coa

Ceramides Mixture, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. It is involved in the regulation of cell cycle arrest, growth inhibition, and modulation of telomerase activity.

Methylglutaric acid is a leucine metabolite. A large amount of methylglutaric acid is identified in urine of patients with deficiency of 3-methylglutaconyl coenzyme A hydratase (PMID 6181239 ). Methylglutaric acid is also found to be associated with 3-hyd

Pimeloyl-CoA is a CoA derivative formed from pimelate, serving as a precursor in the biotin biosynthesis pathway of certain bacteria.

Crotonyl-CoA tetrasodium is the tetrasodium salt form of Crotonyl-CoA. It serves as an intermediate in butyrate fermentation and in the metabolism of lysine and tryptophan. This compound plays a crucial role in the metabolism of fatty acids and amino acids.

(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA ((6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-coenzyme A) acts as an NLRX1 modulator. This compound shows potential for research into immune and metabolism-related diseases.

Dephospho-CoA (dpCoA) is an endogenous compound extracted from Escherichia coli and Lactobacillus plantarum, and is an intermediate in coenzyme A biosynthesis.

Selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM). Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo. Lau et al (2000) HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol.Cell. 5 589 PMID:10882143 |Liu et al (2008) The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature. 451 846 PMID:18273021 |Burns et al (2005) Iso-coenzyme A. J.Biol.Chem. 280 16550 PMID:15708855 |Cebrat et al (2003) Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorg.Med.Chem. 11 3307 PMID:12837541

Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2).

Acetyl-CoA Carboxylase-IN-1 (ACC-IN-1) is an efficient inhibitor of acetyl-CoA carboxylase (ACC), with antibacterial activity, and can be applied in the study of metabolic diseases.

Malonyl CoA serves as a substrate in fatty acid biosynthesis while inhibiting fatty acid oxidation. It also acts as a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1 [1] [2].

Lys-CoA TFA, a selective p300 histone acetyltransferase (HAT) inhibitor (IC 50 =50-500 nM), exhibits a specificity that exceeds 100-fold over PCAF (IC 50 =200 μM). This compound effectively suppresses transcriptional activation dependent on p300 HAT activity [1] [2].

Palmitoyl CoA lithium (Palmitoyl coenzyme A lithium) is a major component of fatty acids involved in the carnitine shuttle system, beta-oxidation, and the tricarboxylic acid cycle, and can be used to study metabolic disorders in the body.

Crotonyl-CoA, an intermediate in the fermentation of butyric acid as well as in the metabolism of lysine and tryptophan, plays a crucial role in the metabolism of fatty acids and amino acids [1].

HMG-CoA Reductase-IN-1, an inhibitor of HMG-CoA reductase, demonstrates strong inhibitory activity on HMGR and affinity for OATP1B1, with pIC50 and pKm values of 8.54 and 1.98, respectively. It is utilized in hypercholesterolemia research [1].

Caffeoyl-CoA can be isolated from the leaf tissues of Gramineae, exhibiting a Km value of 1.45 μM [1].

1-Pyrenebutanoyl-CoA, a type of coenzyme A, can non-competitively inhibit (K i = 2 pM) phosphorylating (ADP-stimulated) respiration in rat liver mitochondria and competitively inhibit (K i = 2.1 pM and 15 pM) carnitine palmitoyl-CoA transferase and octanoyl-CoA transferase [1].

Angeloyl-CoA, a CoA-activated derivative of angelic acid, exhibits anticancer activity and can be synthesized using yeast [1].

Palmitoleoyl-CoA lithium is the lithium salt form of Palmitoleoyl-CoA. It can be activated and transported to mitochondria for metabolism, specifically undergoing β-oxidation. Furthermore, it induces a permeability transition in cardiac mitochondrial membranes, leading to mitochondrial dysfunction. Palmitoleoyl-CoA lithium regulates metabolism through conformational control of the AMPK β1-isoform.

Pimeloyl-CoA lithium serves as a biotin precursor in Escherichia coli (E. coli). It is utilized in the study of the de novo biosynthesis pathway of biotin in Escherichia coli (E. coli).

Tetradec-13-ynoicacid-CoA, thioester (Tetradec-13-ynoic acid-coenzyme A thioester) is a derivative of coenzyme A.

Methylmalonyl coenzyme A (Methylmalonyl-CoA) is a metabolic product derived from the breakdown of odd-chain fatty acids, cholesterol, and certain amino acids, such as valine, isoleucine, methionine, and threonine. It is enzymatically converted into succinyl-CoA through the action of methylmalonyl-CoA mutase (MCM) utilizing coenzyme vitamin B12.

p-Coumaroyl-CoA (4-Coumaroyl-CoA) is a derivative of coenzyme A.

Itaconoyl-CoA (Itaconoyl coenzyme A) is a derivative of coenzyme A.

3-Hydroxybutyryl-CoA, a metabolite found in mice, E. coli, and others, contains 3-hydroxybutanoyl as the S-acyl component and serves as an intermediate in butyric acid fermentation and the metabolism of lysine and tryptophan [1].