igf 1

Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides. These isoforms are differentially expressed by various tissues. Mature mouse IGF-I shares 94% and 99% aa sequence identity with human and rat IGF-I, respectively, and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II. IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally. It plays an important role in muscle regeneration and tumor progression. IGF-I binds IGF-I R, IGF-II R, and the insulin receptor. IGF-I association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors.

IGF1 IGF-I Protein, Mouse, Recombinant is expressed in yeast. The predicted molecular weight is 7.7 kDa and the accession number is E9PU89.

IGF1 IGF-I Protein, Salmon, Recombinant is expressed in E. coli. The accession number is Q02815.

Expression system: P. pastoris (Yeast)
Length: 50-119, Full Length of Mature Protein
Activity: Not Tested

IGF1 IGF-I Protein, Bovine, Recombinant is expressed in E. coli. The accession number is P07455.

Expression system: E. coli
Length: 49-118, Full Length of Mature Protein
Activity: ELISA、Organoid Coculture、Cells

Expression system: E. coli
Length: 49-118, Full Length of Mature Protein
Activity: Not Tested

IGF1 IGF-I Protein, Mouse, Recombinant (E. coli) is expressed in E. coli. The accession number is P05017.

IGF1 IGF-I Protein, Rat, Recombinant is expressed in E. coli. The accession number is P08025.

IGF1R CD221 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81 kDa and the accession number is P08069.

The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target. IGF1R CD221 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 105.8 kDa (alpha subunit) and 23 kDa (beta subunit) and the accession number is P08069.

The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target. IGF1R CD221 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 80.59 kDa (alpha subunit) and 19.28 kDa (beta subunit) and the accession number is G7P9I7.

IGF1R CD221 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 105.2 kDa and the accession number is E9QNX9.

GH2 Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues._x000D_ GH2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.01 kDa and the accession number is P01242.

Expression system: HEK293 Cells
Length: 21-272, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 26-272, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 21-163, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-159, Partial
Activity: Not Tested

Expression system: E. coli
Length: 25-381, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 25-381, Full Length of Mature Protein
Activity: Cell Activity

IGF1 IGF-I Protein, Chicken, Recombinant (hFc) is expressed in Yeast. The accession number is P18254.

IGF2 IGF-II Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 Cells. The accession number is P01344-1.

The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins. All three ligands are involved in cell proliferation, apoptosis, protein synthesis and metabolism due to their homologous sequences and structural similarities. Insulin-like growth factor 2, a member of the insulin family, plays an important role in embryonic development, metabolic disorders, and tumorigenesis by combining with three receptors with different degrees of affinity.

Somatotropin(GH) is a member of the somatotropin prolactin family of hormones which play an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. GH stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.