-02252

Species: Human

Expression System: E. coli

Mp1 Protein, Human, Recombinant (His)

TMPJ-01378

Species: Human

Expression System: E. coli

LAMTOR1 Protein, Human, Recombinant (His)

TMPH-01996

Species: Human

Expression System: E. coli

CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi)

TMPK-00283

Species: Human

Expression System: HEK293

CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His)

TMPK-00524

Species: Cynomolgus

Expression System: HEK293

S6K1/RPS6KB1 Protein, Human, Recombinant (GST)

TMPY-04540

Species: Human

Expression System: Baculovirus-Insect Cells

FLT3 Protein, Cynomolgus, Recombinant (hFc)

TMPK-00523

Species: Cynomolgus

Expression System: HEK293

FLT3 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00416

Species: Human

Expression System: CHO

THRB Protein, Human, Recombinant (His)

TMPY-06821

Species: Human

Expression System: E. coli

14-3-3 sigma Protein, Mouse, Recombinant

TMPY-02113

Species: Mouse

Expression System: E. coli

14-3-3 sigma Protein, Human, Recombinant (GST)

TMPY-01263

Species: Human

Expression System: E. coli

14-3-3 sigma Protein, Human, Recombinant

TMPY-01275

Species: Human

Expression System: E. coli

PML Protein, Mouse, Recombinant (His & Myc)

TMPH-02855

Species: Mouse

Expression System: E. coli

Mucolipin-1/MCOLN1 Protein, Human, Recombinant (His)

TMPH-01710

Species: Human

Expression System: in vitro E. coli expression system

Cat No.	Product Name
L1300	PI3K-AKT-mTOR Compound Library	425 compounds
	A unique collection of 425 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;
L3400	Clinical Compound Library	3480 compounds
	A unique collection of 3480 compounds in clinical trial phases for high throughput screening (HTS) and high content screening (HCS);
L2195	Anti-Prostate Cancer Compound Library	2096 compounds
	2096 compounds associated with prostate cancer that can be used for high-throughput and high-content screening.
L2193	Anti-Liver Cancer Compound Library	1816 compounds
	1816 species of compounds related to liver cancer that can be used in anti-liver cancer drug development and pharmacological studies.
L7700	Neural Regeneration Compound Library	529 compounds
	A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening;
L2130	Anti-Cancer Metabolism Compound Library	1280 compounds
	A unique collection of 1280 cancer cellular metabolism related compounds for cancer research and high throughput screening (HTS) and high content screening (HCS);
L2550	Glutamine Metabolism Compound Library	580 compounds
	A unique collection of 580 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and ...