anti-proliferation

CVT-11127 is an StearoylCoA Desaturase-1 (SCD1) inhibitor.

Golotimod (SCV 07) is an antimicrobial dipeptide with immunomodulatory activity that significantly improves the efficacy of anti-tuberculosis therapy, induces thymic and splenic cell proliferation, modulates macrophage function, and inhibits STAT3 signaling.Golotimod has been used in the study of recurrent genital Herpes Simplex Virus 2 (HSV-2) infection and oral mucositis.

Golotimod TFA (SCV 07 TFA) is a dipeptide exhibiting immunomodulatory and antibacterial activity. It reduces recurrent lesions caused by HSV-2, alleviates radiation-induced oral mucositis, and inhibits the homodimerisation of STAT3 molecules in the cytoplasm.

Ternatin is a cyclic heptapeptide first isolated from the mushroom C. versicolor that has been shown to have cytotoxic and anti-adipogenic effects in vitro. It inhibits adipogenesis with an IC50 value of 27 nM and becomes cytotoxic to 3T3-L1 mouse adipocytes at 10-fold higher concentrations. Ternatin is reported to inhibit HCT116 cell proliferation with an IC50 value of 71 nM. Note that this metabolite should not be confused with the plant flavonoid of the same name.

N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate, a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE), functions as a natural inhibitor of pluripotent hematopoietic stem cell proliferation and exhibits anti-inflammatory and antifibrotic properties [1] [2].

Scospondistatin, an anti-angiogenic peptide, inhibits both proliferation and migration of human umbilical vein endothelial cells in vitro [1].

Adamtsostatin 18, an anti-angiogenic peptide derived from proteins with type I thrombospondin motifs, suppresses cell migration and proliferation [1].

LL-37, Human TFA (154947-66-7 free base) is a 37-residue amphipathic helical peptide, the sole human cathelicidin antimicrobial peptide exhibiting moderate antibacterial activity against diverse Gram-negative and Gram-positive bacteria. LL-37, Human TFA binds to negatively charged bacterial membranes, disrupting cellular integrity. It also induces cellular immunomodulation, migration, proliferation, and differentiation, possesses anti-biofilm potential, and inhibits gastric cancer carcinogenesis.

VGB3 is a peptide antagonist of vascular endothelial growth factor receptor 1 (VEGFR1) and VEGFR2, exhibiting anti-angiogenic and anti-tumor properties. It binds to VEGFR1 and VEGFR2, thereby inhibiting VEGF-driven endothelial cell proliferation, migration, and tube formation, as well as suppressing tumor growth and metastasis in a mouse 4T1 breast cancer model.

ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent antitumor capabilities. It effectively inhibits the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induces apoptosis (apoptosis).

Pep1-DNP conjugate 9 is a functionalized peptide composed of a DNP-hapten and an FGFR1-binding peptide. It exhibits good affinity for FGFR1, with a dissociation constant (KD) of 5.01 μM. This compound effectively recruits anti-DNP antibodies to the surface of FGFR1-positive cells, inhibits FGF2-induced proliferation of rat skeletal myoblasts, and induces apoptosis. In mouse models, Pep1-DNP conjugate 9 demonstrates antitumor activity.

FOG-001 is an efficient inhibitor of β-catenin, with an IC50 value lower than 50 nM. This compound can block the interaction between β-catenin and T-cell factor (TCF) transcription factors, thereby interfering with the related signaling pathways. FOG-001 can effectively inhibit cell proliferation and induce cell cycle arrest. In a mouse xenograft tumor model carrying COLO320DM colon cancer cells (with APC and TP53 mutations), FOG-001 exhibits significant anti-tumor activity. Therefore, FOG-001 is applicable to the research on the mechanism of colon cancer occurrence and treatment.

TAT-327 is a cell-penetrating peptide known for selectively inserting into cancer cell membranes and exhibiting potent anti-tumor activity. It effectively inhibits cancer cell proliferation, induces apoptosis, and disrupts the EGFR signaling pathway by suppressing the expression of downstream signals (such as IL-2, TNF-α, and IFN-γ) and the interaction between Eps8 and EGFR. Additionally, TAT-327 significantly inhibits tumor growth in HT-29 xenograft models.

IIIM1 is an orally active anti-inflammatory peptide. It alleviates symptoms of experimental autoimmune encephalomyelitis (EAE) by stimulating the proliferation of regulatory T cells and inducing them to produce RA1, which balances cytokine levels. IIIM1 is applicable for research on multiple sclerosis (MS).